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1. 发明申请

US20090136508A1 METHOD OF DIAGNOSING COLON AND GASTRIC CANCERS 审中-公开
标题翻译：诊断结肠癌和胃癌的方法
公开(公告)号：US20090136508A1
公开(公告)日：2009-05-28
申请号：US12250419
申请日：2008-10-13
申请人： Yusuke NAKAMURA , Yoichi Furukawa
发明人： Yusuke NAKAMURA , Yoichi Furukawa
IPC分类号： A61K39/395 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K39/00 , A61K38/17 , C12N5/02 , C07K16/18 , C07H21/02 , C12Q1/68 , G01N33/53 , A61K31/7088
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
摘要： Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer-associated gene that discriminate between colon or gastric cancer and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌和胃癌的客观方法。在一个实施方案中，诊断方法涉及确定区分结肠癌或胃癌和正常细胞的结肠癌或胃癌相关基因的表达水平。本发明进一步提供筛选用于治疗结肠癌的治疗剂的方法以及接种对抗结肠癌或胃癌的方法。

2. 发明申请

US20120307032A1 IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, IMAGE PROCESSING SYSTEM, PROGRAM, AND RECORDING MEDIUM 有权
标题翻译：图像处理装置，图像处理方法，图像处理系统，程序和记录介质
公开(公告)号：US20120307032A1
公开(公告)日：2012-12-06
申请号：US13483446
申请日：2012-05-30
申请人： Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA , Hideo SATO , Kazuo OMORI , Mitsuharu OHKI
发明人： Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA , Hideo SATO , Kazuo OMORI , Mitsuharu OHKI
IPC分类号： G06K9/62 , H04N7/18
CPC分类号： A61B5/441 , A61B5/0077 , A61B5/103 , G06F19/321 , G06T7/44 , G06T2207/10148 , G06T2207/10152 , G06T2207/20081 , G06T2207/30088 , G06T2207/30201
摘要： Provided is an image processing device including a specifying unit configured to specify a part of a living body within a first image on the basis of a characteristic amount of the first image capturing skin of the living body, and a setting unit configured to set a capturing condition under which a second image indicating a state of the skin of the part is captured in response to the specified part.
摘要翻译：本发明提供一种图像处理装置，其特征在于，包括：指定部，其基于所述生物体的第一图像拍摄皮肤的特征量，指定第一图像内的生物体的一部分;以及设定部，响应于指定部分捕获指示部件的皮肤状态的第二图像的条件。

3. 发明申请

US20120021946A1 METHOD OF DIAGNOSING ESOPHAGEAL CANCER 有权
标题翻译：诊断食管癌的方法
公开(公告)号：US20120021946A1
公开(公告)日：2012-01-26
申请号：US13246639
申请日：2011-09-27
申请人： Yusuke NAKAMURA , Yataro Daigo , Shuichi Nakatsuru
发明人： Yusuke NAKAMURA , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： C40B30/04 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y10T436/25
摘要： In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray representing 32,256 genes was constructed to analyze the expression profiles of 19 esophageal squamous-cell carcinomas (ESCCS) purified by laser-capture microdissection. A detailed genome-wide database for sets of genes that are significantly up- or down-regulated in esophageal cancer is disclosed herein. These genes find use in the development of therapeutic drugs or immunotherapy as well as tumor markers. Additionally, genes associated with lymph-node metastasis and post-surgery recurrence are disclosed herein. Among the candidate molecular target genes, ECT2, CDC45L and DKK1 are further characterized. Treatment of ESCC cells with small interfering RNAs (siRNAs) of ECT2 or CDC45L suppressed growth of the cancer cells. Thus, the data herein provide valuable information for identifying diagnostic systems and therapeutic target molecules for esophageal cancer.
摘要翻译：为了鉴定涉及食管癌发生的分子以及可用于诊断标志物以及新药和免疫治疗靶标的分子，构建了代表32,256个基因的cDNA微阵列，分析19例食管鳞状细胞癌（ESCCS）的表达谱）通过激光捕获显微切割纯化。本文公开了在食管癌中显着上调或下调的基因组的详细全基因组数据库。这些基因可用于治疗药物或免疫治疗以及肿瘤标志物的开发。此外，本文公开了与淋巴结转移和手术后复发相关的基因。在候选分子靶基因中，进一步表征ECT2，CDC45L和DKK1。用ECT2或CDC45L的小干扰RNA（siRNA）处理ESCC细胞抑制癌细胞的生长。因此，本文的数据提供了用于鉴定诊断系统和用于食管癌的治疗靶分子的有价值的信息。

