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1. 发明授权

US5710152A Benzoazine derivative or salt thereof and pharmaceutical compostion comprising the same 失效
标题翻译：苯并嗪衍生物或其盐和包含其的药物组合物
公开(公告)号：US5710152A
公开(公告)日：1998-01-20
申请号：US791269
申请日：1997-01-30
申请人： Yoshihiro Nagao , Yoshikuni Ito , Jiro Kotake , Tadayuki Kouda , Haruyoshi Honda , Susumu Sato , Hideaki Matsuda
发明人： Yoshihiro Nagao , Yoshikuni Ito , Jiro Kotake , Tadayuki Kouda , Haruyoshi Honda , Susumu Sato , Hideaki Matsuda
IPC分类号： C07D417/12 , A61K31/505 , A61K31/535 , A61K31/54
CPC分类号： C07D417/12
摘要： A benzoazine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 represents an alkyl group, alkoxy group, halogen atom, halogenoalkyl group, amino group, hydroxy group, benzyloxy group which may have a substituent, cyano group, carbamoyl group, acyl group, nitro group, carboxy group, or sulfonamide group; R.sup.2 and R.sup.3 may be the same or different and each individually represents a hydrogen atom or an alkyl group, or R.sup.2 and R.sup.3 indicate in combination an alkylene group having 2-7 carbon atoms; R.sup.4 and R.sup.5 may be the same or different and each individually represents a hydrogen atom or an alkyl group; X denotes O, S, or N--R.sup.6 (wherein R.sup.6 represents a hydrogen atom, an alkyl group, or an aryl group or pyridyl group which may have a substituent); m is an integer from 0 to 4; and n is an integer from 1 to 3, or a salt of the benzoazine derivative. The compound exhibits superior effects for reducing blood glucose value, plasma insulin value, and plasma triglyceride value, and is useful as a medicament for preventing or treating diabetes, hyperlipidemia, and obesity.
摘要翻译：由下式（1）表示的苯并嗪衍生物，其中R1表示烷基，烷氧基，卤素原子，卤代烷基，氨基，羟基，可具有取代基的苄氧基，氰基，氨基甲酰基，酰基，硝基，羧基或磺酰胺基; R2和R3可以相同或不同，各自独立地表示氢原子或烷基，或R2和R3组合表示具有2-7个碳原子的亚烷基; R 4和R 5可以相同或不同，各自独立地表示氢原子或烷基; X表示O，S或N-R6（其中R6表示氢原子，烷基或可具有取代基的芳基或吡啶基）; m为0〜4的整数; n为1〜3的整数，或苯并嗪衍生物的盐。该化合物对于降低血糖值，血浆胰岛素值和血浆甘油三酯值具有优异的效果，并且可用作预防或治疗糖尿病，高脂血症和肥胖症的药物。

2. 发明授权

US6124347A Chromene derivatives and salts thereof, and pharmaceuticals containing the same 失效
标题翻译：色烯衍生物及其盐，以及含有它们的药物
公开(公告)号：US6124347A
公开(公告)日：2000-09-26
申请号：US162451
申请日：1998-09-29
申请人： Fumio Ishii , Haruyoshi Honda , Fujiko Konno , Tomomi Okada , Terumitsu Kaihoh , Yoshihiro Nagao , Susumu Sato , Hideaki Matsuda
发明人： Fumio Ishii , Haruyoshi Honda , Fujiko Konno , Tomomi Okada , Terumitsu Kaihoh , Yoshihiro Nagao , Susumu Sato , Hideaki Matsuda
IPC分类号： A61K31/35 , A61K31/352 , A61P3/08 , A61P3/10 , A61P43/00 , C07D311/58 , C07D311/64 , A61K31/353 , C07D311/60
CPC分类号： C07D311/58
摘要： Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.
摘要翻译：公开了由下式表示的色烯衍生物：其中R 1表示烷基，烷氧基或类似基团，R 2表示氢原子或烷基，R 3表示取代或未取代的苯基，萘基或杂环基，m表示 0至4，及其盐; 和含有它们作为有效成分的药物。色烯衍生物及其盐显示优异的AGE形成抑制作用，并且可用作糖尿病并发症的预防剂和治疗剂。

