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1. 发明授权

US5358706A Muco-adhesive polymers 失效
标题翻译：粘胶聚合物
公开(公告)号：US5358706A
公开(公告)日：1994-10-25
申请号：US954753
申请日：1992-09-30
申请人： Lawrence Marlin , Ronald K. Yamamoto
发明人： Lawrence Marlin , Ronald K. Yamamoto
IPC分类号： A61K47/36 , A61K9/00 , A61K9/08
CPC分类号： A61K9/0048 , Y10S514/912 , Y10S514/915
摘要： Cationic polysaccharide polymers and anionic therapeutic agents delivery systems are disclosed which have been found to be substantive to mucosal surfaces. The present delivery system is well suited for the delivery of anionic ophthalmic pharmaceuticals.
摘要翻译：公开了已经发现对粘膜表面是实质的阳离子多糖聚合物和阴离子治疗剂递送系统。本递送系统非常适用于递送阴离子眼药物。

2. 发明授权

US5295978A Biocompatible hydrophilic complexes and process for preparation and use 失效
标题翻译：生物相容的亲水配合物及其制备和使用方法
公开(公告)号：US5295978A
公开(公告)日：1994-03-22
申请号：US635914
申请日：1990-12-28
申请人： You-Ling Fan , Lawrence Marlin
发明人： You-Ling Fan , Lawrence Marlin
IPC分类号： A61L29/00 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00 , C08J7/04 , A61M25/00
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C08J7/042 , A61L2300/404 , A61L2300/606 , C08J2375/12 , C08J2423/06 , C08J2433/10
摘要： Biocompatible polymeric complexes having utility in many fields including medical applications, as well as personal and health care, are provided and can be affixed to a variety of substrate materials which themselves may or may not also be biocompatible. The complexes of this invention are comprised of a carboxylic acid polymer with either a poly(lower-alkylene oxide) or a poly(N-vinyl lactam). Moreover, a complex of an antimicrobial agent such as iodine can be formed with the complex to provide antimicrobial activity. The complexes are also useful for forming biocompatible coatings on medical devices, some of which can render the surface lubricious when exposed to aqueous or body fluids.
摘要翻译：提供了可在许多领域中使用的生物相容性聚合复合物，包括医疗应用以及个人和医疗保健，并且可以固定在本身可能也可能不是生物相容的各种基材上。本发明的络合物由具有聚（低级环氧烷）或聚（N-乙烯基内酰胺）的羧酸聚合物组成。此外，可以与复合物形成抗菌剂如碘的络合物以提供抗微生物活性。复合物也可用于在医疗器械上形成生物相容性涂层，其中一些可以使暴露于水性或体液中的表面光滑。

3. 发明授权

US4381260A Aromatic chromophoric substituted polysiloxane dyes 失效
标题翻译：芳香色发色取代聚硅氧烷染料
公开(公告)号：US4381260A
公开(公告)日：1983-04-26
申请号：US284388
申请日：1981-07-17
申请人： Nan S. Chu , Lawrence Marlin
发明人： Nan S. Chu , Lawrence Marlin
IPC分类号： C09B5/14 , C09B69/00 , C09B69/10 , C09B5/42 , A23L1/27 , A61K47/00 , C09B39/00
CPC分类号： C09B69/008 , C09B5/14 , C09B69/10
摘要： Polymeric dyes of the present invention have the formula: ##STR1## wherein Me represents the methyl group, x can range from 2 to 100, y can range from 20 to 300, and the ratio of x:y is at least 1:10 and is preferably from 1:5 to 1:1. The symbol L represents the divalent group which connects the chromophoric moiety and the polysiloxane moiety together by covalent bonds. L is conveniently a saturated divalent aliphatic group which connects the silicon atom to the chromophoric group by a non-hydrolyzable covalent bond. Chromo represents an aromatic chromophore which imparts color to the polymer molecule. The polmeric dyes of the present invention can be used to dye natural fibers such as silk, wool, and cotton and to color plastics such as nylon, Dynel, Acrilan, acetate, and viscore. In addition, the polymeric dyes can also be used as a food dye when water soluble groups are present (e.g., on the chromophores) to impart water solubility to the polymeric dye. Because of the stability and the high molecular weight of these polymeric dyes, they can be used as colorants for food as well as in pharmaceutical and cosmetic applications.
摘要翻译：本发明的聚合染料具有下式：其中Me表示甲基，x可以在2至100的范围内，y可以在20至300的范围内，x：y的比例至少为1:10，优选为1：5〜1：1。符号L表示通过共价键将发色部分和聚硅氧烷部分连接在一起的二价基团。 L方便地是通过不可水解的共价键将硅原子与发色基团连接的饱和二价脂族基团。色度表示赋予聚合物分子颜色的芳族发色团。本发明的聚酰胺染料可以用于染色天然纤维如丝，羊毛和棉花，并且可以使塑料如尼龙，Dynel，Acrilan，醋酸酯和粘胶染色。此外，当存在水溶性基团（例如在发色团上）时，聚合染料也可以用作食品染料，以赋予聚合染料水溶性。由于这些聚合染料的稳定性和高分子量，它们可以用作食品以及制药和化妆品应用中的着色剂。

