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1. 发明授权

US5466793A Process for preparing 2', 3'- dideoxyinosine 失效
标题翻译：制备2'，3'-二脱氧肌苷的方法
公开(公告)号：US5466793A
公开(公告)日：1995-11-14
申请号：US860605
申请日：1992-03-30
申请人： Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
发明人： Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
IPC分类号： C07H19/04 , C07H19/06 , C07H19/16 , C07H19/173 , C07H19/073
CPC分类号： C07H19/04 , C07H19/06 , C07H19/16 , Y02P20/55
摘要： A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or a silyl protecting group; X is Cl, Br, or I; R.sub.5 is C.sub.1-12 acyl; H.sub.x is hypoxanthine; with hydrogen in the presence of a palladium catalyst; wherein said reduction is conducted in a solvent containing a base of pH 9-11 and wherein the solvent is acetonitrile, aqueous acetonitrile, aqueous ethyl acetate, or aqueous methanol.
摘要翻译：制备2'，3'-二脱氧肌苷的方法，包括还原式IIIa或IIIb的核苷（IIIa）（IIIb）其中R2是氢，C1-12酰基，C1-12烷基，C7- 8芳烷基或甲硅烷基保护基; X是Cl，Br或I; R5是C1-12酰基; Hx是次黄嘌呤; 在钯催化剂存在下用氢气; 其中所述还原在含有pH9-11的碱的溶剂中进行，其中溶剂是乙腈，乙腈水溶液，乙酸乙酯水溶液或甲醇水溶液。

2. 发明授权

US5290927A Process for preparing 2',3'-dideoxyadenosine 失效
标题翻译：制备2'，3'-二脱氧腺苷的方法
公开(公告)号：US5290927A
公开(公告)日：1994-03-01
申请号：US317567
申请日：1989-03-01
申请人： Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
发明人： Yutaka Honda , Hiroshi Shiragami , Hisao Iwagami , Masayuki Arai
IPC分类号： C07H19/04 , C07H19/06 , C07H19/16 , C07H19/173 , C07H19/073
CPC分类号： C07H19/04 , C07H19/06 , C07H19/16
摘要： A process for preparing 2',3'-dideoxyadenosine of the formula ##STR1## wherein B is adenine, wherein R.sup.1 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl, or silyl, said process comprising:reducing a nucleoside of the formula IIIa or IIIb ##STR2## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or silyl; X is Cl, Br or I; R.sup.5 is C.sub.1-12 acyl and B is adenine, with hydrogen in the presence of a palladium catalyst and aqueous solvent mixture of acetonitrile or ethyl acetate and water, said aqueous solvent containing a base selected from the group consisting of sodium hydroxide/sodium acetate and sodium carbonate/sodium acetate, wherein said solvent has a pH of 9-11.
摘要翻译：一种制备式“IMAGE”的2'，3'-二脱氧腺苷的方法，其中B是腺嘌呤，其中R 1是氢，C 1-12酰基，C 1-12烷基，C 7-8芳烷基或甲硅烷基，所述方法包括：（IIIa）（IIIb）其中R2是氢，C1-12酰基，C1-12烷基，C7-8芳烷基或甲硅烷基的式IIIa或IIIb的核苷。 X是Cl，Br或I; R5是C1-12酰基，B是腺嘌呤，在钯催化剂和乙腈或乙酸乙酯与水的水溶剂混合物的存在下，氢气，所述含水溶剂含有选自氢氧化钠/乙酸钠和碳酸钠/乙酸钠，其中所述溶剂的pH为9-11。