3. 发明授权

US06958353B2 Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts 失效
标题翻译：咪唑衍生物或其盐和含有衍生物或盐的药物
公开(公告)号：US06958353B2
公开(公告)日：2005-10-25
申请号：US10258610
申请日：2001-06-08
申请人： Fujiko Konno , Yoshihiro Nagao , Kazuo Isomae , Mari Ohtsuka , Yoshiyuki Takahashi , Fumio Ishii , Hiroyuki Hirota , Sunao Takeda , Noriyuki Kawamoto , Haruyoshi Honda , Susumu Sato
发明人： Fujiko Konno , Yoshihiro Nagao , Kazuo Isomae , Mari Ohtsuka , Yoshiyuki Takahashi , Fumio Ishii , Hiroyuki Hirota , Sunao Takeda , Noriyuki Kawamoto , Haruyoshi Honda , Susumu Sato
IPC分类号： A61P19/02 , A61P19/10 , A61P29/00 , A61P43/00 , C07D233/22 , C07D233/60 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D521/00 , A61K31/4178 , A61K31/444
CPC分类号： C07D401/14 , C07D231/12 , C07D233/22 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/14 , C07D409/14
摘要： The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.
摘要翻译：本发明涉及由式（1）表示的咪唑衍生物：其中R 1和R 2各自表示芳基，杂芳基等; A，X 1和X 2各自表示N或CH; Y和Z各自表示O，S等; R 3，R 4和R 5各自表示氢原子，烷基等; m是1到4的数字; n为0〜4的数，或其盐。本发明还涉及含有衍生物或盐作为活性成分的药物。这些化合物具有抑制NO和IL-6产生的优异效果，可用于预防或治疗由过量产生NO和IL-6引起的疾病。

4. 发明授权

US08150895B2 Quality improvement system 失效
标题翻译：质量改进体系
公开(公告)号：US08150895B2
公开(公告)日：2012-04-03
申请号：US12046897
申请日：2008-03-12
申请人： Hiroyuki Mori , Yoshihiro Nagao , Yoshiaki Hiraoka
发明人： Hiroyuki Mori , Yoshihiro Nagao , Yoshiaki Hiraoka
IPC分类号： G06F7/00
CPC分类号： G06Q10/06
摘要： A quality improvement system using an FMEA table of the invention includes a defect data collecting unit to collect defect data about a defect in a manufacturing or inspection process and an FMEA table update unit to update the FMEA table online based on the data collected by the defect data collecting unit. The FMEA table includes a failure mode, the number of occurrences of the failure mode, and an effect caused by the failure mode. The FMEA table update unit includes an FMEA table editing unit to edit the FMEA table. The FMEA table editing unit edits the number of occurrences of the failure mode when a row including a set of an occurred failure mode and an effect corresponding to the occurred failure mode is previously defined in the FMEA table, and inserts the row into the FMEA table when the row is not defined in the FMEA table.
摘要翻译：使用本发明的FMEA表的质量改进系统包括缺陷数据收集单元，用于收集关于制造或检查过程中的缺陷的缺陷数据和FMEA表更新单元，以基于由缺陷收集的数据在线更新FMEA表数据采集单元 FMEA表包括故障模式，故障模式的发生次数以及故障模式引起的影响。 FMEA表更新单元包括用于编辑FMEA表的FMEA表编辑单元。 FMEA表编辑单元在FMEA表中预先定义了包含一组发生的故障模式和与发生的故障模式相对应的效果的行时，出现故障模式的次数，并将该行插入到FMEA表中当FMEA表中没有定义行时。

