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1. 发明授权

US08923484B2 Motion correction system and method for an x-ray tube 有权
标题翻译： X射线管的运动校正系统和方法
公开(公告)号：US08923484B2
公开(公告)日：2014-12-30
申请号：US13602080
申请日：2012-08-31
申请人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
发明人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
IPC分类号： H01J35/28 , H01J35/24 , H01J35/14
CPC分类号： H01J35/28 , H01J35/025 , H01J35/14
摘要： A motion correction system and method for motion correction for an x-ray tube is presented. One embodiment of the motion correction system includes a sensing unit coupled to an x-ray tube to determine a distance with which an impingement location of an electron beam generated by the x-ray tube deviates from a determined location due to motion of the x-ray tube. The motion correction system further includes a control unit coupled to the sensing unit to generate a control signal corresponding to the distance with which the impingement location of the electron beam deviates. Also, the motion correction system includes a deflection unit coupled to the control unit to steer the electron beam to the determined location based on the generated control signal.
摘要翻译：提出了用于X射线管的运动校正系统和运动校正方法。运动校正系统的一个实施例包括耦合到X射线管的感测单元，以确定由x射线管产生的电子束的冲击位置由于X射线管的运动而偏离确定的位置的距离，射线管。运动校正系统还包括耦合到感测单元的控制单元，以产生对应于电子束的冲击位置偏离的距离的控制信号。此外，运动校正系统包括耦合到控制单元的偏转单元，以基于所生成的控制信号将电子束转向确定的位置。

2. 发明申请

US20140064456A1 MOTION CORRECTION SYSTEM AND METHOD FOR AN X-RAY TUBE 有权
标题翻译：运动校正系统和X射线管的方法
公开(公告)号：US20140064456A1
公开(公告)日：2014-03-06
申请号：US13602080
申请日：2012-08-31
申请人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
发明人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
IPC分类号： H01J35/30
CPC分类号： H01J35/28 , H01J35/025 , H01J35/14
摘要： A motion correction system and method for motion correction for an x-ray tube is presented. One embodiment of the motion correction system includes a sensing unit coupled to an x-ray tube to determine a distance with which an impingement location of an electron beam generated by the x-ray tube deviates from a determined location due to motion of the x-ray tube. The motion correction system further includes a control unit coupled to the sensing unit to generate a control signal corresponding to the distance with which the impingement location of the electron beam deviates. Also, the motion correction system includes a deflection unit coupled to the control unit to steer the electron beam to the determined location based on the generated control signal.
摘要翻译：提出了用于X射线管的运动校正系统和运动校正方法。运动校正系统的一个实施例包括耦合到X射线管的感测单元，以确定由x射线管产生的电子束的冲击位置由于X射线管的运动而偏离确定的位置的距离，射线管。运动校正系统还包括耦合到感测单元的控制单元，以产生对应于电子束的冲击位置偏离的距离的控制信号。此外，运动校正系统包括耦合到控制单元的偏转单元，以基于所生成的控制信号将电子束转向确定的位置。

3. 发明申请

US20070155739A1 Substituted bis-amide metalloprotease inhibitors 审中-公开
标题翻译：取代的双酰胺金属蛋白酶抑制剂
公开(公告)号：US20070155739A1
公开(公告)日：2007-07-05
申请号：US11646650
申请日：2006-12-28
申请人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
发明人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/506 , C07D491/02 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12 , C07D239/28 , C07D409/12 , C07D417/12
摘要： This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.
摘要翻译：本发明涉及式（I）的取代双酰胺嘧啶化合物，其可用于治疗金属蛋白酶介导的疾病，特别是MMP-13相关疾病。

4. 发明申请

US20060293345A1 Heterobicyclic metalloprotease inhibitors 审中-公开
标题翻译：异双环金属蛋白酶抑制剂
公开(公告)号：US20060293345A1
公开(公告)日：2006-12-28
申请号：US11440087
申请日：2006-05-22
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
IPC分类号： A61K31/519 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.
摘要翻译：本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。更具体地说，本发明提供了一类新型的杂双环MMP-13抑制化合物，其表现出与目前已知的MMP-13抑制剂有关的效力。

