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1. 发明授权

US07253151B2 Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant 有权
标题翻译：为了改善IL-12的活性而突变的IL-12P40亚基的基因及其用于DNA疫苗佐剂的基因
公开(公告)号：US07253151B2
公开(公告)日：2007-08-07
申请号：US10221975
申请日：2001-03-15
申请人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
发明人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
IPC分类号： A01N43/04 , A01N63/00 , A01N65/00 , A61K31/70 , C12N5/00 , C12N5/02 , C12Q1/68 , A61K38/24 , A61K38/27 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C12N2770/24222 , Y02A50/412
摘要： The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222(human) or Asn-220(mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
摘要翻译：本发明涉及能够产生具有高活性的人和小鼠来源的IL-12（白细胞介素12）的IL-12p40亚基突变基因，包括上述突变基因的表达载体及其用于DNA疫苗佐剂。特别涉及抑制IL-12p40分泌的IL-12p40突变基因，但通常在IL-12p40的Asn-222（人）或Asn-220（小鼠））氨基酸上突变而分泌活性IL-12p70，作为IL-12，IL-12p70活性形式的竞争性抑制剂。因此，本发明的IL-12p40突变基因可用于针对各种疾病（例如艾滋病，丙型肝炎或乙型肝炎，癌症，流感，结核病和疟疾）的DNA疫苗接种和基因治疗，其基本上需要细胞免疫应答为他们的治疗。

2. 发明授权

US07910564B2 Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant 有权
标题翻译：为了改善IL-12的活性而突变的IL-12P40亚基的基因及其用于DNA疫苗佐剂的基因
公开(公告)号：US07910564B2
公开(公告)日：2011-03-22
申请号：US11832993
申请日：2007-08-02
申请人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
发明人： Young Chul Sung , Sung Hee Lee , Sang Jun Ha , Man Ki Song , Jun Chang
IPC分类号： A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/00 , A01N63/00 , A01N65/00
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C12N2770/24222 , Y02A50/412
摘要： The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL- 12p70 by making mutation at Asn-222 (human) or Asn- 220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
摘要翻译：本发明涉及能够产生具有高活性的人和小鼠来源的IL-12（白细胞介素12）的IL-12p40亚基突变基因，包括上述突变基因的表达载体及其用于DNA疫苗佐剂。特别涉及抑制IL-12p40分泌的IL-12p40突变基因，通常在IL-12p40的Asn-222（人）或Asn-220（小鼠））氨基酸上突变而分泌活性的IL-12p70，作为IL-12，IL-12p70活性形式的竞争性抑制剂。因此，本发明的IL-12p40突变基因可用于针对各种疾病（例如艾滋病，丙型肝炎或乙型肝炎，癌症，流感，结核病和疟疾）的DNA疫苗接种和基因治疗，其基本上需要细胞免疫应答为他们的治疗。

3. 发明申请

US20070269408A1 GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT 有权
标题翻译：用于改善IL-12活性的IL-12p40亚基基因及其用于DNA疫苗补充剂的用途
公开(公告)号：US20070269408A1
公开(公告)日：2007-11-22
申请号：US11832993
申请日：2007-08-02
申请人： Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
发明人： Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
IPC分类号： A61K38/20 , A61K48/00 , C07K14/54 , C07H21/04 , C12P21/04
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C12N2770/24222 , Y02A50/412
摘要： The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222 (human) or Asn-220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
摘要翻译：本发明涉及能够产生具有高活性的人和小鼠来源的IL-12（白细胞介素12）的IL-12p40亚基突变基因，包括上述突变基因的表达载体及其用于DNA疫苗佐剂。特别涉及抑制IL-12p40分泌的IL-12p40突变基因，但通常在IL-12p40的Asn-222（人）或Asn-220（小鼠））氨基酸上突变而分泌活性IL-12p70，作为IL-12，IL-12p70活性形式的竞争性抑制剂。因此，本发明的IL-12p40突变基因可用于针对各种疾病（例如艾滋病，丙型肝炎或乙型肝炎，癌症，流感，结核病和疟疾）的DNA疫苗接种和基因治疗，其基本上需要细胞免疫应答为他们的治疗。

