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1. 发明授权

US10422005B2 Methods for treating colorectal cancer using prognostic genetic markers 有权
公开(公告)号：US10422005B2
公开(公告)日：2019-09-24
申请号：US12214782
申请日：2008-06-20
申请人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
发明人： Hjalmar Nekarda , Jan Friederichs , Bernhard Holzmann , Robert Rosenberg , Anthony Edmund Reeve , Michael Alan Black , John Lindsay McCall , Yu-Hsin Lin , Robert Craig Pollock
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886 , G01N33/574 , G16B20/00 , G16B25/00
摘要： This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods.

2. 发明授权

US08890611B2 Operational amplifier circuits 有权
标题翻译：运算放大器电路
公开(公告)号：US08890611B2
公开(公告)日：2014-11-18
申请号：US13612784
申请日：2012-09-12
申请人： Hung-Chieh Tsai , Chi-Lun Lo , Chen-Yen Ho , Yu-Hsin Lin
发明人： Hung-Chieh Tsai , Chi-Lun Lo , Chen-Yen Ho , Yu-Hsin Lin
IPC分类号： H03F3/45 , H03F3/193 , H03F1/14 , H03F1/32 , H03F3/30
CPC分类号： H03F3/45179 , H03F1/14 , H03F1/3211 , H03F1/483 , H03F3/193 , H03F3/3023 , H03F3/45 , H03F3/45076 , H03F3/45188 , H03F2200/36 , H03F2203/45222 , H03F2203/45521 , H03F2203/45526 , H03F2203/45626
摘要： An operational amplifier circuit includes a first stage amplifier circuit, a second stage amplifier circuit and a first feedforward circuit. The first stage amplifier circuit is coupled to a first input node for receiving a first input signal and amplifying the first input signal to generate a first amplified signal. The second stage amplifier circuit is coupled to the first stage amplifier circuit for receiving the first amplified signal and amplifying the first amplified signal to generate a first output signal at a first output node. The first feedforward circuit is coupled between the first input node and the second stage amplifier circuit for feeding the first input signal forward to the second stage amplifier circuit.
摘要翻译：运算放大器电路包括第一级放大器电路，第二级放大器电路和第一前馈电路。第一级放大器电路耦合到第一输入节点，用于接收第一输入信号并放大第一输入信号以产生第一放大信号。第二级放大器电路耦合到第一级放大器电路，用于接收第一放大信号并放大第一放大信号以在第一输出节点产生第一输出信号。第一前馈电路耦合在第一输入节点和第二级放大器电路之间，用于将第一输入信号向前馈送到第二级放大器电路。

3. 外观设计

USD687742S1 Stem spacer for a bicycle 有权
标题翻译：用于自行车的座垫
公开(公告)号：USD687742S1
公开(公告)日：2013-08-13
申请号：US29426740
申请日：2012-07-10
申请人： Yu-Hsin Lin
设计人： Yu-Hsin Lin

4. 发明授权

US08454966B2 Nanoparticles for protein drug delivery 失效
标题翻译：用于蛋白质药物递送的纳米颗粒
公开(公告)号：US08454966B2
公开(公告)日：2013-06-04
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K38/14 , A61K31/715 , A61K47/36
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译：本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。

5. 发明授权

US08344921B2 Sigma-delta modulator with SAR ADC and truncater having order lower than order of integrator and related sigma-delta modulation method 有权
标题翻译：具有SAR ADC和截断器的Σ-Δ调制器具有低于积分器的阶数和相关的Σ-Δ调制方法
公开(公告)号：US08344921B2
公开(公告)日：2013-01-01
申请号：US13072797
申请日：2011-03-28
申请人： Yu-Hsin Lin , Hung-Chieh Tsai , Sheng-Jui Huang
发明人： Yu-Hsin Lin , Hung-Chieh Tsai , Sheng-Jui Huang
IPC分类号： H03M3/00
CPC分类号： H03M3/30 , H03M3/412 , H03M3/426 , H03M7/3042
摘要： A sigma-delta modulator includes a processing circuit, a quantizer, a truncater and a feedback circuit. The processing circuit receives an input signal and an analog information and generates an integrated signal by perform an integration upon a difference between the input signal and the analog information. The quantizer includes a successive approximation register (SAR) analog-to-digital converter (ADC) for receiving the integrated signal and generating a digital information according to the integrated signal. The truncater receives the digital information and generates a truncated information according to the digital information. The feedback circuit generates the analog information to the processing circuit according to the truncated information, wherein an order of the truncater is lower than an order of the integration.
摘要翻译： Σ-Δ调制器包括处理电路，量化器，截短器和反馈电路。处理电路接收输入信号和模拟信息，并通过根据输入信号和模拟信息之间的差进行积分来产生积分信号。量化器包括用于接收积分信号并根据积分信号产生数字信息的逐次逼近寄存器（SAR）模拟 - 数字转换器（ADC）。截断器接收数字信息并根据数字信息产生截断的信息。反馈电路根据截断的信息向处理电路生成模拟信息，其中截断器的顺序低于积分的顺序。

