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1. 发明授权

US06797713B2 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06797713B2
公开(公告)日：2004-09-28
申请号：US10242346
申请日：2002-09-12
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，鼻窦炎，结膜炎，食物过敏症，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

2. 发明授权

US06894059B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06894059B1
公开(公告)日：2005-05-17
申请号：US09937667
申请日：2000-03-23
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： C07D295/084 , C07D295/088 , C07D295/092 , C07D295/096 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52 , A61K31/44 , A61K31/445
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，窦炎，结膜炎，食物过敏，鲭鱼中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性损伤性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

3. 发明授权

US06686502B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
公开(公告)号：US06686502B1
公开(公告)日：2004-02-03
申请号：US10386226
申请日：2003-03-11
申请人： Xiong Cai , Timothy Lewis
发明人： Xiong Cai , Timothy Lewis
IPC分类号： C07C25904
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

4. 发明授权

US06451801B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06451801B1
公开(公告)日：2002-09-17
申请号：US09534947
申请日：2000-03-24
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症包括优选的哮喘，季节性和常年性变态反应性鼻炎，窦炎，结膜炎，食物过敏，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

5. 发明申请

US20050114578A1 Secure software SMI dispatching using caller address 审中-公开
标题翻译：使用来电者地址安全软件SMI调度
公开(公告)号：US20050114578A1
公开(公告)日：2005-05-26
申请号：US11025194
申请日：2004-12-28
申请人： Timothy Lewis
发明人： Timothy Lewis
IPC分类号： G06F9/46 , G06F1/00 , G06F9/48 , G06F21/00 , G06F13/24
CPC分类号： G06F21/577 , G06F2221/2105
摘要： A system and method securely transfer control to a system management mode (SMM) in response to an SMI by referencing the address of a calling instruction that generated the SMI with a dispatch table only visible in SMM. The entries in the dispatch table provide links between the calling instruction and its target function. To create the dispatch table, a macro can be inserted in the source code of a software product being built that designates a target function. During compilation, the inserted macro is located, and an entry is created linking the calling instruction and the target function. The calling instruction in the final software product provides no indication of the address of the target function.
摘要翻译：系统和方法通过使用仅在SMM中可见的调度表来引用生成SMI的调用指令的地址来将控制安全地传送到响应于SMI的系统管理模式（SMM）。调度表中的条目提供了调用指令与其目标函数之间的链接。要创建调度表，可以在正在构建的指定目标函数的软件产品的源代码中插入一个宏。在编译期间，插入的宏被定位，并创建一个链接调用指令和目标函数的条目。最终软件产品中的调用指令不提供目标功能地址的指示。

6. 发明申请

US20050240749A1 Secure storage of data in a network 审中-公开
标题翻译：安全地存储网络中的数据
公开(公告)号：US20050240749A1
公开(公告)日：2005-10-27
申请号：US11095507
申请日：2005-04-01
申请人： Gary Clemo , Russell Haines , Timothy Lewis
发明人： Gary Clemo , Russell Haines , Timothy Lewis
IPC分类号： G06F3/06 , G06F12/00 , G06F12/14 , G06F17/30 , G06F21/62 , H04L29/06
CPC分类号： G06F3/0638 , G06F3/062 , G06F3/067 , G06F16/10 , G06F21/6218 , G06F2221/2129 , G06F2221/2149
摘要： A method of storing an item of data is described, performed in a general purpose computer in a network, and comprises identifying available storage means in the network, gathering information concerning the availability of data storage capacity in the identified available storage means, fragmenting the item of data in accordance with a fragmentation policy and distributing resultant fragments of data, in accordance with a distribution policy, among the identified available storage means. A computer apparatus is also described, operable in a network for managing and effecting storage of an item of data in a remote storage location in said network, and comprises storage space identification means for identifying network accessible storage means in the network, storage availability information gathering means for gathering information concerning the availability of data storage capacity in the available storage means, fragmentation means for fragmenting the item of data in accordance with a fragmentation policy and distribution means for distributing resultant fragments of data, in accordance with a distribution policy, among the identified available storage means.
摘要翻译：描述了存储数据项的方法，在网络中的通用计算机中执行，并且包括识别网络中的可用存储装置，收集关于所识别的可用存储装置中的数据存储容量的可用性的信息，将该项目分段的数据，并且根据分发策略在所识别的可用存储装置之间分发数据的结果片段。还描述了一种计算机设备，可在网络中操作以管理和实现在所述网络中的远程存储位置中的数据项的存储，并且包括用于识别网络中的网络可访问存储装置的存储空间识别装置，存储可用性信息收集用于收集关于可用存储装置中的数据存储容量的可用性的信息的装置，用于根据分段策略和分发装置分割数据项的分段装置，用于根据分发策略分发所产生的数据片段识别可用存储装置。

