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1. 发明申请

US20140213647A1 COMPOUND USEFUL FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME AND COMPOSITION INCLUDING SAME 审中-公开
标题翻译：用于预防或治疗有用的牙刷综合征的组合物和包括其的组合物
公开(公告)号：US20140213647A1
公开(公告)日：2014-07-31
申请号：US14118347
申请日：2012-05-16
申请人： Won suk Sun , Hyo Jin Jeon , Dongsun Min , Woongsik Kim , Taeksu Kim , Do-Seung Kum , Keun-Ho Ryu , Hae-In Rhee , Yang Hae Park , Hyun-Joo Son , Eun-ju Park , Bong-yong Lee , Hojin Namgung , Minseok Park , Minseok Kang
发明人： Won suk Sun , Hyo Jin Jeon , Dongsun Min , Woongsik Kim , Taeksu Kim , Do-Seung Kum , Keun-Ho Ryu , Hae-In Rhee , Yang Hae Park , Hyun-Joo Son , Eun-ju Park , Bong-yong Lee , Hojin Namgung , Minseok Park , Minseok Kang
IPC分类号： C07C69/145
CPC分类号： C07C69/145 , A61K31/047 , A61K31/08 , A61K31/085 , A61K31/22
摘要： The present invention provides a compound of formula (I) or a prodrug thereof useful for treating or preventing irritable bowel syndrome, and a composition comprising the compound as an active ingredient. Also, the present invention provides a method for treating or preventing irritable bowel syndrome, which comprises administrating a therapeutically or prophylactically effective amount of the compound or the composition to a subject in need of treating or preventing irritable bowel syndrome.
摘要翻译：本发明提供了可用于治疗或预防肠易激综合征的式（I）化合物或其前药，以及包含该化合物作为活性成分的组合物。此外，本发明提供了治疗或预防肠易激综合征的方法，其包括向需要治疗或预防肠易激综合征的受试者施用治疗或预防有效量的化合物或组合物。

2. 发明申请

US20120128807A1 COMPOSITION FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：用于预防或治疗可疑玻璃体综合征的组合物
公开(公告)号：US20120128807A1
公开(公告)日：2012-05-24
申请号：US13321776
申请日：2010-05-20
申请人： Won Suck Sun , Taek-Su Kim , Woong Sik Kim , Do-Seung Kum , Keun-Ho Ryu , Hae-In Rhee , Hyo Jin Jeon , Dong Sun Min , Yang Hae Park , Hyun-Joo Son , Eun-Ju Park , Bong-Yong Lee , Hojin Namgung , Minseok Park , Euichaul Oh
发明人： Won Suck Sun , Taek-Su Kim , Woong Sik Kim , Do-Seung Kum , Keun-Ho Ryu , Hae-In Rhee , Hyo Jin Jeon , Dong Sun Min , Yang Hae Park , Hyun-Joo Son , Eun-Ju Park , Bong-Yong Lee , Hojin Namgung , Minseok Park , Euichaul Oh
IPC分类号： A61K36/284 , A61P1/00
CPC分类号： A61K36/284 , A23L33/105 , A23V2002/00 , A23V2200/3204 , A23V2250/21
摘要： The present invention relates to a composition or a method for treating or preventing irritable bowel syndrome. The present invention uses Atractylodes japonica rhizome extract, preferably the ethanol water solution extract of Atractylodes japonica rhizome, more preferably the 35-65 v/v % ethanol water solution extract of Atractylodes japonica rhizome for treating or preventing irritable bowel syndrome. Atractylodes japonica rhizome extract shows a surprising effect in suppressing visceral hypersensitivity or improving defecation abnormality caused by stress or bowel irritability.
摘要翻译：本发明涉及治疗或预防肠易激综合征的组合物或方法。本发明使用白术根茎提取物，优选白术的乙醇水溶液提取物，更优选用于治疗或预防肠易激综合征的白术的35-65v / v％乙醇水溶液提取物。白术提取物在抑制内脏超敏反应或改善由应激或肠易激惹引起的排便异常方面表现出惊人的效果。

