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1. 发明授权

US06509104B2 Antithrombogenic polymer coating 失效
公开(公告)号：US06509104B2
公开(公告)日：2003-01-21
申请号：US09730098
申请日：2000-12-05
申请人： Zhi Heng Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
发明人： Zhi Heng Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
IPC分类号： B32B2708
CPC分类号： C08L79/02 , A61L33/0029 , Y10S128/22 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725 , C08L77/00
摘要： An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.

2. 发明授权

US06495657B1 Two dimensional polyamides prepared from unsaturated carboxylic acids and amines 失效
标题翻译：由不饱和羧酸和胺制备的二维聚酰胺
公开(公告)号：US06495657B1
公开(公告)日：2002-12-17
申请号：US09698619
申请日：2000-10-27
申请人： William F. McDonald , Zhi Heng Huang , Stacy C. Wright , Morris Danzig , Andrew C. Taylor
发明人： William F. McDonald , Zhi Heng Huang , Stacy C. Wright , Morris Danzig , Andrew C. Taylor
IPC分类号： C08G6916
CPC分类号： C08G69/26 , C08G69/02 , C08G69/04 , C08G69/265 , Y10S128/22 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725
摘要： A polyamide and a process for preparing the polyamide are disclosed. The process comprises reacting in a reaction mixture a monomer selected from unsaturated carboxylic acids, esters of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and mixtures thereof, and a first amine to form an intermediate reaction product in the reaction mixture, wherein the first amine is selected from RR1NH, RNH2, RR1NH2+, RNH3+ and mixtures thereof, wherein R and R1 can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, and reacting the intermediate reaction product and a second amine to form a polyamide, wherein the second amine is selected from R2R3NH, R2NH2, R2R3NH2+, R2NH3+ and mixtures thereof wherein R2 and R3 can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, wherein multiple of the R, R1, R2, and R3 are in vertically aligned spaced relationship along a backbone formed by the polyamide. In one version of the invention, the monomer is selected from maleic anhydride, maleic acid esters, and mixtures thereof. In another version of the invention, the first amine is an alkylamine, such as tetradecylamine, and the second amine is a polyalkylene polyamine, such as pentaethylenehexamine. In yet another version of the invention, the first amine and the second amine are olefinic or acetylenic amines, such as the reaction products of an alkyldiamine and an acetylenic carboxylic acid. The first amine and the second amine may be the same or different depending on the desired polyamide polymer structure.
摘要翻译：公开了聚酰胺和制备聚酰胺的方法。该方法包括在反应混合物中使选自不饱和羧酸，不饱和羧酸的酯，不饱和羧酸的酸酐及其混合物的单体和第一胺反应以在反应混合物中形成中间反应产物，其中第一胺选自RR1NH，RNH2，RR1NH2 +，RNH3 +及其混合物，其中R和R 1可以相同或不同，并且各自含有约1至50个碳原子，并且任选被杂原子氧，氮，硫和磷取代，并且并且使中间反应产物和第二胺反应以形成聚酰胺，其中第二胺选自R2R3NH，R2NH2，R2R3NH2 +，R2NH3 +及其混合物，其中R2和R3可以相同或不同，并且各自含有约 1和50个碳原子，并且任选被杂原子氧，氮，硫和磷及其组合取代这里R，R 1，R 2和R 3的多个与由聚酰胺形成的骨架处于垂直对齐的间隔关系。在本发明的一个方案中，单体选自马来酸酐，马来酸酯及其混合物。在本发明的另一种形式中，第一种胺是烷基胺，如十四烷基胺，第二种胺是聚亚烷基多胺，如五亚乙基六胺。在本发明的又一版本中，第一种胺和第二种胺是烯属或炔属胺，如烷基二胺和炔属羧酸的反应产物。根据所需的聚酰胺聚合物结构，第一胺和第二胺可以相同或不同。

