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1. 发明申请

US20120100207A1 PROCESS FOR PRODUCING LIPOSOMES BY TWO-STEP EMULSIFICATION METHOD UTILIZING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, PROCESS FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE PROCESS FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY 审中-公开
标题翻译：使用含有特定分散剂的外部水相的生产液体的方法，使用生产脂质体的方法生产脂质体分散剂或干粉的方法，以及生产脂质体的脂肪分散剂或干粉。
公开(公告)号：US20120100207A1
公开(公告)日：2012-04-26
申请号：US13380225
申请日：2010-06-02
申请人： Yasuyuki Motokui , Takeshi Wada , Takeshi Isoda
发明人： Yasuyuki Motokui , Takeshi Wada , Takeshi Isoda
IPC分类号： A61K9/127 , A61P35/00 , A61K31/365 , A61K31/7068 , B82Y5/00
CPC分类号： A61K9/1277 , A61K8/14 , A61K47/10 , A61K47/26 , A61K47/28 , A61K47/36 , A61K47/42 , A61Q19/00
摘要： [Problem] To provide a process for producing liposomes, a liposome dispersion or a dry powder of the dispersion by a two-step emulsification method using an additive (dispersing agent) by which a liposome dispersion and a dry powder thereof which can inhibit leakage of an encapsulated drug or the like from liposomes even in the long-term storage and can be stably used over a long period of time are obtained. [Solution to problem] A process for producing liposomes by a two-step emulsification method characterized by using, in the secondary emulsification step, an outer aqueous phase containing a dispersing agent which forms no molecular self-aggregate or a dispersing agent which exclusively forms molecular self-aggregates having a volume mean particle diameter of not more than 10 nm (said dispersing agent being referred to as a “specific dispersing agent” hereinafter), and a process for producing a liposome dispersion or a dry powder thereof utilizing the process for producing liposomes. The specific dispersing agent preferably contains at least one of gelatin, albumin, dextran and a polyalkylene oxide-based compound.
摘要翻译： [问题]提供一种通过使用添加剂（分散剂）的两步乳化法制备分散体的脂质体分散体或干粉的方法，通过该添加剂（分散剂）可以抑制可抑制渗透的脂质体分散体和干粉即使在长期储存中也可以从长期储存中得到脂质体的包封药物等，能够长时间稳定地使用。 [问题的解决方案]通过两步乳化法制造脂质体的方法，其特征在于，在二次乳化步骤中，使用含有不分子自聚集体的分散剂的外部水相或仅形成分子的分散剂体积平均粒径不大于10nm的自聚集体（所述分散剂在下文中称为“特定分散剂”），以及利用该方法生产脂质体分散体或其干粉的方法脂质体。特定的分散剂优选含有明胶，白蛋白，葡聚糖和聚环氧烷类化合物中的至少一种。