5. 发明申请

US20050102052A1 Method of providing board packaging line program 失效
标题翻译：提供板包装线方案的方法
公开(公告)号：US20050102052A1
公开(公告)日：2005-05-12
申请号：US10674788
申请日：2003-10-01
申请人： Hiroshi Yoshida , Yoshihiro Nagao , Takeshi Nakata , Masanobu Tanigami
发明人： Hiroshi Yoshida , Yoshihiro Nagao , Takeshi Nakata , Masanobu Tanigami
IPC分类号： G05B19/418 , G06F9/445 , H05K13/08 , G05B11/01
CPC分类号： G06F9/445 , H05K13/08 , Y02P90/14 , Y02P90/18
摘要： A method of providing a program for a printed board packaging line is disclosed. A board packaging line coordinating computer downloads the service contract information and the application program contained in the contract information from an application server, and defines the board packaging line covered by the program and the device configuration of the line. The device configuration thus defined is uploaded to the application server, which, based on the device configuration thus uploaded, searches a prepared device driver group for a required device driver. This device driver is downloaded and set in each device by the board packaging line coordinating computer.
摘要翻译：公开了一种为印刷电路板封装线提供程序的方法。董事会包装线协调计算机从应用服务器下载服务合同信息和包含在合同信息中的应用程序，并定义由程序覆盖的电路板封装线和线路的器件配置。将如此定义的设备配置上传到应用服务器，应用服务器根据上传的设备配置搜索所准备的设备驱动程序组中所需的设备驱动程序。该设备驱动程序由板包装线协调计算机下载并设置在每个设备中。

6. 发明申请

US20080228307A1 QUALITY IMPROVEMENT SYSTEM 失效
标题翻译：质量改进体系
公开(公告)号：US20080228307A1
公开(公告)日：2008-09-18
申请号：US12046897
申请日：2008-03-12
申请人： Hiroyuki MORI , Yoshihiro Nagao , Yoshiaki Hiraoka
发明人： Hiroyuki MORI , Yoshihiro Nagao , Yoshiaki Hiraoka
IPC分类号： G06F17/00
CPC分类号： G06Q10/06
摘要： A quality improvement system using an FMEA table of the invention includes a defect data collecting unit to collect defect data about a defect in a manufacturing or inspection process and an FMEA table update unit to update the FMEA table online based on the data collected by the defect data collecting unit. The FMEA table includes a failure mode, the number of occurrences of the failure mode, and an effect caused by the failure mode. The FMEA table update unit includes an FMEA table editing unit to edit the FMEA table. The FMEA table editing unit edits the number of occurrences of the failure mode when a row including a set of an occurred failure mode and an effect corresponding to the occurred failure mode is previously defined in the FMEA table, and inserts the row into the FMEA table when the row is not defined in the FMEA table.
摘要翻译：使用本发明的FMEA表的质量改进系统包括缺陷数据收集单元，用于收集关于制造或检查过程中的缺陷的缺陷数据和FMEA表更新单元，以基于由缺陷收集的数据在线更新FMEA表数据采集单元 FMEA表包括故障模式，故障模式的发生次数以及故障模式引起的影响。 FMEA表更新单元包括用于编辑FMEA表的FMEA表编辑单元。 FMEA表编辑单元在FMEA表中预先定义了包含一组发生的故障模式和与发生的故障模式相对应的效果的行时，出现故障模式的次数，并将该行插入到FMEA表中当FMEA表中没有定义行时。

7. 发明授权

US06944521B2 Method of providing board packaging line program 失效
公开(公告)号：US06944521B2
公开(公告)日：2005-09-13
申请号：US10674788
申请日：2003-10-01
申请人： Hiroshi Yoshida , Yoshihiro Nagao , Takeshi Nakata , Masanobu Tanigami
发明人： Hiroshi Yoshida , Yoshihiro Nagao , Takeshi Nakata , Masanobu Tanigami
IPC分类号： G05B19/418 , G06F9/445 , H05K13/08
CPC分类号： G06F9/445 , H05K13/08 , Y02P90/14 , Y02P90/18
摘要： A method of providing a program for a printed board packaging line is disclosed. A board packaging line coordinating computer downloads the service contract information and the application program contained in the contract information from an application server, and defines the board packaging line covered by the program and the device configuration of the line. The device configuration thus defined is uploaded to the application server, which, based on the device configuration thus uploaded, searches a prepared device driver group for a required device driver. This device driver is downloaded and set in each device by the board packaging line coordinating computer.

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