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1. 发明授权

US07867514B2 Method for stabilizing preparation 有权
标题翻译：稳定制剂的方法
公开(公告)号：US07867514B2
公开(公告)日：2011-01-11
申请号：US10276294
申请日：2001-05-23
申请人： Yuso Tomohira , Tadashi Mukai , Minoru Kashimoto , Masakazu Nagasawa , Tetsuroh Ichiba , Daisuke Kuribayashi , Yoshikazu Oka , Hajime Toguchi
发明人： Yuso Tomohira , Tadashi Mukai , Minoru Kashimoto , Masakazu Nagasawa , Tetsuroh Ichiba , Daisuke Kuribayashi , Yoshikazu Oka , Hajime Toguchi
IPC分类号： A61K9/14 , A61K9/20 , A61K9/48
CPC分类号： A61K9/2054 , A61K9/2013 , A61K47/02 , A61K47/20
摘要： Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.
摘要翻译：公开了一种用于稳定含有药理学物质和十二烷基硫酸钠的固体药物制剂的方法，该方法包括将至少一种选自中性盐，碱性盐和碱性物质的成分掺入制剂中。通过本发明方法制备的含有十二烷基硫酸钠的制剂具有优异的性能，包括高储存稳定性，抑制变色和变质，以及防止其制备物质的药理学溶解速度等性质的改变。

2. 发明授权

US07144585B1 Cilostazol preparation 有权
标题翻译：西洛他唑制剂
公开(公告)号：US07144585B1
公开(公告)日：2006-12-05
申请号：US09555026
申请日：2000-03-21
申请人： Tadashi Mukai , Yuso Tomohira , Masafumi Toda , Keigo Yamada , Yoshikazu Oka
发明人： Tadashi Mukai , Yuso Tomohira , Masafumi Toda , Keigo Yamada , Yoshikazu Oka
IPC分类号： A61K9/14 , A61K9/20 , A61K9/48
CPC分类号： A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1652 , A61K9/2081 , A61K9/5042 , A61K9/5084 , A61K31/4709 , Y10S514/951 , Y10S514/952 , Y10S514/96 , Y10S514/961 , Y10S514/962 , Y10S514/963 , Y10S514/964
摘要： Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.
摘要翻译：提供了一种西洛他唑制剂，其包括将细西洛他唑的细粉末掺入分散和/或增溶剂中，从而提高分散性和/或溶解度。此外，提供了即使在消化道的下部也提高微溶药物例如西洛他唑的吸收性的方法，其中当使用常规方法时，所述药物难以在消化道下部被吸收。根据本发明，西洛他唑即使在消化道下部也被吸收，具有作为溶栓药物，大脑循环改善药物等的作用。

3. 发明授权

US07138143B1 Coated preparation soluble in the lower digestive tract 有权
标题翻译：涂层制剂溶于下消化道
公开(公告)号：US07138143B1
公开(公告)日：2006-11-21
申请号：US10089442
申请日：2000-09-22
申请人： Tadashi Mukai , Daisuke Kuribayashi
发明人： Tadashi Mukai , Daisuke Kuribayashi
IPC分类号： A61K9/16 , A61K9/14 , A61K9/50
CPC分类号： A61K31/4709 , A61K9/5042
摘要： A coating dispersion soluble in the lower digestive tract which is prepared by blending a hydroxypropyl methylcellulose acetate succinate (HPMCAS) soluble at around pH 7 with a conventional plasticizer and an anion surfactant and further adding an acid, wherein the HPMCAS has an average particle size of 10 μm or less and is dispersed at a concentration of 2 to 20% by weight, and the acid is used in an amount of 1 to 10 parts by weight per 100 parts by weight of HPMCAS, and a sustained release coated preparation capable of releasing a medicament in the large intestine at the lower digestive tract, which is prepared by coating a medicament-containing solid preparation such as a granular core with the coating dispersion.
摘要翻译：可溶于下消化道的涂布分散体，其通过将可溶于约pH 7的羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS）与常规增塑剂和阴离子表面活性剂共混制备，并进一步加入酸，其中HPMCAS的平均粒径为 10mum以下，以2〜20重量％的浓度分散，相对于100重量份的HPMCAS，酸的使用量为1〜10重量份，能够释放的缓释包衣制剂在下消化道的大肠中的药物，其通过用涂布分散体涂布含药物的固体制剂例如粒状核来制备。

4. 发明申请

US20100323006A1 PHARMACEUTICAL SOLID PREPARATION COMPRISING BENZAZEPINES AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：包含苯甲酸酯的药物固体制剂及其生产方法
公开(公告)号：US20100323006A1
公开(公告)日：2010-12-23
申请号：US12665642
申请日：2008-06-20
申请人： Shinsuke Nakagawa , Kai Suzuki , Tadashi Mukai
发明人： Shinsuke Nakagawa , Kai Suzuki , Tadashi Mukai
IPC分类号： A61K9/20 , A61K9/00 , A61K31/55
CPC分类号： A61K31/55 , A61K9/1623 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2059
摘要： The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50 wt. % or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 μm, and a 90% cumulative particle diameter of 100 to 200 μm.
摘要翻译：本发明提供了具有优异的崩解性和优异的溶解性的新型药物固体制剂，导致活性成分通过胃肠道的足够的吸收性。本发明的药物固体制剂包含：（a）7-氯-5-羟基-1- [2-甲基-4-（2-甲基苯甲酰氨基）苯甲酰基] -2,3,4,5-四氢-1H- 苯并氮杂和/或其盐; （b）含羟基丙氧基的羟丙基纤维素的量为50重量％％以上; 和（c）选自羧甲基纤维素，羧甲基淀粉，交聚维酮，平均粒径为30〜70μm，90％累积粒径为100〜200μm的低取代羟丙基纤维素中的至少1种。

