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1. 发明申请

US20100172989A1 ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION 审中-公开
标题翻译：具有降低酒精相互作用的抗菌熔体挤压配方
公开(公告)号：US20100172989A1
公开(公告)日：2010-07-08
申请号：US12631010
申请日：2009-12-04
申请人： Wolfgang Roth , Alexander Burst , Martina Zietsch , Wei Liu , Sandeep Dutta
发明人： Wolfgang Roth , Alexander Burst , Martina Zietsch , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/14 , A61K31/485 , A61P25/04
CPC分类号： A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/209 , A61K9/2095 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/485
摘要： The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本发明涉及用于口服给药的组合物。本发明优选包含至少一种用于递送具有在醇中倾倒剂量的药物的药物递送组合物，制备这些剂型的相关方法和治疗有需要的患者的方法包括将本发明组合物施用于患者。最优选地，剂型包括维拉帕米。这些制剂减少了滥用的可能性。在另一种制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

2. 发明申请

US20100278839A1 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY 有权
标题翻译：抗生素稳定性增强的神经生长因子（NGF）抗体
公开(公告)号：US20100278839A1
公开(公告)日：2010-11-04
申请号：US12773488
申请日：2010-05-04
申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
发明人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
IPC分类号： A61K39/395 , C07K16/18 , C12N15/63 , C12N5/10 , A61P25/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/50 , C07K2317/53 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要翻译：本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

3. 发明申请

US20090022798A1 FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
标题翻译：非对称性和限制性阿片类药物的制剂
公开(公告)号：US20090022798A1
公开(公告)日：2009-01-22
申请号：US11780625
申请日：2007-07-20
申请人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
发明人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/24 , A61K31/485 , A61K47/30 , A61P25/04 , A61K9/20
CPC分类号： A61K9/28 , A61K9/0053 , A61K9/209 , A61K31/167 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。这些制剂减少了滥用的可能性。在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

4. 发明授权

US08435523B2 Antibodies against nerve growth factor (NGF) with enhanced in vivo stability 有权
标题翻译：具有增强的体内稳定性的抗神经生长因子（NGF）的抗体
公开(公告)号：US08435523B2
公开(公告)日：2013-05-07
申请号：US12773488
申请日：2010-05-04
申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
发明人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/50 , C07K2317/53 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要翻译：本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

5. 发明申请

US20110229526A1 FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
标题翻译：非对称性和限制性阿片类药物的制剂
公开(公告)号：US20110229526A1
公开(公告)日：2011-09-22
申请号：US12984373
申请日：2011-01-04
申请人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
发明人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/00 , A61K31/485 , A61P29/00 , A61P25/04
CPC分类号： A61K9/28 , A61K9/0053 , A61K9/209 , A61K31/167 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。这些制剂减少了滥用的可能性。在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

6. 发明授权

US11866156B1 Apparatus for vortex generation to improve aerodynamics 有权
公开(公告)号：US11866156B1
公开(公告)日：2024-01-09
申请号：US17531766
申请日：2021-11-21
申请人： Wei Liu
发明人： Wei Liu
IPC分类号： B64C23/06 , B64C21/10
CPC分类号： B64C23/065 , B64C21/10
摘要： This invention is an apparatus for vortex generation by combining the function of means for vortex generation with the functions of the leading-edge aerodynamic surface, the airfoil, and/or the trailing-edge aerodynamic surface.

