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1. 发明授权

US08247201B2 Method for producing an organic acid 有权
标题翻译：有机酸的制造方法
公开(公告)号：US08247201B2
公开(公告)日：2012-08-21
申请号：US12793107
申请日：2010-06-03
申请人： Yoshinori Tajima , Keita Fukui , Kenichi Hashiguchi
发明人： Yoshinori Tajima , Keita Fukui , Kenichi Hashiguchi
IPC分类号： C12P7/46 , C12N9/00 , C12N15/00 , C07H21/04
CPC分类号： C12N9/88 , C08G69/10 , C12P7/46 , C12Y401/01031
摘要： An organic acid is produced by allowing a bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an organic acid and has been modified so that the phosphoenolpyruvate carboxykinase activity is enhanced, which is selected from Enterobacter, Pantoea, Erwinia, Klebsiella and Raoultella bacteria, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.
摘要翻译：有机酸是通过使属于肠杆菌科的细菌，其具有产生有机酸的能力并被修饰以使得磷酸烯醇丙酮酸羧激酶活性增强，其选自肠杆菌属，泛菌属，欧文氏菌属，克雷伯菌属细菌或通过加工细菌获得的产品在含有碳酸根离子，碳酸氢根离子或二氧化碳气体的反应混合物中作用于有机原料以产生有机酸，并收集有机酸。

2. 发明申请

US20100297716A1 METHOD FOR PRODUCING AN ORGANIC ACID 有权
标题翻译：生产有机酸的方法
公开(公告)号：US20100297716A1
公开(公告)日：2010-11-25
申请号：US12793107
申请日：2010-06-03
申请人： Yoshinori Tajima , Keita Fukui , Kenichi Hashiguchi
发明人： Yoshinori Tajima , Keita Fukui , Kenichi Hashiguchi
IPC分类号： C12P7/46
CPC分类号： C12N9/88 , C08G69/10 , C12P7/46 , C12Y401/01031
摘要： An organic acid is produced by allowing a bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an organic acid and has been modified so that the phosphoenolpyruvate carboxykinase activity is enhanced, which is selected from Enterobacter, Pantoea, Erwinia, Klebsiella and Raoultella bacteria, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.
摘要翻译：有机酸是通过使属于肠杆菌科的细菌，其具有产生有机酸的能力并被修饰以使得磷酸烯醇丙酮酸羧激酶活性增强，其选自肠杆菌属，泛菌属，欧文氏菌属，克雷伯菌属细菌或通过加工细菌获得的产品在含有碳酸根离子，碳酸氢根离子或二氧化碳气体的反应混合物中作用于有机原料以产生有机酸，并收集有机酸。

3. 发明授权

US09200304B2 Method for producing 5′-guanylic acid 有权
标题翻译： 5'-鸟苷酸的制备方法
公开(公告)号：US09200304B2
公开(公告)日：2015-12-01
申请号：US12851793
申请日：2010-08-06
申请人： Hiroaki Fukada , Takayuki Asahara , Kenichi Hashiguchi
发明人： Hiroaki Fukada , Takayuki Asahara , Kenichi Hashiguchi
IPC分类号： C12P19/38 , C12N1/00 , C12N1/20 , C07H21/04 , C12P19/32 , C12N9/04
CPC分类号： C12P19/32 , C12N9/0006
摘要： 5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced.
摘要翻译：通过使微生物与叶酸（XMP）反应生成5'-鸟苷酸（GMP），其中所述微生物能将叶酸转化为5'-鸟苷酸并进行了修饰，使得nagD基因不功能正常和5'-鸟苷酸合成酶活性增强。

4. 发明申请

US20050014236A1 Method for producing L-arginine or L-lysine by fermentation 审中-公开
标题翻译：通过发酵生产L-精氨酸或L-赖氨酸的方法
公开(公告)号：US20050014236A1
公开(公告)日：2005-01-20
申请号：US10790224
申请日：2004-03-02
申请人： Yumi Matsuzaki , Jun Nakamura , Kenichi Hashiguchi
发明人： Yumi Matsuzaki , Jun Nakamura , Kenichi Hashiguchi
IPC分类号： C12N1/20 , C12N1/21 , C12P13/08 , C12P13/10 , C12N9/10
CPC分类号： C12P13/10 , C12P13/08
摘要： L-arginine or L-lysine is produced by culturing a coryneform bacterium having an L-arginine- or L-lysine-producing ability and modified so that glutamine synthetase activity is enhanced, e.g., a coryneform bacterium which is modified so that adenylylation of glutamine synthetase is eliminated. L-arginine or L-lysine are produced by culturing the bacterium in a medium and allowing L-arginine or L-lysine to accumulate in the medium, and collecting the L-arginine or L-lysine from the medium.
摘要翻译：通过培养具有L-精氨酸或L-赖氨酸生产能力的棒状细菌产生L-精氨酸或L-赖氨酸，并对其进行了修饰，使得谷氨酰胺合成酶活性得到增强，例如，修饰为使得谷氨酰胺腺苷酰化的棒状细菌合成酶被消除。通过在培养基中培养细菌并使L-精氨酸或L-赖氨酸在培养基中积聚并从培养基中收集L-精氨酸或L-赖氨酸来产生L-精氨酸或L-赖氨酸。

