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1. 发明授权

US09068206B1 System for treatment of biomass to facilitate the production of ethanol 有权
标题翻译：生物质处理系统，方便生产乙醇
公开(公告)号：US09068206B1
公开(公告)日：2015-06-30
申请号：US12716989
申请日：2010-03-03
申请人： Jason Richard Kwiatkowski , William F. McDonald , David Charles Carlson
发明人： Jason Richard Kwiatkowski , William F. McDonald , David Charles Carlson
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C13K1/04 , C13K13/002 , Y02E50/16
摘要： Systems for treating biomass for the production of ethanol are disclosed. The systems are configured to treat a liquid component separated from biomass to yield sugars available to be fermented into a fermentation product. The systems comprise a filter configured to remove particulate matter to provide a filtered component and an apparatus configured to remove inhibitors from the filtered liquid component provide a treated liquid component comprising sugars available for fermentation. Methods for treating for treating biomass useful in the production of a fermentation product are also disclosed. The methods include the steps of filtering a liquid component to remove particulate matter thereby yielding a filtered liquid component, and treating the filtered liquid component to remove inhibitors thereby yielding a treated liquid component comprising sugars available to be fermented into a fermentation product.
摘要翻译：公开了用于处理用于生产乙醇的生物质的系统。这些系统被配置为处理从生物质分离的液体成分以产生可用于发酵的发酵产物的糖。该系统包括被配置成去除颗粒物质以提供过滤组分的过滤器，以及被配置为从过滤的液体组分中除去抑制剂的装置，提供包含可用于发酵的糖的处理液体组分。还公开了处理用于生产发酵产物的生物质的处理方法。所述方法包括以下步骤：过滤液体组分以除去颗粒物从而产生过滤的液体组分，以及处理过滤的液体组分以除去抑制剂，从而产生包含可发酵成发酵产物的糖的处理液体组分。

2. 发明申请

US20140209092A1 SYSTEMS AND METHODS FOR ACID RECYCLE 有权
标题翻译：酸回收的系统和方法
公开(公告)号：US20140209092A1
公开(公告)日：2014-07-31
申请号：US14130878
申请日：2012-07-09
申请人： William F. McDonald , Shannon Scott Urban , Jason L. Martin
发明人： William F. McDonald , Shannon Scott Urban , Jason L. Martin
IPC分类号： C13K13/00 , C13K1/02
CPC分类号： C13K13/002 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/007 , Y02E50/16
摘要： Methods and systems for pretreating lignocellulosic biomass are disclosed. An acid solution between 1% to 1.6% sulfuric acid is applied to the biomass. The biomass is subjected to an elevated temperature to cause the production of xylose, glucose, and furfural. Adjustments to temperature, acid concentration, and time can generate at least 80% or 90% of theoretical xylose, 45% or 50% of the theoretical glucose, and less than 4000 ppm of furfural in the xylose liquor. A portion of the resulting xylose liquor may be separated from the glucan solids. The xylose liquor, still highly acidic, can be recycled to reduce subsequent acid loading requirements. Makeup acid solution is added to the xylose liquor and subsequent biomass to ensure a proper solids to liquids ratio. The biomass is again treated to higher temperatures to yield sugars. The process may be repeated for each subsequent cycle.
摘要翻译：公开了用于预处理木质纤维素生物质的方法和系统。将1％至1.6％硫酸的酸溶液施用于生物质。生物质经历升高的温度以产生木糖，葡萄糖和糠醛。温度，酸浓度和时间的调整可以产生理论木糖的至少80％或90％，理论葡萄糖的45％或50％，和木糖液中的糠醛少于4000ppm。所得木糖液体的一部分可以与葡聚糖固体分离。仍然高度酸性的木糖液体可被再循环以减少随后的酸负荷需求。将补充酸溶液加入到木糖液和随后的生物质中以确保适当的固体与液体的比例。再次将生物质处理至较高温度以产生糖。可以为每个后续循环重复该过程。

3. 发明授权

US06509104B2 Antithrombogenic polymer coating 失效
公开(公告)号：US06509104B2
公开(公告)日：2003-01-21
申请号：US09730098
申请日：2000-12-05
申请人： Zhi Heng Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
发明人： Zhi Heng Huang , William F. McDonald , Stacy C. Wright , Andrew C. Taylor
IPC分类号： B32B2708
CPC分类号： C08L79/02 , A61L33/0029 , Y10S128/22 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725 , C08L77/00
摘要： An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.

