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1. 发明申请

US20140260563A1 EPOXY CHEMISTRY DERIVED MATERIALS AS REVERSED-PHASE AND HYDROPHOBIC INTERACTION CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE 有权
标题翻译：环氧化学衍生的材料作为反相和疏水相互作用色谱介质，其合成和使用方法
公开(公告)号：US20140260563A1
公开(公告)日：2014-09-18
申请号：US13841484
申请日：2013-03-15
申请人： Xiaodong LIU , Liang CAO , Christopher A. POHL
发明人： Xiaodong LIU , Liang CAO , Christopher A. POHL
IPC分类号： B01J20/22 , B01D15/20 , G01N30/02 , B01J20/287
CPC分类号： B01J20/22 , B01D15/20 , B01J20/286 , B01J20/287 , B01J20/3257 , B01J20/3259 , G01N30/02
摘要： This invention provides aqueous-compatible, polar-embedded reversed-phase stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.
摘要翻译：本发明提供含水相容的极性嵌入式反相固相组合物，包含固定相的装置和体系以及使用环氧化物开环反应制备这些组合物的方法。还提供了在分离中使用本发明的固定相的方法。

2. 发明申请

US20140273264A1 EPOXY CHEMISTRY DERIVED MATERIALS AS MIXED MODE CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE 有权
标题翻译：环氧化学衍生的材料作为混合模式色谱介质，其合成和使用方法
公开(公告)号：US20140273264A1
公开(公告)日：2014-09-18
申请号：US13842391
申请日：2013-03-15
申请人： Xiaodong LIU , Liang CAO , Christopher A. POHL
发明人： Xiaodong LIU , Liang CAO , Christopher A. POHL
IPC分类号： B01J20/281
CPC分类号： G01N30/482 , B01J20/289 , B01J20/3257 , B01J20/3259 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J2220/54
摘要： This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.
摘要翻译：本发明提供了混合模式固定相组合物，包含固定相的装置和系统以及使用环氧化物开环反应制备这些组合物的方法。还提供了在分离中使用本发明的固定相的方法。

3. 发明申请

US20140178912A1 SEPARATION OF GLYCANS BY MIXED-MODE LIQUID CHROMATOGRAPHY 有权
标题翻译：通过混合模式液相色谱法分离甘油
公开(公告)号：US20140178912A1
公开(公告)日：2014-06-26
申请号：US13724178
申请日：2012-12-21
申请人： Xiaodong LIU , Udayanath AICH , Christopher A. POHL
发明人： Xiaodong LIU , Udayanath AICH , Christopher A. POHL
IPC分类号： C08B37/00 , B01J43/00 , B01J41/20
CPC分类号： C08B37/0063 , B01D15/3847 , B01J20/286 , B01J20/3285 , B01J41/20 , B01J43/00 , B01J2220/54 , C07K1/165 , G01N30/482 , B01D15/363 , B01D15/305 , B01D15/325 , B01D15/362
摘要： An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.
摘要翻译：本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中聚糖分离和聚糖混合物分析的方式相互作用。将介质并入用于色谱分析的装置和系统中。还提供了使用本发明的多峰介质来分析聚糖的方法。

4. 发明申请

US20140370614A1 HILIC / ANION-EXCHANGE / CATION-EXCHANGE MULTIMODAL MEDIA 有权
公开(公告)号：US20140370614A1
公开(公告)日：2014-12-18
申请号：US13918481
申请日：2013-06-14
申请人： Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
发明人： Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
IPC分类号： B01J20/281
CPC分类号： G01N30/482 , B01D15/305 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J43/00
摘要： The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.
摘要翻译：本发明提供了聚集的多峰色谱介质。本发明的介质包括在阴离子交换，阳离子交换和亲水相互作用层析方式中有活性的基团。本发明提供了制备这些介质并将其用于分析物分离的方法。还提供了并入介质的分离装置和并入这些分离装置的系统。