6. 发明授权

US08028389B2 Method for fabricating a surface acoustic wave device 有权
标题翻译：声表面波装置的制造方法
公开(公告)号：US08028389B2
公开(公告)日：2011-10-04
申请号：US11944207
申请日：2007-11-21
申请人： Jyh-Shin Chen , Sheng-Wen Chen , Hui-Ling Kao , Yu-Sheng Kung , Yu-Hsin Lin , Yi-Chiuen Hu
发明人： Jyh-Shin Chen , Sheng-Wen Chen , Hui-Ling Kao , Yu-Sheng Kung , Yu-Hsin Lin , Yi-Chiuen Hu
IPC分类号： H04R17/10 , B44C1/22
CPC分类号： H03H9/02622 , H03H3/08 , Y10T29/42 , Y10T29/49155
摘要： A novel surface acoustic wave device with a decreased velocity dispersion and a low insertion loss as well as the fabrication method therefore is provided. The surface acoustic wave device includes a substrate, an insulating layer with an indentation on the substrate, a silicon layer divided by an etched window with a first portion on the insulating layer and a second portion suspended above the indentation, a piezoelectric layer on the first and the second portions of the silicon layer, and at least an electrode on the piezoelectric layer.
摘要翻译：提供了一种具有降低的速度色散和低插入损耗的新型弹性表面波器件及其制造方法。表面声波装置包括基板，在基板上具有凹陷的绝缘层，由蚀刻窗口分隔的硅层，绝缘层上具有第一部分，第二部分悬置在凹陷部分上，第一部分上的压电层和硅层的第二部分，以及压电层上的至少一个电极。

7. 发明申请

US20110181334A1 TRACK AND HOLD CIRCUIT AND RELATED RECEIVING DEVICE WITH TRACK AND HOLD CIRCUIT EMPLOYED THEREIN 有权
标题翻译：跟踪和保持电路跟踪和相关接收设备跟踪并保持已使用的电路
公开(公告)号：US20110181334A1
公开(公告)日：2011-07-28
申请号：US12695164
申请日：2010-01-28
申请人： Hung-Chieh Tsai , Yu-Hsin Lin , Chi-Lun Lo , Jong-Woei Chen
发明人： Hung-Chieh Tsai , Yu-Hsin Lin , Chi-Lun Lo , Jong-Woei Chen
IPC分类号： H03L5/00
CPC分类号： H03G3/3052 , H03G1/0088
摘要： An operational circuit includes: a gain control circuit arranged to provide a gain value upon an input signal according to a set of control signals, wherein the gain control circuit includes a first resistor-based network and a second resistor-based network; an operational amplifier coupled to the gain control circuit and arranged to generate an output signal according to the input signal and the gain value; and a first capacitor coupled to the operational amplifier and arranged to hold the output signal between a first input terminal and a first output terminal of the operational amplifier, wherein when the operational circuit is operating, a first terminal of the first capacitor is consistently coupled to the first input terminal of the operational amplifier, and a second terminal of the first capacitor is consistently coupled to the first output terminal of the operational amplifier.
摘要翻译：运算电路包括：增益控制电路，被配置为根据一组控制信号在输入信号上提供增益值，其中所述增益控制电路包括第一电阻器网络和第二电阻器网络; 运算放大器，耦合到所述增益控制电路并被布置成根据所述输入信号和所述增益值产生输出信号; 以及耦合到所述运算放大器并被布置成将所述输出信号保持在所述运算放大器的第一输入端和所述第一输出端之间的第一电容器，其中当所述运算电路运行时，所述第一电容器的第一端始终耦合到运算放大器的第一输入端和第一电容器的第二端一致地耦合到运算放大器的第一输出端。

8. 发明申请

US20100330167A1 Nanoparticles for protein drug delivery 失效
公开(公告)号：US20100330167A1
公开(公告)日：2010-12-30
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/48 , A61K39/00 , A61K31/00
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.

