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1. 发明授权

US5509899A Medical device with lubricious coating 失效
标题翻译：带有光滑涂层的医疗器械
公开(公告)号：US5509899A
公开(公告)日：1996-04-23
申请号：US310730
申请日：1994-09-22
申请人： You-Ling Fan , Lawrence Marlin , Ronald A. Sahatjian , Steven A. Schultz
发明人： You-Ling Fan , Lawrence Marlin , Ronald A. Sahatjian , Steven A. Schultz
IPC分类号： A61L29/00 , A61L29/06 , A61L29/08 , A61L33/00 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0045 , A61L29/06 , A61L29/085 , A61M25/104
摘要： A medical balloon and catheter in which the balloon (14) is wrapped and folded upon itself tortuously and tightly so outer surfaces (12) contact each other for insertion into the body and in which the balloon is free of bridging and adhesion between abutting surfaces. The balloon has a base of a continuous polymeric surface (10) expandable from a folded, wrapped configuration with surfaces touching each other into a balloon when inflated. A lubricious, biocompatible, hydrogel coating (11) is disposed on the polymeric surface and a thin, lubricious, blood-compatible coating (12) is disposed upon the hydrogel coating and adheres to it to prevent abutting surfaces of the folded polymeric surfaces from adhering to each other during inflation and to prevent delamination of the hydrogel coating and/or rupture of the balloon. Preferably the blood-compatible coating (12) is polyethylene glycol, methoxy polyethylene glycol or mixtures thereof having a molecular weight between about 100 and 20,000 grams per gram mole.
摘要翻译：一种医用气囊和导管，其中气囊（14）被折叠地紧密地包裹并折叠，所以外表面（12）彼此接触以插入到身体中，并且气球在邻接表面之间没有桥接和粘附。气囊具有可从折叠的包裹构造展开的连续聚合物表面（10）的基部，当膨胀时，表面彼此接触成一个气球。光滑的生物相容的水凝胶涂层（11）设置在聚合物表面上，并且薄的，润滑的，与血液相容的涂层（12）设置在水凝胶涂层上并粘附到其上以防止折叠的聚合物表面的邻接表面粘附并且防止水凝胶涂层分层和/或气囊破裂。优选地，血液相容性涂层（12）是聚乙二醇，甲氧基聚乙二醇或其分子量为约100至20,000克/克摩尔的其混合物。

2. 发明授权

US09034346B2 Implantable or insertable medical device resistant to microbial growth and biofilm formation 有权
标题翻译：可植入或可插入的医疗器械抗微生物生长和生物膜形成
公开(公告)号：US09034346B2
公开(公告)日：2015-05-19
申请号：US13357033
申请日：2012-01-24
申请人： Kathleen M. Miller , Gregory T. Sydney , Kurt Geitz , Peter L. Dayton , Ronald A. Sahatjian
发明人： Kathleen M. Miller , Gregory T. Sydney , Kurt Geitz , Peter L. Dayton , Ronald A. Sahatjian
IPC分类号： A61L2/232 , A61L29/16 , A61L31/16
CPC分类号： A61L2/232 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/206 , A61L2300/21 , A61L2300/404 , A61L2300/45 , Y10T428/1334 , Y10T428/1352 , Y10T428/1372 , Y10T428/1379 , Y10T428/1386 , Y10T428/1393
摘要： Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
摘要翻译：公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和用于抑制微生物附着的微生物粘附/生物膜合成抑制剂以及合成和积累生物膜在医疗器械的表面上。还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

3. 发明申请

US20110172753A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20110172753A1
公开(公告)日：2011-07-14
申请号：US13053461
申请日：2011-03-22
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprosthesis are disclosed.
摘要翻译：公开内置假体。

