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1. 发明授权

US07259155B2 Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US07259155B2
公开(公告)日：2007-08-21
申请号：US10838297
申请日：2004-05-05
申请人： Yasuhiro Sakai , Kazuyoshi Miyata , Takahiro Tomoyasu , Akiyoshi Kuroda , Yasuhide Inoue , Akifumi Hagi , Shinya Miki , Norihiro Yoshinaga , Masako Doi , Yoshihiko Tsuda , Seiichirou Kanou
发明人： Yasuhiro Sakai , Kazuyoshi Miyata , Takahiro Tomoyasu , Akiyoshi Kuroda , Yasuhide Inoue , Akifumi Hagi , Shinya Miki , Norihiro Yoshinaga , Masako Doi , Yoshihiko Tsuda , Seiichirou Kanou
IPC分类号： A61K31/517 , A61K31/675 , A01N43/54 , C07D239/72 , C07D265/32 , C07D413/00 , C07F9/02 , C07D401/00 , C07D403/02 , C07F9/28 , C07F9/547
CPC分类号： C07F9/65586 , C07F9/65068 , C07F9/65583
摘要： The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1–3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.
摘要翻译：本发明提供由通式其中R 1，R 2，R 3和R 4代表的膦酸二酯化合物， / SUB>相同或不同，代表氢，卤素，低级烷基或低级烷氧基; R 5是在苯环上具有1-3个选自低级烷基，卤素取代的低级烷基，低级烷氧基，卤素取代的低级烷氧基，苯氧基，苄氧基，羟基，卤素，硝基，低级烷硫基，二（低级烷基）氨基，低级链烷氨基，吡咯烷基和苯基等，条件是R 5不是单（低级烷氧基）苯基; 和R 6是低级烷基; 和含有该化合物作为活性成分的ACAT-1抑制剂。

2. 发明申请

US20050256087A1 Phosphonic acid diester compounds 失效
标题翻译：膦酸二酯化合物
公开(公告)号：US20050256087A1
公开(公告)日：2005-11-17
申请号：US10838297
申请日：2004-05-05
申请人： Yasuhiro Sakai , Kazuyoshi Miyata , Takahiro Tomoyasu , Akiyoshi Kuroda , Yasuhide Inoue , Akifumi Hagi , Shinya Miki , Norihiro Yoshinaga , Masako Doi , Yoshihiko Tsuda , Seiichirou Kanou
发明人： Yasuhiro Sakai , Kazuyoshi Miyata , Takahiro Tomoyasu , Akiyoshi Kuroda , Yasuhide Inoue , Akifumi Hagi , Shinya Miki , Norihiro Yoshinaga , Masako Doi , Yoshihiko Tsuda , Seiichirou Kanou
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/6509 , C07F9/6558
CPC分类号： C07F9/65586 , C07F9/65068 , C07F9/65583
摘要： The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5 is phenyl having on the phenyl ring 1-3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5 is not mono(lower alkoxy)pheny; and R6 is lower alkyl; and an ACAT-1 inhibitor containing the compound as an active ingredient.
摘要翻译：本发明提供由通式其中R 1，R 2，R 3和R 4代表的膦酸二酯化合物， / SUB>相同或不同，代表氢，卤素，低级烷基或低级烷氧基; R 5是在苯环上具有1-3个选自低级烷基，卤素取代的低级烷基，低级烷氧基，卤素取代的低级烷氧基，苯氧基，苄氧基，羟基，卤素，硝基，低级烷硫基，二（低级烷基）氨基，低级链烷氨基，吡咯烷基和苯基等，条件是R 5不是单（低级烷氧基）苯基; 和R 6是低级烷基; 和含有该化合物作为活性成分的ACAT-1抑制剂。

