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1. 发明申请

US20090136508A1 METHOD OF DIAGNOSING COLON AND GASTRIC CANCERS 审中-公开
标题翻译：诊断结肠癌和胃癌的方法
公开(公告)号：US20090136508A1
公开(公告)日：2009-05-28
申请号：US12250419
申请日：2008-10-13
申请人： Yusuke NAKAMURA , Yoichi Furukawa
发明人： Yusuke NAKAMURA , Yoichi Furukawa
IPC分类号： A61K39/395 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K39/00 , A61K38/17 , C12N5/02 , C07K16/18 , C07H21/02 , C12Q1/68 , G01N33/53 , A61K31/7088
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
摘要： Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer-associated gene that discriminate between colon or gastric cancer and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌和胃癌的客观方法。在一个实施方案中，诊断方法涉及确定区分结肠癌或胃癌和正常细胞的结肠癌或胃癌相关基因的表达水平。本发明进一步提供筛选用于治疗结肠癌的治疗剂的方法以及接种对抗结肠癌或胃癌的方法。

2. 发明申请

US20110228662A1 OPTICAL DISK REPRODUCING APPARATUS 有权
标题翻译：光盘再现设备
公开(公告)号：US20110228662A1
公开(公告)日：2011-09-22
申请号：US13150758
申请日：2011-06-01
申请人： Yusuke NAKAMURA , Masakazu Ikeda
发明人： Yusuke NAKAMURA , Masakazu Ikeda
IPC分类号： G11B20/10
CPC分类号： G11B7/005 , G11B20/10009 , G11B20/10037 , G11B20/10046 , G11B20/10055 , G11B20/10111 , G11B20/1012 , G11B20/10212 , G11B20/1496 , G11B2220/213 , G11B2220/2579
摘要： The present invention relates to an optical disk reproducing apparatus, and provides a technology capable of supporting even a situation in which a reproduction signal characteristic is changed due to a factor other than recording density of an optical disk by using PRML of different constrained length and capable of improving reading accuracy. The optical disk reproducing apparatus includes a PRML circuit of first constrained length (for example, 4) and a PRML circuit of second constrained length (for example, 5). Equalization error values obtained during calculation of equalization learning in respective circuits are compared with each other in a determination circuit. Switching control of a switch is performed so that an output of one of the PRML circuits having a smaller equalization error value is selected.
摘要翻译：光盘重放装置技术领域本发明涉及光盘重放装置，并且提供了一种能够通过使用不同约束长度的PRML而能够支持再现信号特性由于光盘的记录密度而不是由记录密度而变化的情况的技术提高阅读精度。光盘再现装置包括第一约束长度（例如4）的PRML电路和第二约束长度的PRML电路（例如5）。在各个电路中的均衡学习计算中获得的均衡误差值在确定电路中彼此进行比较。执行开关的开关控制，使得选择具有较小均衡误差值的PRML电路之一的输出。

3. 发明申请

US20090103831A1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND PROGRAM THEREFOR 失效
标题翻译：图像处理装置，图像处理方法及其程序
公开(公告)号：US20090103831A1
公开(公告)日：2009-04-23
申请号：US12252559
申请日：2008-10-16
申请人： Yusuke NAKAMURA , Shinichiro Gomi , Masami Ogata
发明人： Yusuke NAKAMURA , Shinichiro Gomi , Masami Ogata
IPC分类号： G06K9/40
CPC分类号： G06T5/10 , G06T5/007 , G06T7/13 , G06T7/40
摘要： An image processing apparatus processes an input image while also considering the luminous intensity information thereof, and thereby generates an output image wherein the apparent object surface roughness has been enhanced with respect to the input image. The image processing apparatus includes a luminous intensity information separator that separates the input image information into global luminous intensity information and local luminous intensity information, a shadow component generator that generates a shadow component of the image on the basis of the local luminous intensity information, and an image compositor that generates an output image by adding shadow image information to the input image information, with the shadow image information being generated from the shadow component and from a value based on the input image information.
摘要翻译：图像处理装置在考虑其输出图像的同时考虑其输入图像，并且产生相对于输入图像增强了表观物体表面粗糙度的输出图像。该图像处理装置包括将输入图像信息分离为全局发光强度信息和局部发光强度信息的发光强度信息分离器，基于局部发光强度信息生成图像的阴影分量的阴影分量发生器，以及图像合成器，其通过将阴影图像信息添加到输入图像信息，并且从阴影分量生成阴影图像信息和基于输入图像信息的值来生成输出图像。