4. 发明申请

US20100074613A1 PHOTOGRAPHING APPARATUS AND METHOD, AND PROGRAM 有权
标题翻译：摄影装置与方法及程序
公开(公告)号：US20100074613A1
公开(公告)日：2010-03-25
申请号：US12554388
申请日：2009-09-04
申请人： Tomonori MASUNO , Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA
发明人： Tomonori MASUNO , Shinichiro GOMI , Masaru SUZUKI , Yusuke NAKAMURA
IPC分类号： G03B41/00
CPC分类号： H04N5/232 , G03B41/00 , H04N1/00183 , H04N5/23222 , H04N5/23293 , H04N2101/00
摘要： A photographing apparatus includes the following elements. A photographing unit photographs an object. A position detecting unit detects the position of the photographing apparatus. A direction detecting unit detects the direction of the photographing apparatus when the object is photographed. An angle-of-view detecting unit detects the angle of view of the photographed image. A recommended-composition information obtaining unit obtains recommended-composition information including a recommended angle of view of the image photographed at the detected position and a recommended direction. An angle-of-view comparing unit compares the detected angle of view with the recommended angle of view. An angle-of-view adjusting unit adjusts the angle of view in accordance with the result of the comparison. A direction comparing unit compares the detected direction with the recommended direction. A presenting unit presents, in accordance with the result of the comparison, direction-change instruction information for instructing the direction of the photographing apparatus to be changed.
摘要翻译：摄影装置包括以下元件。拍摄单元拍摄物体。位置检测单元检测拍摄设备的位置。方向检测单元在拍摄对象时检测拍摄装置的方向。视角检测单元检测拍摄图像的视角。推荐构图信息获取单元获取包括在检测位置拍摄的图像和推荐方向的推荐视角的推荐构图信息。视角比较单元将检测到的视角与推荐的视角进行比较。视角调整单元根据比较结果来调节视角。方向比较单元将检测到的方向与推荐方向进行比较。呈现单元根据比较结果呈现用于指示要改变拍摄设备的方向的方向改变指示信息。

5. 发明申请

US20090290472A1 Optical information recording apparatus, optical information recording method, optical information recording/reproducing apparatus and optical information recording/reproducing method 有权
标题翻译：光信息记录装置，光信息记录方法，光信息记录/再现装置和光信息记录/再现方法
公开(公告)号：US20090290472A1
公开(公告)日：2009-11-26
申请号：US12453538
申请日：2009-05-14
申请人： Yusuke NAKAMURA
发明人： Yusuke NAKAMURA
IPC分类号： G11B7/00
CPC分类号： G11B20/1426 , G11B7/0065 , G11B2020/1457 , G11B2020/1469 , G11B2220/2504
摘要： An optical information recording/reproducing apparatus using holography comprises a signal generation unit that modulates input data, adds at least one control bit to each group of N bits, performs an NRZI-modulation on the modulated data, determines the at least one control bit such that a digital sum value of the NRZI-modulated data is 0, performs NRZI modulation on the data whose at least one control bit was determined, and rearranges the data to generate 2-dimensional data; a pickup that records the 2-dimensional data in a hologram disc and reproduces the 2-dimensional data from the hologram disc; and a signal processing unit that corrects the 2-dimensional data reproduced by the pickup, performs NRZI-modulation on the 2-dimensional data that has undergone a binarization operation, removes the at least one control bit added during the recording, and demodulates the data according to a modulation rule used during the recording.
摘要翻译：使用全息术的光学信息记录/再现装置包括：信号产生单元，其对输入数据进行调制;将至少一个控制位加到每一组N位;对调制数据执行NRZI调制;确定至少一个控制位， NRZI调制数据的数字和值为0，对确定了至少一个控制位的数据执行NRZI调制，并重新排列数据以生成二维数据; 记录全息图盘中的二维数据的拾取器，并再现来自全息图盘的二维数据; 以及信号处理单元，其校正由拾取器再现的2维数据，对经过二值化操作的二维数据执行NRZI调制，去除在记录期间添加的至少一个控制位，并解调数据根据记录期间使用的调制规则。