5. 发明申请

US20080033009A1 Solid Pharmaceutical Formulation 有权
标题翻译：固体药物制剂
公开(公告)号：US20080033009A1
公开(公告)日：2008-02-07
申请号：US11596219
申请日：2005-05-19
申请人： Tadashi Mukai
发明人： Tadashi Mukai
IPC分类号： A61K47/36 , A61K31/47
CPC分类号： A61K9/1652 , A61K31/00 , A61K31/4709
摘要： This invention provides a solid pharmaceutical formulation having high physical strength and further having excellent drug release properties and digestibility of excipients when administered, which comprises (a) an active medical ingredient and (b) a pre-gelatinized starch in an amount of 10 to 90% by weight, said pre-gelatinized starch being prepared by pre-gelatinizing a cheap and stable usual starch during the procedure for formulation. This invention also provides a method for preparing the solid pharmaceutical formulation.
摘要翻译：本发明提供了具有高物理强度并且进一步具有优异的药物释放性质和赋形剂的消化率的固体药物制剂，其包含（a）活性成分和（b）10至90的预胶化淀粉所述预胶化淀粉通过在制剂过程中预胶化廉价和稳定的常规淀粉来制备。本发明还提供了制备固体药物制剂的方法。

6. 发明授权

US4628456A Course guidance system 失效
标题翻译：课程指导系统
公开(公告)号：US4628456A
公开(公告)日：1986-12-09
申请号：US405767
申请日：1982-08-06
申请人： Itaru Hatano , Kenji Takahashi , Shigeru Hirosawa , Mikio Kanda , Teruo Mimori , Toshio Sasaki , Tadashi Mukai , Tsuneo Takahashi , Shinichiro Yasui , Akira Ichikawa
发明人： Itaru Hatano , Kenji Takahashi , Shigeru Hirosawa , Mikio Kanda , Teruo Mimori , Toshio Sasaki , Tadashi Mukai , Tsuneo Takahashi , Shinichiro Yasui , Akira Ichikawa
IPC分类号： G09B29/10 , G01C21/00 , G01C21/30 , G01C21/36 , G05D1/02 , G06F19/00 , G06F15/50
CPC分类号： G05D1/0274 , G01C21/3667 , G05D1/0272 , G05D2201/0213
摘要： In a course guidance system for use in an automobile, for example, which includes an electronic display, a map, a direction sensor, a speed sensor and the like for deriving the present location of the car and plotting it on the display, the invention provides a course guidance system for a car which causes a linear and/or rotational movement of the driving locus displayed on the display when the map is changed or reset so that the present position can be easily located on the map.
摘要翻译：在用于汽车的课程引导系统中，例如包括用于导出汽车的当前位置并将其绘制在显示器上的电子显示器，地图，方向传感器，速度传感器等，本发明提供了一种用于汽车的路线引导系统，其在地图被改变或重置时引起显示在显示器上的驾驶轨迹的线性和/或旋转运动，使得当前位置可以容易地位于地图上。