4. 发明申请

US20050272210A1 Method for manufacturing gate electrode of semiconductor device using aluminium nitride film 审中-公开
标题翻译：使用氮化铝膜制造半导体器件的栅电极的方法
公开(公告)号：US20050272210A1
公开(公告)日：2005-12-08
申请号：US10998968
申请日：2004-11-30
申请人： Tae Lee , Jun Chang , Dong Park
发明人： Tae Lee , Jun Chang , Dong Park
IPC分类号： H01L21/336 , H01L21/28 , H01L21/318 , H01L21/8234 , H01L21/8238 , H01L29/51
CPC分类号： H01L29/518 , H01L21/28185 , H01L21/28202 , H01L21/2822 , H01L21/823437
摘要： A method for manufacturing gate electrode of semiconductor device using an aluminium nitride film is provided, the method including cleaning a surface of a semiconductor substrate, nitriding the surface of the substrate, forming a gate dielectric film comprising an aluminium nitride film on the surface of a semiconductor substrate, depositing a gate conductive layer and a hard mask layer on the gate dielectric film, and etching the hard mask layer, the gate conductive layer, the gate dielectric film to form a gate electrode.
摘要翻译：提供一种使用氮化铝膜制造半导体器件的栅电极的方法，该方法包括：清洗半导体衬底的表面，对衬底的表面进行氮化，在其表面上形成包含氮化铝膜的栅极电介质膜半导体衬底，在栅极电介质膜上沉积栅极导电层和硬掩模层，并蚀刻硬掩模层，栅极导电层，栅极电介质膜以形成栅电极。

5. 发明申请

US20070141805A1 Method for bonding plastic micro chip 有权
标题翻译：粘合塑料微芯片的方法
公开(公告)号：US20070141805A1
公开(公告)日：2007-06-21
申请号：US10583149
申请日：2004-12-17
申请人： Jun Chang , Dae Hur , Chanil Chung , Jun Park , Han Jo
发明人： Jun Chang , Dae Hur , Chanil Chung , Jun Park , Han Jo
IPC分类号： H01L21/30 , H01L21/46
CPC分类号： B29C65/4895 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B29C59/14 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/54 , B29C65/548 , B29C66/02 , B29C66/028 , B29C66/1122 , B29C66/3022 , B29C66/53461 , B29C66/54 , B29C66/542 , B29C66/71 , B29C66/73161 , B29C66/8322 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0026 , B29L2031/756 , H01L25/046 , H01L2924/0002 , Y10T156/1064 , B29C59/16 , B29C65/00 , H01L2924/00 , B29K2067/003 , B29K2025/06
摘要： Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.
摘要翻译：公开了一种用于制造塑料微芯片的上基板和下基板的方法，其包括上基板，下基板和具有预定高度的样品填充空间，用于在上基板和下基板之间填充样品。根据该方法，通过在上基板和下基板之间引入有机溶剂来粘合上基板和下基板。另外，本发明提供使用该方法制造微芯片的方法和根据该方法制造的微芯片。根据本发明，可以容易且精确地粘合塑料微芯片的上下基板。

6. 发明申请

US20060134856A1 Method for manufacturing capacitor of semiconductor element 失效
标题翻译：制造半导体元件电容器的方法
公开(公告)号：US20060134856A1
公开(公告)日：2006-06-22
申请号：US11089122
申请日：2005-03-24
申请人： Ho Cho , Jun Chang , Eun Lee , Su Chae , Young Kim
发明人： Ho Cho , Jun Chang , Eun Lee , Su Chae , Young Kim
IPC分类号： H01L21/8242
CPC分类号： H01L21/02312 , H01L21/02178 , H01L21/02181 , H01L21/022 , H01L21/3144 , H01L28/60
摘要： A method for manufacturing a capacitor of a semiconductor element including: forming a bottom electrode of the capacitor on a semiconductor substrate; performing rapid thermal nitrification (RTN) on the upper surface of the bottom electrode; performing a thermal process on the obtained structure having the bottom electrode in a furnace under a nitride atmosphere to eliminate stress generated by the RTN; forming Al2O3 and HfO2 dielectric films on the nitrified bottom electrode; and forming a plate electrode of the capacitor on the Al2O3 and HfO2 dielectric films. The thermal process is performed after the RTN performed on the surface of the bottom electrode, so that stress, generated from the RTN, is alleviated, thereby allowing the capacitor to obtain a high capacitance and lowering leakage current.
摘要翻译：一种制造半导体元件的电容器的方法，包括：在半导体衬底上形成电容器的底部电极; 在底电极的上表面进行快速热硝化（RTN）; 对所获得的在氮化物气氛下的炉中具有底部电极的结构进行热处理以消除由RTN产生的应力; 在硝化的底部电极上形成Al 2 O 3 N 3和HfO 2 N 2电介质膜; 以及在Al 2 O 3和HfO 2 N 2电介质膜上形成电容器的平板电极。在底电极表面进行RTN之后进行热处理，从而可以减轻由RTN产生的应力，从而使电容器获得高电容，降低漏电流。

