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1. 发明申请

US20100036002A1 PHARMACEUTICAL COMPOSITION COMPRISING POROUS DRY MATRIX 审中-公开
标题翻译：包含多孔干燥基质的药物组合物
公开(公告)号：US20100036002A1
公开(公告)日：2010-02-11
申请号：US12520678
申请日：2007-12-25
申请人： Masaki Ishibashi , Katsunori Kobayashi , Hidetoshi Hamamoto
发明人： Masaki Ishibashi , Katsunori Kobayashi , Hidetoshi Hamamoto
IPC分类号： A61K47/38 , A61K47/30
CPC分类号： A61K47/30 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/795
摘要： The invention provides a porous dry matrix preparation comprising at least a polymeric thickener and an excipient ingredient, wherein (1) the content of the polymeric thickener is down to 0.5 w/w % and up to 14 w/w %, (2) the content of the excipient ingredient is down to 30 w/w % and up to 80 w/w %, (3) the void ratio is not less than 20%, and (4) the water activity is not more than 0.55, or water content is not more than 10 w/w %.
摘要翻译：本发明提供一种包含至少一种聚合物增稠剂和赋形剂成分的多孔干燥基质制剂，其中（1）聚合物增稠剂的含量低至0.5w / w％且至多14w / w％，（2）赋形剂成分含量低至30w / w％至80w / w％，（3）空隙率不小于20％，（4）水分活度不大于0.55，或水含量不超过10w / w％。

2. 发明授权

US5948662A Bacillus-derived transglutaminase 失效
标题翻译：芽孢杆菌衍生的转谷氨酰胺酶
公开(公告)号：US5948662A
公开(公告)日：1999-09-07
申请号：US989667
申请日：1997-12-12
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
IPC分类号： C12N15/09 , A23J3/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/04 , C12R1/125 , C12R1/19
CPC分类号： C12N9/1044 , Y10S435/839
摘要： A method for processing a protein, a non-proteinaceous amino acid polymer, or a non-proteinaceous amino acid polymer, or a peptide or derivatives thereof having a crosslinked structure, which entails contacting glutamine and lysine residues in a protein, a non-proteinaceous amino acid polymer, a peptide or derivatives thereof with a transglutaminase obtained from Bacillus subtilus to form intermolecular or intramolecular, crosslinked .epsilon.(.delta.-Glu)-Lys bonds between or in the molecules of the protein, non-proteinaceous amino acid polymer, peptide or derivatives thereof, wherein the transglutaminase has the physicochemical properties described herein.
摘要翻译：用于处理蛋白质，非蛋白质氨基酸聚合物或非蛋白质氨基酸聚合物的方法或具有交联结构的肽或其衍生物，其需要使蛋白质中的谷氨酰胺和赖氨酸残基接触，非蛋白质氨基酸聚合物，肽或其衍生物与从枯草芽孢杆菌获得的转谷氨酰胺酶在蛋白质，非蛋白质氨基酸聚合物，肽或肽的分子之间或之内形成分子间或分子内交联的ε（δ-Glu）-Lys键其衍生物，其中转谷氨酰胺酶具有本文所述的物理化学性质。

3. 发明授权

US07485328B2 Composition for preventing atherosclerosis 失效
标题翻译：用于预防动脉粥样硬化的组合物
公开(公告)号：US07485328B2
公开(公告)日：2009-02-03
申请号：US11522411
申请日：2006-09-18
申请人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
发明人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
IPC分类号： A61K36/00
CPC分类号： A61K36/31 , A23L33/105 , A23V2002/00 , A61K36/286 , A23V2250/21 , A23V2200/326
摘要： The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of preventing an atherosclerotic disease.
摘要翻译：本发明提供通过有机溶剂萃取作为动脉粥样硬化预防剂的脱脂植物种子获得的组合物。本发明还提供含有该组合物的食品和药物组合物，以及预防动脉粥样硬化疾病的方法。

4. 发明授权

US09750924B2 Adhesive patching aid for microneedle adhesive skin patch 有权
公开(公告)号：US09750924B2
公开(公告)日：2017-09-05
申请号：US13574496
申请日：2011-01-20
申请人： Katsunori Kobayashi , Hidetoshi Hamamoto
发明人： Katsunori Kobayashi , Hidetoshi Hamamoto
IPC分类号： A61M5/32 , A61M37/00 , A61M25/02
CPC分类号： A61M37/0015 , A61M2025/0253 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： The invention provides an applicator that holds a microneedle to facilitate puncture of the skin and includes an assisting tool as a supporting base to set the microneedle and an adhesive sheet such as a tape and the like, on the side face of the assisting tool to enable close adhesion of the microneedle puncturing the skin.

5. 发明授权

US09636490B2 Microneedle 有权
公开(公告)号：US09636490B2
公开(公告)日：2017-05-02
申请号：US13881322
申请日：2011-10-24
申请人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
发明人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
IPC分类号： A61M5/00 , A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 μm and satisfying the expression H/D≧5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).

