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1. 发明授权

US06822083B1 TSA305 gene 失效
标题翻译： TSA305基因
公开(公告)号：US06822083B1
公开(公告)日：2004-11-23
申请号：US09555367
申请日：2000-05-30
申请人： Yosuke Harada , Kouichi Ozaki
发明人： Yosuke Harada , Kouichi Ozaki
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a pancreas-specific gene comprising a base sequence coding for the amino acid sequence shown under SEQ ID NO:1, which gene is effective particularly in the fields of study, diagnosis and treatment, among others, of pancreatic carcinoma.
摘要翻译：本发明提供了一种胰腺特异性基因，其包含编码SEQ ID NO：1所示氨基酸序列的碱基序列，该基因特别在胰腺癌的研究，诊断和治疗领域尤其有效。

2. 发明申请

US20140141987A1 METHOD FOR DIAGNOSING ARRHYTHMIA BASED ON SINGLE NUCLEOTIDE POLYMORPHISM IN CHROMOSOME 1Q24, NEURL GENE, OR CUX2 GENE 审中-公开
标题翻译：基于1Q24，NEURL基因或CUX2基因的单核苷酸多态性诊断ARRHYTHMIA的方法
公开(公告)号：US20140141987A1
公开(公告)日：2014-05-22
申请号：US14002531
申请日：2012-03-14
申请人： Kouichi Ozaki , Toshihiro Tanaka
发明人： Kouichi Ozaki , Toshihiro Tanaka
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method for diagnosing arrhythmia such as atrial fibrillation is provided. A single nucleotide polymorphism present in the region 24 of the long arm of the chromosome 1, NEURL gene, or CUX2 gene is analyzed, and the risk of developing arrhythmia and/or the presence or absence of the onset of arrhythmia is diagnosed on the basis of the analysis result.
摘要翻译：提供了一种用于诊断心房颤动的心律失常的方法。分析存在于染色体1的长臂区域24中的单核苷酸多态性，NEURL基因或CUX2基因，并且基于心律失常发生的风险和/或心律失常发作的存在或不存在被诊断的分析结果。

3. 发明申请

US20100148649A1 DISPLAY DEVICE, METHOD OF MANUFACTURING THEREOF, AND METHOD OF IMPROVING VISIBILITY 失效
标题翻译：显示装置，其制造方法和改进可见性的方法
公开(公告)号：US20100148649A1
公开(公告)日：2010-06-17
申请号：US12304646
申请日：2007-06-06
申请人： Toshiki Nakata , Toshio Saruyama , Toyohiko Fujisawa , Toru Imaizumi , Kouichi Ozaki , Takaki Aoyama
发明人： Toshiki Nakata , Toshio Saruyama , Toyohiko Fujisawa , Toru Imaizumi , Kouichi Ozaki , Takaki Aoyama
IPC分类号： H01J99/00 , H01J9/00
CPC分类号： G09F9/33 , B24C1/06 , B24C1/08 , G09F2013/222
摘要： A display device having a surface with light-emitting regions and non-light-emitting regions, wherein the aforementioned light-emitting regions and non-light-emitting regions are subjected to simultaneous surface treatment selected from: (1) brush treatment; (2) blast treatment; or (3) combined brush and blast treatment, whereby after the aforementioned treatment the surfaces of the light-emitting regions have a 60°-mirror-surface glossiness according to JIS Z 8741 exceeding 20%, while the surfaces of the non-light-emitting regions have a 60°-mirror-surface glossiness according to JIS Z 8741 not exceeding 20%, has good visibility of images reproduced by the display, which is especially suitable for outdoor application.
摘要翻译：具有发光区域和非发光区域的表面的显示装置，其中上述发光区域和非发光区域经受同时的表面处理，其选自：（1）刷子处理; （2）爆破处理; 或（3）组合式刷涂和喷砂处理，由此在上述处理之后，发光区域的表面根据JIS Z 8741具有超过20％的60°镜面光泽度，而非发光区域的表面，发光区域根据JIS Z 8741不超过20％具有60°镜面光泽度，对于显示器再现的图像具有良好的可视性，这特别适用于户外应用。

4. 发明申请

US20130022975A1 METHOD FOR DETECTING ARTERIOSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3 审中-公开
标题翻译：在人类色素5P15.3单核细胞多态性基础上检测异常性疾病的方法
公开(公告)号：US20130022975A1
公开(公告)日：2013-01-24
申请号：US13579463
申请日：2011-02-18
申请人： Kouichi Ozaki , Toshihiro Tanaka , Yusuke Nakamura
发明人： Kouichi Ozaki , Toshihiro Tanaka , Yusuke Nakamura
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： An atherosclerotic disease such as myocardial infarction or angina pectoris is detected by analyzing a single nucleotide polymorphism on human chromosome 5p15.3, and by associating results of the analysis with the risk of the onset thereof. Examples of the single nucleotide polymorphism on human chromosome 5p15.3 include a nucleotide corresponding to the nucleotide at position 61 in the nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, and a polymorphism at a nucleotide which is in linkage disequilibrium with the above nucleotide.
摘要翻译：通过分析人染色体5p15.3上的单核苷酸多态性，并通过将分析结果与其发病风险相关联来检测动脉粥样硬化性疾病如心肌梗塞或心绞痛。人染色体5p15.3上的单核苷酸多态性的实例包括对应于SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3的核苷酸序列中第61位的核苷酸的核苷酸，与上述核苷酸连接不平衡的核苷酸。

