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1. 发明授权

US07435588B2 Systems for detection and production of respiratory, herpes and enteric viruses 有权
标题翻译：用于检测和产生呼吸道，疱疹和肠道病毒的系统
公开(公告)号：US07435588B2
公开(公告)日：2008-10-14
申请号：US11414439
申请日：2006-04-28
申请人： Yung T. Huang , Joseph A. Jollick, Jr.
发明人： Yung T. Huang , Joseph A. Jollick, Jr.
IPC分类号： C12N7/00
CPC分类号： C12Q1/70 , C12N7/00 , C12N2710/10051 , C12N2710/16151 , C12N2760/16151 , C12N2760/16251 , C12N2770/20051 , C12N2770/32351
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

2. 发明申请

US20100173280A1 Systems for Detection and Production of Respiratory, Herpes and Enteric Viruses 审中-公开
标题翻译：呼吸道，疱疹和肠道病毒检测和生产系统
公开(公告)号：US20100173280A1
公开(公告)日：2010-07-08
申请号：US11992450
申请日：2006-09-19
申请人： Yung T. Huang , Joseph A. Jollick, JR.
发明人： Yung T. Huang , Joseph A. Jollick, JR.
IPC分类号： C12Q1/70 , C12N5/077 , C12N7/01
CPC分类号： C12N7/00 , C12N2503/00 , C12N2760/16251 , G01N33/56983 , G01N2333/03 , G01N2333/085 , G01N2333/11 , G01N2333/115
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

3. 发明授权

US08142997B2 Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses 有权
标题翻译：用于检测呼吸道，疱疹和肠道病毒的混合细胞诊断系统
公开(公告)号：US08142997B2
公开(公告)日：2012-03-27
申请号：US12253127
申请日：2008-10-16
申请人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
发明人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
IPC分类号： C12Q1/70
CPC分类号： C12Q1/02 , C12N7/00 , C12N2710/16611 , C12N2760/16051 , C12N2770/20011 , C12N2770/32311 , C12Q1/04 , C12Q1/18 , G01N2333/11 , G01N2333/29 , G01N2333/295
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

4. 发明授权

US06306582B1 Mixed cell diagnostic systems 有权
公开(公告)号：US06306582B1
公开(公告)日：2001-10-23
申请号：US09551945
申请日：2000-04-19
申请人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
发明人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
IPC分类号： C12Q170
CPC分类号： G01N33/5091 , C12N5/0697 , C12N2502/256 , C12N2502/27 , C12N2502/30 , C12N2503/04 , C12Q1/04
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.

5. 发明申请

US20100233674A1 Cells for detection and production of influenza and parainfluenza viruses 审中-公开
标题翻译：用于检测和产生流感和副流感病毒的细胞
公开(公告)号：US20100233674A1
公开(公告)日：2010-09-16
申请号：US11642131
申请日：2006-12-19
申请人： Yung T. Huang , Yunsheng Li
发明人： Yung T. Huang , Yunsheng Li
IPC分类号： C12Q1/70 , C12N5/10 , C12N7/00
CPC分类号： A61K39/155 , A61K39/00 , A61K39/12 , A61K39/145 , C12N5/0688 , C12N7/00 , C12N9/64 , C12N2760/16111 , C12N2760/16134 , C12N2760/16151 , C12N2760/18611 , C12N2760/18651 , G01N33/56983 , G01N2333/11 , G01N2333/115
摘要： The invention provides cell lines that are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic cells with increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.
摘要翻译：本发明提供可用于快速检测和产生流感和副流感病毒的细胞系。特别地，本发明涉及对甲型流感，乙型流感或副流感病毒3感染的敏感性增加或能提高感染性病毒粒子生产力的转基因细胞。本发明适用于培养临床流行性感冒和副流感病毒分离物，以及用于生产用于疫苗制剂的流感和副流感病毒，作为用于诊断应用的抗原制剂和用于筛选抗病毒药物。

6. 发明授权

US06946291B2 Mixed cell diagnostic systems 有权
公开(公告)号：US06946291B2
公开(公告)日：2005-09-20
申请号：US10813852
申请日：2004-03-30
申请人： David R. Scholl , Patricia Gail Ray Goodrum , Yung T. Huang
发明人： David R. Scholl , Patricia Gail Ray Goodrum , Yung T. Huang
IPC分类号： C12N5/071 , C12Q1/04 , G01N33/50 , C12N5/00
CPC分类号： C12N5/0697 , C12N5/0688 , C12N2502/256 , C12N2502/27 , C12N2503/04 , C12Q1/04 , G01N33/5091 , G01N2333/11 , G01N2333/115
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.