4. 发明申请

US20080286783A1 NOVEL METHOD OF DETECTING GENETIC POLYMORPHISM 有权
标题翻译：检测遗传多态性的新方法
公开(公告)号：US20080286783A1
公开(公告)日：2008-11-20
申请号：US12058318
申请日：2008-03-28
申请人： Naoya HOSONO , Mitsuaki KUBO , Yusuke NAKAMURA
发明人： Naoya HOSONO , Mitsuaki KUBO , Yusuke NAKAMURA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2561/109 , C12Q2537/157
摘要： The present invention provides a novel polymorphism detecting method suitable for the detection and identification of copy number variation.Provided is a method of determining the genotype of a subject in a genomic region comprising an SNP site, comprising a step for performing typing of the SNP site by the invader assay with a DNA-containing sample comprising the genomic region from the subject as the template, wherein fluorescence is measured on a real time basis. The copy number ratio of both alleles is determined using the fluorescence intensity ratio of each allele at a time before saturation of fluorescence intensity. Preferably, the present method further comprises a step for amplifying the genomic region comprising an SNP site prior to the invader step. In this step of amplification, a plurality of regions comprising a plurality of SNP sites can be simultaneously amplified. Furthermore, the present method enables the determination of the copy number of each allele when combined with quantitative PCR.
摘要翻译：本发明提供了一种适用于检测和鉴定拷贝数变异的新型多态性检测方法。提供了确定包含SNP位点的基因组区域中受试者的基因型的方法，其包括通过使用含有来自受试者的基因组区域作为模板的含有DNA的样品通过侵入测定进行SNP位点的分型的步骤其中荧光是实时测量的。使用荧光强度饱和之前的每个等位基因的荧光强度比来确定两个等位基因的拷贝数比。优选地，本方法还包括在入侵者步骤之前扩增包含SNP位点的基因组区域的步骤。在该扩增步骤中，可以同时扩增包含多个SNP位点的多个区域。此外，当与定量PCR组合时，本方法能够确定每个等位基因的拷贝数。

5. 发明申请

US20120243393A1 OPTICAL INFORMATION RECORDING METHOD, OPTICAL INFORMATION REPRODUCTION METHOD AND OPTICAL DISK DEVICE 有权
标题翻译：光信息记录方法，光信息再现方法和光盘设备
公开(公告)号：US20120243393A1
公开(公告)日：2012-09-27
申请号：US13479734
申请日：2012-05-24
申请人： Koichiro NISHIMURA , Yusuke NAKAMURA
发明人： Koichiro NISHIMURA , Yusuke NAKAMURA
IPC分类号： G11B7/126
CPC分类号： G11B20/10009 , G11B7/00456 , G11B7/1267 , G11B20/10046 , G11B20/10055 , G11B20/10194 , G11B20/10212 , G11B20/10222 , G11B20/10481
摘要： When a phase shift is to be evaluated, based on a difference between an output from a waveform equalization circuit to equalize an input reproduced signal to a predetermined target equalization characteristic and the target equalization characteristic, the phase shift of the reproduced signal relative to a channel clock, a group delay characteristic with respect to the frequency of the waveform equalization circuit is fixed. Hence, an equalized waveform as an output from the waveform equalization circuit can preserve phase shift information of the inputted reproduced signal to correctly detect the phase shift of the reproduced waveform using the equalized waveform. It is hence possible to realize, with high precision, optimal value learning of various parameters for the recording, reproduction, and servo by use of the phase shift as an index.
摘要翻译：当要评估相移时，基于来自波形均衡电路的输出之间的差以将输入再现信号均衡到预定的目标均衡特性和目标均衡特性，再现信号相对于通道的相移时钟，相对于波形均衡电路的频率的组延迟特性是固定的。因此，作为来自波形均衡电路的输出的均衡波形可以保存输入的再现信号的相移信息，以使用均衡波形来正确地检测再现波形的相移。因此，通过使用相移作为指标，可以高精度地实现用于记录，再现和伺服的各种参数的最佳值学习。