3. 发明授权

US06939554B2 Antimicrobial polymer 失效
标题翻译：抗微生物聚合物
公开(公告)号：US06939554B2
公开(公告)日：2005-09-06
申请号：US10068054
申请日：2002-02-05
申请人： William F. McDonald , Zhi-Heng Huang , Stacy C. Wright
发明人： William F. McDonald , Zhi-Heng Huang , Stacy C. Wright
IPC分类号： A01N25/10 , A01N31/06 , A01N31/14 , A01N33/06 , A01N43/40 , A01N47/44 , A01N59/12 , A61L27/34 , A61L27/54 , C08G69/02 , C08G69/48 , C08K5/00 , A01N25/00 , A61K31/74
CPC分类号： C08G69/48 , A01N25/10 , A01N31/06 , A01N31/14 , A01N33/06 , A01N43/40 , A01N47/44 , A01N59/12 , A61L27/34 , A61L27/54 , A61L2300/106 , A61L2300/202 , A61L2300/206 , A61L2300/208 , A61L2300/404 , A61L2300/442 , A61L2300/606 , C08G69/02 , C08K5/0058
摘要： A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl; and the antimicrobial agent is chlorhexidine, dimethylchlorophenol, cetyl pyridinium chloride, gentian violet, triclosan, thymol, iodine, and mixtures thereof.
摘要翻译：公开了具有抗微生物性质的聚合物组合物和用于使底物抗微生物剂表面呈现的方法。该组合物包含（i）沿形成聚合物的主链的含氨基侧链的聚合物的交联化学组合，（ii）选自季铵化合物，龙胆紫化合物，取代或未取代的酚，双胍化合物，碘化合物及其混合物，和（iii）含有能够与氨基反应的官能团的交联剂。在一个实施方案中，聚合物是由马来酸酐或马来酸酯单体和烷基胺形成的聚酰胺，从而在聚酰胺主链的一侧制备具有氨基取代的烷基链的聚酰胺; 交联剂是具有通式（A）3 P的膦，其中A是羟烷基; 抗菌剂为氯己定，二甲基氯苯酚，氯化十六烷基吡啶，龙胆紫，三氯生，百里酚，碘及其混合物。

4. 发明授权

US06797743B2 Antimicrobial polymer 失效
标题翻译：抗微生物聚合物
公开(公告)号：US06797743B2
公开(公告)日：2004-09-28
申请号：US09850324
申请日：2001-05-07
申请人： William F. McDonald , Stacy C. Wright , Andrew C. Taylor
发明人： William F. McDonald , Stacy C. Wright , Andrew C. Taylor
IPC分类号： C08K308
CPC分类号： A61Q17/005 , A01N25/10 , A01N59/16 , A61K8/88 , A61K2800/54 , A61K2800/58 , A61Q19/00 , C08K3/015 , C08K3/08 , C08K3/24 , A01N59/20 , A01N25/34 , A01N25/24 , A01N2300/00
摘要： A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from metals, metal alloys, metal salts, metal complexes and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one example embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl; and the metallic antimicrobial agent is selected from chelated silver ions, silver metal, chelated copper ions, copper metal, chelated zinc ions, zinc metal and mixtures thereof.
摘要翻译：公开了具有抗微生物性质的聚合物组合物和用于使底物抗微生物剂表面呈现的方法。聚合物组合物包含（i）沿着形成聚合物的骨架的含氨基侧链的聚合物的交联化学组合，（ii）选自金属，金属合金，金属盐，金属络合物及其混合物的抗微生物剂，和（iii）含有能够与氨基反应的官能团的交联剂。在一个示例性实施方案中，聚合物是由马来酸酐或马来酸酯单体和烷基胺形成的聚酰胺，从而在聚酰胺主链的一面上制备具有氨基取代的烷基链的聚酰胺; 交联剂是具有通式（A）3P的膦，其中A是羟烷基; 金属抗菌剂选自螯合银离子，银金属，螯合铜离子，铜金属，螯合锌离子，锌金属及其混合物。

