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1. 发明申请

US20070269408A1 GENES OF IL-12p40 SUBUNIT MUTATED FOR IMPROVING THE ACTIVITY OF IL-12 AND USE THEREOF FOR DNA VACCINE ADJUVANT 有权
标题翻译：用于改善IL-12活性的IL-12p40亚基基因及其用于DNA疫苗补充剂的用途
公开(公告)号：US20070269408A1
公开(公告)日：2007-11-22
申请号：US11832993
申请日：2007-08-02
申请人： Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
发明人： Young Chul SUNG , Sung Lee , Sang Ha , Man Song , Jun Chang
IPC分类号： A61K38/20 , A61K48/00 , C07K14/54 , C07H21/04 , C12P21/04
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C12N2770/24222 , Y02A50/412
摘要： The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12 (interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222 (human) or Asn-220 (mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.
摘要翻译：本发明涉及能够产生具有高活性的人和小鼠来源的IL-12（白细胞介素12）的IL-12p40亚基突变基因，包括上述突变基因的表达载体及其用于DNA疫苗佐剂。特别涉及抑制IL-12p40分泌的IL-12p40突变基因，但通常在IL-12p40的Asn-222（人）或Asn-220（小鼠））氨基酸上突变而分泌活性IL-12p70，作为IL-12，IL-12p70活性形式的竞争性抑制剂。因此，本发明的IL-12p40突变基因可用于针对各种疾病（例如艾滋病，丙型肝炎或乙型肝炎，癌症，流感，结核病和疟疾）的DNA疫苗接种和基因治疗，其基本上需要细胞免疫应答为他们的治疗。

2. 发明申请

US20070026005A1 Vaccine composition comprising il-12 adjuvant encapsulated in controlled-release microsphere 审中-公开
标题翻译：包含包被在控释微球中的il-12佐剂的疫苗组合物
公开(公告)号：US20070026005A1
公开(公告)日：2007-02-01
申请号：US10571196
申请日：2004-09-09
申请人： Young Sung , Su Park , Jun Chang , Jong Son , Sung Lee , Won Kim , Byong Kim
发明人： Young Sung , Su Park , Jun Chang , Jong Son , Sung Lee , Won Kim , Byong Kim
IPC分类号： A61K39/00
CPC分类号： A61K9/1635 , A61K9/0019 , A61K9/0043 , A61K9/1641 , A61K9/1647 , A61K39/39 , A61K2039/543 , A61K2039/55538 , A61K2039/55555 , A61K2039/57
摘要： Disclosed is a vaccine composition including a pathogenic antigen and IL-12 encapsulated in controlled release microspheres. Also, the present invention discloses a method of enhancing the adjuvant effect of IL-12 by employing an IL-12 adjuvant encapsulated in controlled release microspheres. IL-12, used as an adjuvant for a co-administered vaccine antigen in the vaccine composition, is released in vivo for a prolonged period of time by being encapsulated in controlled release microspheres, thereby maximizing its adjuvant effect.
摘要翻译：公开了一种疫苗组合物，其包含包封在控释微球中的病原性抗原和IL-12。此外，本发明公开了通过使用包封在控释微球中的IL-12佐剂来提高IL-12的佐剂效果的方法。用作疫苗组合物中共同施用的疫苗抗原的佐剂的IL-12通过封装在控释微球体中在体内释放较长时间，从而最大化其佐剂效应。

3. 发明授权

US09859142B2 Edge seal for lower electrode assembly 有权
公开(公告)号：US09859142B2
公开(公告)日：2018-01-02
申请号：US13277873
申请日：2011-10-20
申请人： David Schaefer , Ambarish Chhatre , Keith William Gaff , Sung Lee
发明人： David Schaefer , Ambarish Chhatre , Keith William Gaff , Sung Lee
IPC分类号： F16J15/02 , H01L21/683 , H01J37/32 , H01L21/687
CPC分类号： H01L21/6833 , H01J37/32513 , H01J37/32715 , H01J37/32724 , H01L21/68757 , Y10T29/49826
摘要： A lower electrode assembly useful for supporting a semiconductor substrate in a plasma processing chamber includes a temperature controlled lower base plate, an upper plate, a mounting groove surrounding a bond layer and an edge seal comprising an elastomeric band having an outer concave surface in an uncompressed state, the band mounted in the groove such that upper and lower ends of the band are axially compressed and a maximum outward bulging of the band is no greater than a predetermined distance.

4. 发明申请

US20170098191A1 MOBILIZED LAUNDRY SERVICE SYSTEM 审中-公开
公开(公告)号：US20170098191A1
公开(公告)日：2017-04-06
申请号：US15047168
申请日：2016-02-18
申请人： Chang Shin Lee , Sung Lee
发明人： Chang Shin Lee , Sung Lee
IPC分类号： G06Q10/08 , B60P9/00 , G06Q10/10
CPC分类号： G06Q10/08355 , B60P9/00 , G06Q10/04 , G06Q10/047 , G06Q10/06311 , G06Q10/1097
摘要： A distributed laundry system having mobilized laundry vehicles, including true laundry conveyors in the vehicles, and including a specialized distributed computer network in the vehicles to handle the circumstances of mobile laundry operations, such as special laundry instructions. In addition, procedures and operations which allow the vehicles to cooperate to provide efficient pickup and drop off services at locations of the customers' choices (such as at home or work), including flexible territories for the trucks, customer user interfaces on mobile devices such as cell phones, mobile computing devices and the like, and precise time estimates of pick-up and drop-off times.

