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1. 发明授权

US09345835B2 Cartridge stopper for an intradermal delivery system 有权
标题翻译：用于皮内递送系统的塞子塞子
公开(公告)号：US09345835B2
公开(公告)日：2016-05-24
申请号：US12737453
申请日：2009-07-17
申请人： Ying Xu , Robert Banik , Lionel Vedrine
发明人： Ying Xu , Robert Banik , Lionel Vedrine
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24
CPC分类号： A61M5/31511 , A61M5/24 , A61M5/2466 , A61M5/31515 , A61M5/31551 , A61M5/31573 , A61M5/31585 , A61M2005/2407
摘要： A device for delivering a medicament intradermally includes a cartridge (112) having a first end (110) and a second end (114) and defining a volume (111) therebetween. The volume (111) is adapted to contain the medicament. A driving member (121) has a first end (126) and a second end (128). The first end (126) of the driving member (121) is disposed in the cartridge (112) and the second end (128) of the driving member (121) is disposed outside the cartridge (112). A stopper (115) is slidably disposed in the cartridge volume (111). The driving member (121) is releasably disposed in the stopper (115) such that when the driving member (121) is retracted from the cartridge (112) the stopper (115) is disengaged from the driving member (121) and remains in the cartridge volume (111).
摘要翻译：用于皮内递送药物的装置包括具有第一端（110）和第二端（114）并且在其间限定体积（111）的药筒（112）。体积（111）适于容纳药物。驱动构件（121）具有第一端（126）和第二端（128）。驱动构件（121）的第一端（126）设置在盒（112）中，并且驱动构件（121）的第二端（128）设置在盒（112）的外部。止动器（115）可滑动地设置在盒体积（111）中。驱动构件（121）可释放地设置在止动件（115）中，使得当驱动构件（121）从盒（112）缩回时，止动件（115）与驱动构件（121）脱离并保持在盒体积（111）。

2. 发明授权

US10195340B2 Self-injection device 有权
公开(公告)号：US10195340B2
公开(公告)日：2019-02-05
申请号：US13516547
申请日：2009-12-16
申请人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
发明人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
IPC分类号： A61M5/145 , A61M5/142
摘要： A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).

3. 发明授权

US09623184B2 Cartridge for containing and dispensing a medicament 有权
公开(公告)号：US09623184B2
公开(公告)日：2017-04-18
申请号：US13513087
申请日：2010-12-03
申请人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
发明人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
IPC分类号： A61M5/24 , A61M5/31 , A61M5/28 , A61J1/06 , A61M5/315 , A61M5/34
CPC分类号： A61M5/24 , A61J1/062 , A61M5/2448 , A61M5/2466 , A61M5/28 , A61M5/284 , A61M5/3134 , A61M5/3135 , A61M5/31525 , A61M5/31533 , A61M5/347 , A61M2005/2488 , A61M2005/2492 , A61M2005/3123 , A61M2005/3126 , A61M2005/3132 , A61M2005/31516 , A61M2207/00 , B65B3/003 , B65B3/022 , B65B7/2821 , B65B63/08 , Y10T29/494
摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

4. 发明授权

US09480804B2 Monodose nasal drug delivery system 有权
标题翻译： Monodose鼻给药系统
公开(公告)号：US09480804B2
公开(公告)日：2016-11-01
申请号：US13517496
申请日：2010-12-23
申请人： Lionel Vedrine
发明人： Lionel Vedrine
IPC分类号： A61M11/00 , A61M15/08 , A61M5/28 , B05B11/02
CPC分类号： A61M11/007 , A61M5/282 , A61M15/08 , B05B11/02
摘要： A delivery device for delivery of a medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being movable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray.
摘要翻译：一种用于将药物输送给使用者的输送装置，包括限定储存药剂的容器的容器，容纳容器的容器，布置在主体和容器中的一个上的喷嘴，用于接收从容器中排出的药物，以及推动器，其可致动以将药物从容器储存器推动通过喷嘴，所述推动器可响应于致动力而从静止位置相对于所述主体移动到完全启动位置。该组件特别适用于需要以喷雾形式输送药物的鼻注射器。

