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1. 发明申请

US20120203792A1 SYSTEMS AND METHODS FOR MAPPING SEQUENCE READS 审中-公开
标题翻译：用于绘制序列读数的系统和方法
公开(公告)号：US20120203792A1
公开(公告)日：2012-08-09
申请号：US13363717
申请日：2012-02-01
申请人： Zheng ZHANG , Fiona HYLAND , Sowmi UTIRAMERUR
发明人： Zheng ZHANG , Fiona HYLAND , Sowmi UTIRAMERUR
IPC分类号： G06F17/30
CPC分类号： G16B30/00
摘要： Systems, methods, and computer program products for aligning a fragment sequence to a target sequencing. The alignment is allowed at most one gap, such as an insertion or a deletion. In some embodiments, both a gapped alignment and an ungapped alignment can be produced. A selection can be made between the gapped alignment and the ungapped alignment based on a quality value for each alignment.
摘要翻译：用于将片段序列与靶序列对齐的系统，方法和计算机程序产品。允许对齐至多一个间隙，例如插入或删除。在一些实施例中，可以产生间隙对准和无间隙对准。基于每个对准的质量值，可以在间隙对准和无间隙对准之间进行选择。

2. 发明申请

US20120011086A1 SYSTEMS AND METHODS FOR SEQUENCE DATA ALIGNMENT QUALITY ASSESSMENT 有权
标题翻译：序列数据对齐质量评估的系统和方法
公开(公告)号：US20120011086A1
公开(公告)日：2012-01-12
申请号：US13177267
申请日：2011-07-06
申请人： Zheng ZHANG , Sowmi Utiramerur , Fiona Hyland
发明人： Zheng ZHANG , Sowmi Utiramerur , Fiona Hyland
IPC分类号： G06N3/02
CPC分类号： G06F19/24 , G06F19/22 , G06N3/126 , G06N7/005
摘要： A computer-implemented method for classifying alignments of paired nucleic acid sequence reads is disclosed. A plurality of paired nucleic acid sequence reads is received, wherein each read is comprised of a first tag and a second tag separated by an insert region. Potential alignments for the first and second tags of each read to a reference sequence is determined, wherein the potential alignments satisfies a minimum threshold mismatch constraint. Potential paired alignments of the first and second tags of each read are identified, wherein a distance between the first and second tags of each potential paired alignment is within an estimated insert size range. An alignment score is calculated for each potential paired alignment based on a distance between the first and second tags and a total number of mismatches for each tag.
摘要翻译：公开了用于分类配对核酸序列读数的计算机实现的方法。接收多个配对的核酸序列读取，其中每个读取包括由插入区域分隔的第一标签和第二标签。确定每个读取到参考序列的第一和第二标签的潜在对准，其中所述电位对准满足最小阈值失配约束。识别每个读取的第一和第二标签的潜在配对比对，其中每个潜在配对对准的第一和第二标签之间的距离在估计的插入尺寸范围内。基于第一和第二标签之间的距离和每个标签的总失配数，针对每个潜在配对对齐计算对准分数。

3. 发明申请

US20130073214A1 SYSTEMS AND METHODS FOR IDENTIFYING SEQUENCE VARIATION 审中-公开
标题翻译：用于识别序列变异的系统和方法
公开(公告)号：US20130073214A1
公开(公告)日：2013-03-21
申请号：US13623709
申请日：2012-09-20
申请人： Fiona HYLAND , Eric TSUNG , Vasisht TADIGOTLA , Zheng ZHANG , Dumitru BRINZA , Onur SAKARYA , Xing XU
发明人： Fiona HYLAND , Eric TSUNG , Vasisht TADIGOTLA , Zheng ZHANG , Dumitru BRINZA , Onur SAKARYA , Xing XU
IPC分类号： G06F19/10
CPC分类号： G16B30/00
摘要： Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position.
摘要翻译：用于确定变体的系统和方法可以接收映射读取和调用变量。在实施例中，用于读取的流动空间信息可以与参考的对应部分的流动空间表示对齐。可以将具有潜在变体的位置的读数分组，并且可以为该变体计算得分。根据分数，可以提供可能的变体列表。在各种实施例中，可以识别在一个位置存在多个潜在变体的低频变体。