3. 发明授权

US5985858A Phosphonic diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US5985858A
公开(公告)日：1999-11-16
申请号：US91946
申请日：1998-06-26
申请人： Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
发明人： Kazuyoshi Miyata , Yasuhiro Sakai , Yasuo Shoji , Yoshihiko Tsuda , Yasuhide Inoue , Keigo Sato , Shinya Miki
IPC分类号： C07F9/6509 , C07F9/6539 , C07F9/6553 , C07F9/6558 , C07F9/6561 , A61K31/67 , A61K31/675
CPC分类号： C07F9/650964 , C07F9/6539 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lower alkyl group, a halogen atom, a halogen-substituted lower alkyl group, a lower alkanoyl group, a nitro group, a benzoyl group, a cyano group, an N-lower alkylcarbamoyl group, an N-phenyl-lower alkylcarbamoyl group, an N-(halogen-substituted phenyl)carbamoyl group and an N,N-di-lower alkylcarbamoyl group; a 1,3,4-thiadiazol-2-yl group having a halogen-substituted lower alkyl group as a substituent; a thiazolyl group; a pyridyl group which may be substituted by a halogen atom; a benzothiazol-2-yl group having 1 to 2 lower alkoxy groups on the phenyl ring; or a 4,5-dihydrothieno[3,2-e]benzothiazol-2-yl group; R.sup.2 represents a hydrogen atom or a phenyl lower alkyl group; R.sup.3 and R.sup.4 each represents a lower alkyl group; and A represents a heterocyclic ring selected from the group consisting of a pyrazine ring, a thiophene ring and a phenyl-substituted thiazole ring; the derivative being of value as an agent for treating and preventing hyperlipidemia, diabetes and cataract, or as an antitumor agent.
摘要翻译： PCT No.PCT / JP96 / 03775第 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年12月24日PCT公布。公开号WO97 / 24360 PCT 日期：1997年7月10日由下式（1）表示的膦酸二酯衍生物：其中R1表示环烷基; 可以具有1〜3个选自低级烷氧基，低级烷基，卤素原子，卤素取代的低级烷基，低级烷酰基，硝基，苯甲酰基的取代基的苯基，氰基，N-低级烷基氨基甲酰基，N-苯基 - 低级烷基氨基甲酰基，N-（卤素取代的苯基）氨基甲酰基和N，N-二低级烷基氨基甲酰基; 具有卤素取代的低级烷基作为取代基的1,3,4-噻二唑-2-基; 噻唑基可被卤素原子取代的吡啶基; 在苯环上具有1至2个低级烷氧基的苯并噻唑-2-基; 或4,5-二氢噻吩并[3,2-e]苯并噻唑-2-基; R2表示氢原子或苯基低级烷基; R3和R4各自表示低级烷基; A表示选自吡嗪环，噻吩环和苯基取代的噻唑环的杂环; 该衍生物作为治疗和预防高脂血症，糖尿病和白内障或作为抗肿瘤剂的药剂是有价值的。

4. 发明授权

US06468992B1 Phosphonic acid diester derivatives 失效
标题翻译：膦酸二酯衍生物
公开(公告)号：US06468992B1
公开(公告)日：2002-10-22
申请号：US09674145
申请日：2000-12-13
申请人： Yasuhiro Sakai , Kazuyoshi Miyata , Kenichi Kawamura , Yoshihiko Tsuda , Yasuhide Inoue
发明人： Yasuhiro Sakai , Kazuyoshi Miyata , Kenichi Kawamura , Yoshihiko Tsuda , Yasuhide Inoue
IPC分类号： C07F940
CPC分类号： C07F9/4065 , C07F9/4006 , C07F9/58 , C07F9/650952
摘要： The present invention provides novel phosphonic acid diester derivatives useful as medicines. The phosphonic acid diester derivatives are represented by the general formula: wherein R1 represents amino group, N-lower alkylamino group, N-lower alkenylamino group, or the like; R2 and R3 represent hydrogen atom, lower alkyl group, halogen atom, lower alkoxy group, or the like; R4 represents hydrogen atom, lower alkyl group or phenyl(lower)alkyl group; R5 and R6 represent lower alkyl group; X, Y and Z represent that all of them are carbon atoms or one of them is nitrogen atom and the other two are carbon atoms; Q represents a single bond or alkylene group; or the pharmacologically acceptable salts thereof.
摘要翻译：本发明提供了可用作药物的新型膦酸二酯衍生物。膦酸二酯衍生物由以下通式表示：其中R1表示氨基，N-低级烷基氨基，N-低级链烯基氨基等; R2和R3表示氢原子，低级烷基，卤素原子，低级烷氧基等; R4表示氢原子，低级烷基或苯基（低级）烷基; R5和R6表示低级烷基; X，Y和Z表示全部为碳原子或其中一个为氮原子，另外两个是碳原子; Q表示单键或亚烷基;或其药理学上可接受的盐。