4. 发明申请

US20140234911A1 SYSTEMS AND METHODS FOR HYDROLYSIS OF BIOMASS 有权
标题翻译：生物质水解的系统和方法
公开(公告)号：US20140234911A1
公开(公告)日：2014-08-21
申请号：US13980255
申请日：2012-01-18
申请人： Neelakantam V. Narendranath , William F. McDonald
发明人： Neelakantam V. Narendranath , William F. McDonald , Jason Alan Bootsma
IPC分类号： C12P19/14 , C12P19/02
CPC分类号： C12P19/14 , C12M21/12 , C12M43/02 , C12M45/04 , C12M45/06 , C12P7/10 , C12P19/02 , C12P2201/00 , C13K1/02 , Y02E50/16 , Y02E50/17
摘要： Systems and methods are disclosed for treating lignocellulosic biomass to be supplied to a fermentation system for production of a fermentation product. The systems and methods comprise pre-treating the biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose and lignin. The systems and methods also comprise treating the solids component of the pre-treated biomass into a treated component. The biomass comprises lignocellulosic material. Treating the solids component comprises application of an enzyme formulation and makeup water to form a slurry. The enzyme formulation comprises a cellulase enzyme. The makeup water includes a clarified thin stillage composition and/or an anaerobic membrane digester effluent composition.
摘要翻译：公开了用于处理供应到用于生产发酵产物的发酵系统的木质纤维素生物质的系统和方法。系统和方法包括将生物质预处理成预处理的生物质并将预处理的生物质分离成包含糖和包含纤维素和木质素的固体组分的液体组分。所述系统和方法还包括将预处理的生物质的固体组分处理成经处理的组分。生物质包括木质纤维素材料。处理固体组分包括施用酶制剂和补充水以形成浆料。酶制剂包含纤维素酶。补充水包括澄清的薄釜组合物和/或厌氧膜蒸煮器流出物组合物。

5. 发明授权

US08597431B2 Biomass pretreatment 有权
标题翻译：生物质预处理
公开(公告)号：US08597431B2
公开(公告)日：2013-12-03
申请号：US12888957
申请日：2010-09-23
申请人： William F. McDonald , David Charles Carlson , Wiley D. Bradford
发明人： William F. McDonald , David Charles Carlson , Wiley D. Bradford
IPC分类号： C13K1/02 , B01J19/00
CPC分类号： C13K1/02 , Y02E50/16
摘要： A system for pre-treating biomass for the production of ethanol is provided. The system comprises a method for pre-treating biomass. The method comprises supplying biomass to a steaming bin, wherein the biomass is mixed with water, and inputting the steamed biomass to a first pretreatment reactor, wherein the steamed biomass comprises liquids and solids. The method also comprises removing a bulk of liquids from the solids and feeding the solids into a second pretreatment reactor. The method further comprises applying a pressure drop to the solids in the second pretreatment reactor, wherein the pressure drop opens up a structure of the solids, and sending the solids to a fermentation process for ethanol processing.
摘要翻译：提供了一种用于预处理用于生产乙醇的生物质的系统。该系统包括预处理生物质的方法。该方法包括将生物量提供给蒸汽箱，其中生物质与水混合，并将蒸出的生物质输入到第一预处理反应器中，其中蒸的生物质包含液体和固体。该方法还包括从固体中除去大量液体并将固体进料到第二预处理反应器中。该方法还包括向第二预处理反应器中的固体施加压降，其中压降打开固体的结构，并将固体送至用于乙醇加工的发酵方法。

