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1. 发明授权

US08795222B2 Device and method for treatment of surface infections with nitric oxide 有权
标题翻译：用一氧化氮治疗表面感染的装置和方法
公开(公告)号：US08795222B2
公开(公告)日：2014-08-05
申请号：US13006218
申请日：2011-01-13
申请人： Alex Stenzler , Christopher C. Miller
发明人： Alex Stenzler , Christopher C. Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

2. 发明授权

US08770188B2 Metered dose inhaler spacer 有权
标题翻译：计量剂量吸入器垫片
公开(公告)号：US08770188B2
公开(公告)日：2014-07-08
申请号：US13077849
申请日：2011-03-31
申请人： Alex Stenzler , Steve Han
发明人： Alex Stenzler , Steve Han
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M15/0015 , A61M15/0018 , A61M15/002 , A61M15/009 , A61M2205/3334
摘要： A metered dose inhaler (MDI) spacer has a body that defines a dose receiving chamber. A proximal end portion coupled between the body and a mouth port through which a metered dose may be inhaled by a user of the MDI spacer. A distal end portion is coupled with the body. A combined one-way and flow rate control valve coupled with the distal end portion is configured for permitting external airflow into and prohibiting internal airflow out of the dose receiving chamber. A collar coupled with the distal end portion is configured for receiving an actuator shaft of a metered dose inhaler and for forming a seal about an aerosol nozzle of the metered dose inhaler such that a metered dose of medication is admissible into the dose receiving chamber via the collar while airflow into and out of the dose receiving chamber via the collar is prohibited.
摘要翻译：定量吸入器（MDI）间隔物具有限定剂量接收室的主体。连接在主体和口端口之间的近端部分，计量剂量可由MDI间隔物的使用者吸入。远端部分与身体联接。与远端部分结合的组合的单向和流量控制阀构造成允许外部气流进入并阻止内部空气流出剂量接收室。与远端部分联接的套环被构造成用于接收计量剂量吸入器的致动器轴并且用于围绕计量剂量吸入器的气溶胶喷嘴形成密封，使得计量剂量的药物可以经由在通过衣领进入和离开剂量接收室的气流被禁止的情况下。

3. 发明授权

US08534277B2 Device, system and method for targeting aerosolized particles to a specific area of the lungs 有权
标题翻译：用于将雾化颗粒靶向肺的特定区域的装置，系统和方法
公开(公告)号：US08534277B2
公开(公告)日：2013-09-17
申请号：US12183747
申请日：2008-07-31
申请人： Alex Stenzler , William C. Zimlich , Gerhard Scheuch , Bernhard Müllinger , Tobias Kolb , Tobias Hoffmann , Andreas Wenker , Axel Fischer , Sascha Roeder
发明人： Alex Stenzler , William C. Zimlich , Gerhard Scheuch , Bernhard Müllinger , Tobias Kolb , Tobias Hoffmann , Andreas Wenker , Axel Fischer , Sascha Roeder
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00
CPC分类号： A61M15/00 , A61M11/005 , A61M11/08 , A61M15/0013 , A61M15/002 , A61M2016/0021 , A61M2202/064 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2230/06 , A61M2230/201 , A61M2230/40
摘要： The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.
摘要翻译：本发明涉及将雾化的颗粒施用于肺的特定区域，特别是将雾化的药物制剂靶向递送至肺的特定区域。更具体地，本发明涉及通过调节装置的雾化参数来将雾化的颗粒沉积到肺的特定区域的装置和方法。本发明还涉及用于疾病管理的装置，系统和方法，其中基于监测至少一个健康参数来调整雾化参数。