5. 发明授权

US5922866A Process for preparing quinazolin-4-one derivatives 失效
标题翻译：喹唑啉-4-酮衍生物的制备方法
公开(公告)号：US5922866A
公开(公告)日：1999-07-13
申请号：US11826
申请日：1998-02-25
申请人： Kazuyoshi Miyata , Yasuhisa Kurogi , Yasuhiro Sakai , Yoshihiko Tsuda
发明人： Kazuyoshi Miyata , Yasuhisa Kurogi , Yasuhiro Sakai , Yoshihiko Tsuda
IPC分类号： C07D239/90 , C07D239/91 , C07F9/6512 , C07F9/32 , C07F9/40 , C07D239/96
CPC分类号： C07D239/91 , C07D239/90 , C07F9/65122 , C07F9/65127 , C07F9/65128
摘要： The present invention provides a novel process for preparing a series of quinazolin-4-one derivatives in high yields with reduced amounts of byproducts, the process comprising reacting, in the presence of a base, a trialkylsilyl halide with a compound represented by the formula ##STR1## wherein; R.sup.5 is a phenyl group which may have 1 to 3 substituents each selected from a lower alkyl group, a lower alkoxy group or a halogen atom, a lower alkyl group, a phenyl-lower alkyl group which may have a halogen atom as a substituent on the phenyl ring, a lower alkenyl group, a lower alkoxy-lower alkyl group or a lower alkynyl group; R.sup.6 is a lower alkyl group, a halogen-substituted lower alkyl group, a lower alkoxycarbonyl group or a phenyl group which may have, as a substituent, a lower alkyl group or a group of the formula ##STR2## wherein A is an oxygen atom or a single bond, Z is a lower alkylene group, R.sup.7 is a lower alkyl group and R.sup.8 is a lower alkoxy group, a phenyl group or a phenyl-lower alkoxy group which may have a halogen atom on the phenyl ring;to produce the quinazolin-4-one derivatives which is valuable as pharmaceuticals or intermediates for synthesis thereof and represented by the formula ##STR3## wherein R.sup.1,R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as defined above.
摘要翻译： PCT No.PCT / JP96 / 02388 Sec。 371日期：1998年2月25日 102（e）1998年2月25日PCT PCT 1996年8月26日PCT公布。公开号WO97 / 08153 日期1997年3月6日本发明提供了一种制备一系列具有降低量副产物的喹唑啉-4-酮衍生物的新方法，该方法包括在碱存在下使三烷基甲硅烷基卤化物与化合物由下式表示： R5是可以具有1〜3个选自低级烷基，低级烷氧基或卤素原子的取代基的苯基，低级烷基，可具有卤素原子作为取代基的苯基 - 低级烷基苯环，低级烯基，低级烷氧基 - 低级烷基或低级炔基; R6是低级烷基，卤素取代的低级烷基，低级烷氧基羰基或苯基，其可以具有低级烷基或下式基团的取代基：其中A是氧原子或单键，Z为低级亚烷基，R7为低级烷基，R8为低级烷氧基，苯基或在苯环上可具有卤素原子的苯基 - 低级烷氧基; 以产生作为药物或其合成中间体而有价值的喹唑啉-4-酮衍生物，由下式表示，其中R 1，R 2，R 3，R 4，R 5和R 6如上所定义。