4. 发明申请

US20120054671A1 MULTI-TOUCH INTERFACE GESTURES FOR KEYBOARD AND/OR MOUSE INPUTS 有权
标题翻译：用于键盘和/或鼠标输入的多触屏界面
公开(公告)号：US20120054671A1
公开(公告)日：2012-03-01
申请号：US12871639
申请日：2010-08-30
申请人： Robert Lee THOMPSON , Xueliang HUA , Zheng ZHANG , Juan CASARES , Wenlong SHAO , Li-Zhu ZHANG
发明人： Robert Lee THOMPSON , Xueliang HUA , Zheng ZHANG , Juan CASARES , Wenlong SHAO , Li-Zhu ZHANG
IPC分类号： G06F3/033
CPC分类号： G06F3/038 , G06F3/04883 , G06F2203/0383 , G06F2203/04805 , G06F2203/04808
摘要： A computing device includes a touch screen displaying a graphical user interface (GUI) and a processing unit programmed to recognize gestures made on the touch screen and execute, in response thereto, a process associated with the gestures. The gestures include at least one of: a tap that causes an animation to be overlaid on the GUI at a location of the tap and, if a cursor is overlaid on the GUI, also causes the cursor to be moved to the location of the tap, a press-and-hold that causes a cursor overlaid on the GUI to be moved to a location of the press-and-hold, a press-and-hold in combination with a tap that causes a mouse right-click command to be executed, a press-and-hold that exceeds a predetermined amount of time in combination with a drag that causes a resizing of the GUI, a simultaneous three-tap that causes a keyboard to be launched and overlaid on the GUI to not obscure the portion of the GUI on top of which the simultaneous three-tap gesture was made, and a two-finger sweep that causes content within the GUI to be scrolled.
摘要翻译：计算设备包括显示图形用户界面（GUI）的触摸屏和被编程为识别在触摸屏上制作的手势并且响应于此而执行与手势相关联的处理的处理单元。手势包括以下中的至少一个：点击，其使动画在水龙头的位置上覆盖在GUI上，并且如果光标重叠在GUI上，则还使光标移动到水龙头的位置，将使GUI上重叠的光标移动到按住位置的按住按钮，与按下鼠标右键的命令组合的按钮组合按住并保持结合导致GUI调整大小的拖动超过预定时间量的按压和按压，同时三分键盘使得键盘被启动并重叠在GUI上以不使该部分变得模糊的GUI，其上同时进行三点击手势，以及使GUI内的内容滚动的双指扫描。

5. 发明申请

US20110270533A1 SYSTEMS AND METHODS FOR ANALYZING NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：用于分析核酸序列的系统和方法
公开(公告)号：US20110270533A1
公开(公告)日：2011-11-03
申请号：US13097677
申请日：2011-07-13
申请人： Zheng ZHANG , Danwei Guo , Yuandan Lou , Asim Siddiqui , Dumitru Brinza
发明人： Zheng ZHANG , Danwei Guo , Yuandan Lou , Asim Siddiqui , Dumitru Brinza
IPC分类号： G06F19/00
CPC分类号： G16B30/00
摘要： Nucleic acid sequence mapping/assembly methods are disclosed. The methods initially map only a contiguous portion of each read to a reference sequence and then extends the mapping of the read at both ends of the mapped contiguous portion until the entire read is mapped (aligned). In various embodiments, a mapping score can be calculated for the read alignment using a scoring function, score (i, j)=M+mx, where M can be the number of matches in the extended alignment, x can be the number of mismatches in the alignment, and m can be a negative penalty for each mismatch. The mapping score can be utilized to rank or choose the best alignment for each read.
摘要翻译：公开了核酸序列作图/装配方法。这些方法首先将每个读取的连续部分映射到参考序列，然后扩展映射的连续部分的两端的读取映射，直到整个读取被映射（对齐）。在各种实施例中，可以使用评分函数score（i，j）= M + mx来计算读取对齐的映射分数，其中M可以是扩展对齐中的匹配数，x可以是不匹配的数量在对齐中，m可以是每个不匹配的负面惩罚。映射分数可用于对每次读取进行排序或选择最佳对齐。