7. 发明授权

US06875600B2 Mixed cell diagnostic systems 失效
标题翻译：混合细胞诊断系统
公开(公告)号：US06875600B2
公开(公告)日：2005-04-05
申请号：US10407789
申请日：2003-04-04
申请人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
发明人： David R. Scholl , Yung T. Huang , Patricia Gail Ray Goodrum
IPC分类号： C12N15/09 , C12N5/071 , C12N5/10 , C12N7/01 , C12Q1/04 , C12Q1/70 , G01N33/50 , C12N7/00
CPC分类号： G01N33/5091 , C12N5/0697 , C12N2502/256 , C12N2502/27 , C12N2502/30 , C12N2503/04 , C12Q1/04
摘要： The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of a organisms to antimicrobial agents.
摘要翻译：本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。

8. 发明授权

US07186504B2 Cells for detection of enteroviruses 有权
标题翻译：用于检测肠道病毒的细胞
公开(公告)号：US07186504B2
公开(公告)日：2007-03-06
申请号：US10861724
申请日：2004-06-03
申请人： Yung T. Huang
发明人： Yung T. Huang
IPC分类号： C12Q1/70 , C12N7/00 , C12N7/02
CPC分类号： C12N5/0686 , C07K14/70596 , C12N7/00 , C12N2503/00 , C12N2510/02 , C12N2770/32311 , C12N2770/32611 , G01N33/56983
摘要： The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.
摘要翻译：本发明提供可用于快速检测肠道病毒的细胞系。特别地，本发明提供转基因非洲绿猴肾细胞系和水牛绿猴肾细胞系。本发明提供了与目前用于肠道病毒检测的其它细胞类型相比，对单细胞型和混合细胞型培养物中肠道病毒感染具有增加的敏感性的细胞系。与其衍生的细胞类型相比，本发明的细胞也可以容忍更多数量的肠道病毒的感染。

9. 发明授权

US06610474B1 Cells for detection of influenza and parainfluenza viruses 失效
标题翻译：用于检测流行性感冒和副流感病毒的细胞
公开(公告)号：US06610474B1
公开(公告)日：2003-08-26
申请号：US10133910
申请日：2002-04-25
申请人： Yung T. Huang
发明人： Yung T. Huang
IPC分类号： C12Q170
CPC分类号： C12N9/6454 , G01N33/56983 , Y10S435/975
摘要： The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells which show increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious virions. The invention is suitable for use in culturing clinical influenza and parainfluenza virus isolates and for the production of influenza and parainfluenza virus for vaccine formulations, as antigen preparations for diagnostic applications, and for screening antiviral drugs.
摘要翻译：本发明提供可用于快速检测和产生流感和副流感病毒的细胞系。特别地，本发明涉及对甲型流感，乙型流感或副流感病毒3感染的敏感性增加或能提高感染性病毒粒子的生产力的转基因貂肺细胞。本发明适用于培养临床流行性感冒和副流感病毒分离物，以及用于生产用于疫苗制剂的流感和副流感病毒，作为用于诊断应用的抗原制剂和用于筛选抗病毒药物。

10. 发明授权

US06458577B1 Methods of culturing and assaying a virus in a specimen and compositions and cell lines for doing the same 失效
标题翻译：在样品和组合物和细胞系中培养和测定病毒的方法
公开(公告)号：US06458577B1
公开(公告)日：2002-10-01
申请号：US08860305
申请日：1997-08-28
申请人： Yung T. Huang
发明人： Yung T. Huang
IPC分类号： C12N701
CPC分类号： C12N7/00 , C12N2710/16651
摘要： This invention relates to a method for culturing a virus including the steps of: (A) providing cells from a cell line susceptible to infection by the virus and a specimen; (B) treating the cells with a compound of formula RC(O)Q, wherein Q is R, OR, OX or X, each R is independently hydrogen or a hydrocarbyl group containing 1 to about 10 carbon atoms and wherein X is hydrogen or a cation; © inoculating the treated cells with the specimen; and (D) incubating the inoculated cells to allow viral growth to proceed.
摘要翻译：本发明涉及一种用于培养病毒的方法，包括以下步骤：（A）从易感染病毒的细胞系和样品提供细胞; （B）用式RC（O）Q化合物处理细胞，其中Q为R，OR，OX或X，每个R独立地为氢或含有1至约10个碳原子的烃基，其中X为氢或阳离子（C）用试样接种经处理的细胞; 和（D）孵育接种的细胞以允许进行病毒生长。

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