7. 发明申请

US20070026005A1 Vaccine composition comprising il-12 adjuvant encapsulated in controlled-release microsphere 审中-公开
标题翻译：包含包被在控释微球中的il-12佐剂的疫苗组合物
公开(公告)号：US20070026005A1
公开(公告)日：2007-02-01
申请号：US10571196
申请日：2004-09-09
申请人： Young Sung , Su Park , Jun Chang , Jong Son , Sung Lee , Won Kim , Byong Kim
发明人： Young Sung , Su Park , Jun Chang , Jong Son , Sung Lee , Won Kim , Byong Kim
IPC分类号： A61K39/00
CPC分类号： A61K9/1635 , A61K9/0019 , A61K9/0043 , A61K9/1641 , A61K9/1647 , A61K39/39 , A61K2039/543 , A61K2039/55538 , A61K2039/55555 , A61K2039/57
摘要： Disclosed is a vaccine composition including a pathogenic antigen and IL-12 encapsulated in controlled release microspheres. Also, the present invention discloses a method of enhancing the adjuvant effect of IL-12 by employing an IL-12 adjuvant encapsulated in controlled release microspheres. IL-12, used as an adjuvant for a co-administered vaccine antigen in the vaccine composition, is released in vivo for a prolonged period of time by being encapsulated in controlled release microspheres, thereby maximizing its adjuvant effect.
摘要翻译：公开了一种疫苗组合物，其包含包封在控释微球中的病原性抗原和IL-12。此外，本发明公开了通过使用包封在控释微球中的IL-12佐剂来提高IL-12的佐剂效果的方法。用作疫苗组合物中共同施用的疫苗抗原的佐剂的IL-12通过封装在控释微球体中在体内释放较长时间，从而最大化其佐剂效应。

8. 发明申请

US20060146811A1 On-chip network interfacing apparatus and method 有权
标题翻译：片上网络接口设备及方法
公开(公告)号：US20060146811A1
公开(公告)日：2006-07-06
申请号：US11300731
申请日：2005-12-14
申请人： Jin Han , Young Bae , Han Cho , Jun Chang
发明人： Jin Han , Young Bae , Han Cho , Jun Chang
IPC分类号： H04L12/50
CPC分类号： H04L49/10 , H04L49/109 , H04L49/3009 , H04L49/3018 , H04L49/503
摘要： An on-chip network interfacing apparatus and method are provided. The apparatus includes a plurality of on-chip network ports; a switch receiving data from a first on-chip network port of the on-chip network ports and transmitting the received data to a second on-chip network port of the on-chip network ports; and an interface unit interfacing an advanced microcontroller bus architecture (AMBA) signal received from an Internet protocol module, which is designed according to an AMBA on-chip bus protocol, and outputting the interfacing result to the first on-chip network port; and interfacing the on-chip network signal received from the first on-chip network port, and outputting the interfacing result to the Internet protocol module. Accordingly, it is possible to establish communications at increased speeds by interfacing a signal according to the AMBA 2.0 on-chip bus protocol with a signal according to the on-chip network protocol.
摘要翻译：提供了片上网络接口设备和方法。该装置包括多个片上网络端口; 从所述片上网络端口的第一片上网络端口接收数据并将所接收的数据发送到所述片上网络端口的第二片上网络端口; 以及接口单元，其连接从根据AMBA片上总线协议设计的因特网协议模块接收的先进的微控制器总线架构（AMBA）信号，并将接口结果输出到第一片上网络端口; 并且连接从第一片上网络端口接收的片上网络信号，并将接口结果输出到因特网协议模块。因此，可以通过将根据AMBA 2.0片上总线协议的信号与根据片上网络协议的信号进行接口来以增加的速度建立通信。