3. 发明授权

US5451671A Method of purifying 2',3'-dideoxynucleosides 失效
标题翻译： 2'，3'-双脱氧核苷的纯化方法
公开(公告)号：US5451671A
公开(公告)日：1995-09-19
申请号：US76964
申请日：1993-06-16
申请人： Hiroshi Shiragami , Masayuki Arai , Kunisuke Izawa , Yutaka Honda , Yasuhiro Tanaka , Toshihide Yukawa , Satoji Takahashi
发明人： Hiroshi Shiragami , Masayuki Arai , Kunisuke Izawa , Yutaka Honda , Yasuhiro Tanaka , Toshihide Yukawa , Satoji Takahashi
IPC分类号： C07H1/06 , C07H19/04 , C07H19/173
CPC分类号： C07H1/06 , C07H19/04
摘要： A crude 2',3'-dideoxynucleoside compound is purified by extracting with an organic solvent, or crystallizing, the 2',3'-dideoxynucleoside compound from a basic aqueous solution having a pH of not less than 12 containing the same. In another embodiment of purification a basic aqueous solution having a pH of not less than 11 of a crude 2',3'-dideoxynucleoside derivative is brought into contact with a nonpolar porous resin, whereby the derivative is adsorbed on the resin, and then the thus adsorbed derivative is desorbed with an aqueous alcoholic solution.2',3'-Dideoxynucleoside compounds which have utility as anti-AIDS drugs or anti-virus drugs can be isolated and purified in high purity and in high yield from their crude products containing impurities.
摘要翻译：粗制的2'，3'-二脱氧核苷化合物通过用有机溶剂萃取，或从含有其的pH不低于12的碱性水溶液中结晶2'，3'-二脱氧核苷化合物而纯化。在纯化的另一个实施方案中，使粗制的2'，3'-二脱氧核苷衍生物的pH不低于11的碱性水溶液与非极性多孔树脂接触，由此将衍生物吸附在树脂上，然后将因此吸附的衍生物用含水醇溶液解吸。具有作为抗艾滋病药物或抗病毒药物的作用的2'，3'-二脱氧核苷化合物可以从其含有杂质的粗产物中以高纯度和高产率分离和纯化。

4. 发明授权

US06765100B2 Method for producing epoxide crystal 失效
标题翻译：环氧化物晶体的制备方法
公开(公告)号：US06765100B2
公开(公告)日：2004-07-20
申请号：US09973191
申请日：2001-10-10
申请人： Tomoyuki Onishi , Naoko Hirose , Yasuyuki Otake , Takashi Nakano , Yutaka Honda , Masakazu Nakazawa , Kunisuke Izawa
发明人： Tomoyuki Onishi , Naoko Hirose , Yasuyuki Otake , Takashi Nakano , Yutaka Honda , Masakazu Nakazawa , Kunisuke Izawa
IPC分类号： C07D30124
CPC分类号： C07C269/06 , C07B2200/07 , C07C269/08 , C07D263/24 , C07D303/36 , C07C271/16
摘要： The invention relates to a method for industrially producing highly pure (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide (crystal) or (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol. The method for producing N-carbamate-protected &bgr;-aminoepoxide crystal, includes one or more of the following steps (a) to (d): (a) dissolving (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol containing at least the diastereomer as an impurity in a solvent including at least one or more selected from aromatic hydrocarbon solvent, saturated hydrocarbon solvent, aqueous mixture solvent, acetone and 2-propanol, to remove insoluble matters; (b) treating the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol with a base, thereby converting the N-carbamate-protected &bgr;-aminoalcohol to (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide; (c) treating the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide containing at least the diastereomer as an impurity with an acid, thereby converting the diastereomer as an impurity to (4S, 5R) or (4R, 5S) oxazolidin-2-one derivative, and optionally separating and removing the resulting oxazolidin-2-one derivative in water or an aqueous mixture solvent; and (d) crystallizing the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide in a mixture solvent of water and water-miscible organic solvent. By the methods of the present invention, highly pure (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide or (2R, 3S) or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol can be efficiently produced.
摘要翻译：本发明涉及工业生产高纯度（2R，3S） - 或（2S，3R）-N-氨基甲酸酯保护的β-氨基环氧化物（晶体）或（2R，3S） - 或（2S，3R）-N 氨基甲酸酯保护的β-氨基醇。制备N-氨基甲酸酯保护的β-氨基环氧化物晶体的方法包括一个或多个以下步骤（a）至（d）:( a）将（2R，3S） - 或（2S，3R）-N-氨基甲酸酯在包含至少一种或多种选自芳族烃溶剂，饱和烃溶剂，含水混合物溶剂，丙酮和2-丙醇的溶剂的溶剂中至少含有作为杂质的非对映体的β-保护的β-氨基醇，以除去不溶物;（b）用碱处理（2R，3S） - 或（2S，3R）-N-氨基甲酸酯保护的β-氨基醇，从而将N-氨基甲酸酯保护的β-氨基醇转化为（2R，3S） - 或（2S，3R ）-N-氨基甲酸酯保护的β-氨基环氧化物;（c）用酸处理至少含有非对映体作为杂质的（2R，3S） - 或（2S，3R）-N-氨基甲酸酯保护的β-氨基环氧化物，由此将非对映异构体作为杂质转化为（4S，5R）或（4R，5S）恶唑烷-2-酮衍生物，任选分离和除去得到的恶唑烷-2-酮衍生物在水或含水混合溶剂中; 和（d）在水和水混溶性有机溶剂的混合溶剂中结晶（2R，3S） - 或（2S，3R）-N-氨基甲酸酯保护的β-氨基环氧化物。通过本发明的方法，高纯度（2R，3S） - 或（2S，3R）-N-氨基甲酸酯保护的β-氨基环氧化物或（2R，3S）或（2S，3R）-N-氨基甲酸酯保护的β - 氨基醇可以有效地生产。

