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1. 发明申请

US20120326721A1 SIMULTANEOUS AND DYNAMIC DETERMINATION OF LONGITUDINAL AND TRANSVERSAL RELAXATION TIMES OF A NUCLEAR SPIN SYSTEM 有权
标题翻译：核弹簧系统的纵向和横向松弛时间的同时和动态确定
公开(公告)号：US20120326721A1
公开(公告)日：2012-12-27
申请号：US13582800
申请日：2011-03-10
申请人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
发明人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
IPC分类号： G01R33/56 , G01R33/34
CPC分类号： G01R33/50 , G01R33/5601 , G01R33/5613 , G01R33/5616
摘要： The invention relates to a magnetic resonance imaging method for simultaneous and dynamic determination of a longitudinal relaxation time T1 and a transversal relaxation time T2 of the nuclear spin system of an object, in the context of DCE or DSE MRI. In this respect, the invention makes use of a steady-state gradient echo pulse sequence comprising an EPI readout module.
摘要翻译：本发明涉及一种用于在DCE或DSE MRI的背景下同时和动态地确定物体的核自旋系统的纵向弛豫时间T1和横向弛豫时间T2的磁共振成像方法。在这方面，本发明利用包括EPI读出模块的稳态梯度回波脉冲序列。

2. 发明授权

US09588205B2 Simultaneous and dynamic determination of longitudinal and transversal relaxation times of a nuclear spin system 有权
标题翻译：同时和动态地确定核自旋系统的纵向和横向弛豫时间
公开(公告)号：US09588205B2
公开(公告)日：2017-03-07
申请号：US13582800
申请日：2011-03-10
申请人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
发明人： Stefanie Remmele , Wei Liu , Tobias Ratko Voigt , Christian Stehning
IPC分类号： G01R33/50 , G01R33/56 , G01R33/561
CPC分类号： G01R33/50 , G01R33/5601 , G01R33/5613 , G01R33/5616
摘要： The invention relates to a magnetic resonance imaging method for simultaneous and dynamic determination of a longitudinal relaxation time T1 and a transversal relaxation time T2 of the nuclear spin system of an object, in the context of DCE or DSE MRI. In this respect, the invention makes use of a steady-state gradient echo pulse sequence comprising an EPI readout module.
摘要翻译：本发明涉及一种用于在DCE或DSE MRI的背景下同时和动态地确定物体的核自旋系统的纵向弛豫时间T1和横向弛豫时间T2的磁共振成像方法。在这方面，本发明利用包括EPI读出模块的稳态梯度回波脉冲序列。

3. 发明授权

US09507000B2 Flow insensitive magnetization preparation pulse for T2* contrast 有权
标题翻译：用于T2 *对比度的流动不敏感磁化准备脉冲
公开(公告)号：US09507000B2
公开(公告)日：2016-11-29
申请号：US13123128
申请日：2009-10-05
申请人： Christian Stehning , Jurgen Erwin Rahmer , Stefanie Remmele , Ulrike Blume , Tobias Richard Schaeffter
发明人： Christian Stehning , Jurgen Erwin Rahmer , Stefanie Remmele , Ulrike Blume , Tobias Richard Schaeffter
IPC分类号： A61B5/055 , G01R33/50 , G01R33/48 , G01R33/56
CPC分类号： G01R33/50 , A61B5/055 , G01R33/4828 , G01R33/5602
摘要： A magnetic resonance system comprises a magnetic resonance scanner (10) including a main magnet (12) generating a static magnetic field biasing nuclear spins toward aligning along a direction of the static magnetic field, magnetic field gradient coils (14), a radio frequency coil (16), and a controller (20, 22) configured to: (a) drive the radio frequency coil to selectively tip spins predominantly of short T2* out of the direction of the static magnetic field; (b) drive at least one of the magnetic field gradient coils and the radio frequency coil to dephase said spins predominantly of short T2* tipped out of the direction of the static magnetic field; and (c) drive the magnetic field gradient coils and the radio frequency coil to acquire magnetic resonance data that is predominantly T2* weighted due to preceding operations (a) and (b).
摘要翻译：磁共振系统包括磁共振扫描器（10），该磁共振扫描器（10）包括主磁体（12），该主磁体产生静磁场，该静磁场偏置核自旋以沿着静磁场的方向排列，磁场梯度线圈（14），射频线圈（16），以及控制器（20,22），其被配置为：（a）驱动所述射频线圈以选择性地从所述静态磁场的方向上引导主要具有短T2 *的自旋; （b）驱动所述磁场梯度线圈和所述射频线圈中的至少一个，以使所述自旋以主要从所述静态磁场方向倾斜的短T2 *去除; 和（c）驱动磁场梯度线圈和射频线圈以获得由于先前操作（a）和（b）而主要为T2 *加权的磁共振数据。