4. 发明申请

US20080145469A1 EXTRUSION APPARATUS FOR MAKING MULTILAYER ARTICLES 有权
标题翻译：挤出装置制作多层文章
公开(公告)号：US20080145469A1
公开(公告)日：2008-06-19
申请号：US12032054
申请日：2008-02-15
申请人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
发明人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
IPC分类号： B29C47/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M2025/1075 , B29C47/0023 , B29C47/065 , B29C47/263 , B29K2067/00 , B29K2067/006 , B29K2077/00 , B29L2022/022 , B29L2031/7542 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/1393 , Y10T428/31736 , Y10T428/31786
摘要： In certain aspects of the invention, an extrusion apparatus for making a multilayer article includes multiple discs, each of which has at least one passageway configured to permit fluid flow therethrough in a flow direction. At least one of the discs includes a cone shaped portion extending substantially parallel to the flow direction.
摘要翻译：在本发明的某些方面，用于制造多层制品的挤出装置包括多个盘，每个盘具有至少一个通道，其构造成允许流体在流动方向上流过其中。至少一个盘包括基本上平行于流动方向延伸的锥形部分。

5. 发明授权

US5919145A Bodily sample collection balloon catheter 失效
标题翻译：身体样本采集球囊导管
公开(公告)号：US5919145A
公开(公告)日：1999-07-06
申请号：US787303
申请日：1997-01-24
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61B10/00 , A61B10/04 , A61M29/02
CPC分类号： A61B10/04 , A61M2025/109 , A61M25/104
摘要： Treating a patient by collecting a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a polymer on its outer surface capable of receiving a substantial amount of bodily sample. The catheter is positioned within the body and the sample is taken by exposing the polymer by placing it in proximity within a desired location so that the bodily sample is received by the polymer. The catheter is removed from the patient and the sample is collected outside the body.
摘要翻译：通过从患者体内的深处收集身体样品并将样品收集在身体外部以便于治疗患者来治疗患者。以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。远侧部分在其外表面上包括能够接收大量身体样品的聚合物。导管定位在体内，并且通过将聚合物放置在所需位置附近而使聚合物暴露而使样品被采集，使得身体样品被聚合物接收。从患者身上取出导管，将样品收集在体外。

6. 发明授权

US5797877A Medical device balloons containing thermoplastic elastomers 失效
公开(公告)号：US5797877A
公开(公告)日：1998-08-25
申请号：US653117
申请日：1996-05-24
申请人： Bruce Hamilton , Ronald A. Sahatjian
发明人： Bruce Hamilton , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61L29/00 , A61L29/04 , A61M25/00 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/049 , A61M25/0045 , A61M25/1002 , A61M2025/1075 , A61M25/1038
摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.

7. 发明授权

US5533516A Sample collection 失效
标题翻译：样品收集
公开(公告)号：US5533516A
公开(公告)日：1996-07-09
申请号：US392101
申请日：1995-02-22
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04 , A61B17/00 , A61B17/22 , A61F2/958
CPC分类号： A61B10/0275 , A61B10/04 , A61B17/320725 , A61B2017/00292 , A61B2017/22001 , A61M2025/1072 , A61M2025/1086 , A61M2025/109 , A61M25/10
摘要： Taking a bodily sample, e.g., a cell sample, from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a membrane with openings that communicate with space that communicates with a source of suction force. The catheter is positioned within the body. The sample is taken by exposing the membrane by placing it in proximity with a desired location so that the bodily sample is received by the membrane. The catheter is removed from the patient, the sample is collected outside the body, treated, disposed onto a device, such as a graft, stent, or catheter, and reintroduced into the body at a desired site.
摘要翻译：从患者体内的深处取出身体样品，例如细胞样品，并将样品收集在身体外部，以便于患者的治疗。以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。远端部分包括具有开口的膜，所述开口与空气连通，其与吸力源连通。导管位于体内。通过将膜放置在所需位置附近，使膜暴露于样品，使得身体样品被膜接收。将导管从患者身上取出，将样品收集在身体外部，进行处理，置于诸如移植物，支架或导管的装置上，并在期望的位置重新引入体内。