2. 发明申请

US20120225117A1 PROCESS FOR PRODUCTION OF W/O/W EMULSION, PROCESS FOR PRODUCTION OF LIPOSOME EMPLOYING THE PROCESS, AND POROUS MEMBRANE FOR USE IN THE PROCESSES 审中-公开
标题翻译：用于生产W / O / W乳液的方法，生产使用过程的脂质体的方法和用于过程的多孔膜
公开(公告)号：US20120225117A1
公开(公告)日：2012-09-06
申请号：US13510845
申请日：2010-11-15
申请人： Takeshi Isoda , Yasuyuki Motokui , Takeshi Wada
发明人： Takeshi Isoda , Yasuyuki Motokui , Takeshi Wada
IPC分类号： A61K9/133 , A61K31/7068 , A61P35/00 , A61P31/04 , A61P29/00 , A61P3/02 , A61P39/06 , A61K31/365 , A61P31/10 , B82Y40/00 , B82Y5/00
CPC分类号： B01J13/04 , A61K9/113 , A61K9/127 , B01J13/12
摘要： The present invention provides a liposome production process which enables production of a liposome that has a nano-size particle diameter and a high water-soluble drug encapsulation rate. The process for producing a W1/O/W2 emulsion of the present invention includes the steps of (1) emulsifying an organic solvent (O) that is a volatile organic solvent, an aqueous solvent (W1) and a mixed lipid component (F1) to give a W1/O emulsion; and (2) dispersing the W1/O emulsion produced in step (1) in an aqueous solvent (W2) by use of a porous membrane, to give a W1/O/W2 emulsion, wherein the porous membrane has been surface-treated with a hydrophilic drug so as to allow its surface to have a water contact angle of 0 to 42° in the air.
摘要翻译：本发明提供了能够生产具有纳米尺寸粒径和高水溶性药物包封率的脂质体的脂质体制造方法。制备本发明的W1 / O / W2乳液的方法包括以下步骤：（1）乳化作为挥发性有机溶剂的有机溶剂（O），水性溶剂（W1）和混合脂质成分（F1）得到W1 / O乳液; 和（2）通过使用多孔膜将步骤（1）中制备的W1 / O乳液分散在水性溶剂（W2）中，得到W1 / O / W2乳液，其中多孔膜已经用一种亲水药物，以使其表面在空气中具有0至42°的水接触角。

3. 发明申请

US20060239925A1 Method of manufacturing pharmaceutical preparation containing liposomes 审中-公开
标题翻译：制备含有脂质体的药物制剂的方法
公开(公告)号：US20060239925A1
公开(公告)日：2006-10-26
申请号：US11402713
申请日：2006-04-12
申请人： Takeshi Wada , Eiichi Ueda , Yasuyuki Motokui
发明人： Takeshi Wada , Eiichi Ueda , Yasuyuki Motokui
IPC分类号： A61K49/04 , A61K9/127
CPC分类号： A61K9/1277 , A61K9/1271
摘要： A method of manufacturing a liposome-containing preparation is disclosed, comprising (a) mixing one or more constituents of a liposome membrane, an aqueous solution of a water-soluble chemical and supercritical carbon dioxide at a temperature of 32 to 65° C. in a pressure vessel, and (b) evacuate the carbon dioxide to form an aqueous dispersion of liposomes enclosing an aqueous solution of a water-soluble chemical, wherein the constituents include at least one phospholipid exhibiting a transition temperature.
摘要翻译：公开了一种制备含脂质体的制剂的方法，其包括（a）在32至65℃的温度下将脂质体膜，水溶性化学物质和超临界二氧化碳的水溶液中的一种或多种组分混合在压力容器，和（b）抽空二氧化碳以形成包围水溶性化学物质的水溶液的脂质体的水性分散体，其中所述成分包括至少一种呈现转变温度的磷脂。

4. 发明授权

US09279186B2 Metal member manufacturing method and metal member 有权
标题翻译：金属构件制造方法和金属构件
公开(公告)号：US09279186B2
公开(公告)日：2016-03-08
申请号：US13574854
申请日：2010-10-22
申请人： Hidemi Kato , Takeshi Wada , Kunio Yubuta , Akihisa Inoue
发明人： Hidemi Kato , Takeshi Wada , Kunio Yubuta , Akihisa Inoue
IPC分类号： C23F4/04 , C23C26/02 , C23F1/00 , C22B9/02 , C22B26/22
CPC分类号： C23C26/02 , B22F2998/00 , C22B9/02 , C22B26/22 , C23F1/00 , C23F4/04 , Y02P10/234 , Y10T428/12479 , C22C1/0425 , C22C1/0433 , C22C33/02
摘要： A metallic material containing both a second constituent and a third constituent having positive and negative heats of mixing relative to a first constituent, respectively, and including a compound, an alloy or a nonequilibrium alloy having a melting point that is higher than the solidifying point of a metal bath made of the first constituent is placed in the metal bath. The metal bath is controlled to a temperature lower than a minimum value of a liquidus temperature within a range of compositional variations in which the amount of the third constituent in the metallic material decreases down to a point where the metallic material becomes substantially the second constituent so that the third constituent is selectively dissolved into the metal bath.
摘要翻译：一种含有第二成分和第三成分的金属材料，分别具有相对于第一成分的正和负的混合热，并且包括熔点高于凝固点的化合物，合金或非平衡合金将由第一成分制成的金属浴放置在金属浴中。将金属浴控制在低于液相线温度的最小值的温度范围内，其中金属材料中的第三成分的量减少到金属材料基本上变成第二成分的程度第三组分选择性地溶解到金属浴中。

