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1. 发明申请

US20060024770A1 Immunoassay element 失效
公开(公告)号：US20060024770A1
公开(公告)日：2006-02-02
申请号：US11230127
申请日：2005-09-19
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/537 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.

2. 发明授权

US07820402B2 Immunoassay element 失效
标题翻译：免疫测定元件
公开(公告)号：US07820402B2
公开(公告)日：2010-10-26
申请号：US11230127
申请日：2005-09-19
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.
摘要翻译：用于通过确定由免疫反应引起的酶标记的抗原或抗体的酶活性的变化来定量分析抗原的免疫测定元件。免疫测定元件包括含有在标记酶存在下形成可扩散材料的不扩散基底的底物层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。作为非扩散性底物，使用能够仅与标记酶反应并且不能使片段化酶反应的底物。当使用内源活性葡糖苷酶作为标记酶，并且使用外源活性葡糖苷酶时，试剂层中的断裂酶，底物层的非扩散性基质优选为内型选择性反应性底物，其中是指具有对内源性葡糖苷酶特异性的反应性的底物。高精度，高重现性和良好的储存稳定性实现了高灵敏度测定。

3. 发明申请

US20050084953A1 Immunoassay element 审中-公开
标题翻译：免疫测定元件
公开(公告)号：US20050084953A1
公开(公告)日：2005-04-21
申请号：US10961459
申请日：2004-10-07
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.
摘要翻译：用于通过确定由免疫反应引起的酶标记的抗原或抗体的酶活性的变化来定量分析抗原的免疫测定元件。免疫测定元件包括含有在标记酶存在下形成可扩散材料的不扩散基底的底物层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。作为非扩散性底物，可以使用能够仅与前体酶反应并且不能使片段化酶反应的底物。当使用内源活性葡糖苷酶作为标记酶，并且使用外源活性葡糖苷酶时，试剂层中的断裂酶，底物层的非扩散性基质优选为内型选择性反应性底物，其中是指具有对内源性葡糖苷酶特异性的反应性的底物。高精度，高重现性和良好的储存稳定性实现了高灵敏度测定。

4. 发明授权

US07105128B2 Dry analytical element using water-soluble indicator for colorimetry 有权
公开(公告)号：US07105128B2
公开(公告)日：2006-09-12
申请号：US10281564
申请日：2002-10-28
申请人： Hideaki Tanaka , Yoshihide Iwaki , Yoshiki Sakaino , Kazuya Kawasaki , Yoshikazu Amano
发明人： Hideaki Tanaka , Yoshihide Iwaki , Yoshiki Sakaino , Kazuya Kawasaki , Yoshikazu Amano
IPC分类号： G01N31/22
CPC分类号： G01N33/525 , G01N33/84
摘要： This invention relates to a dry analytical element using a water-soluble indicator which improves measuring accuracy, which comprises a water-impermeable support, a water-permeable layer and a spreading layer having a function to spread a liquid uniformly, wherein a water-soluble indicator for colorimetry is incorporated into the s preading layer.

5. 发明授权

US5496708A Reagent composition for quantitative analysis of inorganic phosphorous and dry analysis element utilizing the same 失效
标题翻译：用于定量分析无机磷和干分析元素的试剂组合物
公开(公告)号：US5496708A
公开(公告)日：1996-03-05
申请号：US259616
申请日：1994-06-14
申请人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
发明人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/48 , G01N31/22
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/97
摘要： A reagent composition for the quantitative analysis of inorganic phosphorus, composted of xanthosine, purine nucleoside phosphorylase, xanthine oxidase and a color-former. The color-former is a precursor for forming a dye in the presence of hydrogen peroxide and peroxidase. The reagent composition of the invention is improved in storage stability and has a wider determination range. Also provided is a dry analysis element composed of reagent layer containing the inventive reagent composition.
摘要翻译：用于定量分析无机磷的试剂组合物，堆肥的黄嘌呤，嘌呤核苷磷酸化酶，黄嘌呤氧化酶和成色剂。成色剂是在过氧化氢和过氧化物酶存在下形成染料的前体。本发明的试剂组合物的贮存稳定性提高，判定范围更广。还提供了由包含本发明试剂组合物的试剂层组成的干分析元件。

6. 发明授权

US06767450B2 Ion selective electrode 有权
标题翻译：离子选择电极
公开(公告)号：US06767450B2
公开(公告)日：2004-07-27
申请号：US09823840
申请日：2001-03-30
申请人： Masaaki Terashima , Osamu Seshimoto , Yoshikazu Amano
发明人： Masaaki Terashima , Osamu Seshimoto , Yoshikazu Amano
IPC分类号： G01N27333
CPC分类号： G01N27/333
摘要： A composite ion selective electrode comprising a calcium ion selective electrode member and a hydrogen ion selective electrode member which is characterized in that a calcium ion selective membrane of the calcium ion selective electrode member has a thickness of 5 to 30 &mgr;m, and the hydrogen ion selective membrane of the hydrogen ion selective electrode member contains tri-n-dodecyl-amine and trisethylhexyl trimellitate. Each of the calcium ion selective electrode member and the hydrogen ion selective electrode member can be employed singly.
摘要翻译： 1.一种复合离子选择电极，其包含钙离子选择电极部件和氢离子选择电极部件，其特征在于，所述钙离子选择电极部件的钙离子选择性膜的厚度为5〜30μm，氢离子选择性氢离子选择电极构件的膜包含三正十二烷基胺和偏苯三酸三乙基己酯。钙离子选择电极构件和氢离子选择电极构件中的每一个可以单独使用。