5. 发明授权

US09375529B2 Extended use medical device 有权
标题翻译：延长使用医疗器械
公开(公告)号：US09375529B2
公开(公告)日：2016-06-28
申请号：US12585061
申请日：2009-09-02
申请人： Gary Searle , Keith N Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
发明人： Gary Searle , Keith N Knapp , Roman Tunkel , Peter Skutnik , Lionel Vedrine
IPC分类号： A61M5/168 , A61M5/142 , A61M5/172 , A61M5/31 , A61M5/14 , A61M5/38 , A61M5/46 , A61M5/158
CPC分类号： A61M5/158 , A61M5/1413 , A61M5/14212 , A61M5/14224 , A61M5/14248 , A61M5/16886 , A61M5/1723 , A61M5/3134 , A61M5/385 , A61M5/46 , A61M2005/14208 , A61M2005/14268 , A61M2005/1585 , A61M2005/16872 , A61M2205/16 , A61M2205/702 , A61M2209/045 , A61M2230/005 , A61M2230/201
摘要： Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.
摘要翻译：提供了一种扩展使用的独立的，可穿戴的医疗设备。该装置优选地配置有输注展开机构，用于将输注针可变地插入和缩回到不同的深度，或者将输注针从输注部位完全缩回，然后在整个输注期间在预定时间段之后重新插入输注针循环，以延长输注部位的生存能力。另一个实施例包括双针展开机构，其也可以可变地插入和缩回输注针。优选地提供流量传感器用于检测通过输注套管的流动的停止并且发出针部署机构以尝试在不同深度输注或部署第二输注针。优选地，可重新填充的储存器组件用于通过扩展使用该装置来供应药物。另一实施例包括实现上述特征的部分可再利用和部分一次性医疗装置。

6. 发明授权

US08323238B2 Medical injector with rotatable body portions 有权
标题翻译：具有旋转体部分的医用注射器
公开(公告)号：US08323238B2
公开(公告)日：2012-12-04
申请号：US13063829
申请日：2009-09-18
申请人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Lionel Vedrine
发明人： Richard A. Cronenberg , Asif Fayyaz , Atul Patel , Lionel Vedrine
IPC分类号： A61M37/00
CPC分类号： A61M5/2033 , A61M5/2448 , A61M5/3129 , A61M5/31553 , A61M5/3156 , A61M2005/2073
摘要： A medical injector is provided herein which includes first and second body portions rotatably coupled together; a displaceable plunger disposed in at least one of the first and second body portions; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first portion against force of the spring. The releasable retainer releases the plunger upon a predetermined extent of relative rotation between the first and second body portions, thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon rotation of injector body portions, thereby minimizing premature or failed activations.
摘要翻译：本文提供了一种医疗注射器，其包括可旋转地联接在一起的第一和第二主体部分; 设置在所述第一和第二主体部分中的至少一个中的可移位柱塞; 设置成使柱塞前进的弹簧; 以及用于抵抗弹簧的力而将柱塞保持在第一部分中的可释放保持器。可释放的保持器在第一和第二主体部分之间的预定的相对旋转程度上释放柱塞，从而允许弹簧推进柱塞。有利地，本发明提供一种具有自动柱塞驱动器的医用注射器，其在喷射器主体部分的旋转时被触发，由此最小化过早或失败的激活。

7. 发明申请

US20120277684A1 CARTRIDGE FOR CONTAINING AND DISPENSING A MEDICAMENT 有权
标题翻译：用于包含和分配药物的药盒
公开(公告)号：US20120277684A1
公开(公告)日：2012-11-01
申请号：US13513087
申请日：2010-12-03
申请人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
发明人： Richard Cronenberg , Lionel Vedrine , Patrick Begley
IPC分类号： A61M5/31 , B21D51/16 , A61M5/34
CPC分类号： A61M5/24 , A61J1/062 , A61M5/2448 , A61M5/2466 , A61M5/28 , A61M5/284 , A61M5/3134 , A61M5/3135 , A61M5/31525 , A61M5/31533 , A61M5/347 , A61M2005/2488 , A61M2005/2492 , A61M2005/3123 , A61M2005/3126 , A61M2005/3132 , A61M2005/31516 , A61M2207/00 , B65B3/003 , B65B3/022 , B65B7/2821 , B65B63/08 , Y10T29/494
摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.
摘要翻译：一种用于容纳和分配药物的药筒（100），所述药筒（100）包括其中具有内腔（10B）的药筒本体（104），可移动地设置在所述内腔（108）内的止动件（112）所述隔膜（116,148）设置在所述内部空腔（108）的与所述止动件（112）的相对的端部处，用于将所述药物容纳在所述内腔（108）内。盒（100）还包括整体形成为盒体（104）的整体结构的连接螺纹（120），螺纹（120）设置在药筒主体（104）的第一端，用于连接笔针直接到药筒体（104）刺穿隔膜（116,148），并提供药物与笔针的患者端之间的连通。

8. 发明授权

US07967010B2 Spray or injection device allowing at least two preset doses of product to be delivered 有权
标题翻译：喷雾或注射装置允许至少两个预设剂量的产品被输送
公开(公告)号：US07967010B2
公开(公告)日：2011-06-28
申请号：US12690159
申请日：2010-01-20
申请人： Lionel Vedrine , Frederic Perot , Laurent Barrelle
发明人： Lionel Vedrine , Frederic Perot , Laurent Barrelle
IPC分类号： B05B7/00 , B05B11/00
CPC分类号： A61M5/2429 , A61M5/2459 , A61M5/315 , A61M5/31595 , A61M11/007 , A61M11/06 , A61M15/0065 , A61M15/08 , B05B11/02 , B05B11/025
摘要： A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.
摘要翻译：一种喷雾或注射装置，其包括外壳或推动器，其包括至少一个突出部，其可在第一径向位置和第二径向位置之间径向移动，所述突片在第一径向位置之间，其中突片不阻碍推动器相对于外壳的移动，该卡舌反对推动器的移动。推动器或壳体分别包括至少一个斜面形突起，其被构造成使突片进入第二径向位置，然后允许其返回到第一径向位置。推动器或套管还包括推动器和套管之间的至少一个止动件，以描绘对应于第一剂量的药物的第一冲程的结束，以及对应于第二剂量的药物的第二冲程的开始。

