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1. 发明申请

US20090325868A1 Materials And Methods For FOXP3 Tumor Suppression 有权
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：US20090325868A1
公开(公告)日：2009-12-31
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K38/16 , A61K31/7052 , A61K31/4375 , A61K31/40 , A61K31/7064 , C12N5/00 , C12Q1/02 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

2. 发明授权

US08158596B2 Materials and methods for FOXP3 tumor suppression 有权
标题翻译： FOXP3肿瘤抑制的材料和方法
公开(公告)号：US08158596B2
公开(公告)日：2012-04-17
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

3. 发明授权

US09427413B2 Uses of hypoxia-inducible factor inhibitors 有权
标题翻译：缺氧诱导因子抑制剂的使用
公开(公告)号：US09427413B2
公开(公告)日：2016-08-30
申请号：US13513659
申请日：2010-06-25
申请人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
发明人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号： A01N43/00 , A61K31/33 , A61K31/00 , A61K31/395 , A61K31/498 , A61K31/565 , A61K45/06
CPC分类号： A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
摘要翻译：本发明涉及使用缺氧诱导因子（HIF抑制剂）治疗血液癌症。本发明还涉及使用HIF抑制剂诱导急性骨髓性白血病缓解。本发明还涉及使用HIF抑制剂抑制癌症干细胞（CSC）的维持或存活功能。

4. 发明申请

US20120264697A1 USES OF HYPOXIA-INDUCIBLE FACTOR INHIBITORS 有权
标题翻译： HYPOXIA诱导因子抑制剂的使用
公开(公告)号：US20120264697A1
公开(公告)日：2012-10-18
申请号：US13513659
申请日：2010-06-25
申请人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
发明人： Yang Liu , Yin Wang , Yan Liu , Sami N. Malek , Pan Zheng
IPC分类号： A61K38/12 , A61P35/00
CPC分类号： A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
摘要翻译：本发明涉及使用缺氧诱导因子（HIF抑制剂）治疗血液癌症。本发明还涉及使用HIF抑制剂诱导急性骨髓性白血病缓解。本发明还涉及使用HIF抑制剂抑制癌症干细胞（CSC）的维持或存活功能。

5. 发明授权

US09060322B2 Method and system for preventing loops in mesh networks 有权
标题翻译：用于防止网状网络环路的方法和系统
公开(公告)号：US09060322B2
公开(公告)日：2015-06-16
申请号：US13281072
申请日：2011-10-25
申请人： Xu Zou , Kangchang Huang , Yan Liu
发明人： Xu Zou , Kangchang Huang , Yan Liu
IPC分类号： H04L12/28 , H04W4/00 , H04W40/02 , H04L12/705 , H04L12/715 , H04L12/707
CPC分类号： H04W40/02 , H04L45/04 , H04L45/18 , H04L45/24
摘要： The present disclosure discloses a network device and/or method for preventing loops in routing paths of network frames in a wireless digital network. The disclosed network device at a network node receives a frame from a wired network. The frame includes a site identifier uniquely corresponding to the wired network, a source physical address, and a destination physical address. If the network node is selected as a representative portal node, the network device forwards the frame. Otherwise, if another network node is selected as the representative portal node, the network device drops the received frame to prevent forming a loop in a routing path corresponding to the frame. If not other network is selected as the representative portal node, the network device floods the frame to other network nodes in the wireless network.
摘要翻译：本公开公开了一种用于防止无线数字网络中的网络帧的路由路径中的环路的网络设备和/或方法。在网络节点处公开的网络设备从有线网络接收帧。帧包括与有线网络唯一对应的站点标识符，源物理地址和目的地物理地址。如果选择网络节点作为代表性门户节点，则网络设备转发该帧。否则，如果选择另一网络节点作为代表门户节点，则网络设备丢弃所接收的帧，以防止在对应于该帧的路由路径中形成环路。如果不选择其他网络作为代表门户网站节点，则网络设备会将该帧洪泛到无线网络中的其他网络节点。