5. 发明授权

US07297521B2 Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing L-arginine 有权
标题翻译：棒状细菌的氨基甲酰磷酸合成酶基因及L-精氨酸的制备方法
公开(公告)号：US07297521B2
公开(公告)日：2007-11-20
申请号：US11011701
申请日：2004-12-15
申请人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
发明人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
IPC分类号： C12P13/10
CPC分类号： C12N9/93 , C12P13/10
摘要： A DNA fragment which encodes a polypeptide defined in the following (a) or (b), and a polypeptide defined in the following (c) or (d): (a) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing, (b) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a large subunit of carbamoyl-phosphate synthetase having the amino acid sequence of SEQ ID NO: 3, (c) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing, (d) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a small subunit of carbamoyl-phosphate synthetase having the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2.
摘要翻译：编码以下（a）或（b）中定义的多肽的DNA片段和以下（c）或（d）中定义的多肽：（a）至少具有氨基酸的氨基酸序列的多肽序列表所示的SEQ ID NO：2中的50〜393的酸值，（b）至少具有序列表所示的序列号2所示的氨基酸序列号为50〜393的氨基酸序列的多肽，包括取代，一个或几个氨基酸的缺失，插入，添加或倒位，并且可以构成具有氨基甲酰磷酸合成酶活性的蛋白质，其具有氨基酸序列SEQ ID NO：3的氨基甲酰磷酸合成酶的大亚基，（c ）具有序列表所示的SEQ ID NO：3的氨基酸序列的多肽，（d）具有序列表所示的SEQ ID NO：3的氨基酸序列的多肽，包括取代，缺失，插入，添加，或反转一个或几个氨基酸，并可构成具有氨基酸 - 磷酸合成酶活性的蛋白质，其具有SEQ ID NO：2中氨基酸序列号为50〜393的氨基酸序列的氨基甲酰磷酸合成酶的小亚基。

6. 发明授权

US06881566B2 Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing L-arginine 有权
标题翻译：棒状细菌的氨基甲酰磷酸合成酶基因及L-精氨酸的制备方法
公开(公告)号：US06881566B2
公开(公告)日：2005-04-19
申请号：US09836470
申请日：2001-04-18
申请人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
发明人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
IPC分类号： C12N9/00 , C12P13/10 , C12N1/20 , C07H21/04
CPC分类号： C12P13/10 , C12N9/93
摘要： A DNA fragment which encodes a polypeptide defined in the following (a) or (b), and a polypeptide defined in the following (c) or (d): (a) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing, (b) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID No: 2 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a large subunit of carbamoyl-phosphate synthetase having the amino acid sequence comprising at least the amino acid numbers 55 to 1113 of SEQ ID NO: 3, (c) a polypeptide which has the amino acid sequence comprising at least the amino acid numbers 55 to 1113 of SEQ ID NO: 3 shown in Sequence Listing, (d) a polypeptide which has the amino acid sequence comprising at least the amino acid numbers 55 to 1113 of SEQ ID NO: 3 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a small subunit of carbamoyl-phosphate synthetase having the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2.
摘要翻译：编码以下（a）或（b）中定义的多肽的DNA片段和以下（c）或（d）中定义的多肽：（a）至少具有氨基酸的氨基酸序列的多肽序列表所示的SEQ ID NO：2中的酸值为50〜393，（b）至少具有序列表所示的SEQ ID No：2的氨基酸序列号为50〜393的氨基酸序列的多肽，包括取代，一个或几个氨基酸的缺失，插入，添加或倒位，并且可以构成具有氨基甲酰基 - 磷酸合成酶活性的蛋白质，其具有氨基酸 - 磷酸合成酶的大亚基，其氨基酸序列至少包含氨基酸数55至 SEQ ID NO：3的1113，（c）具有至少包含序列表所示的SEQ ID NO：3的氨基酸编号55至1113的氨基酸序列的多肽，（d）具有氨基酸的多肽序列至少包含氨基酸编号55至11 包括序列表中所示的SEQ ID NO：3的13个氨基酸残基，其包含一个或多个氨基酸的取代，缺失，插入，添加或倒位，并且可以构成具有氨甲酰磷酸合成酶活性的氨基甲酰磷酸合成酶的小亚基具有SEQ ID NO：2中氨基酸序列号50至393的氨基酸序列。

7. 发明申请

US20050095680A1 Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing L-arginine 有权
公开(公告)号：US20050095680A1
公开(公告)日：2005-05-05
申请号：US11011701
申请日：2004-12-15
申请人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
发明人： Yoko Kuwabara , Kenichi Hashiguchi , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yukiko Mori , Hisao Ito
IPC分类号： C12N1/21 , C12N9/00 , C12P13/10 , C07H21/04 , C12N9/12
CPC分类号： C12N9/93 , C12P13/10
摘要： A DNA fragment which encodes a polypeptide defined in the following (a) or (b), and a polypeptide defined in the following (c) or (d): (a) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing, (b) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a large subunit of carbamoyl-phosphate synthetase having the amino acid sequence of SEQ ID NO: 3, (c) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing, (d) a polypeptide which has the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing including substitution, deletion, insertion, addition, or inversion of one or several amino acids, and can constitute a protein having a carbamoyl-phosphate synthetase activity with a small subunit of carbamoyl-phosphate synthetase having the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2.