4. 发明授权

US5731087A Lubricious coatings containing polymers with vinyl and carboxylic acid moieties 失效
标题翻译：含有乙烯基和羧酸部分的聚合物的润滑涂层
公开(公告)号：US5731087A
公开(公告)日：1998-03-24
申请号：US478990
申请日：1995-06-07
申请人： You Ling Fan , Lawrence Marlin , Lisa M. Bouldin , Isabel Maria Marino
发明人： You Ling Fan , Lawrence Marlin , Lisa M. Bouldin , Isabel Maria Marino
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L31/10 , C08J7/04 , C09D7/12 , C09D127/04 , C09D127/06 , C09D131/04 , C09D133/02 , C09D201/00 , A61L31/00
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , A61L2400/10 , Y10T428/31507 , Y10T428/31573 , Y10T428/31576 , Y10T428/3158 , Y10T428/31587 , Y10T428/31591 , Y10T428/31598 , Y10T428/31645 , Y10T428/31663 , Y10T428/31667 , Y10T428/31692 , Y10T428/31696 , Y10T428/31699 , Y10T428/31743 , Y10T428/31797 , Y10T428/31891 , Y10T428/31909 , Y10T428/3192 , Y10T428/31928 , Y10T428/31935
摘要： Lubricious coatings comprising a binder polymer having a vinyl moiety and a carboxylic acid moiety and a hydrophilic polymer are disclosed. The coatings can be applied to a variety of substrates such as, for example, catheters, stents, dilatation balloons, guide wires, endotracheal tubes, instruments, implants and other biomedical devices and can provide exceptional lubricity and abrasion resistance. Processes for applying the lubricious coatings in either one or two coating steps are also disclosed.
摘要翻译：公开了包含具有乙烯基部分和羧酸部分的粘合剂聚合物和亲水性聚合物的润滑涂层。涂层可以应用于各种基底，例如导管，支架，扩张气球，导丝，气管插管，仪器，植入物和其他生物医学装置，并且可以提供卓越的润滑性和耐磨性。还公开了在一个或两个涂布步骤中涂覆润滑涂层的方法。

5. 发明授权

US5645931A One step thromboresistant lubricious coating 失效
标题翻译：一步抗血栓润滑涂层
公开(公告)号：US5645931A
公开(公告)日：1997-07-08
申请号：US465140
申请日：1995-06-05
申请人： You-Ling Fan , Lawrence Marlin
发明人： You-Ling Fan , Lawrence Marlin
IPC分类号： A61L29/04 , A61L29/08 , A61L33/06 , C08G18/48 , B32B27/40
CPC分类号： C08G18/4833 , A61L29/049 , A61L29/085 , A61L33/068 , Y10T428/26 , Y10T428/263 , Y10T428/31551 , Y10T428/31554 , Y10T428/31573 , Y10T428/31587
摘要： Articles having lubricious polymeric coatings are disclosed. The coatings are comprised of a substantially homogeneous composite of poly(ethylene oxide) and polyisocyanate applied in a single step operation as a mixture in an inert solvent. The coating is believed to form a polymeric complex through an in-situ hydrolysis of the polyisocyanate in the system without substantial crosslinking to form polyurethanes. The polymeric complexes have particular utility in providing medical devices such as catheters with a high degree of abrasion resistance and lubricity when in contact with bodily fluids.
摘要翻译：公开了具有光滑聚合物涂层的制品。涂层由在惰性溶剂中作为混合物的单步操作中施加的聚（环氧乙烷）和多异氰酸酯的基本均匀的复合材料构成。相信该涂层通过体系中的多异氰酸酯的原位水解而形成聚合复合物，而没有实质的交联以形成聚氨酯。当与体液接触时，聚合物复合物在提供具有高耐磨性和润滑性的导管等医疗装置方面具有特别的用途。

