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1. 发明申请

US20130078298A1 GASEOUS NITRIC OXIDE-SEQUESTERING PRODUCTS AND PROCESSES OF PREPARING SAME 审中-公开
标题翻译：气体氮氧化物测序产品及其制备方法
公开(公告)号：US20130078298A1
公开(公告)日：2013-03-28
申请号：US13697374
申请日：2011-05-09
申请人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
发明人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
IPC分类号： B65D25/00 , B65B5/00
CPC分类号： B65D25/00 , A61L15/22 , A61L15/46 , A61L27/14 , A61L27/54 , A61L28/0007 , A61L28/0038 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61L2300/114 , B65B5/00
摘要： A process of preparing articles having gaseous NO sequestered therein is disclosed, as well as articles prepared thereby. Also disclosed are articles having gaseous NO sequestered therewithin and having reduced amount of oxygen-containing and/or nitrogen-containing reactive species. Also disclosed are processes of preparing packaged articles having a non-gas permeable package that comprises gaseous NO therein and packaged articles made therefrom. Also disclosed are charging devices which can be utilized in the above-described processes. The articles prepared by the above-described processes are preferably medical devices such as indwelling catheters, intubation devices and tampons. Tampons having sequestered therein gaseous NO, uses thereof and processes of preparing same are also disclosed.
摘要翻译：公开了一种制备具有气态NO螯合的制品的方法，以及由此制备的制品。还公开了具有在其中螯合的气态NO并具有减少量的含氧和/或含氮反应性物质的制品。还公开了制备具有包含气态NO的非气体可渗透包装的包装制品的包装制品和由其制成的包装制品的方法。还公开了可以在上述处理中使用的充电装置。通过上述方法制备的制品优选为诸如留置导管，插管装置和棉塞的医疗装置。卫生棉条在其中存储有气态NO，其用途及其制备方法也被公开。

2. 发明申请

US20180125882A1 Compositions And Methods For Treating Diseases Or Disorders Using Extended Release Nitric Oxide Releasing Solutions 审中-公开
公开(公告)号：US20180125882A1
公开(公告)日：2018-05-10
申请号：US15675773
申请日：2017-08-13
申请人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00 , A61K9/08 , A61K9/70 , A61K47/12 , C01B21/24
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/08 , A61K9/7007 , A61K47/12 , C01B21/24
摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.

3. 发明申请

US20090255536A1 Biofilm-Inhibiting Catheters and Tubings 审中-公开
标题翻译：生物膜抑制导管和管
公开(公告)号：US20090255536A1
公开(公告)日：2009-10-15
申请号：US12420671
申请日：2009-04-08
申请人： Yossef Av-Gay , Livia Mahler , Christopher C. Miller
发明人： Yossef Av-Gay , Livia Mahler , Christopher C. Miller
IPC分类号： A61L29/16 , A61M16/04 , A61M27/00 , B05D7/24
CPC分类号： A61L29/16 , A61L2300/114 , A61L2300/404 , A61M16/04 , A61M16/0465 , A61M2025/0056
摘要： Antimicrobial and biofilm-inhibiting nitric oxide-releasing medical appliances for installation into a patient, and processes for producing the medical appliances. The medical appliances are configured for conveying materials into and out of the patient's body and may comprise tubings or pouching systems. The medical appliances comprise a gas-permeable cured resin material selected from the group consisting of curable silicones, polyvinyl acetates, thermoplastic elastomers, acrylonitrile-butadiene-styrene copolymer rubber, polyurethanes and selected combinations thereof, wherein the gas-permeable cured resin material comprises a matrix suitable for releasably sequestering therein permeating gases. A plurality of nitric-oxide gas-releasing moieties is sequestered within and through the gas-permeable resin material. Nitric oxide is released from at least a portion of said plurality of nitric oxide gas-releasing moieties upon contact of the medical appliance with a moisture source. Exemplary medical appliances include endotracheal tubes, crichotracheotomy tubes, urinary catheters, wound drainage tubes, central intravenous catheters, peripheral intravenous catheters, and poucing systems.
摘要翻译：用于安装到患者体内的抗菌和生物膜抑制一氧化氮释放医疗器具，以及用于生产医疗器具的方法。医疗器具被配置为将材料输送进入和离开患者身体，并且可以包括管道或包囊系统。所述医疗器具包括选自可固化的硅酮，聚乙酸乙烯酯，热塑性弹性体，丙烯腈 - 丁二烯 - 苯乙烯共聚物橡胶，聚氨酯及其选择的组合的透气性固化树脂材料，其中透气性固化树脂材料包括基质适于在其中可释放地封闭渗透气体。多个一氧化氮气体释放部分被隔离在透气性树脂材料内并通过透气性树脂材料。当医疗器具与湿气源接触时，一氧化氮从所述多个一氧化氮气体释放部分的至少一部分释放。示例性医疗器具包括气管内导管，气管切开术管，导尿管，伤口引流管，中央静脉导管，外周静脉导管和灌注系统。