8. 发明授权

US5948662A Bacillus-derived transglutaminase 失效
标题翻译：芽孢杆菌衍生的转谷氨酰胺酶
公开(公告)号：US5948662A
公开(公告)日：1999-09-07
申请号：US989667
申请日：1997-12-12
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
IPC分类号： C12N15/09 , A23J3/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/04 , C12R1/125 , C12R1/19
CPC分类号： C12N9/1044 , Y10S435/839
摘要： A method for processing a protein, a non-proteinaceous amino acid polymer, or a non-proteinaceous amino acid polymer, or a peptide or derivatives thereof having a crosslinked structure, which entails contacting glutamine and lysine residues in a protein, a non-proteinaceous amino acid polymer, a peptide or derivatives thereof with a transglutaminase obtained from Bacillus subtilus to form intermolecular or intramolecular, crosslinked .epsilon.(.delta.-Glu)-Lys bonds between or in the molecules of the protein, non-proteinaceous amino acid polymer, peptide or derivatives thereof, wherein the transglutaminase has the physicochemical properties described herein.
摘要翻译：用于处理蛋白质，非蛋白质氨基酸聚合物或非蛋白质氨基酸聚合物的方法或具有交联结构的肽或其衍生物，其需要使蛋白质中的谷氨酰胺和赖氨酸残基接触，非蛋白质氨基酸聚合物，肽或其衍生物与从枯草芽孢杆菌获得的转谷氨酰胺酶在蛋白质，非蛋白质氨基酸聚合物，肽或肽的分子之间或之内形成分子间或分子内交联的ε（δ-Glu）-Lys键其衍生物，其中转谷氨酰胺酶具有本文所述的物理化学性质。

9. 发明授权

US5888783A Methods for producing L-valine and L-leucine 失效
标题翻译： L-缬氨酸和L-亮氨酸的生产方法
公开(公告)号：US5888783A
公开(公告)日：1999-03-30
申请号：US793441
申请日：1997-02-28
申请人： Fusao Tomita , Atsushi Yokota , Kenichi Hashiguchi , Masako Ishigooka , Osamu Kurahashi
发明人： Fusao Tomita , Atsushi Yokota , Kenichi Hashiguchi , Masako Ishigooka , Osamu Kurahashi
IPC分类号： C12N1/21 , C12N15/52 , C12N15/70 , C12P13/06 , C12P13/08 , C12N1/20
CPC分类号： C12N15/70 , C12N15/52 , C12P13/06 , C12P13/08
摘要： L-valine is produced by culturing a microorganism belonging to the genus Escherichia with the capability of producing L-valine or L-leucine wherein it requires lipoic acid for growth, a microorganism belonging to the genus Escherichia with the capability of producing L-valine or L-leucine wherein it is deficient in H.sup.+ -ATPase activity, a microorganism belonging to the genus Escherichia with the capability of producing L-valine or L-leucine wherein it requires lipoic acid for growth and is deficient in H.sup.+ -ATPase activity, in the liquid medium to allow the L-valine to be produced and accumulated in a culture medium, and collecting it.
摘要翻译： PCT No.PCT / JP95 / 01719 Sec。 371日期1997年2月28日 102（e）日期1997年2月28日PCT提交1995年8月30日PCT公布。公开号WO96 / 06926 日期：1996年3月7日L-缬氨酸是通过培养属于埃希氏杆菌属的微生物而产生的，其具有产生L-缬氨酸或L-亮氨酸的能力，其中需要硫辛酸用于生长，属于埃希氏杆菌属的微生物，其能力为产生L-缬氨酸或L-亮氨酸，其中H + -ATP酶活性不足，属于具有产生L-缬氨酸或L-亮氨酸能力的埃希氏杆菌属的微生物，其中需要硫辛酸生长并且缺乏H + 在液体培养基中ATP酶活性，以使L-缬氨酸在培养基中产生并积累，并收集。

10. 发明申请

US20110033898A1 METHOD FOR PRODUCING 5'-GUANYLIC ACID 有权
标题翻译：生产5'-胍酸的方法
公开(公告)号：US20110033898A1
公开(公告)日：2011-02-10
申请号：US12851793
申请日：2010-08-06
申请人： Hiroaki Fukada , Takayuki Asahara , Kenichi Hashiguchi
发明人： Hiroaki Fukada , Takayuki Asahara , Kenichi Hashiguchi
IPC分类号： C12P19/38 , C12N1/00 , C12N1/21
CPC分类号： C12P19/32 , C12N9/0006
摘要： 5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced.
摘要翻译：通过使微生物与叶酸（XMP）反应生成5'-鸟苷酸（GMP），其中所述微生物能将叶酸转化为5'-鸟苷酸并进行了修饰，使得nagD基因不功能正常和5'-鸟苷酸合成酶活性增强。

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