5. 发明授权

US5767316A Process for producing 3-amino-2-oxo-1-halogenopropane derivatives 失效
公开(公告)号：US5767316A
公开(公告)日：1998-06-16
申请号：US752169
申请日：1996-11-18
申请人： Yutaka Honda , Satoshi Katayama , Kunisuke Izawa , Masakazu Nakazawa , Takayuki Suzuki , Naoko Kanno
发明人： Yutaka Honda , Satoshi Katayama , Kunisuke Izawa , Masakazu Nakazawa , Takayuki Suzuki , Naoko Kanno
IPC分类号： C07C221/00 , C07C223/02 , C07C227/16 , C07C227/32 , C07C229/22 , C07C229/34 , C07C269/06 , C07C271/22 , C07C319/20 , C07C323/43
CPC分类号： C07C271/22 , C07C221/00 , C07C227/16 , C07C227/32 , C07C229/22 , C07C229/34 , C07C269/06 , C07C319/20 , C07C323/43 , Y02P20/55
摘要： Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.

6. 发明授权

US4925537A Process for separation of hafnium tetrachloride from zirconium tetrachloride and electrode 失效
公开(公告)号：US4925537A
公开(公告)日：1990-05-15
申请号：US330893
申请日：1989-03-31
申请人： Tomoo Kirihara , Ippei Nakagawa , Yoshinobu Seki , Yutaka Honda , Yasuo Ichihara
发明人： Tomoo Kirihara , Ippei Nakagawa , Yoshinobu Seki , Yutaka Honda , Yasuo Ichihara
IPC分类号： C25B1/26 , B01D7/00 , C01G25/04 , C01G27/04 , C25B11/12
CPC分类号： C01G27/04 , C01G25/04
摘要： A process for separation of hafnium tetrachloride from zirconium tetrachloride and electrode is disclosed. Zirconium tetrachloride containing hafnium tetrachloride in natural ratio dissolved in a molten salt is reduced in the first phase electrolysis using an anode composed of a substance formed by firing a mixture of more than one kind of compound selected from the group consisting of silica, silicate containing zirconium or zirconium oxide and carbon with a binder under maintenance of an initial concentration of the zirconium tetrachloride in order to produce zirconium trichloride containing a hafnium content lower than that of the zirconium tetrachloride at a cathode. Next, by using the former cathode as an anode and another cathode in the second phase electrolysis the zirconium tetrachloride is further reduced to yield zirconium trichloride of a lower hafnium content at another cathode and evolve on the anode gaseous zirconium tetrachloride having a high pressure by oxidizing the zirconium trichloride produced in the first phase electrolysis. The evolved zirconium tetrachloride is recovered as zirconium tetrachloride with a low hafnium content. Further, the zirconium tetrachloride with a low hafnium content and the zirconium trichloride with a lower hafnium content are produced by exchanging polarities of the cathode and the anode when the zirconium trichloride on the anode decreases. The second phase electrolysis is carried out repeatedly. After hafnium tetrachloride is concentrated to an expected value in the molten salt in the above mentioned electrolysis, the molten salt is transferred to a separate vessel and is heated to evaporate the tetrachloride highly concentrated hafnium. Thus, zirconium tetrachloride and hafnium tetracholoride are respectively separated with high efficiency. A hafnium content of zirconium tetrachloride separated is able to reduce to less than 100 ppm, and a zirconium content of hafnium tetrachloride separated is also reduced to less than 25 wt %.