6. 发明申请

US20120129234A1 SYSTEM FOR TREATMENT OF BIOMASS TO FACILITATE THE PRODUCTION OF ETHANOL 审中-公开
标题翻译：用于处理生物量以促进乙醇生产的系统
公开(公告)号：US20120129234A1
公开(公告)日：2012-05-24
申请号：US13300244
申请日：2011-11-18
申请人： William F. McDonald , Nicholas Paul Stutzman , David Charles Carlson
发明人： William F. McDonald , Nicholas Paul Stutzman , David Charles Carlson
IPC分类号： C12P7/10 , C12M1/16
CPC分类号： C12P7/06 , C12P7/10 , Y02E50/16
摘要： A method for treating fermented lignocellulosic biomass to be supplied to a distillation system for production of ethanol is provided. The method includes pre-treating lignocellulosic biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose and lignin. The method also includes hydrolysing the solids component of the pre-treated biomass into a hydrolysed biomass comprising sugars and lignin and fermenting the hydrolysed solids component of the pre-treated biomass into a fermentation product comprising ethanol and lignin. The method also includes treating the fermentation product and distilling the treated fermentation product to recover the ethanol. The lignocellulosic biomass comprises cellulose, hemi-cellulose and lignin.
摘要翻译：提供了一种用于处理供应到用于生产乙醇的蒸馏系统的发酵木质纤维素生物质的方法。该方法包括将木质纤维素生物质预处理成预处理的生物质并将预处理的生物质分离成包含糖和包含纤维素和木质素的固体组分的液体组分。该方法还包括将预处理的生物质的固体组分水解成包含糖和木质素的水解生物质，并将预处理的生物质的水解固体组分发酵成包含乙醇和木质素的发酵产物。该方法还包括处理发酵产物并蒸馏经处理的发酵产物以回收乙醇。木质纤维素生物质包括纤维素，半纤维素和木质素。

7. 发明申请

US20110008383A1 COMPOSITIONS OF TOLL-LIKE RECEPTOR AGONISTS AND MALARIA ANTIGENS AND METHODS OF USE 审中-公开
标题翻译：类似受体激动剂和疟疾抗体的组合物和使用方法
公开(公告)号：US20110008383A1
公开(公告)日：2011-01-13
申请号：US12814945
申请日：2010-06-14
申请人： THOMAS J. POWELL , VALERIAN NAKAAR , WILLIAM F. MCDONALD , ELIZABETH H. NARDIN
发明人： THOMAS J. POWELL , VALERIAN NAKAAR , WILLIAM F. MCDONALD , ELIZABETH H. NARDIN
IPC分类号： A61K39/015 , A61P37/04 , A61P33/06
CPC分类号： C07K14/445 , C07K14/255 , C07K2319/40
摘要： Compositions that include at least one fusion protein that includes at least a portion of at least one flagellin and at least a portion of at least one malaria antigen can be employed in methods that stimulate an immune response in a subject, in particular, sterile immunity and a protective immune response in a subject.
摘要翻译：包括至少一种包含至少一种鞭毛蛋白和至少一种疟疾抗原的至少一部分的融合蛋白的组合物可用于刺激受试者的免疫应答的方法，特别是无菌免疫和受试者的保护性免疫反应。

8. 发明申请

US20100233771A1 SYSTEM FOR PRE-TREATMENT OF BIOMASS FOR THE PRODUCTION OF ETHANOL 审中-公开
标题翻译：用于生产乙醇生产的预处理系统
公开(公告)号：US20100233771A1
公开(公告)日：2010-09-16
申请号：US12716984
申请日：2010-03-03
申请人： William F. McDonald , Jason Richard Kwiatkowski , Neelakantam V. Narendranath , Jason Alan Bootsma , David Charles Carlson
发明人： William F. McDonald , Jason Richard Kwiatkowski , Neelakantam V. Narendranath , Jason Alan Bootsma , David Charles Carlson
IPC分类号： C12P7/06 , C12M1/00
CPC分类号： C12P7/06 , C12M21/12 , C12M43/02 , C12N1/18 , C12N1/22 , C12P7/10 , C12P19/02 , C12P2201/00 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： A system for the pre-treatment of biomass for use in a biorefinery to produce ethanol and other bioproducts is disclosed. The system comprises a method comprising the steps of preparing the biomass into prepared biomass; pre-treating the prepared biomass into pre-treated biomass by application of a dilute acid having a concentration of about 0.8 to 1.1 percent by weight at a temperature of about 130 to about 170 degrees Celsius for a period of time in a range of about 8 to 12 minutes. The system also comprises an apparatus for separating the pre-treated biomass into a liquid component comprising pentose and a solids component comprising cellulose and lignin; a fermentation system configured to produce the fermentation product; and a distillation system. The fermentation product comprises ethanol. The biomass comprises lignocellulosic material, comprising corn cobs, corn plant husks, corn plant leaves and corn plant stalks.
摘要翻译：公开了用于预处理用于生物精炼生产乙醇和其他生物产物的生物质的系统。该系统包括一种方法，包括以下步骤：将生物质制备成制备的生物质; 在约130至约170摄氏度的温度下，将浓度为约0.8至1.1重量％的稀酸应用在约8℃的时间段内，将预制的生物质预处理成预处理的生物质至12分钟。该系统还包括用于将预处理的生物质分离成包含戊糖的液体组分和包含纤维素和木质素的固体组分的装置; 配置用于产生发酵产物的发酵系统; 和蒸馏系统。发酵产物包含乙醇。生物质包含木质纤维素材料，包括玉米芯，玉米植物壳，玉米植物叶和玉米植物茎。