7. 发明授权

US5709837A Dry analytical element containing ampholyte 失效
标题翻译：含两性电解质的干分析元素
公开(公告)号：US5709837A
公开(公告)日：1998-01-20
申请号：US545233
申请日：1995-10-19
申请人： Toshihiro Mori , Masashi Ogawa , Yoshikazu Amano
发明人： Toshihiro Mori , Masashi Ogawa , Yoshikazu Amano
IPC分类号： G01N31/22 , G01N33/52 , G01N33/70 , G01N21/17
CPC分类号： G01N33/525 , Y10T436/147777 , Y10T436/171538
摘要： A dry analytical element comprising at least one water-permeable reagent layer and a porous spreading layer laminated in this order on a support, wherein at least one layer which is the water-permeable reagent layer, the porous spreading layer or an optional water-permeable layer contains a water-soluble polybasic amino carboxylic acid which is an ampholyte. By applying an analytical element of the invention, an analyte can be measured at a high sensitivity using a small amount of an enzyme, etc., and shelf file can be extended.
摘要翻译：一种干燥分析元件，其包括依次层叠在载体上的至少一个透水性试剂层和多孔扩散层，其中至少一层作为透水性试剂层，多孔扩散层或任选的透水性层含有两性电解质的水溶性多元氨基羧酸。通过应用本发明的分析元件，可以使用少量的酶等以高灵敏度测量分析物，并且可以延长搁架文件。

8. 发明授权

US06659288B2 Plasma- or serum-collecting device 失效
标题翻译：血浆或血清收集装置
公开(公告)号：US06659288B2
公开(公告)日：2003-12-09
申请号：US09858391
申请日：2001-05-16
申请人： Yoshikazu Amano , Toshihiro Mori
发明人： Yoshikazu Amano , Toshihiro Mori
IPC分类号： B01D3500
CPC分类号： B01D39/2017
摘要： A plasma- or serum-collecting device with simple structure and easy to handle is provided. The device comprises a vacuum blood-drawing tube accommodating a blood-filtering unit, wherein the vacuum tube contains a space above the blood-filtering unit to preserve blood to be filtered and a partition wall under the blood-filtering unit to keep a backspace at reduced pressure, and the blood-filtering unit contains a communicating needle to break the partition wall at the bottom.
摘要翻译：提供了一种结构简单，易于操作的等离子体或血清采集装置。所述装置包括容纳血液净化单元的真空吸血管，其中所述真空管包含所述血液过滤单元上方的空间，以保持要过滤的血液和所述血液净化单元下方的分隔壁以保持退格减压，血液滤过单元含有连通针，以破坏底部的分隔壁。

9. 发明授权

US06255061B1 Analytical element for the analysis of whole blood 失效
标题翻译：全血分析的分析要素
公开(公告)号：US06255061B1
公开(公告)日：2001-07-03
申请号：US09464613
申请日：1999-12-15
申请人： Toshihiro Mori , Takaki Arai , Yoshikazu Amano
发明人： Toshihiro Mori , Takaki Arai , Yoshikazu Amano
IPC分类号： C12Q154
CPC分类号： G01N33/525 , C12Q1/26 , C12Q1/28 , Y10S435/966
摘要： An analytical element for quantitative analysis of glucose, cholesterol, or lactic acid in whole blood, composed of a porous layer which has a void volume of 30 to 80% and containing peroxidase, a leuco dye which gives coloring having an absorption peak in the region of 600 to 700 nm, and an oxidase such as glucose oxidase, cholesterol oxidase, or lactate oxidase, respectively. The porous layer can be placed on a transparent support sheet via an adhesive layer in the form of dots or lines, or a hydrophilic adhesive layer.
摘要翻译：用于定量分析全血中的葡萄糖，胆固醇或乳酸的分析元件，其由空隙体积为30至80％的多孔层和含有过氧化物酶的无机染料组成，所述无色染料在所述区域中具有吸收峰分别为600〜700nm，氧化酶如葡萄糖氧化酶，胆固醇氧化酶或乳酸氧化酶。多孔层可以通过粘合剂层以点或线的形式或亲水性粘合剂层放置在透明支撑片上。

10. 发明授权

US07025212B2 Plasma- or serum-collecting device 失效
标题翻译：血浆或血清收集装置
公开(公告)号：US07025212B2
公开(公告)日：2006-04-11
申请号：US10463987
申请日：2003-06-18
申请人： Yoshikazu Amano , Toshihiro Mori
发明人： Yoshikazu Amano , Toshihiro Mori
IPC分类号： B01D35/00
CPC分类号： B01D39/2017
摘要： A plasma- or serum-collecting device with simple structure and easy to handle is provided. The device comprises a vacuum blood drawing tube accommodating a blood-filtering unit, wherein the vacuum tube contains a space above the blood-filtering unit to preserve blood to be filtered and a partition wall under the blood-filtering unit to keep a backspace at reduced pressure, and the blood-filtering unit contains a communicating needle to break the partition wall at the bottom.
摘要翻译：提供了一种结构简单，易于操作的等离子体或血清采集装置。该装置包括容纳血液净化单元的真空吸血管，其中真空管在血液过滤单元上方包含一个空间，以保持待过滤的血液和血液净化单元下面的分隔壁以使退避空间减小压力，并且血液过滤单元包含连通针以破坏底部的分隔壁。

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