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1. 发明授权

US08158596B2 Materials and methods for FOXP3 tumor suppression 有权
标题翻译： FOXP3肿瘤抑制的材料和方法
公开(公告)号：US08158596B2
公开(公告)日：2012-04-17
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

2. 发明申请

US20090325868A1 Materials And Methods For FOXP3 Tumor Suppression 有权
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：US20090325868A1
公开(公告)日：2009-12-31
申请号：US12119158
申请日：2008-05-12
申请人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
发明人： Yang Liu , Pan Zheng , Xing Chang , Lizhong Wang , Runhua Liu , Yin Wang , Yan Liu , Tao Zuo
IPC分类号： A61K38/16 , A61K31/7052 , A61K31/4375 , A61K31/40 , A61K31/7064 , C12N5/00 , C12Q1/02 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与FOXP3蛋白，编码FOXP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中FOXP3蛋白或FOXP3基因的表达或结构与正常或先前样品的表达或结构进行比较。筛选测试化合物用于抗癌活性的方法，其中还提供了向细胞施用测试化合物并测量FOXP3蛋白或FOXP3基因表达。

3. 发明授权

US06889612B1 Long-distance blast banger 失效
标题翻译：长距离爆炸
公开(公告)号：US06889612B1
公开(公告)日：2005-05-10
申请号：US10745674
申请日：2003-12-29
申请人： Joey Liaw , Kuei-Fu Fan , Shi-Xing Chang , Shu-Fang Chen
发明人： Joey Liaw , Kuei-Fu Fan , Shi-Xing Chang , Shu-Fang Chen
IPC分类号： A01M29/20 , F41A21/18 , F42B4/02 , F42B4/04 , F42B4/16 , F42B5/02 , F42B5/26 , F42B8/02 , F42B8/14 , F42B10/26 , F42B10/38 , F42B14/02
CPC分类号： F42B4/16 , F41A21/18 , F42B4/02 , F42B4/04 , F42B5/02 , F42B5/26 , F42B8/02 , F42B8/14 , F42B10/26 , F42B10/38 , F42B12/20
摘要： A long-distance blast banger including a cartridge loaded with a blast banger made up from plastic material. The blast banger encompasses a sound explosives cup and a delay cup. The sound explosives cup is loaded with a sound explosives agent having components including perchloryl potassium, magnesium powder and aluminum powder. A sufficient sound value is acquired through appropriate compacting of the sound explosives cup, and therefrom realizes uniform shattering of the cup into small fragments that are insufficient to cause injury. Furthermore, at least two helical grooves extending from a bottom to a top of the cartridge are defined on an inner wall thereof, and ear attachments are configured on a base of an outer wall of the blast banger so as to correspond with the helical grooves, thereby engendering a spinning stability effect during flight time of the blast banger, reducing wind resistance, and thus increasing flight range.
摘要翻译：一种长距离的爆炸风扇，包括装有由塑料材料制成的喷丸的筒。爆炸声包括一个声音爆炸物杯和延迟杯。声音爆炸物杯上装有一种具有高氯化钾，镁粉和铝粉等成分的声爆炸剂。通过声音炸药杯的适当压实获得足够的声音值，从而使杯子均匀地破碎成不足以造成伤害的小碎片。此外，从盒的底部延伸到顶部的至少两个螺旋槽被限定在其内壁上，并且耳部附件被构造在鼓风机的外壁的基部上以与螺旋槽对应，从而在爆炸期间产生纺丝稳定性，降低风阻，从而提高飞行范围。

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