7. 发明授权

US11686448B1 Apparatus of projector headlights 有权
公开(公告)号：US11686448B1
公开(公告)日：2023-06-27
申请号：US17699103
申请日：2022-03-19
申请人： Wei Liu
发明人： Wei Liu
IPC分类号： B60Q1/00 , F21S41/683 , F21S41/32 , F21S41/43 , F21S41/25 , F21W102/135
CPC分类号： F21S41/683 , F21S41/25 , F21S41/32 , F21S41/43 , F21W2102/135
摘要： This invention is a projector headlight that, while offering dual beam patterns, boasts a 100% utilization of the light emitted from a light source by one of the following methods: (1) employing a reflective cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern, (2) using reversible cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern with no moving part involved, (3) utilizing a selective light-filter cutoff means to selectively reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern without making use of any moving part, (4) using a low-beam light-emitting subassembly and a high-beam light-emitting subassembly that are separated by partition means to achieve dual beam patterns with no moving part, or (5) adopting a low-beam light-emitting subassembly in low-beam pattern and a high-beam light-emitting subassembly in high-beam pattern without any moving part.

8. 外观设计

USD952959S1 Intelligent pet fountain 有权
公开(公告)号：USD952959S1
公开(公告)日：2022-05-24
申请号：US29778103
申请日：2021-04-10
申请人： Wei Liu
设计人： Wei Liu

9. 发明授权

US09588205B2 Simultaneous and dynamic determination of longitudinal and transversal relaxation times of a nuclear spin system 有权
标题翻译：同时和动态地确定核自旋系统的纵向和横向弛豫时间
公开(公告)号：US09588205B2
公开(公告)日：2017-03-07
申请号：US13582800
申请日：2011-03-10
申请人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
发明人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
IPC分类号： G01R33/50 , G01R33/56 , G01R33/561
CPC分类号： G01R33/50 , G01R33/5601 , G01R33/5613 , G01R33/5616
摘要： The invention relates to a magnetic resonance imaging method for simultaneous and dynamic determination of a longitudinal relaxation time T1 and a transversal relaxation time T2 of the nuclear spin system of an object, in the context of DCE or DSE MRI. In this respect, the invention makes use of a steady-state gradient echo pulse sequence comprising an EPI readout module.
摘要翻译：本发明涉及一种用于在DCE或DSE MRI的背景下同时和动态地确定物体的核自旋系统的纵向弛豫时间T1和横向弛豫时间T2的磁共振成像方法。在这方面，本发明利用包括EPI读出模块的稳态梯度回波脉冲序列。

10. 发明授权

US09349561B2 Impregnated yttric or gadolinium-containing Barium-aluminum-scandate cathodes and their fabrication methods 有权
标题翻译：浸渍钇或钆钡铝钪阴极及其制造方法
公开(公告)号：US09349561B2
公开(公告)日：2016-05-24
申请号：US13340701
申请日：2011-12-30
申请人： Jinshu Wang , Wei Liu , Fan Yang , Xiang Liu , Hongyi Li , Meiling Zhou , Tieyong Zuo
发明人： Jinshu Wang , Wei Liu , Fan Yang , Xiang Liu , Hongyi Li , Meiling Zhou , Tieyong Zuo
IPC分类号： H01J1/14 , H01J1/142 , H01J1/13 , H01J1/144 , H01J9/04 , H01J23/05
CPC分类号： H01J1/142 , H01J1/13 , H01J1/14 , H01J1/144 , H01J9/047 , H01J23/05
摘要： Impregnated rare earth metal-containing barium-aluminum-scandate cathodes with a rare earth oxide doped tungsten matrix and methods for the fabrication thereof are described. In one aspect, an impregnated rare earth metal-containing barium-aluminum-scandate cathode comprises: a rare earth oxide doped tungsten matrix, and an impregnated active substance. The active substance comprises scandium oxide (Sc2O3), a second rare earth oxide, and barium calcium aluminate, wherein the molar ratio of Ba:Ca:Al is about 4:1:1.
摘要翻译：描述了具有稀土氧化物掺杂钨基体的含浸稀土金属的钡 - 铝 - 钪酸盐阴极及其制造方法。一方面，含浸稀土金属的钡 - 铝 - 钪酸盐阴极包括：掺杂稀土氧化物的钨基体和浸渍的活性物质。活性物质包含氧化钪（Sc 2 O 3），第二稀土氧化物和铝酸钡钙，其中Ba:Ca:Al的摩尔比为约4:1:1。

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