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    • 1. 发明授权
    • Immunoassays employing non-particulate chemiluminescent reagent
    • 免疫测定采用非微粒化学发光试剂
    • US09347947B2
    • 2016-05-24
    • US12403299
    • 2009-03-12
    • Pratap SinghYi Feng ZhengLiping GengRoland JanzenCarsten Schelp
    • Pratap SinghYi Feng ZhengLiping GengRoland JanzenCarsten Schelp
    • G01N21/76G01N33/58
    • G01N33/78G01N33/582G01N2333/59
    • Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    • 公开了用于进行测定的方法和试剂。 本发明方法和试剂的实施方案涉及用于确定怀疑含有分析物的样品中分析物的存在和/或量的化学发光试剂。 试剂是非颗粒的并且包含用于分析物的结合配偶体和包含烯属化合物和金属螯合物的化学发光组合物。 在测定的实施方案中,提供了包含疑似含有分析物的样品,如上所述的化学发光试剂和能够产生单线态氧的敏化剂的组合。 该组合经受用于将分析物与分析物的结合配偶体结合的条件。 敏化剂被激活,并且检测由化学发光组合物产生的发光量,其中发光量与样品中分析物的量相关。
    • 5. 发明授权
    • Stabilization of solid support assay reagents
    • 固体支持测定试剂的稳定化
    • US07842475B2
    • 2010-11-30
    • US11970658
    • 2008-01-08
    • Yi Feng ZhengTie Q. Wei
    • Yi Feng ZhengTie Q. Wei
    • G01N33/53
    • G01N33/54353C12Q1/6834G01N33/54333
    • Reagents are disclosed for use in assays for analytes. The reagents are dry assay reagents that may be readily reconstituted for use in the assays. The dry assay reagents comprise a solid support and one or more molecules of a receptor immobilized on the solid support. The receptor comprises one or more binding sites for a ligand. A portion of a total number of the binding sites is bound to a conjugate comprising the ligand linked to a specific binding pair member and a portion of the total number of the binding sites is free. In use in an assay, a combination is provided in an aqueous medium comprising the sample and reagents for detecting the analyte wherein at least one of the reagents comprises the dry assay reagent mentioned above. The combination is incubated under conditions for binding of the analyte to one or more of the reagents. The presence and/or amount of binding of the analyte to one or more of the reagents is detected where the presence and/or amount of the binding is related to the presence and/or amount of the analyte in the sample.
    • 公开了用于分析物测定的试剂。 试剂是可以容易地重构用于测定中的干测定试剂。 干测定试剂包含固体支持物和固定在固体支持物上的一个或多个受体分子。 受体包含一个或多个配体的结合位点。 结合位点总数的一部分与包含与特异性结合对成员连接的配体的缀合物结合,并且结合位点总数的一部分是游离的。 在测定中使用时,在包含样品的水性介质和检测分析物的试剂中提供组合,其中至少一种试剂包含上述干试剂。 将组合物在分析物与一种或多种试剂结合的条件下孵育。 检测分析物与一种或多种试剂结合的存在和/或量,其中结合的存在和/或量与样品中分析物的存在和/或量相关。
    • 6. 发明申请
    • IMMUNOASSAYS EMPLOYING NON-PARTICULATE CHEMILUMINESCENT REAGENT
    • 免费使用非颗粒性发光试剂
    • US20100233725A1
    • 2010-09-16
    • US12403299
    • 2009-03-12
    • Pratap SinghYi Feng ZhengLiping GengRoland JanzenCarsten Schelp
    • Pratap SinghYi Feng ZhengLiping GengRoland JanzenCarsten Schelp
    • G01N33/53
    • G01N33/78G01N33/582G01N2333/59
    • Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    • 公开了用于进行测定的方法和试剂。 本发明方法和试剂的实施方案涉及用于确定怀疑含有分析物的样品中分析物的存在和/或量的化学发光试剂。 试剂是非颗粒的并且包含用于分析物的结合配偶体和包含烯属化合物和金属螯合物的化学发光组合物。 在测定的实施方案中,提供了包含疑似含有分析物的样品,如上所述的化学发光试剂和能够产生单线态氧的敏化剂的组合。 该组合经受用于将分析物与分析物的结合配偶体结合的条件。 敏化剂被激活,并且检测由化学发光组合物产生的发光量,其中发光量与样品中分析物的量相关。