4. 发明授权

US08100125B2 Venturi geometry design for flow-generator patient circuit 有权
标题翻译：文丘里几何设计用于流量发生器患者回路
公开(公告)号：US08100125B2
公开(公告)日：2012-01-24
申请号：US11241303
申请日：2005-09-30
申请人： Steven Duquette , Alex Stenzler , Steve Han
发明人： Steven Duquette , Alex Stenzler , Steve Han
IPC分类号： A61M11/00
CPC分类号： A61M16/0666 , A61M16/0012 , A61M16/0858
摘要： Provided is a universal interface adapted for providing continuous positive airway pressure to a patient when the interface is used with a standard ventilator. The interface is configured to operate at a supply pressure no greater than about 120 centimeters of H2O in order to deliver pressure to the patient of up to about 15 cm of H2O at a flow rate of up to about 12 liters/minute. The universal interface may comprise an interface body having a space pair of breathing passageways intersecting a corresponding of supply passageways. Each one of the breathing passageways is comprised of a patient passageway and an exhalation passageway. Each one of the supply passageways includes a jet venturi having a taper portion. Each one of the exhalation passageways includes a taper portion which tapers outwardly along a direction from the patient passageway toward the exhalation passageway.
摘要翻译：提供了一种通用接口，其适于在接口与标准通气机一起使用时向患者提供持续的正气道压力。该界面构造成在不超过约120厘米H 2 O的供应压力下操作，以便以高达约12升/分钟的流速向患者输送高达约15cm H 2 O的压力。通用接口可以包括具有与供应通道相对应的空间对的呼吸通道的接口体。每个呼吸通道由患者通道和呼气通道组成。每个供应通道包括具有锥形部分的喷射文丘里管。每个呼气通道包括锥形部分，其沿着从患者通道朝向呼气通道的方向向外变细。

5. 发明授权

US08043252B2 Nitric oxide decontamination of the upper respiratory tract 有权
标题翻译：上呼吸道一氧化氮去污
公开(公告)号：US08043252B2
公开(公告)日：2011-10-25
申请号：US12004514
申请日：2007-12-20
申请人： Christopher Miller , Alex Stenzler
发明人： Christopher Miller , Alex Stenzler
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M1/0088 , A61B90/40 , A61H33/14 , A61M1/0031 , A61M13/003 , A61M13/006 , A61M27/00 , A61M35/00 , A61M2202/0275 , A61M2205/3334
摘要： A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. Also provided are several designs for a nasal delivery device for the controlled nasal deliver the nitric oxide containing gas.
摘要翻译：用一氧化氮暴露局部治疗哺乳动物呼吸道的方法包括以下步骤：提供一氧化氮的气体源，并将一氧化氮的气体鼻腔递送到哺乳动物的上呼吸道。还提供了用于受控鼻腔输送含一氧化氮的气体的鼻输送装置的几种设计。

6. 发明申请

US20110112468A1 DEVICE AND METHOD FOR TREATMENT OF SURFACE INFECTIONS WITH NITRIC OXIDE 有权
标题翻译：用氮氧化物处理表面感染的装置和方法
公开(公告)号：US20110112468A1
公开(公告)日：2011-05-12
申请号：US13006218
申请日：2011-01-13
申请人： Alex STENZLER , Christopher C. MILLER
发明人： Alex STENZLER , Christopher C. MILLER
IPC分类号： A61M37/00
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

7. 发明申请

US20090107497A1 Method and device to prevent ventilator acquired pneumonia using nitric oxide 审中-公开
标题翻译：使用一氧化氮预防呼吸机获得性肺炎的方法和装置
公开(公告)号：US20090107497A1
公开(公告)日：2009-04-30
申请号：US11978940
申请日：2007-10-29
申请人： Alex Stenzler , Arthur S. Slutsky
发明人： Alex Stenzler , Arthur S. Slutsky
IPC分类号： A61M16/04 , A61M37/00 , A61M16/00
CPC分类号： A61M16/04 , A61M1/0062 , A61M16/0438 , A61M16/0463 , A61M16/0465 , A61M16/0479 , A61M16/0486 , A61M16/122 , A61M2016/102 , A61M2202/0266 , A61M2202/0275
摘要： A respiratory assist device and method for the prevention of ventilator acquired pneumonia in a patient is described. The respiratory assist device administers nitric oxide to the oropharyngeal area in order to decontaminate or prevent the contamination of secretions that collect in the oropharyngeal area during intubation of the patient. The respiratory assist device and method may be adapted for use, for example, as an endotracheal tube or as a tracheotomy tube.
摘要翻译：描述了一种用于预防患者呼吸机获得性肺炎的呼吸辅助装置和方法。呼吸辅助装置向口咽区域施用一氧化氮，以便在患者的插管期间净化或防止在口咽部区域收集的分泌物的污染。呼吸辅助装置和方法可适用于例如气管内导管或气管切开管。

