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1. 发明授权

US06894059B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06894059B1
公开(公告)日：2005-05-17
申请号：US09937667
申请日：2000-03-23
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： C07D295/084 , C07D295/088 , C07D295/092 , C07D295/096 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52 , A61K31/44 , A61K31/445
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，窦炎，结膜炎，食物过敏，鲭鱼中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性损伤性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

2. 发明授权

US06797713B2 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06797713B2
公开(公告)日：2004-09-28
申请号：US10242346
申请日：2002-09-12
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，鼻窦炎，结膜炎，食物过敏症，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

3. 发明授权

US06451801B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06451801B1
公开(公告)日：2002-09-17
申请号：US09534947
申请日：2000-03-24
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症包括优选的哮喘，季节性和常年性变态反应性鼻炎，窦炎，结膜炎，食物过敏，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

4. 发明授权

US06524851B1 Hybrid nucleic acid molecules and vectors including &bgr;-globin regulatory elements 失效
标题翻译：杂交核酸分子和载体包括β-珠蛋白调节元件
公开(公告)号：US06524851B1
公开(公告)日：2003-02-25
申请号：US09411449
申请日：1999-10-01
申请人： James Ellis
发明人： James Ellis
IPC分类号： C12N1500
CPC分类号： C07K14/805 , A61K48/00 , C07K2319/00
摘要： The invention relates to hybrid nucleic acid molecules for gene therapy in cells of the erythroid lineage, and in particular &agr;-, &bgr;-, &dgr;-, &egr;, &ggr;-, or &zgr;-globin nucleotide sequences operably linked to &bgr;-globin regulatory elements. The hybrid nucleic acid molecules, at single copy, are capable of producing a polypeptide. The hybrid nucleic acid molecules are useful for treatment of hemoglobinopathies such as sickle cell anemia or &bgr;-thalassemia. The hybrid nucleic acid molecules are useful at single copy for erythroid expression at single copy of RNA and polypeptides in transgenic animals.
摘要翻译：本发明涉及用于在红细胞谱系的细胞中进行基因治疗的杂交核酸分子，特别是与β珠蛋白调节元件可操作地连接的α，β，δ-，εi，γ或zeta珠蛋白核苷酸序列。单拷贝的杂交核酸分子能够产生多肽。杂交核酸分子可用于治疗血红蛋白病，例如镰状细胞性贫血或β-地中海贫血。杂交核酸分子在单拷贝中可用于转基因动物中单核苷酸和多肽的单拷贝。

5. 发明申请

US20110053166A1 STEM CELL EXPRESSION CASSETTES 审中-公开
标题翻译：干细胞表达盒
公开(公告)号：US20110053166A1
公开(公告)日：2011-03-03
申请号：US12920059
申请日：2009-02-27
申请人： James Ellis , Akitsu Hotta
发明人： James Ellis , Akitsu Hotta
IPC分类号： C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C12N15/85 , C12N15/06 , C12Q1/04
CPC分类号： C12N15/85 , C12N2740/13043 , C12N2740/15043 , C12N2830/008 , C12N2830/30 , C12N2830/60
摘要： A stem cell expression cassette, comprising a nucleic acid comprising a pluripotent stem cell specific promoter, and a tag sequence, wherein the pluripotent stem cell specific promoter and tag sequences are operatively linked, is provided. Also provided are methods of identifying and methods of selecting a pluripotent cell, using the stem cell expression cassette.
摘要翻译：提供了包含多能干细胞特异性启动子的核酸和其中多能干细胞特异性启动子和标签序列可操作地连接的标签序列的干细胞表达盒。还提供了使用干细胞表达盒鉴定和选择多能细胞的方法的方法。