5. 发明授权

US6030917A Combinatorial synthesis and analysis of organometallic compounds and catalysts 失效
公开(公告)号：US6030917A
公开(公告)日：2000-02-29
申请号：US898715
申请日：1997-07-22
申请人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
发明人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
IPC分类号： B01J19/00 , C07B61/00 , C07F15/00 , C07F15/04 , C08F4/70 , C08F10/00 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01J4/00 , G01N21/64 , G01N29/036 , G01N29/24 , G01N29/34 , G01N29/44 , B01J31/00 , B01J37/00 , C08F4/02
CPC分类号： G01N21/6402 , B01J19/0046 , B82Y30/00 , C07F15/0066 , C07F15/045 , C08F10/00 , G01J4/00 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N2291/02818 , G01N2291/0423 , G01N2291/106
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

6. 发明授权

US08497264B2 Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use 有权
公开(公告)号：US08497264B2
公开(公告)日：2013-07-30
申请号：US13047693
申请日：2011-03-14
申请人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
发明人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
IPC分类号： C07D513/10 , C07D498/20 , A61K31/547 , A61K31/5386
CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

7. 发明申请

US20130018064A1 Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use 有权
标题翻译：氨基杂芳基化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US20130018064A1
公开(公告)日：2013-01-17
申请号：US13511360
申请日：2010-11-19
申请人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
发明人： Nick A. Paras , Yuan Cheng , Timothy Powers , James Brown , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Qiufen Xue , Bryant Yang
IPC分类号： A61K31/506 , A61P25/28 , A61K31/4709 , C07D401/08 , C07D401/06
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

8. 发明授权

US06453627B1 Skirt assembly for manufactured housing units 失效
标题翻译：制造住房单元的裙子组件
公开(公告)号：US06453627B1
公开(公告)日：2002-09-24
申请号：US09685373
申请日：2000-10-10
申请人： Timothy Powers
发明人： Timothy Powers
IPC分类号： B60R2700
CPC分类号： E04B1/34342 , B60P3/36
摘要： A skirt assembly system for use on a mobile home. The skirt assembly system includes a plurality of telescoping studs. The skirt assembly system also includes a plurality of tracks wherein the stud are secured within the tracks with an edged of the stud facing out. The skirt assembly system also includes studs fastened to a side wall of the tracks. The skirt assembly system also includes a brace connected to the telescoping studs on one side thereof and connected to a bottom of the mobile home on an opposite end of the brace.
摘要翻译：用于移动家庭的裙子组装系统。裙部组装系统包括多个伸缩螺柱。裙部组装系统还包括多个轨道，其中螺柱固定在轨道内，螺柱的边缘朝外。裙部组装系统还包括固定到轨道的侧壁的螺柱。裙部组装系统还包括在其一侧连接到伸缩式螺柱的支架，并且在支架的相对端上连接到移动式家庭的底部。

9. 发明授权

US08735384B2 Amino heteroaryl compounds as beta-secretase modulators and methods of use 有权
标题翻译：氨基杂芳基化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US08735384B2
公开(公告)日：2014-05-27
申请号：US13522823
申请日：2011-01-14
申请人： Nick A. Paras , James Brown , Yuan Cheng , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Ana Elena Minatti , Thomas Nixey , Timothy Powers , Christopher M. Tegley , Qiufen Xue , Bryant Yang , Wenge Zhong
发明人： Nick A. Paras , James Brown , Yuan Cheng , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Ana Elena Minatti , Thomas Nixey , Timothy Powers , Christopher M. Tegley , Qiufen Xue , Bryant Yang , Wenge Zhong
IPC分类号： A61K31/535 , A01N57/00 , A61K31/675
CPC分类号： C07D401/10 , C07D215/38 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D413/10 , C07D471/04 , C07D471/08 , C07D498/08
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein ring A, B1, B2, B3, L, R1, R2, ring Z, m and n of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula (I), intermediates and processes useful for the preparation of compounds of Formula (I).
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式（I）; 其中式I中的环A，B1，B2，B3，L，R1，R2，环Z，m和n定义在本文中。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式（I）的其它实施方案，可用于制备式（I）化合物的中间体和方法。

10. 发明授权

US08404198B2 Apparatus for and method of processing biological samples 有权
标题翻译：生物样品处理装置及其处理方法
公开(公告)号：US08404198B2
公开(公告)日：2013-03-26
申请号：US12549311
申请日：2009-08-27
申请人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Korneija Zgonc
发明人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Korneija Zgonc
IPC分类号： B01L9/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译：本发明提供了用于自动化生物处理的系统，装置，装置和方法。适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动珠基分离。在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA，以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。

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