6. 发明申请

US20150150843A1 CARDIOPROTECTIVE COMPOUNDS, THEIR USE WITH CHEMOTHERAPY, AND METHODS FOR IDENTIFYING THEM 审中-公开
标题翻译：保护性化合物，其与化疗有关的使用方法及其鉴定方法
公开(公告)号：US20150150843A1
公开(公告)日：2015-06-04
申请号：US14402512
申请日：2013-05-16
申请人： Randall T. Peterson , Yan Liu
发明人： Randall T. Peterson , Yan Liu
IPC分类号： A61K31/352 , A61K49/00
CPC分类号： A61K31/352 , A61K31/17 , A61K31/37 , A61K31/496 , A61K31/704 , A61K49/0008 , A61K2300/00
摘要： The invention provides a method of reducing anthracycline-induced cardiotoxicity by administering a toxicity-reducing compound, such as a compound of Formulas (I), (II) or (III) or a combination thereof, and/or diphenyl urea (DPU), dexrazoxane (DEX), to a patient receiving an anthracycline. The invention also provides a method of identifying toxicity-reducing compounds.
摘要翻译：本发明提供了通过施用毒性降低化合物，例如式（I），（II）或（III）的化合物或其组合和/或二苯基脲（DPU），降低蒽环类诱导的心脏毒性的方法，右美沙芬（DEX）给予接受蒽环类抗生素的患者。本发明还提供鉴定毒性降低化合物的方法。

7. 发明授权

US08895302B2 Directed differentiation of primate pluripotent stem cells into functional basal forebrain cholinergic neurons (BFCNs) and medium spiny gabaergic projection neurons 有权
标题翻译：灵长类多能干细胞定向分化为功能性基底前脑胆碱能神经元（BFCNs）和中度多刺的神经元投射神经元
公开(公告)号：US08895302B2
公开(公告)日：2014-11-25
申请号：US13207202
申请日：2011-08-10
申请人： Su-Chun Zhang , Yan Liu , Lixiang Ma
发明人： Su-Chun Zhang , Yan Liu , Lixiang Ma
IPC分类号： C12N5/02 , C12N5/0793 , G01N33/50
CPC分类号： C12N5/0619 , C12N2501/01 , C12N2501/105 , C12N2501/115 , C12N2501/13 , C12N2501/15 , C12N2501/155 , C12N2501/392 , C12N2501/41 , C12N2502/086 , C12N2506/02 , C12N2506/45 , C12N2533/52 , G01N33/5058 , G01N2500/10
摘要： Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
摘要翻译：公开了将灵长类多能干细胞有效转化为GABA神经元或胆碱能神经元的方法及其应用。

8. 发明授权

US08879233B2 Electrostatic chuck with polymer protrusions 有权
标题翻译：具有聚合物突起的静电卡盘
公开(公告)号：US08879233B2
公开(公告)日：2014-11-04
申请号：US13266657
申请日：2010-05-13
申请人： Richard A. Cooke , Nate Richard , Steven Donnell , Mark Vose , Yan Liu
发明人： Richard A. Cooke , Nate Richard , Steven Donnell , Mark Vose , Yan Liu
IPC分类号： H01T23/00 , H01L21/683 , H01L21/687
CPC分类号： H01L21/6831 , H01L21/6875
摘要： In accordance with an embodiment of the invention, there is provided an electrostatic chuck. The electrostatic chuck comprises a surface layer activated by a voltage in an electrode to form an electric charge to electrostatically clamp a substrate to the electrostatic chuck. The surface layer includes a plurality of polymer protrusions and a charge control layer to which the plurality of polymer protrusions adhere, the plurality of polymer protrusions extending to a height above portions of the charge control layer surrounding the plurality of polymer protrusions to support the substrate upon the plurality of polymer protrusions during electrostatic clamping of the substrate.
摘要翻译：根据本发明的实施例，提供了一种静电卡盘。静电卡盘包括由电极中的电压激活的表面层，以形成电荷以将基板静电夹持到静电卡盘。表面层包括多个聚合物突起和电荷控制层，多个聚合物突起粘附在该电荷控制层上，多个聚合物突起延伸到围绕多个聚合物突起的电荷控制层的部分上方的高度，以将基底支撑在在基板的静电夹持期间的多个聚合物突起。