5. 发明授权

US06399714B1 Crosslinked polyamide 失效
标题翻译：交联聚酰胺
公开(公告)号：US06399714B1
公开(公告)日：2002-06-04
申请号：US09671784
申请日：2000-09-27
申请人： Zhi H. Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
发明人： Zhi H. Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
IPC分类号： C08G6391
CPC分类号： C09D175/04 , C08G18/603 , C08G69/04 , C08G69/08 , C08G69/14 , C08L63/00 , C08L77/00 , C08L77/02 , Y10T428/31544 , Y10T428/31562 , Y10T428/31663 , Y10T428/31725 , Y10T428/31779 , Y10T428/31938
摘要： A crosslinked polyamide material and a process for preparing the crosslinked polyamide material are disclosed. The crosslinked polyamide material comprises a crosslinked chemical combination of (1) a polyamide of the formula: wherein n is between about 50 and 10,000, wherein each R is between 1 and 50 carbon atoms alone and is optionally substituted with heteroatoms, oxygen, nitrogen, sulfur, or phosphorus and combinations thereof, wherein multiple of the R are in vertically aligned spaced relationship along a backbone forming the polyamide, and wherein two or more of the R contain an amino group; and (2) a crosslinking agent containing at least two functional groups capable of reacting with the amino groups of the polyamide. In one embodiment of the invention, the crosslinking agent is an aliphatic or aromatic isocyanate compound having 2 or more —N═C═O groups. In another embodiment of the invention, the crosslinking agent is an aliphatic aldehyde or aromatic aldehyde compound having 2 or more —CHO groups. In still another embodiment of the invention, the crosslinking agent is selected from a phosphine having the general formula (A)2P(B) and mixtures thereof, wherein A is hydroxyalkyl, and B is hydroxyalkyl, alkyl, or aryl. In yet another embodiment of the invention, the crosslinking agent is selected from the group consisting of epoxy resins having more than one epoxide group per molecule.
摘要翻译：公开了交联聚酰胺材料和制备交联聚酰胺材料的方法。交联的聚酰胺材料包括（1）下式的聚酰胺的交联化学组合：其中n在约50和10,000之间，其中每个R单独在1至50个碳原子之间，并且任选地被杂原子，氧，氮，硫或磷及其组合，其中R的多个与形成聚酰胺的骨架处于垂直对准的间隔关系，并且其中两个或更多个R含有氨基; 和（2）含有至少两个能够与聚酰胺的氨基反应的官能团的交联剂。在本发明的一个实施方案中，交联剂是具有2个或更多个-N = C = O基团的脂族或芳族异氰酸酯化合物。在本发明的另一个实施方案中，交联剂是具有2个或更多个-CHO基团的脂族醛或芳族醛化合物。在本发明的另一个实施方案中，交联剂选自具有通式（A）2P（B）的膦及其混合物，其中A为羟烷基，B为羟烷基，烷基或芳基。在本发明的另一个实施方案中，交联剂选自每分子具有多于一个环氧基团的环氧树脂。

6. 发明授权

US08945380B1 System for treatment of biomass to facilitate the production of ethanol 有权
公开(公告)号：US08945380B1
公开(公告)日：2015-02-03
申请号：US12716989
申请日：2010-03-03
申请人： Jason Richard Kwiatkowski , William F. McDonald , David Charles Carlson
发明人： Jason Richard Kwiatkowski , William F. McDonald , David Charles Carlson
IPC分类号： B01D36/00
摘要： Systems for treating biomass for the production of ethanol are disclosed. The systems are configured to treat a liquid component separated from biomass to yield sugars available to be fermented into a fermentation product. The systems comprise a filter configured to remove particulate matter to provide a filtered component and an apparatus configured to remove inhibitors from the filtered liquid component provide a treated liquid component comprising sugars available for fermentation. Methods for treating for treating biomass useful in the production of a fermentation product are also disclosed. The methods include the steps of filtering a liquid component to remove particulate matter thereby yielding a filtered liquid component, and treating the filtered liquid component to remove inhibitors thereby yielding a treated liquid component comprising sugars available to be fermented into a fermentation product.

7. 发明授权

US06951902B2 Two dimensional polymer that generates nitric oxide 失效
标题翻译：产生一氧化氮的二维聚合物
公开(公告)号：US06951902B2
公开(公告)日：2005-10-04
申请号：US10222370
申请日：2002-08-16
申请人： William F. McDonald , Amy B. Koren
发明人： William F. McDonald , Amy B. Koren
IPC分类号： A61K9/70 , C08L77/00 , C08G69/10
CPC分类号： A61K9/7007
摘要： A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2− groups covalently bonded to amino groups on the polymer.
摘要翻译：公开了一种生成一氧化氮的聚合物组合物和通过将聚合物组合物的涂层施加到基底而使基底不发生表面的方法。该组合物包括：（1）（i）具有含有氨基侧链的聚合物的交联化学组合，形成聚合物的主链，和（ii）含有与氨基反应的官能团的交联剂; 和（2）与交联的化学组合相关的多个产生一氧化氮的官能团。一旦暴露于生理环境，涂层会产生一氧化氮，从而抑制血小板聚集。在一个实施方案中，产生一氧化氮的官能团由嵌入聚合物组合物中的硝化化合物（例如硝酸纤维素）提供。在另一个实施方案中，产生一氧化氮的官能团包含与聚合物上的氨基共价键合的N 2 O 2 O 2 O-O 2 - 。