5. 发明授权

US08859755B2 Method for preparing ribonucleoside phosphorothioate 有权
标题翻译：核糖核苷硫代磷酸酯的制备方法
公开(公告)号：US08859755B2
公开(公告)日：2014-10-14
申请号：US13582531
申请日：2011-03-04
申请人： Takeshi Wada , Yohei Nukaga
发明人： Takeshi Wada , Yohei Nukaga
IPC分类号： C07H21/00 , C07H19/10 , C07H21/02 , C07H19/20 , C07H19/06 , C07H19/16
CPC分类号： C07H19/20 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/02 , Y02P20/55
摘要： A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2′-hydroxyl group of RNA.
摘要翻译：基于氧氮杂磷烷基方法制备硫代磷酸酯RNA的方法，其中使用氰基乙氧基甲基代替叔丁基二甲基甲硅烷基作为RNA的2'-羟基的保护基。

6. 发明申请

US20120320623A1 ILLUMINATING DEVICE AND DISPLAY DEVICE 审中-公开
标题翻译：照明设备和显示设备
公开(公告)号：US20120320623A1
公开(公告)日：2012-12-20
申请号：US13581381
申请日：2011-03-01
申请人： Takeshi Wada
发明人： Takeshi Wada
IPC分类号： F21V8/00
CPC分类号： G02F1/133615 , G02B6/0088 , G02B6/009
摘要： An illuminating device includes a light guide plate; a light source that is located opposite at least two adjacent end faces of four end faces of the light guide plate; and a chassis that has an opening through which light emanating from a light emission surface of the light guide plate passes. At least one optical sheet that includes a corner portion with an interior angle of greater than 90 degrees in a position corresponding to a corner portion of the light guide plate that is sandwiched between the two end faces opposite the light source is disposed between the light emission surface of the light guide plate and the chassis.
摘要翻译：照明装置包括导光板; 光源，其与所述导光板的四个端面的至少两个相邻的端面相对; 以及具有从导光板的发光面发出的光通过的开口的底架。至少一个光学片包括在对应于导光板的夹在与光源相对的两个端面之间的导光板的角部的位置处具有大于90度的内角的角部，导光板和底盘的表面。

7. 发明授权

US08288527B2 Oligo-aminosaccharide compound 失效
标题翻译：寡糖类化合物
公开(公告)号：US08288527B2
公开(公告)日：2012-10-16
申请号：US12659425
申请日：2010-03-09
申请人： Takeshi Wada , Rintaro Iwata
发明人： Takeshi Wada , Rintaro Iwata
IPC分类号： C08B37/00 , C07H5/04 , C07H5/06
CPC分类号： C07H15/18 , C07H15/04
摘要： An oligo-aminosaccharide compound formed by binding 3 to 6 saccharides, such as 2,6-diamino-2,6-dideoxy-α-(1→4)-D-glucopyranose oligomers, or a salt thereof, which has high affinity to a double-stranded nucleic acid.
摘要翻译：通过结合3〜6个糖类形成的寡氨基糖化合物，例如2,6-二氨基-2,6-二脱氧-α-（1→4）-D-吡喃葡萄糖低聚物或其盐，其对双链核酸。