3. 发明申请

US20080284470A1 Direct Digital Synthesizer and Nuclear Magnetic Resonance Instrument Using the Same 失效
标题翻译：直接数字合成器和使用它的核磁共振仪器
公开(公告)号：US20080284470A1
公开(公告)日：2008-11-20
申请号：US12120385
申请日：2008-05-14
申请人： Minseok Park , Michiya Okada , Shuya Hagiwara , Hideki Tanaka
发明人： Minseok Park , Michiya Okada , Shuya Hagiwara , Hideki Tanaka
IPC分类号： H03B21/00 , G01V3/14
CPC分类号： G01R33/3607
摘要： A DDS (direct digital synthesizer) remarkably increased in the number of frequencies which can be output while maintaining the phase coherency, and an NMR instrument using such a DDS are provided. A DDS including phase accumulators and a phase-to-amplitude modulator is provided with a plurality of phase accumulators operating with fixed phase implements which are equal to powers of 2, a controller for outputting each bit of a frequency tuning word as control data, a plurality of switches for outputting an output of an associated one of the phase accumulators when an associated one of the control data supplied from the controller is 1 and outputting 0 when the associated one of the control data is 0, and an adder for adding up outputs of the switches.
摘要翻译： DDS（直接数字合成器）在保持相位一致性的同时可以输出的频率数量显着增加，并且提供使用这种DDS的NMR仪器。包括相位累加器和相位到幅度调制器的DDS设置有多个相位累加器，其以等于2的功率的固定相位工具操作;控制器，用于输出频率调谐字的每个位作为控制数据; 多个开关，用于当从所述控制器提供的所述控制数据中的相关一个之一输出相关联的一个所述相位累加器的输出，并且当所述控制数据中的相关一个为0时输出0;以及加法器，的开关。

4. 发明申请

US20060006868A1 Superconductor probe coil for NMR apparatus 失效
标题翻译：核磁共振仪用超导体探针线圈
公开(公告)号：US20060006868A1
公开(公告)日：2006-01-12
申请号：US11227291
申请日：2005-09-16
申请人： Hiroshi Morita , Michiya Okada , Tsuyoshi Wakuda , Tomomi Kikuta , Minseok Park
发明人： Hiroshi Morita , Michiya Okada , Tsuyoshi Wakuda , Tomomi Kikuta , Minseok Park
IPC分类号： G01V3/00
CPC分类号： G01R33/34076 , G01R33/34007 , G01R33/34023 , G01R33/34046 , G01R33/34053 , G01R33/34069 , G01R33/34092 , H01F6/06 , H01F41/048
摘要： An NMR apparatus which includes an NMR probe coil of a superconductor made of magnesium 2-boride formed on the surface of a substrate made of a flexible organic polymer material.
摘要翻译：一种NMR装置，其包括由柔性有机聚合物材料制成的基板的表面上形成的由2-硼化镁制成的超导体的NMR探针线圈。

