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1. 发明授权

US5534269A Method of producing sustained-release preparation 失效
标题翻译：缓释制剂的制备方法
公开(公告)号：US5534269A
公开(公告)日：1996-07-09
申请号：US270838
申请日：1994-07-05
申请人： Yasutaka Igari , Kazumichi Yamamoto , Kayoko Okamoto , Yutaka Yamagata
发明人： Yasutaka Igari , Kazumichi Yamamoto , Kayoko Okamoto , Yutaka Yamagata
IPC分类号： A61K9/16 , A61K9/52 , A61K9/14
CPC分类号： A61K9/1694 , A61K9/1647 , Y10S514/964
摘要： A method of producing a sustained-release preparation which includes permitting a water-soluble polypeptide to permeate into a biodegradable matrix in the aqueous solution. The production method of the present invention makes possible the permeation of a water-soluble polypeptide into a biodegradable matrix without bringing the water-soluble polypeptide into contact with an organic solvent. Hence the water-soluble polypeptide is prepared without affecting the water-soluble polypeptide bioactivity and is thus effective for use as a pharmaceutical.
摘要翻译：一种制备缓释制剂的方法，其包括使水溶性多肽渗透到水溶液中的可生物降解的基质中。本发明的制备方法使水溶性多肽渗入可生物降解的基质成为可能，而不会使水溶性多肽与有机溶剂接触。因此，制备水溶性多肽而不影响水溶性多肽生物活性，因此有效地用作药物。

2. 发明授权

US06267981B1 Method of producing sustained-release preparation 失效
标题翻译：缓释制剂的制备方法
公开(公告)号：US06267981B1
公开(公告)日：2001-07-31
申请号：US09571728
申请日：2000-05-15
申请人： Kayoko Okamoto , Yutaka Yamagata , Yasutaka Igari , Masafumi Misaki
发明人： Kayoko Okamoto , Yutaka Yamagata , Yasutaka Igari , Masafumi Misaki
IPC分类号： A61F200
CPC分类号： A61K38/27 , A61K9/1647 , A61K9/5031 , A61K38/28
摘要： This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.
摘要翻译：本发明提供包含可生物降解的聚合物金属盐和活性多肽的持续释放制剂，其具有增强的生物活性多肽捕获，抑制初始爆发以及生物活性多肽的恒定长期释放。

3. 发明授权

US06376461B1 Sustained-release preparation 失效
公开(公告)号：US06376461B1
公开(公告)日：2002-04-23
申请号：US09426716
申请日：1999-10-26
申请人： Yasutaka Igari , Yutaka Yamagata , Satoshi Iinuma , Hiroaki Okada , Kazumichi Yamamoto
发明人： Yasutaka Igari , Yutaka Yamagata , Satoshi Iinuma , Hiroaki Okada , Kazumichi Yamamoto
IPC分类号： A01N3718
CPC分类号： A61K9/5031 , A61K9/0019 , A61K31/00 , A61K38/1816 , A61K38/193 , A61K38/212 , A61K38/27 , A61K38/28
摘要： According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity. According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.

4. 发明授权

US6087324A Sustained-release preparation 失效
公开(公告)号：US6087324A
公开(公告)日：2000-07-11
申请号：US644631
申请日：1996-04-22
申请人： Yasutaka Igari , Yutaka Yamagata
发明人： Yasutaka Igari , Yutaka Yamagata
IPC分类号： A01N37/18 , A61K9/14 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/22 , A61K28/18
CPC分类号： A61K9/5031 , A61K31/00 , A61K38/1816 , A61K38/193 , A61K38/212 , A61K38/27 , A61K38/28 , A61K9/0019
摘要： According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity.According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.