6. 发明申请

US20090107153A1 PRESSURE RELIEF OFFSHORE SYSTEM 审中-公开
标题翻译：压力救济海洋系统
公开(公告)号：US20090107153A1
公开(公告)日：2009-04-30
申请号：US12260570
申请日：2008-10-29
申请人： James Ellis , Patronella Van Emde Boas , Hein Wille
发明人： James Ellis , Patronella Van Emde Boas , Hein Wille
IPC分类号： F16L55/045 , F17C6/00 , F17C13/00 , F16L55/05 , F17C13/04
CPC分类号： B63B27/24 , Y10T137/2605
摘要： An offshore hydrocarbon transfer system (10) wherein a conduit (24) connects a floating structure (12) to a second structure (22) to carry hydrocarbons between them, and one of the structures has a shutoff valve (30) that produces a pressure surge in the conduit if the shut-off valve closes too fast. The invention provides a surge protection apparatus (40) with an overflow container (50) that receives hydrocarbons in the event of a pressure surge. The overflow container lies adjacent to the conduit and is connected to the conduit by a pressure relief valve (60). In one apparatus (40), the overflow container lies coaxial with a relief conduit section (42), and includes an elastic outer wall (44) that surrounds the conduit section. In another apparatus, the overflow container (72) lies completely outside the conduit section (42), and can be removed after it has filled with hydrocarbons.
摘要翻译：一种近海烃转移系统（10），其中导管（24）将浮动结构（12）连接到第二结构（22）以在它们之间承载烃，并且所述结构之一具有产生压力的截止阀（30）如果关闭阀关闭得太快，则导管中的电涌。本发明提供具有溢流容器（50）的浪涌保护装置（40），该溢流容器在压力波动的情况下接收碳氢化合物。溢流容器位于导管附近，并通过一个泄压阀（60）与导管连接。在一个装置（40）中，溢流容器与释放导管部分（42）同轴，并且包括围绕导管部分的弹性外壁（44）。在另一装置中，溢流容器（72）完全位于导管部分（42）的外部，并且可以在填充有碳氢化合物之后被移除。

7. 发明申请

US20050241659A1 Wrapping materials for smoking articles 审中-公开
公开(公告)号：US20050241659A1
公开(公告)日：2005-11-03
申请号：US11176720
申请日：2005-07-07
申请人： Charles Ashcraft , James Ellis , James Hutchens , Gregory Pierce , John Tomel , Don White , Sara Williard , Pau Chapman , Mark Powell
发明人： Charles Ashcraft , James Ellis , James Hutchens , Gregory Pierce , John Tomel , Don White , Sara Williard , Pau Chapman , Mark Powell
IPC分类号： A24D1/02
CPC分类号： A24D1/025
摘要： Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer.

8. 发明授权

US08668646B2 Integrated sensor for medical applications 有权
标题翻译：集成传感器用于医疗应用
公开(公告)号：US08668646B2
公开(公告)日：2014-03-11
申请号：US12825770
申请日：2010-06-29
申请人： Marc Stein , James Ellis
发明人： Marc Stein , James Ellis
IPC分类号： A61B8/00
CPC分类号： A61B5/6878 , A61B5/4509 , A61B5/4528 , A61B5/6846 , A61B5/7239 , A61B8/15 , Y10T307/615
摘要： A sensing assemblage (1) for capturing a transit time, phase, or frequency of energy waves propagating through a medium is disclosed to measure a parameter of the muscular-skeletal system. The sensing assemblage (1) comprises a transducer (2) and a waveguide (3). The transducer (2) is coupled to the waveguide (3) at a first location. A second transducer (11) can be coupled to the waveguide (3) at a second location. An interface material that is transmissive to acoustic energy waves can be placed between transducers (402, 404) and a waveguide (414) to improve transfer. The interface material (408, 410) can affix the transducers (402, 404) to the waveguide (414). Alternatively, a reflecting feature (5) can be placed at a second location of the waveguide (3) to reflect acoustic waves back to the transducer (2) where transducer (2) emits energy waves into the medium and detects propagated energy waves.
摘要翻译：公开了用于捕获通过介质传播的能量波的传播时间，相位或频率的感测组件（1），以测量肌肉 - 骨骼系统的参数。感测组件（1）包括换能器（2）和波导（3）。换能器（2）在第一位置处耦合到波导（3）。第二传感器（11）可以在第二位置处耦合到波导（3）。对声能波透射的界面材料可以放置在换能器（402,404）和波导（414）之间，以改善转移。界面材料（408,410）可以将换能器（402,404）固定到波导（414）上。或者，反射特征（5）可以放置在波导（3）的第二位置处，以将声波反射回到换能器（2），其中换能器（2）将能量波发射到介质中并检测传播的能量波。