6. 发明授权

US08790929B2 Reagent for diluting blood sample and method for measuring mean corpuscular volume by using the same 有权
标题翻译：用于稀释血液样本的试剂和通过使用相同的方法测量平均红细胞体积
公开(公告)号：US08790929B2
公开(公告)日：2014-07-29
申请号：US12497952
申请日：2009-07-06
申请人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
发明人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
IPC分类号： G01N33/48
CPC分类号： G01N1/38 , G01N15/1209 , G01N2015/1236
摘要： The invention provides a reagent for diluting a blood sample, comprising water, polyoxyethylene alkyl ether having a hydroxyl value of 52 to 60, and an osmo-regulator for regulating the osmotic pressure of the reagent in the range of 150 to 400 mOsm/kg, as well as a method for measuring the mean corpuscular volume of a blood sample.
摘要翻译：本发明提供了一种用于稀释血液样品的试剂，包括水，羟值为52至60的聚氧乙烯烷基醚和用于调节试剂渗透压的渗透压调节剂，范围为150-400mOsm / kg，以及用于测量血液样品的平均红细胞体积的方法。

7. 发明授权

US08298622B2 Silica aerogel coating and its production method 有权
标题翻译：二氧化硅气凝胶涂料及其制备方法
公开(公告)号：US08298622B2
公开(公告)日：2012-10-30
申请号：US11407907
申请日：2006-04-21
申请人： Hiroyuki Nakayama , Kazuhiro Yamada , Yasuhiro Sakai , Maki Yamada
发明人： Hiroyuki Nakayama , Kazuhiro Yamada , Yasuhiro Sakai , Maki Yamada
IPC分类号： C08F2/48
CPC分类号： B01J19/123 , C01B33/1585
摘要： Methods for producing a silica aerogel coating by: producing a wet gel formed by the hydrolysis and polymerization of an alkoxysilane having an ultraviolet-polymerizable unsaturated group; organically modifying the wet gel with an organic-modifying agent to obtain an organically modified silica having a modification ratio of 10-30% based on a total amount of Si—OH in the wet gel; coating a dispersion of the organically modified silica on a substrate to form a layer; and subjecting the layer of the organically modified silica to ultraviolet irradiation and baking, wherein the silica aerogel coating includes the organically modified silica and wherein the silica aerogel coating has a refractive index in the range of 1.05-1.2.
摘要翻译：二氧化硅气凝胶涂层的制造方法：制造通过具有紫外线聚合性不饱和基团的烷氧基硅烷的水解和聚合而形成的湿凝胶; 用有机改性剂有机改性湿凝胶，得到基于湿凝胶中Si-OH总量的改性比为10-30％的有机改性二氧化硅; 将有机改性二氧化硅的分散体涂布在基材上以形成层; 并对有机改性二氧化硅层进行紫外线照射和烘烤，其中二氧化硅气凝胶涂层包括有机改性二氧化硅，其中二氧化硅气凝胶涂层的折射率在1.05-1.2范围内。

8. 发明申请

US20060239886A1 Silica aerogel coating and its production method 有权
标题翻译：二氧化硅气凝胶涂料及其制备方法
公开(公告)号：US20060239886A1
公开(公告)日：2006-10-26
申请号：US11407907
申请日：2006-04-21
申请人： Hiroyuki Nakayama , Kazuhiro Yamada , Yasuhiro Sakai , Maki Yamada
发明人： Hiroyuki Nakayama , Kazuhiro Yamada , Yasuhiro Sakai , Maki Yamada
IPC分类号： C01B33/12
CPC分类号： B01J19/123 , C01B33/1585
摘要： A method for producing a silica aerogel coating comprising the steps of organically modifying a wet gel formed by the hydrolysis and polymerization of an alkoxysilane having an ultraviolet-polymerizable unsaturated group, and subjecting a layer of the resultant organically modified silica to ultraviolet irradiation and baking.
摘要翻译：一种二氧化硅气凝胶涂层的制造方法，其特征在于，对通过具有紫外线聚合性不饱和基团的烷氧基硅烷的水解和聚合形成的湿凝胶进行有机改性，并对所得有机改性二氧化硅层进行紫外线照射和烘烤。