6. 发明申请

US20090147637A1 OPTICAL DISK REPRODUCING DEVICE AND PHASE-LOCKED LOOP CIRCUIT 审中-公开
标题翻译：光盘再现设备和相位锁定环路
公开(公告)号：US20090147637A1
公开(公告)日：2009-06-11
申请号：US12328113
申请日：2008-12-04
申请人： Yusuke NAKAMURA , Masakazu IKEDA , Koichiro NISHIMURA
发明人： Yusuke NAKAMURA , Masakazu IKEDA , Koichiro NISHIMURA
IPC分类号： G11B5/09
CPC分类号： G11B20/10009 , G11B20/10037 , G11B20/10046 , G11B20/10222 , G11B20/10425 , G11B20/14 , G11B20/22 , G11B2220/2537
摘要： Provided is an optical disk reproducing device for controlling false detection of synchronization signals due to intersymbol interference, and stably improving accuracy of frequency acquisition of a PLL even when offset and so on occur. A signal width close to an original mark length is obtained to use for frequency acquisition of the PLL by, for example, using two different slice thresholds and taking a width between a rising of a result of slicing at one threshold and a falling of a result of slicing at the other threshold as a synchronization signal width. When asymmetric properties due to offset, asymmetry, etc. occur, an amount of corrections on the slice threshold is calculated, and it is reflected on a threshold previously set to always obtain a correct synchronization signal width.
摘要翻译：提供一种用于控制由于符号间干扰导致的同步信号的错误检测的光盘再现装置，并且即使发生偏移等，也能稳定地提高PLL的频率获取的精度。获得接近原始标记长度的信号宽度，以便通过例如使用两个不同的切片阈值并且在一个阈值的切片结果的上升与结果的下降之间的宽度来使用PLL的频率采集在另一阈值处切片为同步信号宽度。当发生由于偏移，不对称等引起的不对称性质时，计算切片阈值上的校正量，并将其反映在预先设定为始终获得正确的同步信号宽度的阈值上。

7. 发明申请

US20110228662A1 OPTICAL DISK REPRODUCING APPARATUS 有权
标题翻译：光盘再现设备
公开(公告)号：US20110228662A1
公开(公告)日：2011-09-22
申请号：US13150758
申请日：2011-06-01
申请人： Yusuke NAKAMURA , Masakazu Ikeda
发明人： Yusuke NAKAMURA , Masakazu Ikeda
IPC分类号： G11B20/10
CPC分类号： G11B7/005 , G11B20/10009 , G11B20/10037 , G11B20/10046 , G11B20/10055 , G11B20/10111 , G11B20/1012 , G11B20/10212 , G11B20/1496 , G11B2220/213 , G11B2220/2579
摘要： The present invention relates to an optical disk reproducing apparatus, and provides a technology capable of supporting even a situation in which a reproduction signal characteristic is changed due to a factor other than recording density of an optical disk by using PRML of different constrained length and capable of improving reading accuracy. The optical disk reproducing apparatus includes a PRML circuit of first constrained length (for example, 4) and a PRML circuit of second constrained length (for example, 5). Equalization error values obtained during calculation of equalization learning in respective circuits are compared with each other in a determination circuit. Switching control of a switch is performed so that an output of one of the PRML circuits having a smaller equalization error value is selected.
摘要翻译：光盘重放装置技术领域本发明涉及光盘重放装置，并且提供了一种能够通过使用不同约束长度的PRML而能够支持再现信号特性由于光盘的记录密度而不是由记录密度而变化的情况的技术提高阅读精度。光盘再现装置包括第一约束长度（例如4）的PRML电路和第二约束长度的PRML电路（例如5）。在各个电路中的均衡学习计算中获得的均衡误差值在确定电路中彼此进行比较。执行开关的开关控制，使得选择具有较小均衡误差值的PRML电路之一的输出。

8. 发明申请

US20090103831A1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND PROGRAM THEREFOR 失效
标题翻译：图像处理装置，图像处理方法及其程序
公开(公告)号：US20090103831A1
公开(公告)日：2009-04-23
申请号：US12252559
申请日：2008-10-16
申请人： Yusuke NAKAMURA , Shinichiro Gomi , Masami Ogata
发明人： Yusuke NAKAMURA , Shinichiro Gomi , Masami Ogata
IPC分类号： G06K9/40
CPC分类号： G06T5/10 , G06T5/007 , G06T7/13 , G06T7/40
摘要： An image processing apparatus processes an input image while also considering the luminous intensity information thereof, and thereby generates an output image wherein the apparent object surface roughness has been enhanced with respect to the input image. The image processing apparatus includes a luminous intensity information separator that separates the input image information into global luminous intensity information and local luminous intensity information, a shadow component generator that generates a shadow component of the image on the basis of the local luminous intensity information, and an image compositor that generates an output image by adding shadow image information to the input image information, with the shadow image information being generated from the shadow component and from a value based on the input image information.
摘要翻译：图像处理装置在考虑其输出图像的同时考虑其输入图像，并且产生相对于输入图像增强了表观物体表面粗糙度的输出图像。该图像处理装置包括将输入图像信息分离为全局发光强度信息和局部发光强度信息的发光强度信息分离器，基于局部发光强度信息生成图像的阴影分量的阴影分量发生器，以及图像合成器，其通过将阴影图像信息添加到输入图像信息，并且从阴影分量生成阴影图像信息和基于输入图像信息的值来生成输出图像。