4. 发明申请

US20130225978A1 MAGNETIC RESONANCE IMAGING SYSTEM, COMPUTER SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR SENDING CONTROL MESSAGES TO AN ANESTHESIA SYSTEM 审中-公开
标题翻译：磁共振成像系统，计算机系统和计算机程序产品，用于向ANESTHESIA系统发送控制消息
公开(公告)号：US20130225978A1
公开(公告)日：2013-08-29
申请号：US13819097
申请日：2011-08-24
申请人： Stefanie Remmele , Christian Stehning
发明人： Stefanie Remmele , Christian Stehning
IPC分类号： G01R33/56 , A61B5/055
CPC分类号： G01R33/5608 , A61B5/055 , A61M16/01 , A61M16/024 , A61M16/104 , A61M2016/102 , A61M2016/1025 , A61M2016/103 , A61M2205/057 , A61M2230/005 , A61M2230/43 , A61M2230/432 , A61M2230/435 , G01R33/30 , G01R33/5601 , G01R33/56366
摘要： A magnetic resonance imaging system (500) comprising: a magnet (502) for generating a magnetic field; a radio frequency system (516) for acquiring magnetic resonance data; a magnetic field gradient coil (510) for spatial encoding of the magnetic spins of nuclei within the imaging volume; a magnetic field gradient coil power supply (512) for supplying current to the magnetic field gradient coil; an anesthesia system interface (532) for sending control messages to an anesthesia system (524) for controlling the delivery of inhalation gases to a subject and a computer system comprising a processor (534) and a memory (538, 540), wherein the memory contains instructions (542, 544, 546, 548, 550, 552) for execution by the processor, wherein execution of the instructions causes the processor to: control (100, 200, 300, 400) the operation of the magnetic resonance imaging system to acquire magnetic resonance data, and to send (102, 202, 302, 402) control messages to the anesthesia system via the anesthesia system interface.
摘要翻译：一种磁共振成像系统（500），包括：用于产生磁场的磁体（502）; 射频系统（516），用于获取磁共振数据; 磁场梯度线圈（510），用于对所述成像体积内的核的磁旋转进行空间编码; 用于向磁场梯度线圈提供电流的磁场梯度线圈电源（512）; 麻醉系统接口（532），用于将控制消息发送到麻醉系统（524），用于控制向对象输送吸入气体;以及计算机系统，包括处理器（534）和存储器（538,540），其中所述存储器包含用于由处理器执行的指令（542,544,546,548,550,552），其中所述指令的执行使得所述处理器将所述磁共振成像系统的操作（100,200,300,400）控制为获取磁共振数据，并通过麻醉系统接口将（102,202,302,402）控制消息发送到麻醉系统。

