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    • 1. 发明授权
    • Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
    • 来自具有高度保守基序的革兰氏阳性细菌的表面蛋白和识别它们的抗体
    • US06790448B2
    • 2004-09-14
    • US10140372
    • 2002-05-08
    • Yi XuMagnus A. O. Hook
    • Yi XuMagnus A. O. Hook
    • A01N6300
    • C07K14/3156A61K39/00A61K2039/505C07K14/31C07K14/315C07K16/1267Y10S930/29
    • Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAWEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
    • 提供了含有这些序列的分离的肽序列和蛋白质,其可用于预防和治疗由革兰氏阳性菌引起的感染。 已经显示肽序列在革兰氏阳性细菌的表面蛋白中是高度保守的基序,并且这些共有序列包括氨基酸序列如LPXTG(SEQ ID NO:13),ALKTGKIDIIISGMTSTPERKK(SEQ ID NO:14),VEGAWEKPVAEAYLKQN (SEQ ID NO:15)和EYAGVDIDLAKKIAK(SEQ ID NO:16)。 由于高度保守的区域,包括这些序列的序列和蛋白质可用于产生能识别这些高度保守的基序和含有它们的蛋白质的抗体,因此可用于治疗或预防引起的广泛感染 通过革兰氏阳性菌。
    • 3. 发明授权
    • LCD projector
    • US10809603B1
    • 2020-10-20
    • US16563827
    • 2019-09-07
    • Yi Xu
    • Yi Xu
    • G03B21/00G03B21/16G03B21/20G03B21/14G03B33/08H04N9/31
    • The invention discloses a novel LCD projector, comprising an imaging system with single-light path system for LCD projector time-division display, a lighting system with PCS (P light converted into S light) function, a three-primary-colors LED light source with microlenses, and a heat dissipation system with dust-proof and self-cleaning function; the monochrome LCD screen of the imaging system has a high light transmittance and resolution, achieving higher brightness and resolution; the lighting part has a polarized light conversion function, which converts the useless P light into useful S light, improving the light utilization and increasing the brightness; a transparent antifouling coating is applied on the optical components of the heat dissipation system to reduce dust adsorption; ultrasonic vibrators are mounted on the optical components to shake off the dust attached; the light source uses the microlens to converge the three-primary-color LED light source to improve light efficiency and uniformity.
    • 4. 发明申请
    • NOVEL PROJECTOR
    • US20200096848A1
    • 2020-03-26
    • US16198749
    • 2018-11-21
    • Yi Xu
    • Yi Xu
    • G03B21/16G03B21/20G03B21/00G02B27/28G02B27/30
    • The invention discloses a novel projector, comprising a sealed shell of electronic projector, an illumination system and a LED light source system, wherein the sealed shell is provided with an optical and internal circulation cooling assembly inside by area; the optical assembly comprises the projector working assembly. The invention is inside a sealed shell; the cold air far below normal temperature generated by semiconductor refrigeration piece takes away the heat on optical device, improving the heat dissipation efficiency. Simultaneously, because the cold air is inside a sealed shell, the optical device can be placed in a dust-free environment. The polarized light conversion prism converts the useless P light in conventional projector imagining into the useful S light, improving the light utilization, and increasing the brightness of projection at the same power. The LED light source is collimated by the collimating lens to meet PCS conversion requirement for polarized light converter.
    • 5. 发明申请
    • PATTERN CHANGE DISCOVERY BETWEEN HIGH DIMENSIONAL DATA SETS
    • 高维数据集之间的模式变化发现
    • US20140122039A1
    • 2014-05-01
    • US14060743
    • 2013-10-23
    • Yi XuZhongfei Mark Zhang
    • Yi XuZhongfei Mark Zhang
    • G06F17/50
    • G06F17/18G06K9/6232
    • The general problem of pattern change discovery between high-dimensional data sets is addressed by considering the notion of the principal angles between the subspaces is introduced to measure the subspace difference between two high-dimensional data sets. Current methods either mainly focus on magnitude change detection of low-dimensional data sets or are under supervised frameworks. Principal angles bear a property to isolate subspace change from the magnitude change. To address the challenge of directly computing the principal angles, matrix factorization is used to serve as a statistical framework and develop the principle of the dominant subspace mapping to transfer the principal angle based detection to a matrix factorization problem. Matrix factorization can be naturally embedded into the likelihood ratio test based on the linear models. The method may be unsupervised and addresses the statistical significance of the pattern changes between high-dimensional data sets.
    • 高维数据集之间的模式变化发现的一般问题是通过考虑子空间之间的主角的概念来解决,以测量两个高维数据集之间的子空间差异。 当前的方法主要集中在低维数据集的幅度变化检测或处于监督框架下。 主角具有将子空间变化与幅度变化隔离的特性。 为了解决直接计算主角的挑战,矩阵分解被用作统计框架,并开发了主要子空间映射的原理,将基于主角的检测转移到矩阵分解问题。 矩阵分解可以自然地嵌入到基于线性模型的似然比检验中。 该方法可以是无监督的,并且解决了高维数据集之间的模式变化的统计意义。
    • 9. 发明申请
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US20090258390A1
    • 2009-10-15
    • US12455840
    • 2009-06-08
    • Magnus HookSlawomir LukomskiYi Xu
    • Magnus HookSlawomir LukomskiYi Xu
    • C12P21/02C12N1/21C12N15/63G01N33/566C07K14/78C07K16/12
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。