9. 发明申请

US20070091229A1 Vertically aligned liquid crystal display 审中-公开
标题翻译：垂直对齐的液晶显示屏
公开(公告)号：US20070091229A1
公开(公告)日：2007-04-26
申请号：US11449026
申请日：2006-06-08
申请人： Soo Jang , Byoung Jeon , Jun Chang , Sang Han , Dong Cho , Sung Nam
发明人： Soo Jang , Byoung Jeon , Jun Chang , Sang Han , Dong Cho , Sung Nam
IPC分类号： G02F1/1335 , G02F1/1337
CPC分类号： G02F1/133634 , G02B5/3033 , G02B5/3083 , G02F1/133528 , G02F1/1393 , G02F2001/133742 , G02F2413/12
摘要： Disclosed herein is an integrated-type polarizer comprising a polarizing film provided with a biaxial retardation film as a protective film on a first side thereof, the polarizing film having an absorption axis perpendicular to the optical axis of the biaxial retardation film. Also is provided a vertically aligned liquid crystal display comprising a liquid crystal cell filled with liquid crystal molecules of negative dielectric anisotropy between a first and a second polarizer, the respective absorption axes of which are perpendicular to each other, wherein the integrated-type polarizer acts as the first polarizer.
摘要翻译：本文公开了一种集成型偏振器，其包括在其第一侧上设置有作为保护膜的双轴延迟膜的偏振膜，所述偏振膜具有与双轴延迟膜的光轴垂直的吸收轴。还提供了一种垂直取向的液晶显示器，其包括在第一和第二偏振器之间填充有负介电各向异性的液晶分子的液晶单元，其各自的吸收轴彼此垂直，其中集成型偏振器作为第一偏振片。

10. 发明申请

US20070024792A1 In-plane switching liquid crystal display having simple structure 有权
标题翻译：面内切换液晶显示器结构简单
公开(公告)号：US20070024792A1
公开(公告)日：2007-02-01
申请号：US11493025
申请日：2006-07-26
申请人： Jun Chang , Byoung Jeon , Soo Jang
发明人： Jun Chang , Byoung Jeon , Soo Jang
IPC分类号： G02F1/1343
CPC分类号： G02F1/134363 , G02F1/13363 , G02F2001/133635 , G02F2413/03
摘要： An IPS-LCD, in which the direction of an optical axis and retardation values are adjusted according to the disposition of a phase retardation film replacing one protective film, obtains a contrast ratio similar to that of an IPS-LCD having upper and lower protective films, and has a small thickness. The IPS-LCD includes first and second polarizing plates (1, 2), an IPS panel (3), and a first protective film. Absorption axes (4, 5) of the first and second polarizing plates (1, 2) are orthogonal to each other, and an optical axis of a liquid crystal in the IPS panel (3) and the absorption axis (4) are parallel with each other. A second phase retardation film, obtained by coating a biaxial film (17) with a uniaxial C film (11), is disposed between the second polarizing plate (2) and the IPS panel (3) and is used as a second protective film.
摘要翻译：根据更换一个保护膜的相位延迟膜的配置来调整光轴方向和延迟值的IPS-LCD获得与具有上保护膜和下保护膜的IPS-LCD类似的对比度，厚度小。 IPS-LCD包括第一和第二偏振片（1,2），IPS面板（3）和第一保护膜。第一和第二偏振板（1,2）的吸收轴（4,5）彼此正交，并且IPS面板（3）和吸收轴（4）中的液晶的光轴与彼此。通过用单轴C膜（11）涂布双轴膜（17）而获得的第二相位延迟膜设置在第二偏振片（2）和IPS面板（3）之间，并用作第二保护膜。

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