5. 发明申请

US20120004530A1 QUANTIFICATION OF INTRACELLULAR AND EXTRACELLULAR SPIO AGENTS WITH R2 AND R2* MAPPING 审中-公开
标题翻译：使用R2和R2 *映射的细胞内和细胞外细胞代谢物的定量
公开(公告)号：US20120004530A1
公开(公告)日：2012-01-05
申请号：US13256485
申请日：2010-02-09
申请人： Wei Liu , Julien Senegas , Stefanie Remmele
发明人： Wei Liu , Julien Senegas , Stefanie Remmele
IPC分类号： A61B5/055 , A61K49/08
CPC分类号： G01R33/50 , G01R33/5601 , G01R33/5608 , G01R33/58
摘要： Quantitative assessment of magnetic agent tagged cells in a subject comprises: acquiring a series of T2 weighted images of the subject; acquiring a series of T2* weighted images of the subject; and generating a value indicative of quantitative assessment of magnetic agent tagged cells in the subject based on both the T2 weighted images of the subject and the T2* weighted images of the subject. The generating may be further based on predetermined relationships (26) between (i) R2 and intracellular magnetic agent concentration, (ii) R2* and intracellular magnetic agent concentration, (iii) R2 and extracellular magnetic agent concentration, and (iv) R2* and extracellular magnetic agent concentration. Said predetermined relationships may be generated based on R2 and R2* measurements of a plurality of calibration phantoms having different concentrations of substantially purely intracellular magnetic agent and having different concentrations of substantially purely extracellular magnetic agent.
摘要翻译：受试者中磁性剂标记细胞的定量评估包括：获取受试者的一系列T2加权图像; 获取主题的一系列T2 *加权图像; 并且基于受试者的T2加权图像和受试者的T2 *加权图像，生成指示受试者中的磁性标记细胞的定量评估的值。产生可以进一步基于（i）R2和细胞内磁性剂浓度之间的预定关系（26），（ii）R2 *和细胞内磁性剂浓度，（iii）R2和细胞外磁性剂浓度，以及（iv）R2 * 和细胞外磁性剂浓度。所述预定关系可以基于具有不同浓度的基本上纯细胞内的磁性试剂并且具有不同浓度的基本上纯的细胞外磁性剂的多个校准体模的R2和R2 *测量来产生。

6. 发明申请

US20140009156A1 COMPRESSED SENSING MR IMAGE RECONSTRUCTION USING CONSTRAINT FROM PRIOR ACQUISITION 有权
标题翻译：使用来自先前收购的约束的压缩感测MR图像重建
公开(公告)号：US20140009156A1
公开(公告)日：2014-01-09
申请号：US14006244
申请日：2012-02-28
申请人： Mariya Ivanova Doneva , Stefanie Remmele , Peter Bornert , Peter Mazurkewitz , Julien Senegas , Jochen Keupp , Kay Nehrke
发明人： Mariya Ivanova Doneva , Stefanie Remmele , Peter Bornert , Peter Mazurkewitz , Julien Senegas , Jochen Keupp , Kay Nehrke
IPC分类号： G01R33/56
CPC分类号： G01R33/56 , G01R33/4824 , G01R33/5608 , G01R33/5611 , G01R33/56509
摘要： The invention relates to a method of MR imaging of at least a portion of a body (10) of a patient placed in an examination volume of a MR device (1), the method comprising the steps of: subjecting the portion of the body (10) to a first imaging sequence for acquiring a first signal data set (21); subjecting the portion of the body (10) to a second imaging sequence for acquiring a second signal data set (23), wherein the imaging parameters of the second imaging sequence differ from the imaging parameters of the first imaging sequence; reconstructing a MR image from the second signal data set (23) by means of regularization using the first signal data set (21) as prior information. Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).
摘要翻译：本发明涉及放置在MR装置（1）的检查体积中的患者的身体（10）的至少一部分的MR成像方法，该方法包括以下步骤：对身体的部分（ 10）到用于获取第一信号数据集（21）的第一成像序列; 使所述身体（10）的所述部分经受第二成像序列以获取第二信号数据集（23），其中所述第二成像序列的成像参数与所述第一成像序列的成像参数不同; 通过使用第一信号数据集（21）的正则化作为先前信息，从第二信号数据集（23）重建MR图像。此外，本发明涉及MR设备（1）和用于MR设备（1）的计算机程序。