5. 发明申请

US20070202258A1 Micro-pattern forming apparatus, micro-pattern structure, and method of manufacturing the same 审中-公开
标题翻译：微图案形成装置，微图案结构及其制造方法
公开(公告)号：US20070202258A1
公开(公告)日：2007-08-30
申请号：US11512355
申请日：2006-08-30
申请人： Yutaka Yamagata , Hitoshi Ohmori , Hiroshi Kase , Hiromi Nonaka , Ai Kaneko , Kazuya Nitta
发明人： Yutaka Yamagata , Hitoshi Ohmori , Hiroshi Kase , Hiromi Nonaka , Ai Kaneko , Kazuya Nitta
IPC分类号： B05D1/32 , C25D5/00 , B05C5/00
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00371 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2300/0838 , B01L2400/027 , B05B5/025 , B05B5/087 , G03F1/20 , G03F7/12
摘要： There is provided a micro-pattern forming apparatus including an electrospraying part for applying a voltage to a solution containing a sample to electrostatically atomizing the solution; a supporting part (30) for supporting a chip (26), on which the sample in the solution electrostatically atomized by the electrospraying part, is to be deposited; and a fine mask part (24) disposed between the electrospraying part and the supporting part, having a mask pattern for being passed through by the electrostatically atomized solution in order to form a micro-pattern of the sample upon the chip, wherein the mask pattern is made from a photoresist material with concavity and convexity on the side of the supporting part.
摘要翻译：提供一种微图形形成装置，其包括用于向含有样品的溶液施加电压的电喷雾部件以静电雾化溶液; 用于支撑芯片（26）的支撑部分（30），在其上沉积由电喷雾部分静电雾化的溶液中的样品; 以及设置在电喷雾部分和支撑部分之间的精细掩模部分（24），具有通过静电雾化溶液通过的掩模图案，以便在芯片上形成样品的微图案，其中掩模图案由在支撑部分的侧面上具有凹凸的光致抗蚀剂材料制成。

6. 发明授权

US06723347B1 Proces for producing protein powder 失效
标题翻译：生产蛋白粉的方法
公开(公告)号：US06723347B1
公开(公告)日：2004-04-20
申请号：US10088142
申请日：2002-03-15
申请人： Yutaka Yamagata , Takayuki Doen , Naoki Asakawa , Shigeyuki Takada
发明人： Yutaka Yamagata , Takayuki Doen , Naoki Asakawa , Shigeyuki Takada
IPC分类号： A61K914
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/19 , Y10S514/964
摘要： A process for conveniently producing a stable protein powder retaining the higher-order structure at a high level which comprises freezing a protein-containing solution at a cooling rate of about −300 to −10° C./min. and then drying.
摘要翻译：用于方便地制备以高水平保持高级结构的稳定的蛋白质粉末的方法，其包括以约-300至-10℃/分钟的冷却速率冷冻含蛋白质的溶液。然后干燥。

7. 发明授权

US06478661B2 Apparatus and method for processing micro-V grooves 失效
标题翻译：微V槽加工装置及方法
公开(公告)号：US06478661B2
公开(公告)日：2002-11-12
申请号：US09794909
申请日：2001-02-28
申请人： Hitoshi Ohmori , Noboru Ebizuka , Yutaka Yamagata , Shinya Morita , Sei Moriyasu , Muneaki Asami
发明人： Hitoshi Ohmori , Noboru Ebizuka , Yutaka Yamagata , Shinya Morita , Sei Moriyasu , Muneaki Asami
IPC分类号： B24B100
CPC分类号： B24B53/001 , B24B13/015 , B24B19/028 , B24B53/02
摘要： A voltage is applied between a cylindrical cutting grindstone 2 that rotates about a vertical axis Y and a cylindrical truing grindstone 6 that rotates about a horizontal axis X. The vertical outer surface 2a and the horizontal lower surface 2b of the cutting grindstone are trued by a plasma discharge. Then without applying the voltage, the cutting grindstone 2 is trued mechanically by the truing grindstone 6, and while the outer periphery and lower surface of the cutting grindstone are dressed electrolytically, the outer periphery and lower surface are made to contact a workpiece 1 and process a micro-V groove. This method makes it possible to produce an immersion grating with a high resolution using hard, brittle materials such as germanium, gallium arsenide and lithium niobate.
摘要翻译：在围绕垂直轴线Y旋转的圆筒形磨石2和围绕水平轴线X旋转的圆柱形修整磨石6之间施加电压。切割磨石的垂直外表面2a和水平下表面2b由等离子体放电。然后在不施加电压的情况下，通过修整磨石6机械地修整切割磨石2，并且当切割磨石的外周和下表面被电解时，使外周和下表面接触工件1和工艺一个微V槽。该方法使得可以使用诸如锗，砷化镓和铌酸锂的硬的脆性材料来生产具有高分辨率的浸没光栅。

