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1. 发明授权

US6093714A Tricyclic benzazepine compounds 失效
标题翻译：三环苯并氮杂化合物
公开(公告)号：US6093714A
公开(公告)日：2000-07-25
申请号：US973991
申请日：1998-06-17
申请人： Yasuo Ohtsuka , Toshio Nishizuka , Sohjiro Shiokawa , Seiji Tsutsumi , Kenichi Fusihara , Mami Kawaguchi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Takako Iwasaki , Hiroko Ogino , Takashi Shishikura
发明人： Yasuo Ohtsuka , Toshio Nishizuka , Sohjiro Shiokawa , Seiji Tsutsumi , Kenichi Fusihara , Mami Kawaguchi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Takako Iwasaki , Hiroko Ogino , Takashi Shishikura
IPC分类号： C07D249/04 , C07D405/06 , C07D487/04 , C07D491/14 , C07D519/00 , A61K31/41
CPC分类号： C07D405/06 , C07D249/04 , C07D487/04 , C07D491/14 , Y02P20/55
摘要： Tricyclic benzazepine compounds represented by the following formula (I) and pharmacologically acceptable salts thereof are disclosed. These compounds have antiallergic activity and are useful for treatment and prevention of bronchial asthma, eczema, hives, allergic gastrointestinal troubles, allergic rhinitis, allergic conjunctivitis, etc. wherein R represents a hydrogen atom, substituted C.sub.1-6 alkyl or a protective group and R.sup.1, R.sup.2, R.sup.3, and R.sup.4 represent a hydrogen atom, a hydroxyl group, substituted C.sub.1-4 alkyl, substituted C.sub.2-12 alkenyl, substituted C.sub.1-12 alkoxy, or substituted amino.
摘要翻译： PCT No.PCT / JP96 / 01628 Sec。 371日期1998年6月17日第 102（e）1998年6月17日PCT PCT 1996年6月14日PCT公布。公开号WO97 / 00258 日期1997年1月3日公开了由下式（I）表示的三环苯并氮杂化合物及其药理学上可接受的盐。这些化合物具有抗过敏活性，可用于治疗和预防支气管哮喘，湿疹，荨麻疹，过敏性胃肠道疾病，过敏性鼻炎，过敏性结膜炎等。其中R表示氢原子，取代的C 1-6烷基或保护基，R1 ，R2，R3和R4表示氢原子，羟基，取代的C1-4烷基，取代的C2-12烯基，取代的C1-12烷氧基或取代的氨基。

2. 发明授权

US5840895A Triazole intermediates for tricyclic benzazepine and benzothiazepine derivatives 失效
标题翻译：用于三环苯并氮杂和苯并硫氮杂衍生物的三唑中间体
公开(公告)号：US5840895A
公开(公告)日：1998-11-24
申请号：US883313
申请日：1997-06-26
申请人： Yasuo Ohtsuka , Takashi Shishikura , Hiroko Ogino , Kenichi Fushihara , Mami Kawaguchi , Seiji Tsutsumi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Junko Tanaka , Takako Iwasaki , Shigeru Hoshiko , Takashi Tsuruoka
发明人： Yasuo Ohtsuka , Takashi Shishikura , Hiroko Ogino , Kenichi Fushihara , Mami Kawaguchi , Seiji Tsutsumi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Junko Tanaka , Takako Iwasaki , Shigeru Hoshiko , Takashi Tsuruoka
IPC分类号： C07D249/04 , C07D487/04 , C07D513/04
CPC分类号： C07D487/04 , C07D249/04 , C07D513/04 , Y02P20/55
摘要： Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.
摘要翻译：式（II），（III），（IV）和（V）或其盐的化合物是药理活性三环苯并氮杂和苯并硫氮杂衍生物的中间体，其中氢，烷基，苯基烷基或三唑环的保护基，R 1 -R 5表示氢，烷基，烯基，烷氧基，氨基，肟基或羟基，R 41表示氢，可任意取代的C 1-6烷基或羧基保护基组。