6. 发明申请

US20120184916A1 APPLICATOR DEVICE OF PINHOLDER TYPE MICRONEEDLE 审中-公开
标题翻译： PINHOLDER型麦克风的应用器件
公开(公告)号：US20120184916A1
公开(公告)日：2012-07-19
申请号：US13389402
申请日：2010-08-04
申请人： Katsunori Kobayashi , Hidetoshi Hamamoto
发明人： Katsunori Kobayashi , Hidetoshi Hamamoto
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2025/0266 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046
摘要： Provided is a microneedle device which protects a microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture to administer a drug. By studying the relationship between the device to be pressed to the skin and the height of the elevation of the skin surface during the pressing, it is found that there is a positive correlation between the placement and interval of skin fixing members and the height of the elevation of the skin. It is furthermore found that the elevated skin surface is always parallel to the flat plate of the device. This reveals that since the microneedle installed in the device can be inserted at right angle to the skin surface, the skin can reliably be punctuated avoiding the breakage etc. of the small needles of the microneedle. Thus, a microneedle patch which is easily portable and ensures convenient drug administration to the skin can be produced.
摘要翻译：提供一种微针装置，其保护微针，具有容易携带的形状，在使用微针刺穿皮肤的步骤中没有诸如破裂小针的问题，并且确保适当的皮肤穿刺以施用药物。通过研究压制装置与皮肤表面高度之间的关系，发现皮肤固定部件的位置和间隔与皮肤固定部件的高度之间存在正相关皮肤的高度。此外，还发现升高的皮肤表面总是平行于装置的平板。这表明，由于安装在装置中的微针可以与皮肤表面成直角插入，所以可以可靠地标记皮肤，避免微针的小针断裂等。因此，可以制造容易携带并确保方便的向皮肤给药的微针补片。

7. 发明申请

US20120029434A1 APPLICATOR FOR MICRONEEDLE ARRAY 失效
标题翻译：麦克风阵列适用者
公开(公告)号：US20120029434A1
公开(公告)日：2012-02-02
申请号：US13202931
申请日：2010-02-19
申请人： Katsunori Kobayashi , Hidetoshi Hamamoto
发明人： Katsunori Kobayashi , Hidetoshi Hamamoto
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M5/425 , A61M2037/0023
摘要： Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced.
摘要翻译：本发明提供一种微针装置，其保护微针，具有便于携带的形状，在使用微针刺穿皮肤的步骤中没有小针断裂等问题，并且确保适当的皮肤穿刺用于给药。通过研究被压制的装置与被压制在皮肤表面上的高度之间的关系，从而制造装配有微针的装置，其嵌入具有一定深度的凹部中，微针可以是确保和容易地插入并穿刺入皮肤，同时避免了微针的小针断裂等问题。因此，可以制造容易携带并确保方便的皮肤给药的微针贴剂制剂。

8. 发明授权

US07357951B2 Composition for preventing atherosclerosis 失效
标题翻译：用于预防动脉粥样硬化的组合物
公开(公告)号：US07357951B2
公开(公告)日：2008-04-15
申请号：US10960919
申请日：2004-10-12
申请人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
发明人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
IPC分类号： A61K36/286
CPC分类号： A61K36/31 , A23L33/105 , A23V2002/00 , A61K36/286 , A23V2250/21 , A23V2200/326
摘要： The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of preventing an atherosclerotic disease.
摘要翻译：本发明提供通过有机溶剂萃取作为动脉粥样硬化预防剂的脱脂植物种子获得的组合物。本发明还提供含有该组合物的食品和药物组合物，以及预防动脉粥样硬化疾病的方法。

9. 发明申请

US20070009618A1 Composition for preventing atherosclerosis 失效
标题翻译：用于预防动脉粥样硬化的组合物
公开(公告)号：US20070009618A1
公开(公告)日：2007-01-11
申请号：US11522411
申请日：2006-09-18
申请人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
发明人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
IPC分类号： A61K36/31
CPC分类号： A61K36/31 , A23L33/105 , A23V2002/00 , A61K36/286 , A23V2250/21 , A23V2200/326
摘要： The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of preventing an atherosclerotic disease.
摘要翻译：本发明提供通过有机溶剂萃取作为动脉粥样硬化预防剂的脱脂植物种子获得的组合物。本发明还提供含有该组合物的食品和药物组合物，以及预防动脉粥样硬化疾病的方法。

10. 发明申请

US20050136137A1 Composition for preventing atherosclerosis 失效
标题翻译：用于预防动脉粥样硬化的组合物
公开(公告)号：US20050136137A1
公开(公告)日：2005-06-23
申请号：US10960919
申请日：2004-10-12
申请人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
发明人： Naoto Koyama , Kanna Kuribayashi , Koichi Ishii , Katsunori Kobayashi
IPC分类号： A23L1/30 , A61K36/286 , A61K36/31 , A61K35/78
CPC分类号： A61K36/31 , A23L33/105 , A23V2002/00 , A61K36/286 , A23V2250/21 , A23V2200/326
摘要： The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of preventing an atherosclerotic disease.
摘要翻译：本发明提供通过有机溶剂萃取作为动脉粥样硬化预防剂的脱脂植物种子获得的组合物。本发明还提供含有该组合物的食品和药物组合物，以及预防动脉粥样硬化疾病的方法。

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