9. 发明申请

US20090162400A1 Compositions of influenza viral proteins and methods of use thereof 审中-公开
标题翻译：流感病毒蛋白质的组成及其使用方法
公开(公告)号：US20090162400A1
公开(公告)日：2009-06-25
申请号：US11820148
申请日：2007-06-18
申请人： Thomas J. Powell , James W. Huleatt , Valerian Nakaar , Langzhou Song , William F. McDonald , Albert E. Price , Duane D. Hewitt
发明人： Thomas J. Powell , James W. Huleatt , Valerian Nakaar , Langzhou Song , William F. McDonald , Albert E. Price , Duane D. Hewitt
IPC分类号： A61K39/145 , A61P37/04
CPC分类号： A61K39/12 , A61K39/145 , A61K39/385 , A61K2039/55505 , A61K2039/55516 , A61K2039/6018 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2770/24122
摘要： Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
摘要翻译：组合物，融合蛋白质和多肽包含至少一种病原体相关分子模式和流感病毒抗原的至少一种整合膜蛋白的至少一部分。组合物，融合蛋白和多肽用于刺激受试者的免疫应答。

10. 发明授权

US06797743B2 Antimicrobial polymer 失效
标题翻译：抗微生物聚合物
公开(公告)号：US06797743B2
公开(公告)日：2004-09-28
申请号：US09850324
申请日：2001-05-07
申请人： William F. McDonald , Stacy C. Wright , Andrew C. Taylor
发明人： William F. McDonald , Stacy C. Wright , Andrew C. Taylor
IPC分类号： C08K308
CPC分类号： A61Q17/005 , A01N25/10 , A01N59/16 , A61K8/88 , A61K2800/54 , A61K2800/58 , A61Q19/00 , C08K3/015 , C08K3/08 , C08K3/24 , A01N59/20 , A01N25/34 , A01N25/24 , A01N2300/00
摘要： A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from metals, metal alloys, metal salts, metal complexes and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one example embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl; and the metallic antimicrobial agent is selected from chelated silver ions, silver metal, chelated copper ions, copper metal, chelated zinc ions, zinc metal and mixtures thereof.
摘要翻译：公开了具有抗微生物性质的聚合物组合物和用于使底物抗微生物剂表面呈现的方法。聚合物组合物包含（i）沿着形成聚合物的骨架的含氨基侧链的聚合物的交联化学组合，（ii）选自金属，金属合金，金属盐，金属络合物及其混合物的抗微生物剂，和（iii）含有能够与氨基反应的官能团的交联剂。在一个示例性实施方案中，聚合物是由马来酸酐或马来酸酯单体和烷基胺形成的聚酰胺，从而在聚酰胺主链的一面上制备具有氨基取代的烷基链的聚酰胺; 交联剂是具有通式（A）3P的膦，其中A是羟烷基; 金属抗菌剂选自螯合银离子，银金属，螯合铜离子，铜金属，螯合锌离子，锌金属及其混合物。

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