9. 发明申请

US20100331738A1 INTEGRATED SENSOR AND INTERCONNECT FOR MEASURING A PARAMETER OF THE MUSCULAR-SKELETAL SYSTEM 审中-公开
标题翻译：集成传感器和互连用于测量肌肉系统的参数
公开(公告)号：US20100331738A1
公开(公告)日：2010-12-30
申请号：US12825883
申请日：2010-06-29
申请人： Marc Stein , James Ellis
发明人： Marc Stein , James Ellis
IPC分类号： A61B5/103 , H05K1/14
CPC分类号： A61B5/4528 , A61B5/103 , A61B5/4509 , A61B5/6846 , A61B2562/0219 , H05K1/147 , H05K1/148
摘要： A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. Used intra-operatively, the sensing insert device (100) comprises an insert dock (202) and a sensing module (200). The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The sensing module (200) comprises one or more sensing assemblages (1802), electronic circuitry (307), and communication circuitry (320). An interconnect stack within the sensing module (1700) couples at least one circuit board (1612 and 1616) to one or more sensing assemblages (1802). The interconnect stack includes at least one flexible interconnect (1506) that couples to the circuit board (1612 and 1616). The flexible interconnect (1506) can be in a path for conducting an energy wave through the sensing assemblage (1802).
摘要翻译：公开了一种用于测量肌肉 - 骨骼系统的参数的感测插入装置（100）。感测插入装置（100）可以是暂时的或永久的。在操作中使用的感测插入装置（100）包括插入坞（202）和感测模块（200）。感测模块（200）是独立的封装测量装置，其具有耦合到肌肉 - 骨骼系统的至少一个接触表面。感测模块（200）包括一个或多个感测组件（1802），电子电路（307）和通信电路（320）。感测模块（1700）内的互连堆叠将至少一个电路板（1612和1616）耦合到一个或多个感测组件（1802）。互连堆叠包括耦合到电路板（1612和1616）的至少一个柔性互连（1506）。柔性互连（1506）可以在用于通过感测组件（1802）传导能量波的路径中。

10. 发明申请

US20100331737A1 ENCAPSULATED FORCE SENSOR FOR MEASURING A PARAMETER OF THE MUSCULAR-SKELETAL SYSTEM 审中-公开
标题翻译：用于测量肌肉系统参数的密封力传感器
公开(公告)号：US20100331737A1
公开(公告)日：2010-12-30
申请号：US12825736
申请日：2010-06-29
申请人： Marc Stein , James Ellis
发明人： Marc Stein , James Ellis
IPC分类号： A61B5/103
CPC分类号： A61B5/6878 , A61B5/4509 , A61B5/4528 , A61B5/6846 , A61B5/7239 , A61B8/15 , Y10T307/615
摘要： A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. Used intra-operatively, the sensing insert device (100) comprises an insert dock (202) and a sensing module (200). The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The insert dock (202) is a passive component made for different prosthetic component manufacturers as well as for different size prosthetic components. The sensing module (200) fits in an opening or cavity of the insert dock (202). The intra-operative insert device is substantially equal in dimension to an implanted final insert. The sensing insert device (100) is also a permanent prosthetic component. The sensing module (200) residing within the sensing insert device and coupling to a bearing surface of the insert.
摘要翻译：公开了一种用于测量肌肉 - 骨骼系统的参数的感测插入装置（100）。感测插入装置（100）可以是暂时的或永久的。在操作中使用的感测插入装置（100）包括插入坞（202）和感测模块（200）。感测模块（200）是独立的封装测量装置，其具有耦合到肌肉 - 骨骼系统的至少一个接触表面。插入坞（202）是为不同的假肢部件制造商以及用于不同尺寸的假体部件制成的被动部件。感测模块（200）装配在插入坞（202）的开口或空腔中。术中插入装置在尺寸上基本上等于植入的最终插入物。感测插入装置（100）也是永久性假体部件。感测模块（200）位于感测插入装置内并且联接到插入件的支承表面。

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