9. 发明申请

US20080286783A1 NOVEL METHOD OF DETECTING GENETIC POLYMORPHISM 有权
标题翻译：检测遗传多态性的新方法
公开(公告)号：US20080286783A1
公开(公告)日：2008-11-20
申请号：US12058318
申请日：2008-03-28
申请人： Naoya HOSONO , Mitsuaki KUBO , Yusuke NAKAMURA
发明人： Naoya HOSONO , Mitsuaki KUBO , Yusuke NAKAMURA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2561/109 , C12Q2537/157
摘要： The present invention provides a novel polymorphism detecting method suitable for the detection and identification of copy number variation.Provided is a method of determining the genotype of a subject in a genomic region comprising an SNP site, comprising a step for performing typing of the SNP site by the invader assay with a DNA-containing sample comprising the genomic region from the subject as the template, wherein fluorescence is measured on a real time basis. The copy number ratio of both alleles is determined using the fluorescence intensity ratio of each allele at a time before saturation of fluorescence intensity. Preferably, the present method further comprises a step for amplifying the genomic region comprising an SNP site prior to the invader step. In this step of amplification, a plurality of regions comprising a plurality of SNP sites can be simultaneously amplified. Furthermore, the present method enables the determination of the copy number of each allele when combined with quantitative PCR.
摘要翻译：本发明提供了一种适用于检测和鉴定拷贝数变异的新型多态性检测方法。提供了确定包含SNP位点的基因组区域中受试者的基因型的方法，其包括通过使用含有来自受试者的基因组区域作为模板的含有DNA的样品通过侵入测定进行SNP位点的分型的步骤其中荧光是实时测量的。使用荧光强度饱和之前的每个等位基因的荧光强度比来确定两个等位基因的拷贝数比。优选地，本方法还包括在入侵者步骤之前扩增包含SNP位点的基因组区域的步骤。在该扩增步骤中，可以同时扩增包含多个SNP位点的多个区域。此外，当与定量PCR组合时，本方法能够确定每个等位基因的拷贝数。

10. 发明申请

US20120243393A1 OPTICAL INFORMATION RECORDING METHOD, OPTICAL INFORMATION REPRODUCTION METHOD AND OPTICAL DISK DEVICE 有权
标题翻译：光信息记录方法，光信息再现方法和光盘设备
公开(公告)号：US20120243393A1
公开(公告)日：2012-09-27
申请号：US13479734
申请日：2012-05-24
申请人： Koichiro NISHIMURA , Yusuke NAKAMURA
发明人： Koichiro NISHIMURA , Yusuke NAKAMURA
IPC分类号： G11B7/126
CPC分类号： G11B20/10009 , G11B7/00456 , G11B7/1267 , G11B20/10046 , G11B20/10055 , G11B20/10194 , G11B20/10212 , G11B20/10222 , G11B20/10481
摘要： When a phase shift is to be evaluated, based on a difference between an output from a waveform equalization circuit to equalize an input reproduced signal to a predetermined target equalization characteristic and the target equalization characteristic, the phase shift of the reproduced signal relative to a channel clock, a group delay characteristic with respect to the frequency of the waveform equalization circuit is fixed. Hence, an equalized waveform as an output from the waveform equalization circuit can preserve phase shift information of the inputted reproduced signal to correctly detect the phase shift of the reproduced waveform using the equalized waveform. It is hence possible to realize, with high precision, optimal value learning of various parameters for the recording, reproduction, and servo by use of the phase shift as an index.
摘要翻译：当要评估相移时，基于来自波形均衡电路的输出之间的差以将输入再现信号均衡到预定的目标均衡特性和目标均衡特性，再现信号相对于通道的相移时钟，相对于波形均衡电路的频率的组延迟特性是固定的。因此，作为来自波形均衡电路的输出的均衡波形可以保存输入的再现信号的相移信息，以使用均衡波形来正确地检测再现波形的相移。因此，通过使用相移作为指标，可以高精度地实现用于记录，再现和伺服的各种参数的最佳值学习。

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