5. 发明授权

US08931650B2 Vented baby bottle 有权
标题翻译：通风婴儿奶瓶
公开(公告)号：US08931650B2
公开(公告)日：2015-01-13
申请号：US12030629
申请日：2008-02-13
申请人： Bruce McKendry , Sung Lee
发明人： Bruce McKendry , Sung Lee
IPC分类号： A61J11/02 , A61J9/04 , A61J1/20
CPC分类号： A61J9/04 , A61J1/2079 , A61J11/02 , Y10S215/902
摘要： Baby bottles can have a single container, or two containers to create a space for thermal isolation, as selected by the user. The baby bottle can be vented to allow air to enter the bottle through a passageway as liquid is removed. A filter and one-way valve can be provided in the passageway. The passageway can be formed by radially aligning a vent opening in a top cap with a vent opening in a nipple flange, or by providing a channel in the top cap which is always in radial alignment with both the top cap vent opening and the flange vent opening.
摘要翻译：婴儿奶瓶可以具有单个容器或两个容器，以便由用户选择的热隔离空间。当除去液体时，可以将婴儿奶瓶排空，以允许空气通过通道进入瓶子。通道中可以设置过滤器和单向阀。通道可以通过将顶盖中的通气口与乳头法兰中的通气口径向对准，或者通过在顶盖中设置通道，以形成通道，该通道总是与顶盖通气口和法兰通气口开放

6. 发明申请

US20130117986A1 INSTALLATION FIXTURE FOR ELASTOMER BANDS AND METHODS OF USING THE SAME 有权
标题翻译：弹性体的安装方式及其使用方法
公开(公告)号：US20130117986A1
公开(公告)日：2013-05-16
申请号：US13293972
申请日：2011-11-10
申请人： Rish Chhatre , David Schaefer , Sung Lee , Dan Haber
发明人： Rish Chhatre , David Schaefer , Sung Lee , Dan Haber
IPC分类号： B23P11/00 , B23P19/00
CPC分类号： H01L21/68735 , H01L21/67069 , H01L21/6719 , Y10T29/49826 , Y10T29/49863 , Y10T29/53 , Y10T29/53657
摘要： A kit comprising an installation fixture, a plurality of mechanical fasteners and an embedding tool is provided which allows for an elastomer band to be disposed in a mounting groove around a semiconductor substrate support in a manner that relieves the internal stresses of the elastomer band, leading to an elastomer band with a longer operational lifetime. The installation fixture is secured to a substrate support with mechanical fasteners. An elastomer band is placed around an outer circumference of the installation fixture and rotated back and forth to relieve internal stresses of the elastomer band. The fixture is inverted and the elastomer band is slid vertically off the fixture and into the mounting groove. An embedding tool can be used to completely insert the elastomer band into the mounting groove.
摘要翻译：提供一种包括安装夹具，多个机械紧固件和嵌入工具的套件，其允许弹性体带以减轻弹性体带的内部应力的方式设置在半导体衬底支撑件周围的安装槽中，引导到具有更长使用寿命的弹性体带。安装夹具用机械紧固件固定到基板支架上。弹性体带围绕安装夹具的外周放置并且来回旋转以减轻弹性体带的内应力。夹具被倒置，弹性体带从夹具垂直滑入安装槽。可以使用嵌入工具将弹性体带完全插入到安装槽中。

7. 发明申请

US20120047550A1 Method and System for Device Integrity Authentication 有权
标题翻译：设备完整性认证方法与系统
公开(公告)号：US20120047550A1
公开(公告)日：2012-02-23
申请号：US12860247
申请日：2010-08-20
申请人： Sung Lee , Alvaro A. Cardenas , Ryusuke Masuoka
发明人： Sung Lee , Alvaro A. Cardenas , Ryusuke Masuoka
IPC分类号： G06F21/00
CPC分类号： G06F21/57 , H04L63/126 , Y04S40/24
摘要： A networked device performs integrity authentication by determining, using a processor, a measured integrity value of the device. The measured integrity value is compared by the processor to an embedded integrity value of the device. Application of a policy to the device is facilitated by the processor based on the comparison.
摘要翻译：联网设备通过使用处理器确定设备的测量完整性值来执行完整性认证。测量的完整性值由处理器与设备的嵌入式完整性值进行比较。基于比较的处理器便于对设备应用策略。