9. 发明授权

US07875007B2 Syringe accessory 有权
标题翻译：注射器配件
公开(公告)号：US07875007B2
公开(公告)日：2011-01-25
申请号：US10520980
申请日：2003-07-10
申请人： Frederic Perot , Lionel Vedrine
发明人： Frederic Perot , Lionel Vedrine
IPC分类号： A61M5/00 , A61M5/31
CPC分类号： A61M5/344 , A61F9/0017 , A61M2005/3139
摘要： According to the invention, the accessory (1) comprises a body (15) of roughly semi-tubular shape, first means of holding the syringe comprising a distal transverse wall (20) connected to one end of said body (15), and pierced with a hole (22) for the passage of the needle (7) through it, and second means of holding the syringe comprising a bearing zone (61) against which the proximal flange (10) or the lateral lugs that the syringe body (5) comprises is or are intended to bear so as to provide support for the user's fingers; the distance between said distal transverse wall (20) and said bearing zone (61) is such that the adapter (8) connecting the needle (7) to the syringe body (5) is kept bearing against said distal transverse wall (20) when said flange (10) or said lateral lugs are bearing against said bearing zone (61).
摘要翻译：根据本发明，附件（1）包括大致半管形的主体（15），第一装置保持注射器，其包括连接到所述主体（15）的一端的远侧横向壁（20）具有用于针（7）通过其的通孔（22），以及保持注射器的第二装置，其包括轴承区（61），近侧凸缘（10）或侧向凸耳与注射器主体（5））包括或旨在承担以便为用户的手指提供支持; 所述远端横向壁（20）和所述支承区域（61）之间的距离使得将针（7）连接到注射器主体（5）的适配器（8）保持抵靠所述远侧横向壁（20）所述凸缘（10）或所述侧向凸耳与所述轴承区（61）相对。

10. 发明申请

US20090069754A1 DEVICE FOR INJECTION OF A PRODUCT, IN PARTICULAR FOR MEDICAL USE 有权
标题翻译：用于注射产品的装置，特别用于医疗用途
公开(公告)号：US20090069754A1
公开(公告)日：2009-03-12
申请号：US10573226
申请日：2004-09-14
申请人： Lionel Vedrine
发明人： Lionel Vedrine
IPC分类号： A61M5/315
CPC分类号： A61M5/2429 , A61M5/2033 , A61M5/2459 , A61M5/326 , A61M2005/3263
摘要： The present invention relates to a device (1) for injection of a product, comprising: a body (2) receiving a hollow injection needle (4) and a container (10) containing the product to be injected; means (5 to 7; 28, 29) for holding the needle in position, means (39, 41, 45) for holding the container (10) in position,; and a piston (11) engaged in the container (10), characterized in that it additionally comprises: first actuating means (42) of means (5 à 7; 28, 29) for holding the needle (4) in position, second actuating means (32) of means (39, 41, 45) for holding the container (10) in position, said first and second actuating means (42, 32) making it possible, at the end of the injection, to respectively release the means (5 à 7; 28, 29) for holding the needle (4) in position before, or simultameously to, the release of the means (39, 41, 45) for holding the container (10) in position, a container support (9) which is mounted slidably on the body (2) and is displaceable relative to the latter in order to perform the injection, means (3, 47, 48) for holding the container support (9) in position, means (49) actuating the release of the means (3, 20, 47, 48) for holding the container support (9) permitting injection in position.
摘要翻译：本发明涉及一种用于注射产品的装置（1），包括：容纳中空注射针（4）的主体（2）和容纳待注射产品的容器（10）; 用于将针保持在适当位置的装置（5至7; 28,29），用于将容器（10）保持在适当位置的装置（39,41,45）; 以及接合在所述容器（10）中的活塞（11），其特征在于，其还包括：用于将针（4）保持在适当位置的装置（5; 7; 28,29）的第一致动装置（42）用于将容器（10）保持在适当位置的装置（39,41,45）的装置（32），所述第一和第二致动装置（42,32）使得在注射结束时可以分别释放装置（5→7; 28,29），用于在将容器（10）保持在适当位置之前或相似地将所述针（4）保持在适当位置的位置，容器支架（用于将容器支撑件（9）保持在适当位置的装置（3,47,48），该装置（49）致动（9），所述装置可滑动地安装在所述主体（2）上并且可相对于所述主体用于保持容器支撑件（9）的装置（3,20,47,48）的释放允许注射就位。

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