9. 发明申请

US20140252316A1 QUANTUM DOTS, RODS, WIRES, SHEETS, AND RIBBONS, AND USES THEREOF 有权
标题翻译：量子，线，线，片和RIBBONS及其用途
公开(公告)号：US20140252316A1
公开(公告)日：2014-09-11
申请号：US14238775
申请日：2012-10-03
申请人： Hao Yan , Zhengtao Deng , Yan Liu
发明人： Hao Yan , Zhengtao Deng , Yan Liu
IPC分类号： H01L29/06 , H01L29/775 , H01L29/66
CPC分类号： C09K11/883 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B19/002 , C01B19/007 , C01G9/08 , C01G19/00 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/04 , C01P2004/16 , C01P2004/17 , C01P2004/64 , C01P2004/86 , C01P2004/88 , C09K11/02 , C09K11/08 , C09K11/0811 , C09K11/54 , C09K11/565 , C09K11/574 , C09K11/661 , G01N33/588 , H01B1/02 , H01L29/0669 , H01L29/122 , H01L29/127 , H01L29/22 , H01L29/66977 , H01L29/775 , Y10T428/12431 , Y10T428/294
摘要： Described are ZnxCd1-xSySe1-y/ZnSzSe1-z core/shell nanocrystals, CdTe/CdS/ZnS core/shell/shell nanocrystals, optionally ally doped Zn(S,Se,Te) nano- and quantum wires, and SnS quantum sheets or ribbons, methods for making the same, and their use in biomedical and photonic applications, such as sensors for analytes in cells and preparation of field effect transistors.
摘要翻译：描述了ZnxCd1-xSySe1-y / ZnSzSe1-z核/壳纳米晶体，CdTe / CdS / ZnS核/壳/壳纳米晶体，任选地掺杂Zn（S，Se，Te）纳米和量子线，以及SnS量子片或丝带，制造方法，以及它们在生物医学和光子应用中的应用，如细胞中分析物的传感器和场效应晶体管的制备。

10. 发明授权

US08738361B2 Systems and methods for extracting patterns from graph and unstructered data 有权
标题翻译：从图形和非结构化数据中提取模式的系统和方法
公开(公告)号：US08738361B2
公开(公告)日：2014-05-27
申请号：US12496252
申请日：2009-07-01
申请人： Wojciech Gryc , Richard Lawrence , Yan Liu
发明人： Wojciech Gryc , Richard Lawrence , Yan Liu
IPC分类号： G06F17/27
CPC分类号： G06F17/27 , G06F17/2745
摘要： A computing system receives input data having both graph and unstructured data and computes a current log likelihood of the input data. The computing system compares the current log likelihood with a previous log likelihood of the input data. If the current log likelihood is larger than the previous log likelihood, the computing system update topic modeling parameters, community modeling parameters, and the link generation parameter until the computing system obtains a maximal value of the log likelihood of the input data. Then, the computing system creates a graph indicating topic similarity between the input data based on the topic modeling parameters, creates another graph indicating community similarity between entities associated with the input data based on the community modeling parameters, and predicts a link existence between input data or entities based on the link generation parameter, the topic modeling parameter and the community modeling parameter.
摘要翻译：计算系统接收具有图形和非结构化数据的输入数据，并计算输入数据的当前对数似然性。计算系统将当前对数似然率与输入数据的先前对数似然比较。如果当前对数似然度大于先前的对数似然度，则计算系统更新主题建模参数，社区建模参数和链路生成参数，直到计算系统获得输入数据的对数似然性的最大值。然后，计算系统基于主题建模参数创建指示输入数据之间的主题相似性的图形，基于社区建模参数创建指示与输入数据相关联的实体之间的社区相似性的另一图形，并且预测输入数据之间的链接存在或基于链接生成参数，主题建模参数和社区建模参数的实体。

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