7. 发明申请

US20130338930A1 DETERMINATION OF A MAGNETIC RESONANCE IMAGING PULSE SEQUENCE PROTOCOL CLASSIFICATION 有权
标题翻译：磁共振成像脉冲序列协议分类的确定
公开(公告)号：US20130338930A1
公开(公告)日：2013-12-19
申请号：US14002206
申请日：2012-02-21
申请人： Julien Senegas , Stefanie Remmele , Michael Lee
发明人： Julien Senegas , Stefanie Remmele , Michael Lee
IPC分类号： G01R33/54 , G06F19/00
CPC分类号： G01R33/54 , G01R33/543 , G01R33/546 , G01R33/5608 , G06F11/327 , G06F19/00 , G06F19/321 , G06F19/34 , G16H40/63
摘要： A medical imaging device (300) comprising a magnetic resonance imaging system (302). The medical image device further comprises a memory (334) containing machine executable instructions (370, 372, 374, 376, 378, 380, 382, 384, 386) for execution by a processor (328). Execution of the instructions causes the processor to receive (100, 204) a pulse sequence protocol (340). Execution of the instructions further causes the processor to determine (102, 206) a pulse sequence type classification (342) descriptive of the pulse sequence protocol. Execution of the instructions further cause the processor to determine (104, 208) a magnetic resonance contrast classification (344), wherein the choice of the magnetic resonance contrast classification depends upon the pulse sequence type classification. Execution of the instructions further causes the processor to determine (106, 210) a pulse sequence protocol classification (346). The pulse sequence protocol classification is determined by the pulse sequence type classification and the magnetic resonance contrast classification.
摘要翻译：一种包括磁共振成像系统（302）的医学成像装置（300）。医学图像设备还包括用于由处理器（328）执行的机器可执行指令（370,372,374,376,378,380,382,384,386）的存储器（334）。执行指令使得处理器接收（100,204）脉冲序列协议（340）。执行指令还使处理器确定（102,206）描述脉冲序列协议的脉冲序列类型分类（342）。执行指令还使得处理器确定（104,208）磁共振对比度分类（344），其中磁共振对比度分类的选择取决于脉冲序列类型分类。执行指令还使处理器确定（106,210）脉冲序列协议分类（346）。脉冲序列协议分类由脉冲序列类型分类和磁共振对比分类决定。

8. 发明授权

US09523750B2 Determination of a magnetic resonance imaging pulse sequence protocol classification 有权
标题翻译：确定磁共振成像脉冲序列协议分类
公开(公告)号：US09523750B2
公开(公告)日：2016-12-20
申请号：US14002206
申请日：2012-02-21
申请人： Julien Senegas , Stefanie Remmele , Michael Lee
发明人： Julien Senegas , Stefanie Remmele , Michael Lee
IPC分类号： G01R33/54 , G01R33/56 , G06F19/00 , G06F11/32
CPC分类号： G01R33/54 , G01R33/543 , G01R33/546 , G01R33/5608 , G06F11/327 , G06F19/00 , G06F19/321 , G06F19/34 , G16H40/63
摘要： A medical imaging device (300) includes a magnetic resonance imaging system (302) and a memory (334) containing machine executable instructions (370, 372, 374, 376, 378, 380, 382, 384, 386) for execution by a processor (328). Execution of the instructions causes the processor to receive (100, 204) a pulse sequence protocol (340). Execution of the instructions further causes the processor to determine (102, 206) a pulse sequence type classification (342) descriptive of the pulse sequence protocol. Execution of the instructions further cause the processor to determine (104, 208) a magnetic resonance contrast classification (344). The choice of the magnetic resonance contrast classification depends upon the pulse sequence type classification. Execution of the instructions further causes the processor to determine (106, 210) a pulse sequence protocol classification (346). The pulse sequence protocol classification is determined by the pulse sequence type classification and the magnetic resonance contrast classification.
摘要翻译：医疗成像设备（300）包括磁共振成像系统（302）和包含机器可执行指令（370,372,374,384,378,380,382,384,386）的存储器，用于由处理器执行（328）。执行指令使得处理器接收（100,204）脉冲序列协议（340）。执行指令还使处理器确定（102,206）描述脉冲序列协议的脉冲序列类型分类（342）。执行指令还使处理器确定（104,208）磁共振对比度分类（344）。磁共振对比度分类的选择取决于脉冲序列类型分类。执行指令还使处理器确定（106,210）脉冲序列协议分类（346）。脉冲序列协议分类由脉冲序列类型分类和磁共振对比分类决定。

