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1. 发明申请

US20180125882A1 Compositions And Methods For Treating Diseases Or Disorders Using Extended Release Nitric Oxide Releasing Solutions 审中-公开
公开(公告)号：US20180125882A1
公开(公告)日：2018-05-10
申请号：US15675773
申请日：2017-08-13
申请人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00 , A61K9/08 , A61K9/70 , A61K47/12 , C01B21/24
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/08 , A61K9/7007 , A61K47/12 , C01B21/24
摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.

2. 发明申请

US20160051579A1 NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开
标题翻译：牛血液呼吸综合征和其他呼吸道疾病的氧化氮治疗
公开(公告)号：US20160051579A1
公开(公告)日：2016-02-25
申请号：US14779541
申请日：2014-12-30
申请人： Alex STENZLER , Chrlstopher C. MILLER , Gilly REGEV-SHOSHANI
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译：公开和描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸状况的方法，装置和系统。在一个实施方案中，呼吸状况可以是牛呼吸道疾病复合物（BRDc）。

3. 发明申请

US20130078298A1 GASEOUS NITRIC OXIDE-SEQUESTERING PRODUCTS AND PROCESSES OF PREPARING SAME 审中-公开
标题翻译：气体氮氧化物测序产品及其制备方法
公开(公告)号：US20130078298A1
公开(公告)日：2013-03-28
申请号：US13697374
申请日：2011-05-09
申请人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
发明人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
IPC分类号： B65D25/00 , B65B5/00
CPC分类号： B65D25/00 , A61L15/22 , A61L15/46 , A61L27/14 , A61L27/54 , A61L28/0007 , A61L28/0038 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61L2300/114 , B65B5/00
摘要： A process of preparing articles having gaseous NO sequestered therein is disclosed, as well as articles prepared thereby. Also disclosed are articles having gaseous NO sequestered therewithin and having reduced amount of oxygen-containing and/or nitrogen-containing reactive species. Also disclosed are processes of preparing packaged articles having a non-gas permeable package that comprises gaseous NO therein and packaged articles made therefrom. Also disclosed are charging devices which can be utilized in the above-described processes. The articles prepared by the above-described processes are preferably medical devices such as indwelling catheters, intubation devices and tampons. Tampons having sequestered therein gaseous NO, uses thereof and processes of preparing same are also disclosed.
摘要翻译：公开了一种制备具有气态NO螯合的制品的方法，以及由此制备的制品。还公开了具有在其中螯合的气态NO并具有减少量的含氧和/或含氮反应性物质的制品。还公开了制备具有包含气态NO的非气体可渗透包装的包装制品的包装制品和由其制成的包装制品的方法。还公开了可以在上述处理中使用的充电装置。通过上述方法制备的制品优选为诸如留置导管，插管装置和棉塞的医疗装置。卫生棉条在其中存储有气态NO，其用途及其制备方法也被公开。

4. 发明授权

US08795222B2 Device and method for treatment of surface infections with nitric oxide 有权
标题翻译：用一氧化氮治疗表面感染的装置和方法
公开(公告)号：US08795222B2
公开(公告)日：2014-08-05
申请号：US13006218
申请日：2011-01-13
申请人： Alex Stenzler , Christopher C. Miller
发明人： Alex Stenzler , Christopher C. Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