7. 发明授权

US4532514A Course guidance system with speeded-up display function 失效
标题翻译：课程指导系统具有加速显示功能
公开(公告)号：US4532514A
公开(公告)日：1985-07-30
申请号：US407999
申请日：1982-08-13
申请人： Itaru Hatano , Kenji Takahashi , Shigeru Hirosawa , Mikio Kanda , Shinichiro Yasui , Akira Ichikawa , Teruo Mimori , Toshio Sasaki , Tadashi Mukai , Thuneo Takahashi
发明人： Itaru Hatano , Kenji Takahashi , Shigeru Hirosawa , Mikio Kanda , Shinichiro Yasui , Akira Ichikawa , Teruo Mimori , Toshio Sasaki , Tadashi Mukai , Thuneo Takahashi
IPC分类号： G01C21/00 , G01C21/36 , G01D7/00 , G05D1/02 , G08G1/0969 , G08G1/137 , G09B29/10 , G08G1/12
CPC分类号： G01C21/367 , G08G1/0969 , G08G1/137 , G09B29/106
摘要： A course guidance system includes a direction sensor and a speed sensor both fitted to a moving body, a display mounted in the moving body and a map displayed in a manner corresponding to the display surface of the display and in which the present position of the moving body is derived by the direction sensor and the speed sensor and is plotted on the display in a manner corresponding to the map. The improvement comprises a locus memory for sequentially storing an X component value and a Y component value of the driving position based on a predetermined driving distance obtained from the speed sensor and on the driving position obtained from the direction sensor, a locus display memory for storing data in a manner corresponding to the display surface of the display, the data being obtained by reading the contents of the locus memory in a manner corresponding to the scale of reduction of the map, and a display for plotting the driving locus of the moving body on the display surface based on the contents of the locus display memory, wherein the data to be read when the contents of the locus memory is transferred to the locus display memory are divided into a plurality of groups each consisting of a data line to be read at a predetermined interval which are sequentially read and transferred, and the plotted line of the driving locus to be displayed is displayed sequentially and progressively from a rough display to a dense display.
摘要翻译：课程引导系统包括方向传感器和安装在移动体上的速度传感器，安装在移动体中的显示器和以与显示器的显示表面对应的方式显示的地图，并且其中移动的当前位置身体由方向传感器和速度传感器导出，并以对应于地图的方式绘制在显示器上。该改进包括轨迹存储器，用于基于从速度传感器获得的预定行驶距离和从方向传感器获得的驾驶位置顺序地存储驾驶位置的X分量值和Y分量值，轨迹显示存储器，用于存储以对应于显示器的显示表面的方式的数据，通过以与地图的缩小比例相对应的方式读取轨迹存储器的内容而获得的数据，以及用于绘制移动体的驾驶轨迹的显示基于轨迹显示存储器的内容，显示表面上的轨迹存储器的内容被传送到轨迹显示存储器时要读取的数据被划分为多个组，每组由要读取的数据线组成按顺序读取和传送的预定间隔，顺序地显示要显示的驾驶轨迹的绘制线从粗略显示到密集显示。

8. 发明授权

US4445279A Magnetic course detector 失效
标题翻译：磁场检测器
公开(公告)号：US4445279A
公开(公告)日：1984-05-01
申请号：US408000
申请日：1982-08-13
申请人： Noboru Tsushima , Masashi Fuse , Toshio Sasaki , Masayuki Ogata , Teruo Mimori , Tadashi Mukai
发明人： Noboru Tsushima , Masashi Fuse , Toshio Sasaki , Masayuki Ogata , Teruo Mimori , Tadashi Mukai
IPC分类号： G01C17/30 , G01C17/28 , G01C17/38
CPC分类号： G01C17/38
摘要： Disclosed is a magnetic course detector capable of accurately detecting the bearing of the course of a traveling body independently of the position a magnetic bearing sensor is installed in the traveling body through rotatably mounting the magnetic bearing sensor and making corrections for the offset and sensitivity of its output.
摘要翻译：本发明公开了一种能够通过可旋转地安装磁性轴承传感器来精确地检测行走体的行程的轴承，而不依赖于将磁性轴承传感器安装在行驶体中的位置，并对其偏移和灵敏度进行修正输出。

9. 发明授权

US08883121B2 Oral preparation useful in measurement capacity to metabolize pyridine 有权
标题翻译：用于测量吡啶代谢能力的口服制剂
公开(公告)号：US08883121B2
公开(公告)日：2014-11-11
申请号：US11989286
申请日：2006-07-24
申请人： Yoshiharu Inoue , Tadashi Mukai
发明人： Yoshiharu Inoue , Tadashi Mukai
IPC分类号： A61K49/00 , A61K9/16 , A61K9/14 , A61K9/20 , A61K51/12
CPC分类号： A61K49/0004 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K51/1255
摘要： An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc., with high accuracy and with little variation due to individual differences. The oral preparation is prepared using a powder material obtained by mixing and pulverizing (a) an isotope-labeled compound and/or a pyrimidine metabolite compound and (b) a sugar and/or a sugar alcohol.
摘要翻译：本发明的目的是提供一种口服制剂，其可用于以高精度诊断吡啶代谢能力障碍，嘧啶代谢率等的存在或程度，并且由于个体差异而几乎没有变化。使用通过混合和粉碎（a）同位素标记的化合物和/或嘧啶代谢物化合物和（b）糖和/或糖醇获得的粉末材料来制备口服制剂。

10. 发明申请

US20080233048A1 Oral Preparation Useful in Measurement Capacity to Metabolize Pyridine 有权
标题翻译：口服制剂可用于代谢吡啶的测定能力
公开(公告)号：US20080233048A1
公开(公告)日：2008-09-25
申请号：US11989286
申请日：2006-07-24
申请人： Yoshiharu Inoue , Tadashi Mukai
发明人： Yoshiharu Inoue , Tadashi Mukai
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K51/1255
摘要： An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc., with high accuracy and with little variation due to individual differences. The oral preparation is prepared using a powder material obtained by mixing and pulverizing (a) an isotope-labeled compound and/or a pyrimidine metabolite compound and (b) a sugar and/or a sugar alcohol.
摘要翻译：本发明的目的是提供一种口服制剂，其可用于以高精度诊断吡啶代谢能力障碍，嘧啶代谢率等的存在或程度，并且由于个体差异而几乎没有变化。使用通过混合和粉碎（a）同位素标记的化合物和/或嘧啶代谢物化合物和（b）糖和/或糖醇获得的粉末材料来制备口服制剂。

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