6. 发明申请

US20110027289A1 METHOD FOR TREATING SYNOVIAL SARCOMA 有权
标题翻译：治疗SARCOMA的方法
公开(公告)号：US20110027289A1
公开(公告)日：2011-02-03
申请号：US12769599
申请日：2010-04-28
申请人： Yusuke NAKAMURA , Toyomasa Katagiri , Chikako Fukukawa
发明人： Yusuke NAKAMURA , Toyomasa Katagiri , Chikako Fukukawa
IPC分类号： A61K39/395 , A61K31/713 , A61K31/7105 , C12N5/071 , A61P35/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/34 , C07K2317/732 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject is provided.
摘要翻译：公开了使用差异表达基因检测滑膜肉瘤的方法。还公开了鉴定用于治疗滑膜肉瘤的药剂的方法。此外，提供了治疗或预防与受试者中的卷曲同源物10（FZD10）相关的疾病的方法。

7. 发明申请

US20100290705A1 Image Processing Apparatus and Method, Image Capturing Apparatus, and Program 有权
标题翻译：图像处理装置和方法，图像捕获装置和程序
公开(公告)号：US20100290705A1
公开(公告)日：2010-11-18
申请号：US12740451
申请日：2009-09-08
申请人： Yusuke NAKAMURA
发明人： Yusuke NAKAMURA
IPC分类号： G06K9/34
CPC分类号： G06T3/0056 , G06T11/60 , G06T2210/22 , H04N1/3872 , H04N5/232 , H04N5/23222 , H04N5/23229 , H04N5/23293 , H04N5/2621 , H04N2101/00
摘要： The present invention relates to an image processing apparatus and method, an image capturing apparatus, and a program which make it possible to crop an image with an optimal composition even for a subject other than a person.A composition pattern setting section 33 sets a composition pattern corresponding to an input image, on the basis of the number of salient regions to which attention is directed in the input image, and the scene of the input image. On the basis of the composition pattern set by the composition pattern setting section 33, a composition analyzing section 34 determines a crop region in the input image which is optimal for an image to be cropped in the composition pattern from the input image. The present invention is applicable to, for example, an image processing apparatus that adjusts the composition of a captured image.
摘要翻译：本发明涉及一种图像处理装置和方法，图像捕获装置和程序，使得即使对于除了人之外的对象也可以以最佳组合来裁剪图像。合成图案设定部分33基于输入图像中关注的突出区域的数量和输入图像的场景来设置与输入图像相对应的合成图案。根据由构图图案设定部33设定的构图图案，构图分析部34根据输入图像确定输入图像中的剪裁区域，该剪切区域对于要被裁剪的图像最佳。本发明可应用于例如调整拍摄图像的构图的图像处理装置。

8. 发明申请

US20080152240A1 Image-Processing Device, Image-Processing Method, Program of Image-Processing Method, and Recording Medium Recording Program of Image-Processing Method 失效
标题翻译：图像处理装置，图像处理方法，图像处理方法的程序和图像处理方法的记录介质记录程序
公开(公告)号：US20080152240A1
公开(公告)日：2008-06-26
申请号：US11954781
申请日：2007-12-12
申请人： Shinichiro GOMI , Yusuke NAKAMURA , Masami OGATA
发明人： Shinichiro GOMI , Yusuke NAKAMURA , Masami OGATA
IPC分类号： G06K9/36 , G06K9/40
CPC分类号： G06T5/002 , G06T7/13 , G06T2207/20021 , G06T2207/20192
摘要： An image-processing device including a pulverization-core unit configured to divide input-image data into blocks, generate basic blocks by reducing each of the blocks in size, and arrange the basic blocks into the blocks so that processed-image data including at least one noise particle of the input-image data is generated, where the noise particle included in the processed-image data is reduced in size, an edge-detection unit configured to detect an edge degree from the input-image data, and an edge-blend unit configured to subject a pixel value of the input-image data and a pixel value of the processed-image data to load addition and output output-image data based on the detection result so that a weight to the pixel value of the input-image data increases as the edge degree increases is provided.
摘要翻译：一种图像处理装置，包括被配置为将输入图像数据划分成块的粉碎核心单元，通过减小每个块的大小来生成基本块，并且将基本块排列成块，使得处理图像数据至少包括产生输入图像数据的一个噪声粒子，其中包括在处理图像数据中的噪声粒子的尺寸减小，被配置为从输入图像数据检测边缘度的边缘检测单元，混合单元，其被配置为对所述输入图像数据的像素值和所述经处理图像数据的像素值进行加载，并且基于所述检测结果来输出输出图像数据，使得对所述输入图像数据的像素值进行加权，当提供边缘度增加时，图像数据增加。