5. 发明授权

US07516742B2 Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing 有权
标题翻译：将吸入一氧化氮输送到间歇给药的自发呼吸和机械通气患者的方法和装置
公开(公告)号：US07516742B2
公开(公告)日：2009-04-14
申请号：US11234849
申请日：2005-09-23
申请人： Alex Stenzler , Christopher C. Miller , Bevin McMullin
发明人： Alex Stenzler , Christopher C. Miller , Bevin McMullin
IPC分类号： A61M16/00
CPC分类号： A61M16/12 , A61M16/0833 , A61M16/1015 , A61M16/203 , A61M16/204 , A61M2016/0039 , A61M2016/102 , A61M2016/1025 , A61M2202/0275
摘要： A device and method is disclosed for delivering NO to a patient. The device utilizes a single controller that controls two separate flow controllers to deliver an oxygen-containing gas and a NO-containing gas to the patient to provide NO-containing gas at a flow profile that is proportional or quasi-proportional to a flow profile of the oxygen-containing gas throughout patient inspiration. The controller further comprises logic for setting a nitric oxide delivery profile comprising at least two different concentrations of nitric oxide containing gas and for automatically switching between the at least two different concentrations of nitric oxide containing gas on a timed basis.
摘要翻译：公开了用于将NO递送给患者的装置和方法。该装置使用单个控制器，其控制两个单独的流量控制器以向患者输送含氧气体和含NO的气体，以提供含NO气体的流动分布，该流动分布与流动分布成比例或准成比例含氧气体贯穿患者的灵感。控制器还包括用于设定包含至少两种不同浓度的一氧化氮的气体的一氧化氮输送曲线的逻辑，并且用于在定时基础上自动切换至少两种不同浓度的一氧化氮气体。

6. 发明授权

US07955294B2 Intermittent dosing of nitric oxide gas 有权
标题翻译：间歇给药一氧化氮气体
公开(公告)号：US07955294B2
公开(公告)日：2011-06-07
申请号：US11598221
申请日：2006-11-10
申请人： Alex Stenzler , Christopher C. Miller , Bevin B. McMullin
发明人： Alex Stenzler , Christopher C. Miller , Bevin B. McMullin
IPC分类号： A61M35/00 , A61M16/10
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

7. 发明申请

US20080287861A1 Device and method for treatment of wounds with nitric oxide 审中-公开
标题翻译：用一氧化氮治疗伤口的装置和方法
公开(公告)号：US20080287861A1
公开(公告)日：2008-11-20
申请号：US11982430
申请日：2007-10-31
申请人： Alex Stenzler , Christopher C. Miller
发明人： Alex Stenzler , Christopher C. Miller
IPC分类号： A61M37/00
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

8. 发明授权

US09603599B2 Feature to reengage safety switch of tissue stapler 有权
公开(公告)号：US09603599B2
公开(公告)日：2017-03-28
申请号：US13328344
申请日：2011-12-16
申请人： Christopher C. Miller , Edward G. Chekan , Johnny H. Alexander, III , John F. Cummings , Carl J. Shurtleff , Adam R. Dunki-Jacobs , Barry T. Jamison , Joseph E. Young , Cortney E. Henderson
发明人： Christopher C. Miller , Edward G. Chekan , Johnny H. Alexander, III , John F. Cummings , Carl J. Shurtleff , Adam R. Dunki-Jacobs , Barry T. Jamison , Joseph E. Young , Cortney E. Henderson
IPC分类号： A61B17/068 , A61B17/115
CPC分类号： A61B17/1155 , A61B17/115 , A61B2017/00367 , A61B2017/00407 , A61B2017/00862 , A61B2090/034 , A61B2090/0811
摘要： A surgical instrument includes an anvil selectively coupleable to a stapling head assembly and a trigger operable to fire staples into tissue compressed between the anvil and the stapling head assembly. In some versions, a lockout member may engage a securing feature to prevent actuation of the anvil relative to the stapling head assembly. For instance, a tab may engage a slot on an actuator, a screen door lock may provide frictional resistance or engage teeth on the actuator, a door may actuate into engagement with one or more recesses, geared teeth may mesh with teeth on the actuator, the lockout member may include a ratcheting assembly to engage actuator, and/or a push button may actuate into a recess while disengaging the lockout member. Alternatively, in some versions, the trigger actuation assembly may be disengaged prior to firing. An anvil position indicator may restrict engagement of the trigger actuation assembly.