7. 发明授权

US4663232A Acrylic fiber having excellent durability and dyeability and process for preparation thereof 失效
标题翻译：丙烯酸纤维具有优异的耐久性和染色性及其制备方法
公开(公告)号：US4663232A
公开(公告)日：1987-05-05
申请号：US728276
申请日：1985-04-29
申请人： Kenji Kamide , Yutaka Honda , Shuji Kajita
发明人： Kenji Kamide , Yutaka Honda , Shuji Kajita
IPC分类号： D01F6/40 , D01D5/06 , D01F6/18 , D01F6/38 , D02J1/22 , D02G3/00
CPC分类号： D01F6/18 , Y10T428/2978 , Y10T428/298
摘要： Disclosed is an acrylic fiber composed of an acrylonitrile homopolymer or copolymer whose surface consists of particulate and/or microfibrillar structures having a width of 0.01 to 0.5 .mu.m and a length of 0.05 to 10 .mu.m and fibrillar structures formed by aggregation of the particulate and/or microfibrillar structures and having a width of 0.1 to 10 .mu.m and a length of at least 50 .mu.m. The fiber is prepared by spinning a dope of an acrylonitrile homopolymer or copolymer in a solvent at a draft ratio of at least 5 into a coagulating bath comprising a solvent and a coagulant and having a composition such that a skin layer is not formed on the coagulated fiber; taking up the coagulated fiber from the coagulating bath so that the retention time in the coagulating bath is within 60 seconds; and then drawing the fiber in a drawing bath comprising a solvent and a coagulant and having a coagulating property to the dope and a composition such that a skin layer is not formed on the fiber.
摘要翻译：公开了由丙烯腈均聚物或共聚物组成的丙烯酸纤维，其表面由宽度为0.01至0.5μm和长度为0.05至10μm的颗粒和/或微原纤维结构组成，并且通过颗粒和 /或微原纤维结构，宽度为0.1〜10μm，长度为50μm以上。纤维通过将丙烯腈均聚物或共聚物的涂料在溶剂中以至少5的牵伸比纺丝到包含溶剂和凝结剂的凝结浴中并具有使得在凝固物上不形成表皮层的组合物来制备纤维; 从凝固浴中吸收凝固纤维，使得凝固浴中的停留时间在60秒以内; 然后在包含溶剂和凝结剂的拉伸浴中将纤维拉伸到涂料上并具有凝胶性的组合物，使得在纤维上不形成表皮层。

