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1. 发明授权

US08158596B2 Materials and methods for FOXP3 tumor suppression 有权
标题翻译： FOXP3肿瘤抑制的材料和方法
公开(公告)号：US08158596B2
公开(公告)日：2012-04-17
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

2. 发明申请

US20090325868A1 Materials And Methods For FOXP3 Tumor Suppression 有权
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：US20090325868A1
公开(公告)日：2009-12-31
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K38/16 , A61K31/7052 , A61K31/4375 , A61K31/40 , A61K31/7064 , C12N5/00 , C12Q1/02 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

3. 发明授权

US07087202B2 Particulate reinforced aluminum composites, their components and the near net shape forming process of the components 有权
标题翻译：颗粒增强铝复合材料，其组分和组分的近净形状成型过程
公开(公告)号：US07087202B2
公开(公告)日：2006-08-08
申请号：US10628528
申请日：2003-07-28
申请人： Deming Liu , Chou Kee Peter Liu , Jian Zhong Fan , Jun Xu , Tao Zuo , Zhao Zu Gao
发明人： Deming Liu , Chou Kee Peter Liu , Jian Zhong Fan , Jun Xu , Tao Zuo , Zhao Zu Gao
IPC分类号： B22F3/12
CPC分类号： C22F1/047 , B22D17/007 , B22F2009/041 , B22F2998/10 , C22C2001/1073 , C22F1/04 , Y10T428/256 , B22F9/04 , B22F3/04 , C22C1/1036
摘要： This invention concerns particulate reinforced Al-based composites, and the near net shape forming process of their components. The average size of the reinforced particle in the invented composites is 0.1–3.5 μm and the volume percentage is 10–40%, and a good interfacial bonding between the reinforced particulate and the matrix is formed with the reinforced particles uniformly distributed. The production method of its billet is to have the reinforced particles and Al-base alloy powder receive variable-speed high-energy ball-milling in the balling drum. Then, with addition of a liquid surfactant, the ball-mill proceeds to carry on ball-milling. After the ball-milling, the produced composite powder undergoes cold isostatic pressing and the subsequent vacuum sintering or vacuum hot-pressing to be shaped into a hot compressed billet, which in turn undergoes semisolid thixotropic forming and may be shaped into complex-shaped components. These components can be used in various fields. This product is featured with excellent property, good machinability, stable quality, component near net shape forming and cost effective and higher performance.
摘要翻译：本发明涉及颗粒增强的基于Al的复合材料及其组分的近净形状形成过程。本发明复合材料中增强颗粒的平均尺寸为0.1-3.5μm，体积百分比为10-40％，增强颗粒与基质之间形成良好的界面结合，增强颗粒均匀分布。钢坯的生产方法是将球磨机中的增强颗粒和Al基合金粉末接受可变速高能球磨。然后，加入液体表面活性剂，使球磨机进行球磨。在球磨后，所生产的复合粉末进行冷等静压，随后进行真空烧结或真空热压成型为热压缩坯料，其又进行半固体触变形成并且可以成形为复杂形状的组分。这些组件可用于各种领域。本产品具有优良的性能，良好的机械加工性，质量稳定性，近净成型成分，成本效益高，性能更高。

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