9. 发明申请

US20130175319A1 TISSUE STAPLER SAFETY SWITCH FEATURE TO PREVENT PREMATURE JAW OPENING 有权
标题翻译：组织安全开关安全切换功能，防止普通打开开关
公开(公告)号：US20130175319A1
公开(公告)日：2013-07-11
申请号：US13344071
申请日：2012-01-05
申请人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Julia F. Serber
发明人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Julia F. Serber
IPC分类号： A61B17/068
CPC分类号： A61B17/1155 , A61B2017/2946 , A61B2090/0811
摘要： A surgical stapler comprises an anvil assembly, an anvil shaft, a driver, an actuating arm, a safety switch, and a safety feature. The anvil assembly couples with the anvil shaft. The driver drives a plurality of staples into tissue. The actuating arm is in communication with the surgical stapler and is configured to actuate the driver to drive the plurality of staples into tissue. The safety switch is moveable between a locked and an unlocked position. The safety switch prevents operation of the actuating arm when the safety switch is in the locked position. The safety switch enables operation of the actuating arm when the safety switch is in the unlocked position. The safety feature may prevent operation of the driver even when the safety switch is in the unlocked position or prevent operation of the safety switch.
摘要翻译：手术吻合器包括砧组件，砧座轴，驱动器，致动臂，安全开关和安全特征。砧组件与砧轴相连。驱动器将多个订书钉驱动到组织中。所述致动臂与所述外科缝合器连通并且构造成致动所述驱动器以将所述多个钉驱动到组织中。安全开关可在锁定位置和解锁位置之间移动。当安全开关处于锁定位置时，安全开关可防止操作臂的操作。当安全开关处于未锁定位置时，安全开关可操作执行臂。即使当安全开关处于解锁位置或防止安全开关的操作时，安全功能也可以防止驾驶员的操作。

10. 发明授权

US09186148B2 Tissue stapler anvil feature to prevent premature jaw opening 有权
标题翻译：组织吻合器砧特点，以防止过早的颚开口
公开(公告)号：US09186148B2
公开(公告)日：2015-11-17
申请号：US13344061
申请日：2012-01-05
申请人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
发明人： Kevin D. Felder , John F. Cummings , Joseph P. Schowalter , Patrick J. Swindon , Johnny H. Alexander, III , Patrick A. Weizman , Cory G. Kimball , Edward G. Chekan , Joseph E. Young , Christopher C. Miller , Barry T. Jamison , John V. Hunt , Kent P. Baker , Cortney E. Henderson , Chester O. Baxter, III , Jerome R. Morgan , Adam R. Dunki-Jacobs , Venkataramanan Mandakolathur Vasudevan , Carl J. Shurtleff , Julia F. Serber
IPC分类号： A61B17/068 , A61B17/115 , A61B17/072 , A61B17/00 , A61B17/29 , A61B19/00
CPC分类号： A61B17/064 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/115 , A61B17/1155 , A61B2017/00876 , A61B2017/07214 , A61B2017/0725 , A61B2017/2946 , A61B2090/0811
摘要： A surgical instrument includes a handle assembly having a trigger operable to fire a staple driver to staple tissue. The instrument includes a pointed rod to which an anvil may be coupled. An anvil detection feature is included to determine when the anvil is coupled to the rod. In some versions, the anvil detection feature comprises a translatable rod that inhibits a lockout feature from disengaging. In other versions, an anvil sensing tube is disposed about the pointed rod and interferes with actuation of the trigger in a first position. A recess in the tube permits trigger to actuate when the anvil sensing tube is in the second position. Alternatively, a resilient tab is coupled to the pointed rod and resists actuation of the staple driver. A trigger lockout assembly may include a spring-loaded button that “pops” out when a push rod is actuated, thereby freeing a pivotable lockout feature.
摘要翻译：一种手术器械包括具有触发器的手柄组件，该触发器可操作以将钉子驱动器射击至钉组织。该仪器包括可连接砧座的尖杆。包括砧检测功能以确定砧座何时与杆连接。在一些形式中，砧座检测特征包括一个能够阻止锁定特征脱离的可平移杆。在其他形式中，砧感知管围绕尖的杆设置并且在第一位置上干扰触发器的致动。当砧座感测管处于第二位置时，管中的凹部允许触发器致动。或者，弹性突舌连接到尖的杆并抵抗钉驱动器的致动。触发器锁定组件可以包括弹簧加载的按钮，当按压推杆时“弹出”按钮，从而释放可枢转的锁定特征。

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