9. 发明授权

US09317580B2 Imaging protocol update and/or recommender 有权
标题翻译：成像协议更新和/或推荐
公开(公告)号：US09317580B2
公开(公告)日：2016-04-19
申请号：US13983070
申请日：2012-01-31
申请人： Eric Cohen-Solal , Michael Chun-Chieh Lee , Julien Senegas , Sebastian Peter Michael Dries , Jens Von Berg , Stefanie Remmele
发明人： Eric Cohen-Solal , Michael Chun-Chieh Lee , Julien Senegas , Sebastian Peter Michael Dries , Jens Von Berg , Stefanie Remmele
IPC分类号： G06F17/30 , G06F19/00
CPC分类号： G06F17/30598 , G06F19/00 , G06F19/321 , G06F19/325 , G16H50/70
摘要： A method includes obtaining electronically formatted information about previously performed imaging procedures, classifying the information into groups of protocols based on initially selected protocols for the previously performed imaging procedures and generating data indicative thereof, identifying deviations between the classified information and the corresponding initially selected protocols for the previously performed imaging procedures, and generating a signal indicative of the deviations. A method includes recommending at least one of a plurality of protocols for an imaging procedure based on at least one of a score, a probability, or a pre-determined rule, which is based on extracted medical concepts from patient information and extracted medical concepts from previously imaged patient information, and generating a signal indicative of the recommendation.
摘要翻译：一种方法包括获得关于先前执行的成像过程的电子格式化信息，基于对先前执行的成像过程的最初选择的协议将信息分类成协议组，并且生成指示其的数据，识别分类信息与相应的最初选择的协议之间的偏差先前执行的成像过程，并且产生指示偏差的信号。一种方法包括基于得分，概率或预定规则中的至少一个推荐用于成像过程的多个协议中的至少一个，其基于来自患者信息的提取的医学概念和来自患者信息的提取的医学概念先前成像的患者信息，以及产生指示推荐的信号。

10. 发明申请

US20110196224A1 FLOW INSENSITIVE MAGNETIZATION PREPARATION PULSE FOR T2* CONTRAST 有权
标题翻译：用于T2 *对比度的流动敏感磁化准备脉冲
公开(公告)号：US20110196224A1
公开(公告)日：2011-08-11
申请号：US13123128
申请日：2009-10-05
申请人： Christian Stehing , Jurgen Erwin Rahmer , Stefanie Remmele , Ulrike Blume , Tobias Richard Schaeffter
发明人： Christian Stehing , Jurgen Erwin Rahmer , Stefanie Remmele , Ulrike Blume , Tobias Richard Schaeffter
IPC分类号： A61B5/055
CPC分类号： G01R33/50 , A61B5/055 , G01R33/4828 , G01R33/5602
摘要： A magnetic resonance system comprises a magnetic resonance scanner (10) including a main magnet (12) generating a static magnetic field biasing nuclear spins toward aligning along a direction of the static magnetic field, magnetic field gradient coils (14), a radio frequency coil (16), and a controller (20, 22) configured to: (a) drive the radio frequency coil to selectively tip spins predominantly of short T2* out of the direction of the static magnetic field; (b) drive at least one of the magnetic field gradient coils and the radio frequency coil to dephase said spins predominantly of short T2* tipped out of the direction of the static magnetic field; and (c) drive the magnetic field gradient coils and the radio frequency coil to acquire magnetic resonance data that is predominantly T2* weighted due to preceding operations (a) and (b).
摘要翻译：磁共振系统包括磁共振扫描器（10），该磁共振扫描器（10）包括主磁体（12），该主磁体产生静磁场，该静磁场偏置核自旋以沿着静磁场的方向排列，磁场梯度线圈（14），射频线圈（16），以及控制器（20,22），其被配置为：（a）驱动所述射频线圈以选择性地从所述静态磁场的方向上引导主要具有短T2 *的自旋; （b）驱动所述磁场梯度线圈和所述射频线圈中的至少一个，以使所述自旋以主要从所述静态磁场方向倾斜的短T2 *去除; 和（c）驱动磁场梯度线圈和射频线圈以获得由于先前操作（a）和（b）而主要为T2 *加权的磁共振数据。

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