5. 发明申请

US20050206383A1 Nuclear magnetic resonance spectrometer and method for operation thereof 失效
标题翻译：核磁共振光谱仪及其操作方法
公开(公告)号：US20050206383A1
公开(公告)日：2005-09-22
申请号：US11059372
申请日：2005-02-17
申请人： Minseok Park , Hiroshi Morita , Hideta Habara
发明人： Minseok Park , Hiroshi Morita , Hideta Habara
IPC分类号： G01R33/30 , G01R33/34 , G01V3/00
CPC分类号： G01R33/30
摘要： There is providesd a nuclear magnetic resonance spectrometer having a high sensitiveness by simultaneously realizing a high uniformity of a static magnetic field and a high measuring sensitiveness. A sample tube used in the nuclear magnetic resonance spectrometer is constructed in a structure in which the shape of a sample placed in a measuring space can be changed. The change in shape of the sample can be achieved by controlling the pressure applied to the sample. There is at least one surface of contact between the sample placed in the measuring space and a gas existing around the sample, and the shape of such surface is maintained by the surface tension of the sample. In this case, a central portion of a magnet, into which the sample tube is inserted, filled with a sterilizing gas having a pressure higher than the atmospheric pressure, and the sample having a surface of contact with the gas is maintained in a sterile state. A measuring coil used in the nuclear magnetic resonance spectrometer is disposed on a rotatable curved surface symmetrical with respect to a rotational axis provided by a longitudinal center axis of the sample tube.
摘要翻译：通过同时实现静磁场的高均匀性和高测量灵敏度，提供了具有高灵敏度的核磁共振光谱仪。在核磁共振光谱仪中使用的样品管被构造成可以改变放置在测量空间中的样品的形状的结构。可以通过控制施加到样品上的压力来实现样品的形状变化。在放置在测量空间中的样品和存在于样品周围的气体之间存在至少一个接触表面，并且通过样品的表面张力保持这种表面的形状。在这种情况下，将样品管插入其中的磁体的中心部填充有压力高于大气压的灭菌气体，并且与气体接触的表面的样品保持在无菌状态。在核磁共振光谱仪中使用的测量线圈设置在相对于由样品管的纵向中心轴线提供的旋转轴线对称的可旋转曲面上。

6. 发明授权

US08400747B2 Superconducting coil, superconducting magnet, and method of operating superconducting magnet 有权
标题翻译：超导线圈，超导磁体和超导磁体的操作方法
公开(公告)号：US08400747B2
公开(公告)日：2013-03-19
申请号：US13181578
申请日：2011-07-13
申请人： Yota Ichiki , Tsuyoshi Wakuda , Minseok Park
发明人： Yota Ichiki , Tsuyoshi Wakuda , Minseok Park
IPC分类号： H02H7/00
CPC分类号： H01F6/02
摘要： In a superconducting coil, a parallel conductor includes a plurality of superconducting wires bundled and wound in a coil. The superconducting wires have at least two connections therebetween. A current source connected to the superconducting wires to form a loop via the superconducting wires and the connection to supply a current in the loop when a quench is detected. A superconducting magnet includes the superconducting coil, a persistent current switch connected to the superconducting coil, and a quench detector configured to detect quench occurring in the superconducting coil.
摘要翻译：在超导线圈中，并联导体包括多个缠绕在线圈中的超导线。超导线在其间具有至少两个连接。连接到超导线的电流源通过超导线和连接来形成环路，以在检测到淬火时提供回路中的电流。超导磁体包括超导线圈，连接到超导线圈的持续电流开关和配置成检测在超导线圈中发生的淬火的淬火检测器。

7. 发明授权

US07292035B2 NMR.ESR antennas and spectrometers using these 失效
公开(公告)号：US07292035B2
公开(公告)日：2007-11-06
申请号：US11483777
申请日：2006-07-11
申请人： Hideta Habara , Minseok Park
发明人： Hideta Habara , Minseok Park
IPC分类号： G01V3/00
CPC分类号： G01R33/34053 , G01R33/62
摘要： An NMR/ESR antenna is inserted into a magnet device for generating a static magnetic field, and irradiates a sample with an electromagnetic wave to detect a signal generated from the sample. The NMR/ESR antenna comprises a sample tube, an NMR solenoid coil, an ESR microwave cavity, and a microwave guide. The solenoid coil has a central axis coaxial with a central axis of the ESR microwave cavity, and orthogonal to a direction of a main magnetic field generated by the magnetic device.

8. 发明授权

US07132830B2 Radiofrequency wave transmission circuit using arbitrary waveform generator and NMR apparatus using the same 有权
标题翻译：射频波发射电路采用任意波形发生器和NMR装置使用
公开(公告)号：US07132830B2
公开(公告)日：2006-11-07
申请号：US11058356
申请日：2005-02-16
申请人： Hideta Habara , Minseok Park
发明人： Hideta Habara , Minseok Park
IPC分类号： G01V3/00
CPC分类号： G01R33/3607
摘要： An NMR apparatus has a circuit adapted to improve the degree freedom of design and generate an excitation radiofrequency wave pulse suited for a sample to be measured. The radiofrequency wave transmission circuit includes a local oscillator, an IQ modulator having two mixers and two arbitrary waveform generators connected to the IQ modulator. Fourier inverse transform is applied to data inputted to the arbitrary waveform generators.
摘要翻译： NMR装置具有适于提高设计自由度的电路，并产生适用于待测样品的激发射频波脉冲。射频波发送电路包括本机振荡器，具有两个混频器的IQ调制器和连接到IQ调制器的两个任意波形发生器。傅里叶反变换被应用于输入到任意波形发生器的数据。