7. 发明授权

US6145068A Data transfer to a non-volatile storage medium 失效
公开(公告)号：US6145068A
公开(公告)日：2000-11-07
申请号：US931330
申请日：1997-09-16
申请人： Timothy Lewis
发明人： Timothy Lewis
IPC分类号： G06F1/30 , G06F1/00 , G06F3/06 , G06F9/445 , G06F9/46 , G06F9/48 , G06F11/14 , G06F12/16 , H03M7/00 , G06F12/00 , H03M7/30
CPC分类号： G06F9/4418
摘要： To improve the speed of transition to the zero-volt suspend state, system context is saved from volatile random access memory to non-volatile memory, such as a hard disk, using a compression algorithm which speeds the transfer of data to non-volatile memory by recognizing data pages having bytes of a single value. The system context in extended memory of RAM consists of a number of system context memory blocks, and between these memory blocks are memory holes containing information which does not require storage. Initially, the entirety of data in a buffer region of RAM is stored directly to disk. Then, successive pages from each system context memory block are transferred to the buffer, where the page size corresponds to the memory management unit page size. When testing locates a region of heterogeneous entries, then a heterogeneous-data flag, the length of the heterogeneous region, and the heterogeneous data region are transferred to the buffer. When testing determines that a page contains bytes of a single value, then a compression flag representing that value is substituted for that page. When a memory hole is reached, a memory hole flag and the size of the memory hole are transferred to the buffer. On each transfer of a byte of data to the buffer it is determined whether the buffer is full, and when it is full then a write-to-disk is performed. To transition from the zero-volt suspend state back to an operational state, bytes are transferred from the hard disk to the buffer whenever all the bytes currently in the buffer have been transferred to extended memory. When testing of the buffer entries locates a heterogeneous-data flag, the value immediately following the flag is determined, and a data region having a length of that value is transferred to extended memory. When a compression flag is found, a 4 kilobyte page of the corresponding byte value is transferred to extended memory. When a memory hole flag is found, a memory hole with a length of the value immediately following the memory hole flag is created in extended memory.

8. 发明申请

US20070296364A1 Nonlinear motor control techniques 有权
标题翻译：非线性电动机控制技术
公开(公告)号：US20070296364A1
公开(公告)日：2007-12-27
申请号：US11702426
申请日：2007-02-05
申请人： Jeffrey Shoemaker , Timothy Lewis
发明人： Jeffrey Shoemaker , Timothy Lewis
IPC分类号： G05B13/02
CPC分类号： G05B13/042 , Y02T10/82
摘要： The present invention provides a torque loop control method for servomotors utilizing discontinuous pulse width modulation that incorporates measuring the power factor in real time. Also included is a sine wave generator for software-based spectrum analysis.
摘要翻译：本发明提供一种利用不连续脉宽调制的伺服电动机的扭矩环路控制方法，该方法结合实时测量功率因数。还包括用于基于软件的频谱分析的正弦波发生器。

9. 发明申请

US20060146731A1 Distributed network discovery 审中-公开
标题翻译：分布式网络发现
公开(公告)号：US20060146731A1
公开(公告)日：2006-07-06
申请号：US11261514
申请日：2005-10-31
申请人： Timothy Lewis , Gary Clemo
发明人： Timothy Lewis , Gary Clemo
IPC分类号： H04L12/28
CPC分类号： H04W48/16 , H04L67/04 , H04L67/16 , H04L67/18 , Y02D70/1222 , Y02D70/1242 , Y02D70/142 , Y02D70/144 , Y02D70/22
摘要： The invention provides a method of sharing the searching burden for discovering available services in a wireless network. Terminals within the network carry out searches of part of the available spectrum and communicate information between each other to establish a database of collective information.
摘要翻译：本发明提供了一种共享用于发现无线网络中的可用服务的搜索负担的方法。网络内的终端对部分可用频谱进行搜索，并相互通信，建立集体信息数据库。

10. 发明授权

US4636247A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4636247A
公开(公告)日：1987-01-13
申请号：US578033
申请日：1984-02-08
申请人： John M. Clough , Timothy Lewis , Michael B. Gravestock
发明人： John M. Clough , Timothy Lewis , Michael B. Gravestock
IPC分类号： A01N43/50 , A01N43/653 , C07C29/40 , C07C31/36 , C07C45/29 , C07C45/61 , C07C47/24 , C07C49/235 , C07C49/255 , C07C49/84 , C07D233/60 , C07D249/08 , C07D303/20 , C07D303/32 , C07D307/20 , C07D317/14 , C07D317/16 , C07D317/20 , C07D319/06 , C07D405/06 , C07D407/06 , C07D521/00 , A01N43/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07C29/40 , C07C31/36 , C07C45/292 , C07C45/61 , C07C47/24 , C07C49/235 , C07C49/255 , C07C49/84 , C07D233/56 , C07D249/08 , C07D303/32 , C07D307/20 , C07D317/14 , C07D317/16 , C07D317/20 , C07D319/06 , C07D407/06
摘要： Triazoles and imidazoles of the formula (I): ##STR1## and stereoisomers thereof, wherein W is CH or N; Q is optionally substituted aryl (especially optionally substituted phenyl), optionally substituted aralkyl, or alkyl; R.sup.1 is H, alkyl, cycloalkyl, alkenyl, alkynyl, acyl, optionally substituted aralkyl, optionally substituted phenyl, or is an alkyl or aralkyl group substituted with an ether, hydroxyl, carboxylic ester, or ketone group; R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are H, alkyl, cycloalkyl, optionally substituted aralkyl, or optionally substituted phenyl; and acid salts and metal complexes thereof. These compounds are useful as plant growth regulators and fungicides. Other values for R.sup.1 include C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkoxyalkyl and phenyl or benzyl substituted by benzyl.
摘要翻译：式（I）的三唑和咪唑：其中W是CH或N;其中W是CH或N; Q是任选取代的芳基（特别是任选取代的苯基），任选取代的芳烷基或烷基; R 1是H，烷基，环烷基，烯基，炔基，酰基，任选取代的芳烷基，任选取代的苯基，或是被醚，羟基，羧酸酯或酮基取代的烷基或芳烷基; R 2，R 3，R 4，R 5和R 6可以相同或不同，为H，烷基，环烷基，任选取代的芳烷基或任选取代的苯基; 及其酸盐及其金属络合物。这些化合物可用作植物生长调节剂和杀真菌剂。 R1的其它值包括C1-C4烷氧基羰基，C1-C4烷氧基烷基和被苄基取代的苯基或苄基。

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