8. 发明授权

US5628993A Sustained releasable parenteral pharmaceutical preparations and method of producing the same 失效
标题翻译：持续可释放的肠胃外药物制剂及其制备方法
公开(公告)号：US5628993A
公开(公告)日：1997-05-13
申请号：US294972
申请日：1994-08-24
申请人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
发明人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
IPC分类号： A61K9/14 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/70 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/28 , A61K47/14 , A61K38/02
CPC分类号： A61K9/2013 , A61K38/2013 , A61K38/212 , A61K38/28 , A61K9/1617 , A61K9/70 , A61K9/0024
摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.
摘要翻译：肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。生理活性肽或蛋白质的分子量为2,000道尔顿或更多。饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间或者更多。

9. 发明申请

US20120244223A1 ORALLY DISPERSIBLE TABLET 有权
公开(公告)号：US20120244223A1
公开(公告)日：2012-09-27
申请号：US13491887
申请日：2012-06-08
申请人： Yutaka Tanoue , Tetsuya Matsuura , Yutaka Yamagata , Naoki Nagahara
发明人： Yutaka Tanoue , Tetsuya Matsuura , Yutaka Yamagata , Naoki Nagahara
IPC分类号： A61K9/16 , A61P25/18 , A61K31/343
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/5015 , A61K31/343 , A61K47/26 , A61K47/38 , A61K47/40
摘要： The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.
摘要翻译：本发明提供了具有改善的崩解性的制剂，显示药物的生物利用度提高的制剂，其制备方法等。一种快速崩解制剂，其包含颗粒，其包含涂覆有含有糖或糖醇的涂层的药物; 和崩解剂。一种快速崩解制剂的制备方法，包括生产颗粒的步骤，其包括药物，在所得颗粒上形成含有糖或糖醇的包衣层的步骤，以及将包衣颗粒与崩解剂混合并模制该混合物的步骤。

10. 发明授权

US06539642B1 Probe type shape measuring sensor, and NC processing equipment and shape measuring method using the sensor 失效
标题翻译：探头型形状测量传感器，数控加工设备和使用传感器的形状测量方法
公开(公告)号：US06539642B1
公开(公告)日：2003-04-01
申请号：US09763747
申请日：2001-02-27
申请人： Sei Moriyasu , Yutaka Yamagata , Hitoshi Ohmori , Shinya Morita
发明人： Sei Moriyasu , Yutaka Yamagata , Hitoshi Ohmori , Shinya Morita
IPC分类号： G01B520
CPC分类号： G01B21/20 , G01B11/007 , G01B11/2441
摘要： A probe head 10 and a laser interferometric displacement meter 20 are provided. The probe head supports a probe 2 that is capable of contacting a workpiece 1, that is free to move in the direction of the workpiece, and drives the probe towards the workpiece. The displacement meter measures the displacement of the probe with a high accuracy without contact. The probe head 10 is also provided with a probe shaft 12 with steps 11a, 11b at intermediate portions thereof and air bearings 14a, 14b that support the probe shaft on each side of the steps. The air bearings have a high stiffness in the radial direction, and the probe shaft is made to float by using compressed air, thus the resistance of the shaft to sliding is reduced. In addition, another compressed air is supplied to the location of the step and produces a driving force in the direction of the workpiece due to the difference of cross sectional areas on each side of the step, that provides a very small load within a predetermined range. Thereby, the measuring pressure can be adjusted to a constant very small load without reducing the stiffness of the bearings of the probe, and the measuring pressures can be varied freely. Therefore, a sub-micron accuracy of about 0.1 &mgr;m can be obtained, and the equipment can be made compact and is easily applied to on-machine measurements.
摘要翻译：提供探针头10和激光干涉位移计20。探头支撑探头2，该探头2能够接触工件1，该工件可自由地沿工件的方向移动，并将探头驱动向工件。位移仪可以高精度地测量探头的位移而不接触。探针头10还设置有探针轴12，其中间部分具有台阶11a，11b，以及在台阶的每一侧支撑探针轴的空气轴承14a，14b。空气轴承在径向上具有高刚度，并且通过使用压缩空气使探针轴浮动，从而减小了轴的滑动阻力。此外，另一压缩空气被供给到台阶的位置，并且由于台阶两侧的横截面积的差异而在工件的方向上产生驱动力，其在预定范围内提供非常小的载荷。因此，可以将测量压力调整到恒定的非常小的负载，而不降低探针的轴承的刚度，并且测量压力可以自由变化。因此，可以获得约0.1μm的亚微米精度，并且可以使设备紧凑并且容易地应用于机上测量。

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