5. 发明申请

US20120325864A1 Dispenser For Highly Viscous Fluid 审中-公开
标题翻译：高粘度流体分配器
公开(公告)号：US20120325864A1
公开(公告)日：2012-12-27
申请号：US13582100
申请日：2011-02-09
申请人： Toru Imaizumi , Kouichi Ozaki
发明人： Toru Imaizumi , Kouichi Ozaki
IPC分类号： B65D83/76
CPC分类号： B05C5/0225 , B05C5/0212 , B05C11/1013 , B05C11/1034 , H01L21/54
摘要： The present invention relates to a dispenser for discharging a highly viscous fluid which possesses a viscosity ranging from 10 to 1,000 Pa·s at 25° C. and contains filler particles, the dispenser comprising: (i) a highly viscous fluid-supply part (A) equipped with a container (3) containing said highly viscous fluid (M) and possessing an outlet (3a) of said highly viscous fluid, a plunger (2) capable of discharging said highly viscous fluid from said outlet by pressing said highly viscous fluid contained in said container, and a servomotor (4) driving said plunger; and (ii) a highly viscous fluid-discharge part (B) equipped with a pipe (7) arranged for delivering said highly viscous fluid discharged from said outlet, an openable and closable valve (8) connected to said pipe, and a discharge port (9) for discharging said highly viscous fluid. The dispenser according to the present invention can stably discharge a specified amount of a highly viscous fluid containing filler particles for a long period of time, and can be used even in a clean room.
摘要翻译：本发明涉及一种用于排出高粘度流体的分配器，该流体在25℃下具有10至1,000Pa·s的粘度，并且包含填料颗粒，该分配器包括：（i）高粘性流体供应部件 A）配备有容纳所述高粘度流体（M）并且具有所述高粘度流体的出口（3a）的容器（3）;柱塞（2），其能够通过将所述高粘度的压力从所述出口排出所述高粘性流体包含在所述容器中的流体和驱动所述柱塞的伺服马达（4）; 和（ii）高粘度流体排出部分（B），其配备有用于输送从所述出口排出的所述高粘度流体的管道（7），连接到所述管道的可打开和关闭的阀门（8）和排出口（9），用于排出所述高粘性流体。根据本发明的分配器可以长时间稳定地排出含有特定量的高粘性含有填料的流体，并且甚至可以在洁净室中使用。

6. 发明授权

US08158351B2 Method for determining inflammatory disease 失效
标题翻译：确定炎性疾病的方法
公开(公告)号：US08158351B2
公开(公告)日：2012-04-17
申请号：US12304559
申请日：2007-06-15
申请人： Toshihiro Tanaka , Yusuke Nakamura , Aritoshi Iida , Kouichi Ozaki , Masatsugu Hori
发明人： Toshihiro Tanaka , Yusuke Nakamura , Aritoshi Iida , Kouichi Ozaki , Masatsugu Hori
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/6893 , A61K31/7088 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2500/00 , G01N2800/324
摘要： It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an oligonucleotide that can be used for the method, a kit for diagnosing inflammatory diseases, a therapeutic agent for inflammatory diseases, and the like. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one type of gene polymorphism existing in a proteasome subunit α type 6 gene.
摘要翻译：本发明的目的是提供一种用于确定包括心肌梗塞在内的炎性疾病的方法，其中包括鉴定与心肌梗塞相关的多态性和使用基因多态性，可用于该方法的寡核苷酸，试剂盒用于诊断炎性疾病，炎症性疾病的治疗剂等。本发明提供一种测定炎性疾病的方法，其包括检测存在于蛋白酶体亚单位α6型基因中的至少一种基因多态性。

7. 发明申请

US20110129826A1 METHOD FOR DETERMINATION OF INFLAMMATORY DISEASE BY USING SINGLE NUCLEOTIDE POLYMORPHISM IN BRCA1-RELATED PROTEIN (BRAP) GENE 审中-公开
标题翻译：通过在BRCA1相关蛋白（BRAP）基因中使用单核多聚体多态性来确定炎症疾病的方法
公开(公告)号：US20110129826A1
公开(公告)日：2011-06-02
申请号：US12739494
申请日：2008-10-29
申请人： Toshihiro Tanaka , Kouichi Ozaki
发明人： Toshihiro Tanaka , Kouichi Ozaki
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2535/131 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： It is an object of the present invention to identify a novel single nucleotide polymorphism (SNP) associated with the development and advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging inflammatory diseases, which comprises detecting at least one gene polymorphism in the BRCA1-associated protein (BRAP) gene.
摘要翻译：本发明的目的是鉴定与炎性疾病如心肌梗死发展和进步相关的新型单核苷酸多态性（SNP）。本发明提供了一种用于判断炎性疾病的方法，其包括检测BRCA1相关蛋白（BRAP）基因中的至少一种基因多态性。

