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1. 发明申请

US20090258390A1 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US20090258390A1
公开(公告)日：2009-10-15
申请号：US12455840
申请日：2009-06-08
申请人： Magnus Hook , Slawomir Lukomski , Yi Xu
发明人： Magnus Hook , Slawomir Lukomski , Yi Xu
IPC分类号： C12P21/02 , C12N1/21 , C12N15/63 , G01N33/566 , C07K14/78 , C07K16/12
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

2. 发明申请

US20080014613A1 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US20080014613A1
公开(公告)日：2008-01-17
申请号：US11800288
申请日：2007-05-04
申请人： Magnus Hook , Slawomir Lukomski , Yi Xu
发明人： Magnus Hook , Slawomir Lukomski , Yi Xu
IPC分类号： C12P21/00 , C07K14/78 , C07K16/12 , C12N1/00 , G01N33/00 , C12N1/21 , C12N15/63
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

3. 发明申请

US20060035336A1 Prokaryotic collagen-like proteins and uses thereof 有权
公开(公告)号：US20060035336A1
公开(公告)日：2006-02-16
申请号：US11245689
申请日：2005-10-07
申请人： Magnus Hook , Slawomir Lukomski , Yi Xu
发明人： Magnus Hook , Slawomir Lukomski , Yi Xu
IPC分类号： C07H21/04 , C12P21/06 , C12N1/21
CPC分类号： C07H21/04 , C07K14/315 , C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

4. 发明授权

US06953839B2 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US06953839B2
公开(公告)日：2005-10-11
申请号：US10830792
申请日：2004-04-23
申请人： Magnus Höök , Slawomir Lukomski , Yi Xu
发明人： Magnus Höök , Slawomir Lukomski , Yi Xu
IPC分类号： C07H21/04 , C07K14/315 , C12N1/21 , C07K14/00
CPC分类号： C07H21/04 , C07K14/315
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

5. 发明申请

US20100184085A1 Prokaryotic collage-like proteins and uses thereof 审中-公开
标题翻译：原核拼贴样蛋白及其用途
公开(公告)号：US20100184085A1
公开(公告)日：2010-07-22
申请号：US12660596
申请日：2010-03-02
申请人： Magnus Höök , Slawomir Lukomski , Yi Xu
发明人： Magnus Höök , Slawomir Lukomski , Yi Xu
IPC分类号： G01N33/53 , C07K16/00 , C12N15/63 , C12N1/21 , C12P21/06
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

6. 发明授权

US07700731B2 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US07700731B2
公开(公告)日：2010-04-20
申请号：US12455840
申请日：2009-06-08
申请人： Magnus Höök , Slawomir Lukomski , Yi Xu
发明人： Magnus Höök , Slawomir Lukomski , Yi Xu
IPC分类号： A61K38/17 , C07K14/00
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

7. 发明授权

US07238783B2 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US07238783B2
公开(公告)日：2007-07-03
申请号：US11245689
申请日：2005-10-07
申请人： Magnus Höök , Slawomir Lukomski , Yi Xu
发明人： Magnus Höök , Slawomir Lukomski , Yi Xu
IPC分类号： A61K38/17 , C07K14/00
CPC分类号： C07H21/04 , C07K14/315 , C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

8. 发明授权

US07544780B2 Prokaryotic collagen-like proteins and uses thereof 有权
标题翻译：原核胶原蛋白及其用途
公开(公告)号：US07544780B2
公开(公告)日：2009-06-09
申请号：US11800288
申请日：2007-05-04
申请人： Magnus Höök , Slawomir Lukomski , Yi Xu
发明人： Magnus Höök , Slawomir Lukomski , Yi Xu
IPC分类号： A61K38/17 , C07K14/00
CPC分类号： C07K14/78
摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
摘要翻译：本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域哺乳动物胶原蛋白。还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

9. 发明申请

US20050002925A1 Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them 失效
标题翻译：来自具有高度保守基序的革兰氏阳性细菌的表面蛋白和识别它们的抗体
公开(公告)号：US20050002925A1
公开(公告)日：2005-01-06
申请号：US10911507
申请日：2004-08-05
申请人： Yi Xu , Magnus Hook
发明人： Yi Xu , Magnus Hook
IPC分类号： A61K39/00 , C07K14/31 , C07K14/315 , C07K16/12 , A61K39/395
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , C07K14/31 , C07K14/315 , C07K16/1267 , Y10S930/29
摘要： Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
摘要翻译：提供了含有这些序列的分离的肽序列和蛋白质，其可用于预防和治疗由革兰氏阳性菌引起的感染。已经显示肽序列在革兰氏阳性细菌的表面蛋白中是高度保守的基序，并且这些共有序列包括氨基酸序列，例如LPXTG（SEQ ID NO：13），ALKTGKIDIIISGMTSTPERKK（SEQ ID NO：14），VEGAVVEKPVAEAYLKQN （SEQ ID NO：15）和EYAGVDIDLAKKIAK（SEQ ID NO：16）。由于高度保守的区域，包括这些序列的序列和蛋白质可用于产生能识别这些高度保守的基序和含有它们的蛋白质的抗体，因此可用于治疗或预防引起的广泛感染通过革兰氏阳性菌。

10. 发明申请

US20070122416A1 CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE 有权
标题翻译：来自胶原蛋白结合蛋白的交叉反应位移抗体及其鉴定和使用方法
公开(公告)号：US20070122416A1
公开(公告)日：2007-05-31
申请号：US09810428
申请日：2001-03-19
申请人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph Patti , Pratiksha Patel , Paul Domanski
发明人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph Patti , Pratiksha Patel , Paul Domanski
IPC分类号： A61K39/40 , G01N33/554 , C07K16/12
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/56938 , G01N2333/31 , G01N2333/78 , G01N2500/00
摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.
摘要翻译：提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于预防和治疗由这两种细菌引起的感染。此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质。最后，还提供了鉴定，分离和利用置换抗体的方法。

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