8. 发明授权

US08077353B2 Color conversion method, color conversion table created by the color conversion method, image processing apparatus, and color conversion program 有权
标题翻译：颜色转换方法，通过颜色转换方法创建的颜色转换表，图像处理装置和颜色转换程序
公开(公告)号：US08077353B2
公开(公告)日：2011-12-13
申请号：US12469547
申请日：2009-05-20
申请人： Takeshi Wada
发明人： Takeshi Wada
IPC分类号： H04N1/60 , G03F3/08
CPC分类号： H04N1/6058
摘要： There is provided a color conversion method. The method includes: a black correction step of converting the first black corresponding to the first color data having a tone value of 0 to the second black corresponding to the second color data having a tone value of 0 so that when the first black corresponding to the first color data having a tone value other than 0 is converted to a value smaller than a quantization threshold of tone values 0 and 1 of the second color data, a conversion destination becomes greater than or equal to the quantization threshold; a recording agent limit quantity calculating step of setting an upper limit of the sum of tone values for each pixel of the second color data with respect to a predetermined print medium; and a chromatic color correcting step of converting the second chromatic color so that the second color data after conversion in the black correction step does not exceed the upper limit.
摘要翻译：提供了一种颜色转换方法。该方法包括：黑色校正步骤，将具有音调值0的第一颜色数据对应的第一黑色转换为与色调值为0的第二颜色数据相对应的第二黑色，使得当对应于将具有0以外的色调值的第一颜色数据转换为小于第二颜色数据的色调值0和1的量化阈值的值，转换目标变为大于或等于量化阈值; 记录剂限制量计算步骤，用于相对于预定打印介质设置所述第二颜色数据的每个像素的色调值之和的上限; 以及彩色校正步骤，用于转换第二色彩，使得黑色校正步骤中的转换后的第二颜色数据不超过上限。

9. 发明申请

US20110294124A1 METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS 有权
标题翻译：磷化氢修饰核酸的合成方法
公开(公告)号：US20110294124A1
公开(公告)日：2011-12-01
申请号：US13131591
申请日：2009-12-02
申请人： Takeshi Wada , Mamoru Shimizu
发明人： Takeshi Wada , Mamoru Shimizu
IPC分类号： C12Q1/68 , C07H21/00 , G01N21/76 , C12P19/34 , G01N33/53 , G01N21/64
CPC分类号： C07H21/00 , C07H1/00
摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
摘要翻译：本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

10. 发明授权

US07701696B2 Multilayer capacitor 有权
标题翻译：多层电容器
公开(公告)号：US07701696B2
公开(公告)日：2010-04-20
申请号：US12127332
申请日：2008-05-27
申请人： Masaaki Togashi , Takeshi Wada
发明人： Masaaki Togashi , Takeshi Wada
IPC分类号： H01G4/228 , H01G4/06
CPC分类号： H01G4/232
摘要： A first terminal electrode has a first electrode portion disposed on a first face and connected to a first internal electrode, and a second electrode portion disposed on a third face and connected to the first electrode portion. A second terminal electrode has a first electrode portion disposed on a second face and connected to a second internal electrode, and a second electrode portion disposed on the third face and connected to the first electrode portion. Each of the second electrode portions of the first and second terminal electrodes, when viewed along a third direction perpendicular to the third face, is arranged with a gap in the second direction so as to sandwich at least a portion of an end in the first direction of an element body region sandwiched between the first internal electrode and the second internal electrode, at an end in the first direction of the second electrode portion.
摘要翻译：第一端子电极具有设置在第一面上并连接到第一内部电极的第一电极部分和设置在第三面上并连接到第一电极部分的第二电极部分。第二端子电极具有设置在第二面上并连接到第二内部电极的第一电极部分和设置在第三面上并连接到第一电极部分的第二电极部分。当沿垂直于第三面的第三方向观察时，第一和第二端子电极的每个第二电极部分在第二方向上以间隙的方式布置，以便将第一方向上的端部的至少一部分在第二电极部分的第一方向上的端部处夹在第一内部电极和第二内部电极之间的元件体区域。

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