6. 发明授权

US4430235A Polymeric antioxidants 失效
标题翻译：聚合物抗氧化剂
公开(公告)号：US4430235A
公开(公告)日：1984-02-07
申请号：US284389
申请日：1981-07-17
申请人： Nan S. Chu , Lawrence Marlin
发明人： Nan S. Chu , Lawrence Marlin
IPC分类号： C08G77/38 , C08G77/382 , C09K15/32 , C10M155/02 , C07F7/08 , C07F7/10 , C10M3/22 , C10M3/44
CPC分类号： C10M155/02 , C08G77/38 , C08G77/382 , C09K15/328 , C10M2229/045 , C10M2229/046 , C10M2229/047 , C10M2229/048 , C10M2229/052
摘要： Polymeric antioxidants comprising polyorganosiloxane backbones having joined thereto, by non-hydrolyzable linkages, aromatic antioxidant moieties.
摘要翻译：聚合抗氧化剂包括与其结合的聚有机硅氧烷主链，通过不可水解的键，芳族抗氧化剂部分。

7. 发明授权

US5558900A One-step thromboresistant, lubricious coating 失效
标题翻译：一步抗血栓，润滑涂层
公开(公告)号：US5558900A
公开(公告)日：1996-09-24
申请号：US310723
申请日：1994-09-22
申请人： You-Ling Fan , Lawrence Marlin
发明人： You-Ling Fan , Lawrence Marlin
IPC分类号： A61L29/04 , A61L29/08 , A61L33/06 , C08G18/48 , B05D3/02 , A61L29/00
CPC分类号： C08G18/4833 , A61L29/049 , A61L29/085 , A61L33/068 , Y10T428/26 , Y10T428/263 , Y10T428/31551 , Y10T428/31554 , Y10T428/31573 , Y10T428/31587
摘要： A method of making articles having lubricious polymeric coatings are disclosed. The coatings are comprised of a substantially homogeneous composite of poly(ethylene oxide) and polyisocyanate applied in a single step operation as a mixture in an inert solvent. The coating is believed to form a polymeric complex through an in-situ hydrolysis of the polyisocyanate in the system without substantial crosslinking to form polyurethanes. The polymeric complexes have particular utility in providing medical devices such as catheters with a high degree of abrasion resistance and lubricity when in contact with bodily fluids.
摘要翻译：公开了制备具有光滑聚合物涂层的制品的方法。涂层由在惰性溶剂中作为混合物的单步操作中施加的聚（环氧乙烷）和多异氰酸酯的基本均匀的复合材料构成。相信该涂层通过体系中的多异氰酸酯的原位水解而形成聚合复合物，而没有实质的交联以形成聚氨酯。当与体液接触时，聚合物复合物在提供具有高耐磨性和润滑性的导管等医疗装置方面具有特别的用途。