8. 发明申请

US20090235068A1 Method and Apparatus for Identity Verification 有权
标题翻译：用于身份验证的方法和装置
公开(公告)号：US20090235068A1
公开(公告)日：2009-09-17
申请号：US12048096
申请日：2008-03-13
申请人： Zhexuan Song , Seigo Kotani , Sung Lee , Keishiro Tanaka , Houcheng Lee , Jesus Molina , Ryusuke Masuoka , Tomihiro Yamazaki
发明人： Zhexuan Song , Seigo Kotani , Sung Lee , Keishiro Tanaka , Houcheng Lee , Jesus Molina , Ryusuke Masuoka , Tomihiro Yamazaki
IPC分类号： H04L9/32
CPC分类号： H04L9/3231 , H04L9/3263 , H04L2209/80
摘要： A method for identity verification includes receiving a request for proof of identity from a service provider and receiving biometric information associated with a user of a communication device. The method also includes determining that the received biometric information matches a biometric profile that contains biometric information associated with a registered user of the communication device. The method also includes unlocking a private key associated with the registered user in response to determining that the received biometric information matches a biometric profile and sending a request for a digital certificate that is signed with the private key associated with the registered user. The method further includes receiving the digital certificate that includes a public key associated with the registered user and satisfies the request for proof of identity. The method also includes with forwarding the digital certificate to the service provider.
摘要翻译：用于身份验证的方法包括从服务提供商接收身份证明请求并接收与通信设备的用户相关联的生物特征信息。该方法还包括确定所接收的生物特征信息与包含与通信设备的注册用户相关联的生物特征信息的生物特征信息匹配。该方法还包括响应于确定所接收的生物测定信息与生物特征谱匹配并且发送用与注册用户相关联的私钥签名的数字证书的请求来解锁与注册用户相关联的私钥。该方法还包括接收包括与注册用户相关联的公钥的数字证书，并且满足身份证明请求。该方法还包括将数字证书转发到服务提供商。

9. 发明申请

US20090200257A1 VENTED BABY BOTTLE 有权
标题翻译：透明宝宝瓶
公开(公告)号：US20090200257A1
公开(公告)日：2009-08-13
申请号：US12030629
申请日：2008-02-13
申请人： Bruce McKendry , Sung Lee
发明人： Bruce McKendry , Sung Lee
IPC分类号： A61J9/04
CPC分类号： A61J9/04 , A61J1/2079 , A61J11/02 , Y10S215/902
摘要： Baby bottles can have a single container, or two containers to create a space for thermal isolation, as selected by the user. The baby bottle can be vented to allow air to enter the bottle through a passageway as liquid is removed. A filter and one-way valve can be provided in the passageway. The passageway can be formed by radially aligning a vent opening in a top cap with a vent opening in a nipple flange, or by providing a channel in the top cap which is always in radial alignment with both the top cap vent opening and the flange vent opening.
摘要翻译：婴儿奶瓶可以具有单个容器或两个容器，以便由用户选择的热隔离空间。当除去液体时，可以将婴儿奶瓶排空，以允许空气通过通道进入瓶子。通道中可以设置过滤器和单向阀。通道可以通过将顶盖中的通气口与乳头法兰中的通气口径向对准，或者通过在顶盖中设置通道，以形成通道，该通道总是与顶盖通气口和法兰通气口开放

10. 发明授权

US07354418B2 Express kits and cup liners for human milking apparatus 失效
标题翻译：用于挤奶设备的快速套件和杯垫
公开(公告)号：US07354418B2
公开(公告)日：2008-04-08
申请号：US10839968
申请日：2004-05-06
申请人： Sung Lee , Bruce McKendry
发明人： Sung Lee , Bruce McKendry
IPC分类号： A61M1/06
CPC分类号： A61M1/066 , A61M1/06
摘要： A breast pump includes a pump that produces both vacuum and pulsating pressure, at least one express kit, and hoses or the like for connecting the pump to the express kit. The express kit includes a manifold, a milk collection vessel, a rigid cup and a flexible liner. The liner is made of a pliable material, and includes a funnel and a throat. The inside surface of the funnel, which is between the liner and the cup when the liner is installed, has an optional honeycomb structure that creates a forced space between the liner and the cup, while maintaining some degree of flexibility. At the end of the liner inside the throat, a rigid insert or suitable bond maintains some rigidity inside the throat, supports the liner and creates a seal between the liner and the cup at the throat end of the liner.
摘要翻译：吸奶器包括产生真空和脉动压力的泵，至少一个快速套件和用于将泵连接到快速套件的软管等。快递套件包括歧管，收集牛奶，刚性杯和柔性衬里。衬里由柔韧材料制成，包括漏斗和喉咙。当衬垫安装时，在衬套和杯之间的漏斗的内表面具有可选的蜂窝结构，其在衬垫和杯之间产生强制空间，同时保持一定程度的柔性。在喉部内的衬垫的末端，刚性插入物或合适的粘合剂在喉部内部保持一些刚性，支撑衬垫并且在衬垫的喉端处在衬垫和杯之间产生密封。

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