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    • 1. 发明申请
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US20090258390A1
    • 2009-10-15
    • US12455840
    • 2009-06-08
    • Magnus HookSlawomir LukomskiYi Xu
    • Magnus HookSlawomir LukomskiYi Xu
    • C12P21/02C12N1/21C12N15/63G01N33/566C07K14/78C07K16/12
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。
    • 2. 发明申请
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US20080014613A1
    • 2008-01-17
    • US11800288
    • 2007-05-04
    • Magnus HookSlawomir LukomskiYi Xu
    • Magnus HookSlawomir LukomskiYi Xu
    • C12P21/00C07K14/78C07K16/12C12N1/00G01N33/00C12N1/21C12N15/63
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。
    • 4. 发明授权
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US06953839B2
    • 2005-10-11
    • US10830792
    • 2004-04-23
    • Magnus HöökSlawomir LukomskiYi Xu
    • Magnus HöökSlawomir LukomskiYi Xu
    • C07H21/04C07K14/315C12N1/21C07K14/00
    • C07H21/04C07K14/315
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。
    • 5. 发明申请
    • Prokaryotic collage-like proteins and uses thereof
    • 原核拼贴样蛋白及其用途
    • US20100184085A1
    • 2010-07-22
    • US12660596
    • 2010-03-02
    • Magnus HöökSlawomir LukomskiYi Xu
    • Magnus HöökSlawomir LukomskiYi Xu
    • G01N33/53C07K16/00C12N15/63C12N1/21C12P21/06
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。
    • 6. 发明授权
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US07700731B2
    • 2010-04-20
    • US12455840
    • 2009-06-08
    • Magnus HöökSlawomir LukomskiYi Xu
    • Magnus HöökSlawomir LukomskiYi Xu
    • A61K38/17C07K14/00
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。
    • 7. 发明授权
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US07238783B2
    • 2007-07-03
    • US11245689
    • 2005-10-07
    • Magnus HöökSlawomir LukomskiYi Xu
    • Magnus HöökSlawomir LukomskiYi Xu
    • A61K38/17C07K14/00
    • C07H21/04C07K14/315C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。
    • 8. 发明授权
    • Prokaryotic collagen-like proteins and uses thereof
    • 原核胶原蛋白及其用途
    • US07544780B2
    • 2009-06-09
    • US11800288
    • 2007-05-04
    • Magnus HöökSlawomir LukomskiYi Xu
    • Magnus HöökSlawomir LukomskiYi Xu
    • A61K38/17C07K14/00
    • C07K14/78
    • The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
    • 本发明提供重组三螺旋蛋白或胶原样蛋白,其包含原核蛋白或原核蛋白的一个或多个结构域,其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外,提供针对重组胶原样蛋白的抗体,其优选结合整联蛋白。 此外,筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。