5. 发明申请

US20140179008A1 BUFFER KIT AND METHOD OF GENERATING A LINEAR pH GRADIENT 有权
标题翻译：缓冲袋和产生线性pH梯度的方法
公开(公告)号：US20140179008A1
公开(公告)日：2014-06-26
申请号：US13724873
申请日：2012-12-21
申请人： Shanhua LIN , Christopher A. POHL
发明人： Shanhua LIN , Christopher A. POHL
IPC分类号： C09K15/30
CPC分类号： C09K15/30 , B01D15/168 , B01D15/362 , G01N30/34 , Y10T436/10 , Y10T436/108331 , Y10T436/173845 , Y10T436/18
摘要： A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.
摘要翻译：缓冲试剂盒包括第一洗脱液和第二洗脱液。第一洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是一价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。第二洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是单价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。第一洗脱溶液具有第一pH，第二洗脱液具有第二pH，其中第一pH和第二pH是不同的值。缓冲试剂盒提供线性pH梯度，其从至少第一pH至第二pH形成近似的直线。

6. 发明申请

US20140069870A1 GLYCIDOL FUNCTIONALIZED ANION EXCHANGE STATIONARY PHASES 有权
标题翻译：甘氨酸官能化阴离子交换剂固定相
公开(公告)号：US20140069870A1
公开(公告)日：2014-03-13
申请号：US13610495
申请日：2012-09-11
申请人： Christopher A. POHL
发明人： Christopher A. POHL
IPC分类号： B01J41/20 , B01D15/36
CPC分类号： B01J41/20 , B01D15/363 , B01J20/288 , B01J20/3251 , B01J20/3289 , B01J41/09
摘要： Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.
摘要翻译：含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。此外，首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式，然后以交替的顺序用缩水甘油处理，以可预测的方式逐渐改变选择性，从而容易地操纵选择性。通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。使用所有其他已知的系统，碳酸盐在硫酸盐之前洗脱，有时会损害硫酸盐的定量能力。通过缩水甘油处理，碳酸盐可以在硫酸盐之后移动，消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。

7. 发明申请

US20130316466A1 SAMPLE PRETREATMENT AND EXTRACTION 有权
公开(公告)号：US20130316466A1
公开(公告)日：2013-11-28
申请号：US13958810
申请日：2013-08-05
申请人： Kannan SRINIVASAN , Bruce RICHTER , Christopher A. POHL , Brett MURPHY , Brian DORICH , SM Rahmat ULLAH
发明人： Kannan SRINIVASAN , Bruce RICHTER , Christopher A. POHL , Brett MURPHY , Brian DORICH , SM Rahmat ULLAH
IPC分类号： G01N1/34
CPC分类号： G01N1/34 , B01D11/0492 , B01J20/043 , B01J20/10 , B01J20/14 , B01J20/26 , B01J20/3236 , B01J2220/46 , B01J2220/66 , G01N1/4022 , G01N1/4044 , G01N1/405 , G01N30/7206 , G01N30/96 , G01N2001/4061 , Y10T436/10 , Y10T436/255
摘要： A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

8. 发明申请

US20140069176A1 MULTI-COMPONENT ELUENT GENERATING SYSTEM AND METHOD 有权
标题翻译：多分量线性发生系统及方法
公开(公告)号：US20140069176A1
公开(公告)日：2014-03-13
申请号：US13611631
申请日：2012-09-12
申请人： Yan LIU , Petr JANDIK , Christopher A. POHL
发明人： Yan LIU , Petr JANDIK , Christopher A. POHL
IPC分类号： B01D15/08 , G01N30/04 , F17D1/00 , C25B9/18 , G01N30/00
CPC分类号： C25B9/18 , B01D15/166 , B01D15/361 , B01D61/44 , C25B1/02 , C25B1/14 , C25B3/00 , C25B13/00 , G01N30/16 , G01N30/34 , G01N30/96 , G01N2030/965 , Y02E60/34 , Y10T137/0318
摘要： A system and method to generate a concentration gradient eluent flow are described. The concentration gradient eluent flow can include at least two different generants. A liquid can be pumped to an eluent generating device. A first controlling signal can be applied to a first eluent generator to generate a first generant. A second controlling signal can be applied to a second eluent generator to generate a second generant. Either the first and/or the second controlling signal can be varied as a function of time to generate the concentration gradient eluent flow.
摘要翻译：描述了产生浓度梯度洗脱流的系统和方法。浓度梯度洗脱液流可以包括至少两种不同的生成剂。液体可以泵送到洗脱液生成装置。第一控制信号可以应用于第一洗脱液发生器以产生第一发生器。第二控制信号可以应用于第二淋洗液发生器以产生第二发生器。第一和/或第二控制信号可以作为时间的函数而变化以产生浓度梯度洗脱液流。