8. 发明授权

US08398267B2 Illumination device with semiconductor light-emitting elements 失效
标题翻译：具有半导体发光元件的照明装置
公开(公告)号：US08398267B2
公开(公告)日：2013-03-19
申请号：US13449513
申请日：2012-04-18
申请人： Tomohiro Sanpei , Yumiko Hayashida , Masahiro Izumi , Kiyoshi Otani , Yutaka Honda
发明人： Tomohiro Sanpei , Yumiko Hayashida , Masahiro Izumi , Kiyoshi Otani , Yutaka Honda
IPC分类号： F21V7/22
CPC分类号： H05K1/0203 , H01L33/60 , H01L33/62 , H01L33/642 , H01L2224/32188 , H01L2224/32245 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/73265 , H01L2924/01012 , H01L2924/01019 , H01L2924/01078 , H01L2924/3025 , H05K3/0061 , H05K2201/09054 , H05K2201/10106 , H01L2924/00014 , H01L2924/00
摘要： An illumination device includes a base board, an insulator, a conductor, a plurality of semiconductor light-emitting elements and a light-transmissive sealing member. The base board includes a surface and projection portions. The projection portion is formed to become gradually thicker from its end toward the surface of the base board. The insulator is formed on the surface. The conductor is formed on the insulator. The semiconductor light-emitting elements are mounted on the projection portions. The semiconductor light-emitting elements are electrically connected to the conductor via connection members. The sealing member covers the insulator, the projection portions, the semiconductor light-emitting elements and the connection members.
摘要翻译：照明装置包括基板，绝缘体，导体，多个半导体发光元件和透光密封构件。基板包括表面和突出部分。突起部形成为从其端部朝向基板的表面逐渐变厚。绝缘体形成在表面上。导体形成在绝缘体上。半导体发光元件安装在突出部分上。半导体发光元件通过连接构件电连接到导体。密封构件覆盖绝缘体，突出部分，半导体发光元件和连接构件。

9. 发明申请

US20120081897A1 LUMINAIRE 审中-公开
公开(公告)号：US20120081897A1
公开(公告)日：2012-04-05
申请号：US13239429
申请日：2011-09-22
申请人： Kozo OGAWA , Kazunari Higuchi , Shigetoshi Komiyama , Yutaka Honda , Takayoshi Moriyama
发明人： Kozo OGAWA , Kazunari Higuchi , Shigetoshi Komiyama , Yutaka Honda , Takayoshi Moriyama
IPC分类号： F21V13/04
CPC分类号： F21V5/00 , F21V5/007 , F21V5/045 , F21Y2115/10 , G02B3/08
摘要： A luminaire includes a plurality of light-emitting elements, and an optical member. The optical member is formed a refractive area of a Fresnel lens for each of the light-emitting elements individually and a reflective area of the Fresnel lens between the refractive areas.
摘要翻译：照明装置包括多个发光元件和光学构件。光学构件分别形成用于每个发光元件的菲涅尔透镜的折射区域和在折射区域之间的菲涅尔透镜的反射区域。

10. 发明申请

US20090307030A1 RISK MANAGEMENT SUPPORT SERVER AND JOB SUPPORT DEVICE 审中-公开
标题翻译：风险管理支持服务器和工作支持设备
公开(公告)号：US20090307030A1
公开(公告)日：2009-12-10
申请号：US12295116
申请日：2007-03-28
申请人： Yutaka Honda
发明人： Yutaka Honda
IPC分类号： G06Q10/00 , G06F15/16 , G06N5/02
CPC分类号： G06Q40/08 , G06Q10/0635
摘要： A risk management support server possible of obtaining support information according to various viewpoints of risk management is provided. In client (4), a flow controller (111) displays information for selecting a field name by which support information of a temporary DB group (1300A) is classified. The client 4 informs the flow controller (111) of the selected field name. The flow controller (111) classifies pieces of the support information within the temporary DB group (1300A) for each same content using the informed field name. The flow controller (111) displays the pieces of the support information in the client (4), associated with each of the content.
摘要翻译：提供了可以根据各种风险管理观点获取支持信息的风险管理支持服务器。在客户端（4）中，流控制器（111）显示用于选择临时DB组（1300A）的支持信息被分类的字段名称的信息。客户端4通知流量控制器（111）所选择的字段名称。流量控制器（111）使用通知字段名称对每个相同内容对临时DB组（1300A）内的支持信息进行分类。流量控制器（111）在客户端（4）中显示与每个内容相关联的支持信息。

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