8. 发明授权

US5509899A Medical device with lubricious coating 失效
标题翻译：带有光滑涂层的医疗器械
公开(公告)号：US5509899A
公开(公告)日：1996-04-23
申请号：US310730
申请日：1994-09-22
申请人： You-Ling Fan , Lawrence Marlin , Ronald A. Sahatjian , Steven A. Schultz
发明人： You-Ling Fan , Lawrence Marlin , Ronald A. Sahatjian , Steven A. Schultz
IPC分类号： A61L29/00 , A61L29/06 , A61L29/08 , A61L33/00 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0045 , A61L29/06 , A61L29/085 , A61M25/104
摘要： A medical balloon and catheter in which the balloon (14) is wrapped and folded upon itself tortuously and tightly so outer surfaces (12) contact each other for insertion into the body and in which the balloon is free of bridging and adhesion between abutting surfaces. The balloon has a base of a continuous polymeric surface (10) expandable from a folded, wrapped configuration with surfaces touching each other into a balloon when inflated. A lubricious, biocompatible, hydrogel coating (11) is disposed on the polymeric surface and a thin, lubricious, blood-compatible coating (12) is disposed upon the hydrogel coating and adheres to it to prevent abutting surfaces of the folded polymeric surfaces from adhering to each other during inflation and to prevent delamination of the hydrogel coating and/or rupture of the balloon. Preferably the blood-compatible coating (12) is polyethylene glycol, methoxy polyethylene glycol or mixtures thereof having a molecular weight between about 100 and 20,000 grams per gram mole.
摘要翻译：一种医用气囊和导管，其中气囊（14）被折叠地紧密地包裹并折叠，所以外表面（12）彼此接触以插入到身体中，并且气球在邻接表面之间没有桥接和粘附。气囊具有可从折叠的包裹构造展开的连续聚合物表面（10）的基部，当膨胀时，表面彼此接触成一个气球。光滑的生物相容的水凝胶涂层（11）设置在聚合物表面上，并且薄的，润滑的，与血液相容的涂层（12）设置在水凝胶涂层上并粘附到其上以防止折叠的聚合物表面的邻接表面粘附并且防止水凝胶涂层分层和/或气囊破裂。优选地，血液相容性涂层（12）是聚乙二醇，甲氧基聚乙二醇或其分子量为约100至20,000克/克摩尔的其混合物。

9. 发明授权

US5645827A Muco-adhesive polymers 失效
标题翻译：粘胶聚合物
公开(公告)号：US5645827A
公开(公告)日：1997-07-08
申请号：US375498
申请日：1995-01-19
申请人： Lawrence Marlin , Ronald Kenichi Yamamoto
发明人： Lawrence Marlin , Ronald Kenichi Yamamoto
IPC分类号： A61K9/00 , A61K31/74 , A61K47/36
CPC分类号： A61K9/0048 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915
摘要： Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. These compositions are well suited, for example, for the delivery of anionic ophthalmic pharmaceuticals because they can provide clear solution in addition to substantivity.
摘要翻译：公开了包含阳离子多糖聚合物和阴离子治疗剂的组合物，其可以具有增强的对粘膜表面的亲和性。这些组合物非常适合于例如用于递送阴离子眼用药物，因为它们除了具有亲和性之外还能够提供清晰的溶液。

10. 发明授权

US5620738A Non-reactive lubicious coating process 失效
标题翻译：非反应性不良涂层工艺
公开(公告)号：US5620738A
公开(公告)日：1997-04-15
申请号：US486413
申请日：1995-06-07
申请人： You L. Fan , Lawrence Marlin , Lisa M. Bouldin , Isabel M. Marino
发明人： You L. Fan , Lawrence Marlin , Lisa M. Bouldin , Isabel M. Marino
IPC分类号： A61L29/08 , C10M177/00 , B05D1/36 , B05D1/38 , B05D5/08 , B05D7/02
CPC分类号： C10M177/00 , A61L29/085 , A61L2400/10
摘要： Lubricious coatings comprising a binder polymer which is a copolymer of vinyl chloride, vinyl acetate and a carboxylic acid moiety and a hydrophilic polymer are disclosed. The coatings can be applied to a variety of substrates such as, for example, catheters, stents, dilatation balloons, guide wires, endotracheal tubes, instruments, implants and other biomedical devices and can provide exceptional lubricity and abrasion resistance. Processes for applying the lubricious coatings in either one or two coating steps are also disclosed.
摘要翻译：公开了包含作为氯乙烯，乙酸乙烯酯和羧酸部分的共聚物的粘合剂聚合物和亲水性聚合物的润滑涂层。涂层可以应用于各种基底，例如导管，支架，扩张气球，导丝，气管插管，仪器，植入物和其他生物医学装置，并且可以提供卓越的润滑性和耐磨性。还公开了在一个或两个涂布步骤中涂覆润滑涂层的方法。

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