3. 发明授权

US5686442A Tricyclic benzazepine and benzothiazepine derivatives 失效
标题翻译：三环苯并吖庚因和苯并硫氮杂衍生物
公开(公告)号：US5686442A
公开(公告)日：1997-11-11
申请号：US522263
申请日：1995-10-26
申请人： Yasuo Ohtsuka , Takashi Shishikura , Hiroko Ogino , Kenichi Fushihara , Mami Kawaguchi , Seiji Tsutsumi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Junko Tanaka , Takako Iwasaki , Shigeru Hoshiko , Takashi Tsuruoka
发明人： Yasuo Ohtsuka , Takashi Shishikura , Hiroko Ogino , Kenichi Fushihara , Mami Kawaguchi , Seiji Tsutsumi , Megumi Imai , Keiko Shito , Koji Tsuchiya , Junko Tanaka , Takako Iwasaki , Shigeru Hoshiko , Takashi Tsuruoka
IPC分类号： C07D249/04 , C07D487/04 , C07D513/04 , A61K31/55
CPC分类号： C07D487/04 , C07D249/04 , C07D513/04 , Y02P20/55
摘要： The tricyclic benzazepine and benzothiazepine derivatives represented by the formula (I) and pharmacologically acceptable salts thereof are disclosed. ##STR1## wherein Z represents CO, --CR.sup.6 R.sup.7 -- or --S(O).sub.n, R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl. These compounds have anti-allergic effect and are useful for the treatment and prophylaxis of allergic diseases.
摘要翻译： PCT No.PCT / JP94 / 02282 Sec。 371 1995年10月26日第 102（e）日期1995年10月26日PCT 1994年12月28日PCT公布。公开号WO95 / 18130 日期：1995年7月6日公开了由式（I）表示的三环苯并氮杂和苯并硫氮杂衍生物及其药理学上可接受的盐。（I）其中Z表示CO，-CR 6 R 7 - 或-S（O）n，R表示氢，烷基，苯基烷基或三唑环的保护基，R 1 -R 5表示氢，烷基，烯基，烷氧基，氨基，羟基或羟基。这些化合物具有抗过敏作用，可用于治疗和预防过敏性疾病。

4. 发明授权

US4785090A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4785090A
公开(公告)日：1988-11-15
申请号：US704077
申请日：1985-02-21
申请人： Takashi Tsuruoka , Seiji Shibahara , Katsuyoshi Iwamatsu , Tsuneo Okonogi , Satoru Nakabayashi , Yasushi Murai , Hiroko Ogino , Kiyoaki Katano , Takashi Yoshida , Shigeharu Inoue , Shunzo Fukatsu , Shinichi Kondo
发明人： Takashi Tsuruoka , Seiji Shibahara , Katsuyoshi Iwamatsu , Tsuneo Okonogi , Satoru Nakabayashi , Yasushi Murai , Hiroko Ogino , Kiyoaki Katano , Takashi Yoshida , Shigeharu Inoue , Shunzo Fukatsu , Shinichi Kondo
IPC分类号： C07D213/64 , C07D213/68 , C07D221/04 , C07D501/36 , C07D501/38 , A61K31/545
CPC分类号： C07D221/04 , C07D213/64 , C07D213/68
摘要： This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group ##STR6## wherein R.sup.8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.
摘要翻译：这是一类具有下式的抗菌化合物：其中Y是直链或支链烷基或烯基链，3-6个碳原子的环烷基甲基，每个基团任选被卤素取代，或基团< 其中n为0或1-3的整数，A为基团-COR 3，其中R 3为羟基，其中R 4和R 5可以相同或不同，为氢或1-5碳的烷基原子，基团或含有氮和/或硫的5-或6-元杂环基，R 1和R 2可以相同或不同，为氢，1-5个碳原子的烷基或R1 并且R 2可以组合在一起形成3-5个碳原子的亚烷基，Z是下式的基团：其中m是0或3-5的整数，R6是氢或1-3个碳的烷基原子和R 7，当m是3-5的整数时，是1-5个碳原子的烷基，烯基，环丙基，基团 - （CH 2）pB，其中p是0或1-3的整数，B是氨基，烷基取代的氨基羟基，羧基，氨基甲酰基，三氟甲基，磺酸，磺酸酰胺，烷硫基或氰基，或当m为0时，其为1-5个碳原子的烷基，其可任选被卤素，链烯基，基团其中R8是氢，1-4个碳原子的烷基或苯基，或环丙基及其盐。

5. 发明授权

US5141946A Azole derivatives and anti-ulcerative composition containing same 失效
标题翻译：唑衍生物和含有其的抗溃疡组合物
公开(公告)号：US5141946A
公开(公告)日：1992-08-25
申请号：US716622
申请日：1991-06-14
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D487/04 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61P1/04 , C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in whichA, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represnts a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-memebered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integrer from 0 to 2.The compounds are useful in treating ulcers.
摘要翻译：通式（I）的化合物：其中A，B，C和D各自表示-CH =或-N =，条件是其中至少一个为 -N =; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R1表示氢原子，C1-4烷基，卤素原子或C1-4烷氧基; R2表示氢原子，羟基，饱和或不饱和的C1-6烷基，C1-6烷氧基，羧基，可以任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，含有至少一个氮原子的饱和或不饱和五元或六元杂环基团，任选具有一个或多个氮原子和/或氧原子，其可以任选地被缩合和/或取代，-CONR 3 R 4，-NR 3 R 4，-OCOR 3或 - NHCONHR 3其中R3和R4可以相同或不同，表示可以任选被取代的C 1-6烷基或环烷基，m和n各自表示0至2的整数。该化合物可用于处理溃疡