4. 发明申请

US20160051579A1 NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开
标题翻译：牛血液呼吸综合征和其他呼吸道疾病的氧化氮治疗
公开(公告)号：US20160051579A1
公开(公告)日：2016-02-25
申请号：US14779541
申请日：2014-12-30
申请人： Alex STENZLER , Chrlstopher C. MILLER , Gilly REGEV-SHOSHANI
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译：公开和描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸状况的方法，装置和系统。在一个实施方案中，呼吸状况可以是牛呼吸道疾病复合物（BRDc）。

5. 发明授权

US09603599B2 Feature to reengage safety switch of tissue stapler 有权
公开(公告)号：US09603599B2
公开(公告)日：2017-03-28
申请号：US13328344
申请日：2011-12-16
申请人： Christopher C. Miller , Edward G. Chekan , Johnny H. Alexander, III , John F. Cummings , Carl J. Shurtleff , Adam R. Dunki-Jacobs , Barry T. Jamison , Joseph E. Young , Cortney E. Henderson
发明人： Christopher C. Miller , Edward G. Chekan , Johnny H. Alexander, III , John F. Cummings , Carl J. Shurtleff , Adam R. Dunki-Jacobs , Barry T. Jamison , Joseph E. Young , Cortney E. Henderson
IPC分类号： A61B17/068 , A61B17/115
CPC分类号： A61B17/1155 , A61B17/115 , A61B2017/00367 , A61B2017/00407 , A61B2017/00862 , A61B2090/034 , A61B2090/0811
摘要： A surgical instrument includes an anvil selectively coupleable to a stapling head assembly and a trigger operable to fire staples into tissue compressed between the anvil and the stapling head assembly. In some versions, a lockout member may engage a securing feature to prevent actuation of the anvil relative to the stapling head assembly. For instance, a tab may engage a slot on an actuator, a screen door lock may provide frictional resistance or engage teeth on the actuator, a door may actuate into engagement with one or more recesses, geared teeth may mesh with teeth on the actuator, the lockout member may include a ratcheting assembly to engage actuator, and/or a push button may actuate into a recess while disengaging the lockout member. Alternatively, in some versions, the trigger actuation assembly may be disengaged prior to firing. An anvil position indicator may restrict engagement of the trigger actuation assembly.

6. 发明授权

US08795222B2 Device and method for treatment of surface infections with nitric oxide 有权
标题翻译：用一氧化氮治疗表面感染的装置和方法
公开(公告)号：US08795222B2
公开(公告)日：2014-08-05
申请号：US13006218
申请日：2011-01-13
申请人： Alex Stenzler , Christopher C. Miller
发明人： Alex Stenzler , Christopher C. Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

7. 发明申请

US20130175319A1 TISSUE STAPLER SAFETY SWITCH FEATURE TO PREVENT PREMATURE JAW OPENING 有权
标题翻译：组织安全开关安全切换功能，防止普通打开开关
公开(公告)号：US20130175319A1
公开(公告)日：2013-07-11
申请号：US13344071
申请日：2012-01-05
申请人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Julia F. Serber
发明人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Julia F. Serber
IPC分类号： A61B17/068
CPC分类号： A61B17/1155 , A61B2017/2946 , A61B2090/0811
摘要： A surgical stapler comprises an anvil assembly, an anvil shaft, a driver, an actuating arm, a safety switch, and a safety feature. The anvil assembly couples with the anvil shaft. The driver drives a plurality of staples into tissue. The actuating arm is in communication with the surgical stapler and is configured to actuate the driver to drive the plurality of staples into tissue. The safety switch is moveable between a locked and an unlocked position. The safety switch prevents operation of the actuating arm when the safety switch is in the locked position. The safety switch enables operation of the actuating arm when the safety switch is in the unlocked position. The safety feature may prevent operation of the driver even when the safety switch is in the unlocked position or prevent operation of the safety switch.
摘要翻译：手术吻合器包括砧组件，砧座轴，驱动器，致动臂，安全开关和安全特征。砧组件与砧轴相连。驱动器将多个订书钉驱动到组织中。所述致动臂与所述外科缝合器连通并且构造成致动所述驱动器以将所述多个钉驱动到组织中。安全开关可在锁定位置和解锁位置之间移动。当安全开关处于锁定位置时，安全开关可防止操作臂的操作。当安全开关处于未锁定位置时，安全开关可操作执行臂。即使当安全开关处于解锁位置或防止安全开关的操作时，安全功能也可以防止驾驶员的操作。