8. 发明申请

US20090056708A1 DEVICE, SYSTEM AND METHOD FOR TARGETING AEROSOLIZED PARTICLES TO A SPECIFIC AREA OF THE LUNGS 有权
标题翻译：用于将敏化颗粒定向到特定区域的装置，系统和方法
公开(公告)号：US20090056708A1
公开(公告)日：2009-03-05
申请号：US12183747
申请日：2008-07-31
申请人： Alex Stenzler , William C. Zimlich , Gerhard Scheuch , Bernhard Mullinger , Tobias Kolb , Tobias Hoffmann , Andreas Wenker , Axel Fischer , Sascha Roeder
发明人： Alex Stenzler , William C. Zimlich , Gerhard Scheuch , Bernhard Mullinger , Tobias Kolb , Tobias Hoffmann , Andreas Wenker , Axel Fischer , Sascha Roeder
IPC分类号： A61M11/00
CPC分类号： A61M15/00 , A61M11/005 , A61M11/08 , A61M15/0013 , A61M15/002 , A61M2016/0021 , A61M2202/064 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2230/06 , A61M2230/201 , A61M2230/40
摘要： The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.
摘要翻译：本发明涉及将雾化的颗粒施用于肺的特定区域，特别是将雾化的药物制剂靶向递送至肺的特定区域。更具体地，本发明涉及通过调节装置的雾化参数来将雾化的颗粒沉积到肺的特定区域的装置和方法。本发明还涉及用于疾病管理的装置，系统和方法，其中基于监测至少一个健康参数来调整雾化参数。

9. 发明申请

US20080173311A1 Nitric oxide decontamination of the upper respiratory tract 有权
标题翻译：上呼吸道一氧化氮去污
公开(公告)号：US20080173311A1
公开(公告)日：2008-07-24
申请号：US12004514
申请日：2007-12-20
申请人： Christopher Miller , Alex Stenzler
发明人： Christopher Miller , Alex Stenzler
IPC分类号： A61M31/00
CPC分类号： A61M1/0088 , A61B90/40 , A61H33/14 , A61M1/0031 , A61M13/003 , A61M13/006 , A61M27/00 , A61M35/00 , A61M2202/0275 , A61M2205/3334
摘要： A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. Also provided are several designs for a nasal delivery device for the controlled nasal deliver the nitric oxide containing gas.
摘要翻译：用一氧化氮暴露局部治疗哺乳动物呼吸道的方法包括以下步骤：提供一氧化氮的气体源，并将一氧化氮的气体鼻腔递送到哺乳动物的上呼吸道。还提供了用于受控鼻腔输送含一氧化氮的气体的鼻输送装置的几种设计。

10. 发明申请

US20080167603A1 Method and device to prevent ventilator acquired pneumonia using nitric oxide 审中-公开
标题翻译：使用一氧化氮预防呼吸机获得性肺炎的方法和装置
公开(公告)号：US20080167603A1
公开(公告)日：2008-07-10
申请号：US11981570
申请日：2007-10-30
申请人： Alex Stenzler , Arthur Samuel Slutsky
发明人： Alex Stenzler , Arthur Samuel Slutsky
IPC分类号： A61M37/00 , A61M16/00
CPC分类号： A61K33/00 , A61B90/40 , A61H33/14 , A61M13/003 , A61M2202/0275
摘要： A respiratory assist device and method for the prevention of ventilator acquired pneumonia in a patient is described. The respiratory assist device administers nitric oxide to the oropharyngeal area in order to decontaminate or prevent the contamination of secretions that collect in the oropharyngeal area during intubation of the patient. The respiratory assist device and method may be adapted for use, for example, as an endotracheal tube or as a tracheotomy tube.
摘要翻译：描述了一种用于预防患者呼吸机获得性肺炎的呼吸辅助装置和方法。呼吸辅助装置向口咽区域施用一氧化氮，以便在患者的插管期间净化或防止在口咽部区域收集的分泌物的污染。呼吸辅助装置和方法可适用于例如气管内导管或气管切开管。

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