9. 发明授权

US5948473A Method and apparatus for preparing resin-impregnated structures reinforced by continuous fibers 失效
标题翻译：用于制备由连续纤维增强的树脂浸渍结构的方法和设备
公开(公告)号：US5948473A
公开(公告)日：1999-09-07
申请号：US77596
申请日：1998-05-29
申请人： Koichi Saito , Rikio Yonaiyama , Yasuhiro Sakai , Masanori Ishikawa
发明人： Koichi Saito , Rikio Yonaiyama , Yasuhiro Sakai , Masanori Ishikawa
IPC分类号： B29B15/12 , B05D1/18 , B05C3/172
CPC分类号： B29B15/125
摘要： The present invention relates to a method for producing a resin-impregnated structure reinforced by continuous fibers in which a practically endless continuous fiber bundle is dipped in a bath of molten resin and simultaneously passes through a space between a pair of opening pins. The opening pins can be positioned on sides of the bundle so that the continuous fibers are sandwiched by the pins without coming in contact with them. By doing so, the fibers of the bundle can be opened and can be impregnated with the resin. In addition, the foregoing continuous fiber-reinforced resin structure may be cut into pieces having a desired length to provide columnar products.
摘要翻译： PCT No.PCT / JP96 / 03449 Sec。 371日期：1998年5月29日 102（e）日期1998年5月29日PCT 1996年11月25日PCT公布。 WO97 / 19805 PCT公开号日期：1997年6月5日本发明涉及一种由连续纤维增强的树脂浸渍结构体的制造方法，其中将实际上环状的连续纤维束浸渍在熔融树脂浴中，同时通过一对开口针脚。打开销可以位于束的侧面，使得连续纤维被销钉夹持而不与它们接触。通过这样做，可以打开束的纤维并且可以用树脂浸渍。此外，上述连续纤维增强树脂结构可以切割成具有期望长度的片以提供柱状产品。

10. 发明授权

US5670257A Organic-inorganic composite particles and production process therefor 失效
标题翻译：有机 - 无机复合颗粒及其制备方法
公开(公告)号：US5670257A
公开(公告)日：1997-09-23
申请号：US568466
申请日：1995-12-07
申请人： Yasuhiro Sakai , Tadahiro Yoneda , Shigefumi Kuramoto
发明人： Yasuhiro Sakai , Tadahiro Yoneda , Shigefumi Kuramoto
IPC分类号： C08F30/08 , G02F1/1339 , B32B5/15
CPC分类号： G02F1/1339 , C08F30/08 , Y10T428/2982 , Y10T428/2993
摘要： Organic-inorganic composite particles which include a (meth)acrylic resin framework and a polysiloxane framework having in its molecule an organosilicon containing a silicon atom directly and chemically combined with at least one carbon atom of the (meth)acrylic resin framework, and also contain 25 wt % or more of SiO.sub.2 which constitutes the polysiloxane framework and have a mean particle diameter of .gtoreq.0.5 .mu.m. The particles have the mechanical resilience necessary to maintain a constant gap distance between a pair of members to be arranged with the correct gap distance between them, and the hardness and fracture strength necessary to maintain the gap constant with smaller numbers; and also do not readily cause physical damage to the members. The composite particles can be employed as spacers 8 for a liquid crystal display as they stand or with an adhesive layer formed on the surface. The composite particles can also have a conductive layer formed on the surface, and be employed as conductive particles.
摘要翻译：包括（甲基）丙烯酸树脂骨架和聚硅氧烷骨架的有机 - 无机复合颗粒，其分子中含有硅原子的有机硅与（甲基）丙烯酸树脂骨架的至少一个碳原子直接化学结合，并且还含有 25重量％以上的构成聚硅氧烷骨架的SiO 2，其平均粒径为≥0.5μm。颗粒具有必要的机械弹性，以保持一对构件之间的间隙距离与它们之间的正确的间隙距离保持恒定的间隙距离，以及保持间隙恒定的较小数量所需的硬度和断裂强度; 也不会对成员造成身体伤害。复合颗粒可以用作液晶显示器的间隔件8，或者在表面上形成粘合剂层。复合颗粒也可以具有在表面上形成的导电层，并且用作导电颗粒。

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