8. 发明授权

US09663807B2 Systems and methods for hydrolysis of biomass 有权
公开(公告)号：US09663807B2
公开(公告)日：2017-05-30
申请号：US13980255
申请日：2012-01-18
申请人： Neelakantam V. Narendranath , William F. McDonald
发明人： Neelakantam V. Narendranath , William F. McDonald , Jason Alan Bootsma
IPC分类号： C12M1/00 , C12P19/14 , C12P7/10 , C12P19/02 , C13K1/02
CPC分类号： C12P19/14 , C12M21/12 , C12M43/02 , C12M45/04 , C12M45/06 , C12P7/10 , C12P19/02 , C12P2201/00 , C13K1/02 , Y02E50/16 , Y02E50/17
摘要： Systems and methods are disclosed for treating lignocellulosic biomass to be supplied to a fermentation system for production of a fermentation product. The systems and methods comprise pre-treating the biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose and lignin. The systems and methods also comprise treating the solids component of the pre-treated biomass into a treated component. The biomass comprises lignocellulosic material. Treating the solids component comprises application of an enzyme formulation and makeup water to form a slurry. The enzyme formulation comprises a cellulase enzyme. The makeup water includes a clarified thin stillage composition and/or an anaerobic membrane digester effluent composition.

9. 发明申请

US20130164804A1 Low Severity Pretreatment of Lignocellulosic Biomass 审中-公开
标题翻译：低密度木质纤维素生物质预处理
公开(公告)号：US20130164804A1
公开(公告)日：2013-06-27
申请号：US13722761
申请日：2012-12-20
申请人： David C. Walther , William F. McDonald
发明人： David C. Walther , William F. McDonald
IPC分类号： C08B1/00
CPC分类号： C08B1/003 , C08H8/00 , C12P7/065 , C12P7/10 , C12P7/16 , C12P7/28 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , C13K13/007 , Y02E50/10 , Y02E50/16 , Y02E50/17
摘要： Methods are provided for preparing a hydrolysate containing soluble sugar molecules from biomass that contains cellulose and hemicellulose. Hemicellulose sugars are extracted in the process, and the resulting hydrolysate may be used to support microbial fermentation to produce products of interest.
摘要翻译：提供了用于从含有纤维素和半纤维素的生物质制备含有可溶性糖分子的水解产物的方法。在该过程中提取半纤维素糖，并且所得水解产物可用于支持微生物发酵以产生感兴趣的产物。

10. 发明授权

US07204940B2 Conductive polymer-based material 失效
标题翻译：导电聚合物基材料
公开(公告)号：US07204940B2
公开(公告)日：2007-04-17
申请号：US10392347
申请日：2003-03-19
申请人： William F. McDonald , Amy B. Koren , Sunil K. Dourado , Joel I. Dulebohn , Robert J. Hanchar
发明人： William F. McDonald , Amy B. Koren , Sunil K. Dourado , Joel I. Dulebohn , Robert J. Hanchar
IPC分类号： H01B1/22
CPC分类号： H01B1/20 , C08G69/02 , C08G69/04 , C08K3/08 , C09D177/00 , C09D177/06 , H01B1/122 , C08L77/00
摘要： Disclosed are polymer-based coatings and materials comprising (i) a polymeric composition including a polymer having side chains along a backbone forming the polymer, at least two of the side chains being substituted with a heteroatom selected from oxygen, nitrogen, sulfur, and phosphorus and combinations thereof; and (ii) a plurality of metal species distributed within the polymer. At least a portion of the heteroatoms may form part of a chelation complex with some or all of the metal species. In many embodiments, the metal species are present in a sufficient concentration to provide a conductive material, e.g., as a conductive coating on a substrate. The conductive materials may be useful as the thin film conducting or semi-conducting layers in organic electronic devices such as organic electroluminescent devices and organic thin film transistors.
摘要翻译：公开了基于聚合物的涂料和材料，其包含（i）聚合物组合物，其包含沿着形成聚合物的主链的侧链的聚合物，至少两个侧链被选自氧，氮，硫和磷的杂原子取代及其组合; 和（ii）分布在聚合物内的多种金属物质。杂原子的至少一部分可以与一些或全部金属物质形成螯合络合物的一部分。在许多实施方案中，金属物质以足够的浓度存在以提供导电材料，例如作为基底上的导电涂层。导电材料可用作有机电子器件如有机电致发光器件和有机薄膜晶体管中的薄膜导电或半导体层。

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