6. 发明授权

US4988686A Cephem compounds and anti-bacterial agent 失效
标题翻译：头孢烯化合物和抗菌剂
公开(公告)号：US4988686A
公开(公告)日：1991-01-29
申请号：US373176
申请日：1989-06-28
申请人： Kunio Atsumi , Katsuyoshi Iwamatsu , Kenji Sakagami , Hiroko Ogino , Takashi Yoshida
发明人： Kunio Atsumi , Katsuyoshi Iwamatsu , Kenji Sakagami , Hiroko Ogino , Takashi Yoshida
IPC分类号： C07D501/46 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/04 , C07D501/20 , C07D501/24
CPC分类号： C07D501/24 , Y02P20/55
摘要： Disclosed is a novel cephem compound which is either one of a cis- or trans-isomer or a mixture of the cis-and trans-isomers, represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein all of the substituents are as defined hereinbefore. Also disclosed are a process for producing the above compound and its use as an anti-bacterial agent comprising the same.

7. 发明授权

US5200407A Azole derivatives and anti-ulcerative composition containing same 失效
标题翻译：唑衍生物和含有其的抗溃疡组合物
公开(公告)号：US5200407A
公开(公告)日：1993-04-06
申请号：US716621
申请日：1991-06-14
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integer from 0 to 2.
摘要翻译：通式（I）的化合物：其中A，B，C和D各自表示-CH =或-N =，条件是其中至少一个为 -N =; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R1表示氢原子，C1-4烷基，卤素原子或C1-4烷氧基; R2表示氢原子，羟基，饱和或不饱和的C1-6烷基，C1-6烷氧基，羧基，可以任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，含有至少一个氮原子的饱和或不饱和五元或六元杂环基，任选具有一个或多个氮和/或氧原子，其可以任选地被缩合和/或取代，-CONR 3 R 4，-NR 3 R 4，-OCOR 3或 - NHCONHR 3其中R3和R4可以相同或不同，表示可以被任意取代的C 1-6烷基或环烷基，m和n各自表示0〜2的整数。

8. 发明授权

US5185347A Piperidine compounds and antiulcer composition containing the same 失效
标题翻译：哌啶化合物和含有它们的抗微生物组合物
公开(公告)号：US5185347A
公开(公告)日：1993-02-09
申请号：US700985
申请日：1991-05-16
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka , Shigeharu Inoye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka , Shigeharu Inoye
IPC分类号： C07D401/12 , A61K31/4427 , A61K31/445 , A61P1/04 , C07D235/28 , C07D401/14
CPC分类号： C07D235/28
摘要： A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted benzyl group, or a (2,2,6,6-tetramethylpiperidin-1-yl)ethyl group; and n represents 0 or an integer of 1 or 2,and an antiulcer composition containing said piperidine compound.

9. 发明授权

US5028601A Cephalosporin compounds and antibacterial agents 失效
标题翻译：头孢菌素化合物和抗菌剂
公开(公告)号：US5028601A
公开(公告)日：1991-07-02
申请号：US184323
申请日：1988-04-21
申请人： Shinichi Kondo , Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Satoru Nakabayashi , Hiroko Ogino , Takashi Yoshida , Masaji Sezaki
发明人： Shinichi Kondo , Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Satoru Nakabayashi , Hiroko Ogino , Takashi Yoshida , Masaji Sezaki
IPC分类号： C07D501/00 , C07D501/20
CPC分类号： C07D501/00
摘要： Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

10. 发明授权

US5399566A Pyridine derivatives having angiotensin II antagonism 失效
标题翻译：具有血管紧张素II拮抗作用的吡啶衍生物
公开(公告)号：US5399566A
公开(公告)日：1995-03-21
申请号：US752557
申请日：1991-09-10
申请人： Kiyoaki Katano , Hiroko Ogino , Eiki Shitara , Hiromi Watanabe , Jun Nagura , Naomi Osada , Yasuyuki Ichimaru , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka
发明人： Kiyoaki Katano , Hiroko Ogino , Eiki Shitara , Hiromi Watanabe , Jun Nagura , Naomi Osada , Yasuyuki Ichimaru , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka
IPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12 , A61K31/44
CPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12
摘要： The invention provides compounds represented by the following formula (I) ##STR1## or a pharmaceutically acceptable salts thereof wherein A represents ##STR2## B represents a carboxy or tetrazolyl group; and X represents --O--, --NH-- or --S(O).sub.t --.The compounds possess angiotensin II antagonism, and may be used as an antihypertensive agent, a therapeutic agent to congestive heart failure, an antianxiety agent and a cognitive enhancing agent.
摘要翻译： PCT No.PCT / JP91 / 00822 Sec。 371日期1991年9月10日 102（e）1991年9月10日PCT PCT 1991年6月19日PCT公布。 No.W091 / 19697 PCT出版物 1991年12月26日，本发明提供由下式（I）表示的化合物或其药学上可接受的盐，其中A表示羧基或四唑基; X表示-O - ， - NH-或-S（O）t - 。该化合物具有血管紧张素II拮抗作用，可用作抗高血压药，充血性心力衰竭的治疗剂，抗焦虑剂和认知增强剂。

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