9. 发明申请

US20060017441A1 Stabilizer for stabilizing NMR magnetic field and method of the same 有权
标题翻译：用于稳定核磁共振磁场的稳定剂及其方法
公开(公告)号：US20060017441A1
公开(公告)日：2006-01-26
申请号：US11187856
申请日：2005-07-25
申请人： Minseok Park , Hideta Habara
发明人： Minseok Park , Hideta Habara
IPC分类号： G01V3/00
CPC分类号： G01R33/389
摘要： An NMR apparatus provided with a lock device having improved monotonicity without reducing a control range. In a lock device including a lock transmitter, a lock receiver, a lock detector, a lock corrector, a lock power supply and a lock coil, the lock detector performs complex detection of a detection signal and outputs to the lock corrector an absorption signal SA which is a real number component of the detection signal and a dispersion signal SD which is an imaginary number component of the detection signal; the lock corrector obtains a value SC by multiplying together SD/(SD2+SA2) and a value G, and the lock power supply performs adjustment so that a current flowing through the lock coil is proportional to SC. Different constants G are selectively used according to the value of SD/(SD2+SA2).
摘要翻译：一种具有锁定装置的NMR装置，其具有改善的单调性，而不减少控制范围。在包括锁定发送器，锁定接收器，锁定检测器，锁定校正器，锁定电源和锁定线圈的锁定装置中，锁定检测器执行检测信号的复杂检测，并向锁定校正器输出吸收信号SA 其是检测信号的实数分量和作为检测信号的虚数分量的色散信号SD; 锁定校正器通过将SD /（SD ^{2 + SA ^{2>）和值G相乘来获得值SC，并且锁定电源执行调整，使得电流流动通过锁定线圈与SC成正比。根据SD /（SD ^{2 + SA ^{2）的值选择使用不同的常数G。}}}}

10. 发明申请

US20050099182A1 Nuclear magnetic resonance apparatus having a controllable detector 失效
标题翻译：具有可控检测器的核磁共振装置
公开(公告)号：US20050099182A1
公开(公告)日：2005-05-12
申请号：US10919327
申请日：2004-08-17
申请人： Minseok Park , Michiya Okada , Hiroshi Morita
发明人： Minseok Park , Michiya Okada , Hiroshi Morita
IPC分类号： G01R33/32 , G01R33/36 , G01V3/00
CPC分类号： G01R33/3621
摘要： In an NMR apparatus having an analog-to-digital converter for converting the voltage signal V(t) to a digital signal, a reference signal generator for generating reference waves which are digital signals, and a quadrature detector for performing a quadrature detection operation, a detection controller for changing a frequency of or of the reference waves or a time interval of A which is a time interval between data points of digitized NMR signals and also a time interval between data points of the reference waves during detection is installed and furthermore, a storage device for preserving the voltage signal V(t) converted to a digital amount at least until the quadrature detector or the reference signal generator changes the frequency or of the reference waves or the time interval A is installed between the analog-digital converter and the quadrature detector.
摘要翻译：在具有用于将电压信号V（t）转换为数字信号的模拟 - 数字转换器的NMR装置中，用于产生作为数字信号的参考波的参考信号发生器和用于执行正交检测操作的正交检测器，用于改变参考波的频率的检测控制器或作为数字化NMR信号的数据点之间的时间间隔的A的时间间隔以及检测期间参考波的数据点之间的时间间隔的安装，至少直到正交检测器或参考信号发生器改变频率或参考波，或者将时间间隔A安装在模拟数字转换器和正交检测器。

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