9. 发明申请

US20130309777A1 SURROGATE ADDITION DEVICE AND A METHOD OF ANALYTE CONCENTRATION 有权
标题翻译：目前的添加装置和分析浓度的方法
公开(公告)号：US20130309777A1
公开(公告)日：2013-11-21
申请号：US13473318
申请日：2012-05-16
申请人： Rosanne Williamson SLINGSBY , Jing HONG , Douglas M. JAMIESON , Christopher A. POHL
发明人： Rosanne Williamson SLINGSBY , Jing HONG , Douglas M. JAMIESON , Christopher A. POHL
IPC分类号： G01N1/40 , G01N21/17 , G01N30/02 , G01N21/64 , G01N27/62
CPC分类号： G01N1/40 , G01N1/405 , G01N30/00 , G01N33/1893 , Y10T436/24 , Y10T436/255
摘要： A surrogate addition device is described that adds a surrogate compound at a uniform transport rate to a flowing sample stream. The surrogate addition device includes a surrogate reservoir, a flow chamber, and a diffusion barrier. The surrogate reservoir can be configured to contain a surrogate solution where the surrogate solution includes a surrogate compound. The flow chamber includes an inlet port and an outlet port. At least a portion of the diffusion barrier is disposed in between the surrogate reservoir and the flow chamber. The diffusion barrier may include an inner surface that forms a wall of the surrogate reservoir, and an outer surface that forms a wall of the flow chamber. The flow chamber can be configured to receive a flowing sample solution across the outer surface of the diffusion barrier and also to diffuse the surrogate compound from the surrogate reservoir to the flow chamber.
摘要翻译：描述了替代添加装置，其以均匀的输送速率向流动的样品流添加替代化合物。替代添加装置包括代理储存器，流动室和扩散屏障。替代储存器可配置为含有替代溶液，其中替代溶液包含替代化合物。流动室包括入口和出口。扩散阻挡层的至少一部分设置在代理储存器和流动室之间。扩散阻挡层可以包括形成代理储存器的壁的内表面和形成流动室的壁的外表面。流动室可以被配置为在扩散阻挡层的外表面上接收流动的样品溶液，并且还将替代化合物从代理储存器扩散到流动室。

10. 发明申请

US20100224012A1 FLUID SAMPLE DELIVERY SYSTEM AND METHOD 有权
标题翻译：流体样品递送系统和方法
公开(公告)号：US20100224012A1
公开(公告)日：2010-09-09
申请号：US12399786
申请日：2009-03-06
申请人： Walter D. MODIC , Michael McADAMS , Lawrence T. McNARY , Trung K. HUYNH , Christopher A. POHL , Frank HOEFLER
发明人： Walter D. MODIC , Michael McADAMS , Lawrence T. McNARY , Trung K. HUYNH , Christopher A. POHL , Frank HOEFLER
IPC分类号： G01N1/20 , B01D29/00 , B01L3/00 , B01D37/00
CPC分类号： G01N35/025 , B01L3/502 , B01L3/5021 , B01L2300/0681 , B01L2400/0478 , G01N30/14 , G01N30/24 , G01N35/1016 , G01N2035/0441
摘要： A fluid delivery system including a filter for filtering solid particles from a liquid sample, the filter including a first filter member configured to filter solid media from a liquid sample, a second filter member fluidly connected to the first filter member, and a third filter member fluidly connected to a downstream end of the second filter member. The second filter member is configured to filter relatively smaller solid media from the liquid sample than the first filter member, and the third filter member is configured to filter relatively larger solid media from the liquid sample than the second filter member. In various aspects, the system includes a displacement-type plunger needle to draw sample fluid from a vial, a cantilevered carousel for rotatably supporting an array of sample holding vials, and a support for supporting the carousel. Method of using the fluid delivery system are also disclosed.
摘要翻译：一种流体输送系统，包括用于从液体样品过滤固体颗粒的过滤器，所述过滤器包括构造成从液体样品过滤固体介质的第一过滤构件，与第一过滤构件流体连接的第二过滤构件和第三过滤构件流体连接到第二过滤构件的下游端。第二过滤构件被配置为从液体样品中过滤相对较小的固体介质而不是第一过滤构件，并且第三过滤构件被配置为从液体样品中过滤比第二过滤构件更大的固体介质。在各个方面，该系统包括用于从小瓶中抽出样品流体的位移型柱塞针，用于可旋转地支撑样品保持小瓶阵列的悬臂式转盘和用于支撑转盘的支撑件。还公开了使用流体输送系统的方法。

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