6. 发明申请

US20080189049A1 SYSTEM AND METHODS FOR INDEL IDENTIFICATION USING SHORT READ SEQUENCING 有权
标题翻译：使用短读取序列进行索引识别的系统和方法
公开(公告)号：US20080189049A1
公开(公告)日：2008-08-07
申请号：US12026477
申请日：2008-02-05
申请人： Zheng ZHANG
发明人： Zheng ZHANG
IPC分类号： G01N33/48
CPC分类号： G06F19/22
摘要： Systems, methods, and analytical approaches for short read sequence assembly and for the detection of insertions and deletions (indels) in a reference genome. A method suitable for software implementation is presented in which indels may be readily identified in a computationally efficient manner.
摘要翻译：用于短读序列组装和检测参考基因组中插入和缺失（indel）的系统，方法和分析方法。提出了适用于软件实现的方法，其中可以以计算上有效的方式容易地识别输入。

7. 发明申请

US20150056411A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 有权
标题翻译：抗微生物，抗血清生成组合物
公开(公告)号：US20150056411A1
公开(公告)日：2015-02-26
申请号：US14533908
申请日：2014-11-05
申请人： Zheng ZHANG , Jun LI , Chad C. HUVAL , Michael A. BOUCHARD , Arthur J. COURY , Christopher R. LOOSE
发明人： Zheng ZHANG , Jun LI , Chad C. HUVAL , Michael A. BOUCHARD , Arthur J. COURY , Christopher R. LOOSE
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附。

8. 发明申请

US20150045515A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 审中-公开
标题翻译：非反应性，抗微生物，抗组氨酸衍生物
公开(公告)号：US20150045515A1
公开(公告)日：2015-02-12
申请号：US14531383
申请日：2014-11-03
申请人： Jun LI , Zheng ZHANG , Chad C. HUVAL , Michael A. BOUCHARD , Christopher R. LOOSE , Arthur J. COURY
发明人： Jun LI , Zheng ZHANG , Chad C. HUVAL , Michael A. BOUCHARD , Christopher R. LOOSE , Arthur J. COURY
IPC分类号： C08F255/02 , C08G77/38 , C08G18/83 , C08G64/42
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

9. 发明申请

US20120259556A1 SYSTEM AND METHODS FOR INDEL IDENTIFICATION USING SHORT READ SEQUENCING 有权
标题翻译：使用短读取序列进行索引识别的系统和方法
公开(公告)号：US20120259556A1
公开(公告)日：2012-10-11
申请号：US13449898
申请日：2012-04-18
申请人： Zheng ZHANG
发明人： Zheng ZHANG
IPC分类号： G06F19/16
CPC分类号： G06F19/22
摘要： Systems, methods, and analytical approaches for short read sequence assembly and for the detection of insertions and deletions (indels) in a reference genome. A method suitable for software implementation is presented in which indels may be readily identified in a computationally efficient manner.
摘要翻译：用于短读序列组装和检测参考基因组中插入和缺失（indel）的系统，方法和分析方法。提出了适用于软件实现的方法，其中可以以计算上有效的方式容易地识别输入。

10. 发明申请

US20120127206A1 MULTI-TOUCH INTERFACE GESTURES FOR KEYBOARD AND/OR MOUSE INPUTS 审中-公开
标题翻译：用于键盘和/或鼠标输入的多触屏界面
公开(公告)号：US20120127206A1
公开(公告)日：2012-05-24
申请号：US13362854
申请日：2012-01-31
申请人： Robert Lee THOMPSON , Xueliang HUA , Zheng ZHANG , Juan CASARES , Wenlong SHAO , Li-Zhu ZHANG
发明人： Robert Lee THOMPSON , Xueliang HUA , Zheng ZHANG , Juan CASARES , Wenlong SHAO , Li-Zhu ZHANG
IPC分类号： G06F3/041 , G09G5/00
CPC分类号： G06F3/038 , G06F3/04883 , G06F2203/0383 , G06F2203/04805 , G06F2203/04808
摘要： A mouse-and-keyboard based user interface is updated based on gestures made on a touch screen that is displaying the mouse-and-keyboard based user interface. The user interface update process includes the steps of receiving one or more touch events in response to a gesture made on the touch screen, translating the touch events to a mouse-and-keyboard based command, transmitting the mouse-and-keyboard based command to an operating system, and receiving an updated display in response thereto.
摘要翻译：基于鼠标和键盘的用户界面基于在显示基于鼠标和键盘的用户界面的触摸屏上进行的手势来更新。用户界面更新处理包括以下步骤：响应于在触摸屏上所做的手势接收一个或多个触摸事件，将触摸事件转换为基于鼠标和键盘的命令，将基于鼠标和键盘的命令传送到操作系统，并响应于此接收更新的显示。

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