8. 发明授权

US06403785B1 Isolated DNA molecule encoding human TSC403 有权
标题翻译：分离编码人TSC403的DNA分子
公开(公告)号：US06403785B1
公开(公告)日：2002-06-11
申请号：US09601478
申请日：2000-08-03
申请人： Masami Nagata , Kouichi Ozaki , Yoshikazu Shimada , Masato Horie
发明人： Masami Nagata , Kouichi Ozaki , Yoshikazu Shimada , Masato Horie
IPC分类号： C07H2104
CPC分类号： C07K14/4738 , A61K38/00 , C07K14/47 , C07K14/4747
摘要： This invention provides the TSC403 gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, which is a novel gene of great utility particularly in the field of research, diagnosis, therapy, etc. for cancer of the lung, among other diseases. In addition, this invention provides the human ING1L gene comprising a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:4, which is a novel human gene useful for regulating the cell cycle, inhibiting or activating cell proliferation, studies on metabolic aging or apoptosis of cells, pathological exploration, diagnosis and therapy of cancer and other diseases, and screening for the development of new drugs.
摘要翻译：本发明提供了具有编码SEQ ID NO：1的氨基酸序列的核苷酸序列的TSC403基因，其是特别在肺癌的研究，诊断，治疗等方面具有很大效用的新基因，此外，本发明提供了包含编码SEQ ID NO：4的氨基酸序列的核苷酸序列的人ING1L基因，其是可用于调节细胞周期，抑制或激活细胞增殖的新型人基因，研究细胞的代谢老化或细胞凋亡，病理学探索，诊断和治疗癌症等疾病，并筛选新药的发展。

9. 发明授权

US5973060A Silicone rubber particulate composition and methods for the preparation thereof 失效
公开(公告)号：US5973060A
公开(公告)日：1999-10-26
申请号：US245517
申请日：1999-02-05
申请人： Kouichi Ozaki , Norio Matsuda , Makoto Tanoue , Toyohiko Yamadera , Mitsuo Hamada
发明人： Kouichi Ozaki , Norio Matsuda , Makoto Tanoue , Toyohiko Yamadera , Mitsuo Hamada
IPC分类号： C08J3/12 , C08L83/04 , C08L83/00 , C08J9/28
CPC分类号： C08J3/12 , C08L83/04 , C08G77/12 , C08G77/16 , C08G77/20 , C08J2383/04
摘要： A silicone rubber particulate composition useful as an additive for cosmetics, rubbers, resins and paints is disclosed, said composition comprising:(A) a silicone rubber particulate having an average particle size of 0.1 to 1,000 .mu.m;(B) a water-absorptive resin particulate having a water-free average particle size of 0.1 to 1,000 .mu.m; and(C) water,wherein said component (B) is present at a level of 0.01 to 5 weight percent measured on a water-free basis relative to component (A) and said water is present at a level of 10 to 10,000 weight parts for each 100 weight parts of component (B).

10. 发明授权

US5808030A hTFIIIA gene 失效
标题翻译： hTFIIIA基因
公开(公告)号：US5808030A
公开(公告)日：1998-09-15
申请号：US523376
申请日：1995-09-05
申请人： Tsutomu Fujiwara , Satoshi Takeda , Yoshikazu Shimada , Kouichi Ozaki , Sadahito Shin, deceased
发明人： Tsutomu Fujiwara , Satoshi Takeda , Yoshikazu Shimada , Kouichi Ozaki , Sadahito Shin, deceased
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/46
CPC分类号： C07K14/46 , A61K38/00
摘要： An isolated hTFIIIA gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, as disclosed, and in particular the hTFIIIA gene having the nucleotide sequence of SEQ ID NO:2. The gene can be used to express a corresponding hTFIIIA protein. The gene and protein serve as transcription regulating factors, and are useful in the diagnosis or identification of hereditary disease, such as cancer or other diseases resulting from abnormal transcriptional control and, further, in analyzing the mechanisms of action thereof.
摘要翻译：具有编码SEQ ID NO：1的氨基酸序列的核苷酸序列的分离的hTFIIIA基因，特别是具有SEQ ID NO：2的核苷酸序列的hTFIIIA基因。该基因可用于表达相应的hTFIIIA蛋白。该基因和蛋白质用作转录调节因子，并且可用于诊断或鉴定遗传性疾病，例如癌症或由异常转录控制引起的其它疾病，以及进一步分析其作用机制。

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