9. 发明申请

US20120307032A1 IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, IMAGE PROCESSING SYSTEM, PROGRAM, AND RECORDING MEDIUM 有权
标题翻译：图像处理装置，图像处理方法，图像处理系统，程序和记录介质
公开(公告)号：US20120307032A1
公开(公告)日：2012-12-06
申请号：US13483446
申请日：2012-05-30
申请人： Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA , Hideo SATO , Kazuo OMORI , Mitsuharu OHKI
发明人： Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA , Hideo SATO , Kazuo OMORI , Mitsuharu OHKI
IPC分类号： G06K9/62 , H04N7/18
CPC分类号： A61B5/441 , A61B5/0077 , A61B5/103 , G06F19/321 , G06T7/44 , G06T2207/10148 , G06T2207/10152 , G06T2207/20081 , G06T2207/30088 , G06T2207/30201
摘要： Provided is an image processing device including a specifying unit configured to specify a part of a living body within a first image on the basis of a characteristic amount of the first image capturing skin of the living body, and a setting unit configured to set a capturing condition under which a second image indicating a state of the skin of the part is captured in response to the specified part.
摘要翻译：本发明提供一种图像处理装置，其特征在于，包括：指定部，其基于所述生物体的第一图像拍摄皮肤的特征量，指定第一图像内的生物体的一部分;以及设定部，响应于指定部分捕获指示部件的皮肤状态的第二图像的条件。

10. 发明申请

US20120021946A1 METHOD OF DIAGNOSING ESOPHAGEAL CANCER 有权
标题翻译：诊断食管癌的方法
公开(公告)号：US20120021946A1
公开(公告)日：2012-01-26
申请号：US13246639
申请日：2011-09-27
申请人： Yusuke NAKAMURA , Yataro Daigo , Shuichi Nakatsuru
发明人： Yusuke NAKAMURA , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： C40B30/04 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y10T436/25
摘要： In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray representing 32,256 genes was constructed to analyze the expression profiles of 19 esophageal squamous-cell carcinomas (ESCCS) purified by laser-capture microdissection. A detailed genome-wide database for sets of genes that are significantly up- or down-regulated in esophageal cancer is disclosed herein. These genes find use in the development of therapeutic drugs or immunotherapy as well as tumor markers. Additionally, genes associated with lymph-node metastasis and post-surgery recurrence are disclosed herein. Among the candidate molecular target genes, ECT2, CDC45L and DKK1 are further characterized. Treatment of ESCC cells with small interfering RNAs (siRNAs) of ECT2 or CDC45L suppressed growth of the cancer cells. Thus, the data herein provide valuable information for identifying diagnostic systems and therapeutic target molecules for esophageal cancer.
摘要翻译：为了鉴定涉及食管癌发生的分子以及可用于诊断标志物以及新药和免疫治疗靶标的分子，构建了代表32,256个基因的cDNA微阵列，分析19例食管鳞状细胞癌（ESCCS）的表达谱）通过激光捕获显微切割纯化。本文公开了在食管癌中显着上调或下调的基因组的详细全基因组数据库。这些基因可用于治疗药物或免疫治疗以及肿瘤标志物的开发。此外，本文公开了与淋巴结转移和手术后复发相关的基因。在候选分子靶基因中，进一步表征ECT2，CDC45L和DKK1。用ECT2或CDC45L的小干扰RNA（siRNA）处理ESCC细胞抑制癌细胞的生长。因此，本文的数据提供了用于鉴定诊断系统和用于食管癌的治疗靶分子的有价值的信息。

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