8. 发明授权

US09186148B2 Tissue stapler anvil feature to prevent premature jaw opening 有权
标题翻译：组织吻合器砧特点，以防止过早的颚开口
公开(公告)号：US09186148B2
公开(公告)日：2015-11-17
申请号：US13344061
申请日：2012-01-05
申请人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
发明人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
IPC分类号： A61B17/068 , A61B17/115 , A61B17/072 , A61B17/00 , A61B17/29 , A61B19/00
CPC分类号： A61B17/064 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/115 , A61B17/1155 , A61B2017/00876 , A61B2017/07214 , A61B2017/0725 , A61B2017/2946 , A61B2090/0811
摘要： A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature.
摘要翻译：一种手术器械包括具有触发器的手柄组件，该触发器可操作以将钉子驱动器射击至钉组织。该仪器包括可连接砧座的尖杆。包括砧检测功能以确定砧座何时与杆连接。在一些形式中，砧座检测特征包括一个能够阻止锁定特征脱离的可平移杆。在其他形式中，砧感知管围绕尖的杆设置并且在第一位置上干扰触发器的致动。当砧座感测管处于第二位置时，管中的凹部允许触发器致动。或者，弹性突舌连接到尖的杆并抵抗钉驱动器的致动。触发器锁定组件可以包括弹簧加载的按钮，当按压推杆时“弹出”按钮，从而释放可枢转的锁定特征。

9. 发明申请

US20150297782A1 NITRIC OXIDE-RELEASING DRESSINGS 审中-公开
标题翻译：硝酸氧化物发酵
公开(公告)号：US20150297782A1
公开(公告)日：2015-10-22
申请号：US14585008
申请日：2014-12-29
申请人： Christopher C. Miller , Bruce Murray
发明人： Christopher C. Miller , Bruce Murray
IPC分类号： A61L15/44 , A61L15/20 , A61F13/00 , A43B17/00 , A43B7/00 , A61L15/18 , A41B11/00
CPC分类号： A61L15/44 , A41B11/005 , A41B2400/34 , A43B1/0045 , A43B7/00 , A43B7/1455 , A43B17/003 , A43B17/03 , A61F13/00063 , A61F2013/00285 , A61K31/194 , A61K33/00 , A61L15/18 , A61L15/20 , A61L15/46 , A61L2300/114 , A61L2300/404 , A61L2300/602 , A61L2300/608 , A61K2300/00
摘要： A wound dressing comprising nitric oxide gas producing component.
摘要翻译：包含一氧化氮气体产生组分的伤口敷料。

10. 发明申请

US20120108893A1 DEPLOYABLE AND RETRACTABLE MEMBER FOR INJECTION PORT 有权
标题翻译：注射口可配合和可退回的会员
公开(公告)号：US20120108893A1
公开(公告)日：2012-05-03
申请号：US12938719
申请日：2010-11-03
申请人： Christopher C. Miller
发明人： Christopher C. Miller
IPC分类号： A61F2/00
CPC分类号： A61M39/0208 , A61F5/0056
摘要： An apparatus comprises a housing and one or more deployable protrusions. The apparatus defines a fluid reservoir and presents an upper surface. The housing is sized and configured to be implanted within a patient. The protrusions are selectively movable from a first position to a second position. The protrusions are at least partially retracted relative to the housing when the protrusions are in the first position. The protrusions are at least partially extended relative to the housing when the protrusions are in the second position. The protrusions may be in the form of substantially cylindraceous posts, semi-circular members, or other shapes. The protrusions may be actuated mechanically, electromechanically, or otherwise. The apparatus may be provided as an injection port, as part of a gastric band system or otherwise. The deployed protrusions may facilitate location of the implanted port through external palpation of the patient's abdomen.
摘要翻译：一种装置包括壳体和一个或多个可部署突起。该装置限定流体储存器并呈现上表面。外壳的尺寸和构造被植入患者体内。突起可以选择性地从第一位置移动到第二位置。当突起处于第一位置时，突起至少部分地相对于壳体缩回。当突起处于第二位置时，突起至少部分地相对于壳体延伸。突起可以是基本上圆柱形的柱，半圆形构件或其它形状的形式。突起可以机械地，机电地或其他方式致动。该装置可以被提供为注射端口，作为胃束带系统的一部分或以其它方式。部署的突起可以通过患者腹部的外部触诊来促进植入端口的位置。

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