9. 发明申请

US20100109053A1 SEMICONDUCTOR DEVICE HAVING INTEGRATED CIRCUIT WITH PADS COUPLED BY EXTERNAL CONNECTING COMPONENT AND METHOD FOR MODIFYING INTEGRATED CIRCUIT 审中-公开
标题翻译：具有通过外部连接部件连接的片的集成电路的半导体器件和用于修改集成电路的方法
公开(公告)号：US20100109053A1
公开(公告)日：2010-05-06
申请号：US12264272
申请日：2008-11-04
申请人： Ching-Han Jan , Yu-Hsin Lin
发明人： Ching-Han Jan , Yu-Hsin Lin
IPC分类号： H01L23/62 , H01L21/66
CPC分类号： H01L23/60 , H01L24/06 , H01L24/48 , H01L24/49 , H01L2224/05553 , H01L2224/05554 , H01L2224/05599 , H01L2224/4813 , H01L2224/49175 , H01L2224/85399 , H01L2924/00014 , H01L2924/01023 , H01L2924/01033 , H01L2924/01082 , H01L2924/14 , H01L2924/30107 , H01L2224/45099 , H01L2924/00
摘要： The present invention discloses a semiconductor device. The semiconductor device includes an integrated circuit and a connecting component. The integrated circuit includes a first pad; a second pad; a first current guiding circuit, coupled to the first pad and a first reference voltage, for selectively guiding a first specific electrical signal received from the first pad to the first reference voltage; and a second current guiding circuit, coupled to the second pad and a second reference voltage, for selectively guiding a second specific electrical signal received from the second pad to the second reference voltage; and the connecting component is external to the integrated circuit for coupling the first pad and the second pad.
摘要翻译：本发明公开了一种半导体器件。半导体器件包括集成电路和连接部件。集成电路包括第一焊盘; 第二垫第一电流引导电路，耦合到第一焊盘和第一参考电压，用于选择性地将从第一焊盘接收的第一特定电信号引导到第一参考电压; 以及耦合到所述第二焊盘和第二参考电压的第二电流引导电路，用于选择性地将从所述第二焊盘接收的第二特定电信号引导到所述第二参考电压; 并且所述连接部件在所述集成电路的外部用于联接所述第一焊盘和所述第二焊盘。

10. 发明申请

US20090237150A1 BANDGAP REFERENCE CIRCUIT WITH LOW OPERATING VOLTAGE 有权
标题翻译：具有低工作电压的带宽参考电路
公开(公告)号：US20090237150A1
公开(公告)日：2009-09-24
申请号：US12051989
申请日：2008-03-20
申请人： Hung-Chieh Tsai , Yu-Hsin Lin
发明人： Hung-Chieh Tsai , Yu-Hsin Lin
IPC分类号： G05F1/10 , H03F3/16
CPC分类号： H03F3/45183 , G05F3/30 , H03F3/345 , H03F2200/456
摘要： A bandgap reference circuit comprising a current mirror, an operational amplifier, first and second BJT transistors is disclosed. The current mirror comprises a first input terminal, a second input terminal and at least one output terminal. The operational amplifier is coupled to the current mirror, wherein a first transistor and a second transistor respectively coupled to the first and the second input terminals have a zero or near zero threshold voltage. The first and second BJT transistors are coupled to two input terminals of the operational amplifier respectively, wherein at least one of the first and second BJT transistors is coupled to the output terminal of the current mirror through a conductive path.
摘要翻译：公开了一种带隙参考电路，其包括电流镜，运算放大器，第一和第二BJT晶体管。电流镜包括第一输入端，第二输入端和至少一个输出端。运算放大器耦合到电流镜，其中分别耦合到第一和第二输入端的第一晶体管和第二晶体管具有零或接近零的阈值电压。第一和第二BJT晶体管分别耦合到运算放大器的两个输入端，其中第一和第二BJT晶体管中的至少一个通过导电路径耦合到电流镜的输出端。

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