8. 发明授权

US5242462A Percutaneous anti-migration vena cava filter 失效
标题翻译：经皮反流式静脉滤器
公开(公告)号：US5242462A
公开(公告)日：1993-09-07
申请号：US777977
申请日：1991-10-17
申请人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
发明人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
IPC分类号： A61F2/01 , A61F2/06
CPC分类号： A61F2/01 , A61F2002/016 , A61F2002/8486 , A61F2230/005 , A61F2230/0067
摘要： A filter device positionable within a blood vessel for trapping blood clots in that vessel, the filter device comprising a head with a plurality of divergent legs each secured at its proximal end, to the head, each leg having a hook arranged at its distal end.Each leg has a radially outwardly directed radius of curvature to create a conical configuration to the filter assembly, while distributing the stress concentration along the length of the bend, so that the elastic limit of the material, stainless steel in this embodiment, is not exceeded, and which permits compact delivery of the filter, and adequate radially directed force to permit slight hook penetration of a vessel wall.
摘要翻译：一种位于血管内的过滤器装置，用于捕获血管内的血块，该过滤装置包括头部，该头部具有多个分支腿，每个头部在其近端固定到头部，每个腿部具有设置在其远端的钩。每个支腿具有径向向外指向的曲率半径，以在沿弯曲部分的长度分布应力集中的同时向过滤器组件产生锥形结构，使得不超过本实施例中不锈钢材料的弹性极限，并且其允许过滤器的紧密输送和足够的径向力以允许容器壁的轻微的钩子穿透。

9. 发明授权

US4521588A Optical device including birefringent polyhydrazide polymer 失效
标题翻译：光学装置包括双折射聚酰肼聚合物
公开(公告)号：US4521588A
公开(公告)日：1985-06-04
申请号：US601610
申请日：1984-04-18
申请人： Howard G. Rogers , Ruth C. Bilofsky , Russell A. Gaudiana , Ronald A. Sahatjian
发明人： Howard G. Rogers , Ruth C. Bilofsky , Russell A. Gaudiana , Ronald A. Sahatjian
IPC分类号： G02B1/08 , G02B5/30 , C08G73/08
CPC分类号： G02B1/08 , G02B5/305
摘要： Optical devices including a molecularly oriented highly birefringent polymer are disclosed. The devices include molecularly oriented polymers comprising recurring units which exhibit a distribution of high electron density about the long axes of the polymer and the recurring units thereof. Transparent birefringent polymers comprising a plurality of recurring units having a substantially cylindrical distribution of electron density about the long axis of such units and the chain-extended polymers are included in optical devices and articles. The polymers exhibit high birefringence and simulate in a polymer the optical properties of a uniaxial crystal.
摘要翻译：公开了包括分子取向的高双折射聚合物的光学器件。这些装置包括分子取向聚合物，其包含围绕聚合物长轴和其重复单元显示出高电子密度分布的重复单元。包括多个重复单元的透明双折射聚合物包含在光学器件和制品中，所述重复单元具有围绕这种单元的长轴的基本上圆柱形的电子密度分布和扩链聚合物。聚合物表现出高双折射性，并且在聚合物中模拟单轴晶体的光学性质。

10. 发明授权

US4461886A Substituted birefringent polyamide 失效
标题翻译：取代双折射聚酰胺
公开(公告)号：US4461886A
公开(公告)日：1984-07-24
申请号：US486800
申请日：1983-04-20
申请人： Howard G. Rogers , Russell A. Gaudiana , Jeannette S. Manello , Ronald A. Sahatjian
发明人： Howard G. Rogers , Russell A. Gaudiana , Jeannette S. Manello , Ronald A. Sahatjian
IPC分类号： C08G69/26 , C08G69/32 , C08G69/12
CPC分类号： C08G69/32 , C08G69/26
摘要： A class of polyamides comprising recurring units having certain substituted-biphenylene or substituted-stilbene radicals is disclosed. The substituted radicals include substituents so as to confer a non-coplanar molecular configuration and a substantially cylindrical distribution of electron density about the long axis of the recurring units and the chain-extended polymers including such radicals.Molecularly oriented polymers of the invention exhibit optically uniaxial properties. The highly birefringent polymers are suited to application in optical filter and other devices where a refractive and birefringent material is desired.
摘要翻译：公开了一类包含具有某些取代的亚联苯基或取代的二苯乙烯基团的重复单元的聚酰胺。取代的基团包括取代基，以便赋予非共面分子构型，并且围绕重复单元的长轴和包含这种基团的扩链聚合物的电子密度基本上圆柱形的分布。本发明的分子取向聚合物表现出光学单轴性质。高双折射聚合物适用于需要折射和双折射材料的滤光器和其他器件。

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