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1. 发明授权

US08435523B2 Antibodies against nerve growth factor (NGF) with enhanced in vivo stability 有权
标题翻译：具有增强的体内稳定性的抗神经生长因子（NGF）的抗体
公开(公告)号：US08435523B2
公开(公告)日：2013-05-07
申请号：US12773488
申请日：2010-05-04
申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
发明人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/50 , C07K2317/53 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要翻译：本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

2. 发明申请

US20100278839A1 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY 有权
标题翻译：抗生素稳定性增强的神经生长因子（NGF）抗体
公开(公告)号：US20100278839A1
公开(公告)日：2010-11-04
申请号：US12773488
申请日：2010-05-04
申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
发明人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
IPC分类号： A61K39/395 , C07K16/18 , C12N15/63 , C12N5/10 , A61P25/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/50 , C07K2317/53 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要翻译：本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

3. 发明申请

US20090022798A1 FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
标题翻译：非对称性和限制性阿片类药物的制剂
公开(公告)号：US20090022798A1
公开(公告)日：2009-01-22
申请号：US11780625
申请日：2007-07-20
申请人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
发明人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/24 , A61K31/485 , A61K47/30 , A61P25/04 , A61K9/20
CPC分类号： A61K9/28 , A61K9/0053 , A61K9/209 , A61K31/167 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。这些制剂减少了滥用的可能性。在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

4. 发明申请

US20100172989A1 ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION 审中-公开
标题翻译：具有降低酒精相互作用的抗菌熔体挤压配方
公开(公告)号：US20100172989A1
公开(公告)日：2010-07-08
申请号：US12631010
申请日：2009-12-04
申请人： Wolfgang Roth , Alexander Burst , Martina Zietsch , Wei Liu , Sandeep Dutta
发明人： Wolfgang Roth , Alexander Burst , Martina Zietsch , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/14 , A61K31/485 , A61P25/04
CPC分类号： A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/209 , A61K9/2095 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/485
摘要： The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本发明涉及用于口服给药的组合物。本发明优选包含至少一种用于递送具有在醇中倾倒剂量的药物的药物递送组合物，制备这些剂型的相关方法和治疗有需要的患者的方法包括将本发明组合物施用于患者。最优选地，剂型包括维拉帕米。这些制剂减少了滥用的可能性。在另一种制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

5. 发明申请

US20110229526A1 FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
标题翻译：非对称性和限制性阿片类药物的制剂
公开(公告)号：US20110229526A1
公开(公告)日：2011-09-22
申请号：US12984373
申请日：2011-01-04
申请人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
发明人： Joerg Rosenberg , Gerd H. Woehrle , Thomas Y. Kessler , Joerg Breitenbach , Salih Durak , Friedrich W. Richter , Wei Liu , Sandeep Dutta
IPC分类号： A61K9/00 , A61K31/485 , A61P29/00 , A61P25/04
CPC分类号： A61K9/28 , A61K9/0053 , A61K9/209 , A61K31/167 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
摘要翻译：本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。这些制剂减少了滥用的可能性。在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

6. 发明授权

US08761479B2 System and method for analyzing and visualizing spectral CT data 有权
标题翻译：用于分析和可视化光谱CT数据的系统和方法
公开(公告)号：US08761479B2
公开(公告)日：2014-06-24
申请号：US12941162
申请日：2010-11-08
申请人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
IPC分类号： G06K9/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/463 , A61B6/465 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T11/001 , G06T2207/10081 , G06T2207/20104
摘要： A system and method for analyzing and visualizing spectral CT data includes access of a set of image data acquired from a patient comprising spectral CT data, identification of a plurality of target regions of interest (TROIs) and a reference region of interest (RROI) from the set of image data, extraction of a plurality of target spectral Hounsfield unit (HU) curves from image data representing the plurality of TROIs, extraction of a reference spectral HU curve from image data representing the RROI, normalization of the plurality of target spectral HU curves with respect to the reference spectral HU curve, and display of the plurality of normalized target spectral HU curves.
摘要翻译：用于分析和可视化频谱CT数据的系统和方法包括从患者获取的一组图像数据的访问，包括频谱CT数据，多个目标感兴趣区域（TROI）和感兴趣的参考区域（RROI）的识别从图像数据集合，从表示多个TROI的图像数据中提取多个目标光谱Hounsfield单位（HU）曲线，从表示RROI的图像数据中提取参考光谱HU曲线，多个目标光谱HU的归一化相对于参考光谱HU曲线的曲线，以及多个归一化的目标光谱HU曲线的显示。

7. 发明申请

US20120114206A1 SYSTEM AND METHOD FOR ANALYZING AND VISUALIZING SPECTRAL CT DATA 有权
标题翻译：用于分析和可视化光谱数据的系统和方法
公开(公告)号：US20120114206A1
公开(公告)日：2012-05-10
申请号：US12941162
申请日：2010-11-08
申请人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
发明人： Gopal Biligeri Avinash , Sandeep Dutta , Saad Ahmed Sirohey , Ananth P. Mohan
IPC分类号： G06K9/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/463 , A61B6/465 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T11/001 , G06T2207/10081 , G06T2207/20104
摘要： A system and method for analyzing and visualizing spectral CT data includes access of a set of image data acquired from a patient comprising spectral CT data, identification of a plurality of target regions of interest (TROIs) and a reference region of interest (RROI) from the set of image data, extraction of a plurality of target spectral Hounsfield unit (HU) curves from image data representing the plurality of TROIs, extraction of a reference spectral HU curve from image data representing the RROI, normalization of the plurality of target spectral HU curves with respect to the reference spectral HU curve, and display of the plurality of normalized target spectral HU curves.
摘要翻译：用于分析和可视化频谱CT数据的系统和方法包括从患者获取的一组图像数据的访问，包括频谱CT数据，多个目标感兴趣区域（TROI）和感兴趣的参考区域（RROI）的识别从图像数据集合，从表示多个TROI的图像数据中提取多个目标光谱Hounsfield单位（HU）曲线，从表示RROI的图像数据中提取参考光谱HU曲线，多个目标光谱HU的归一化相对于参考光谱HU曲线的曲线，以及多个归一化的目标光谱HU曲线的显示。

8. 发明授权

US08094896B2 Systems, methods and apparatus for detection of organ wall thickness and cross-section color-coding 有权
标题翻译：用于检测器官壁厚和横截面颜色编码的系统，方法和装置
公开(公告)号：US08094896B2
公开(公告)日：2012-01-10
申请号：US12102531
申请日：2008-04-14
申请人： Sandeep Dutta , Csongor Pal Sprencz , Maria-Magdalena Nay , Laurent Launay
发明人： Sandeep Dutta , Csongor Pal Sprencz , Maria-Magdalena Nay , Laurent Launay
IPC分类号： G06K9/00
CPC分类号： G06T7/11 , G06T2207/10081 , G06T2207/30061
摘要： Systems, method and apparatus in which some implementations of respiratory structure imaging includes tracking a portion in a organ, determining wall contours in the portion and color-coding confidence in the wall contours. Some implementations of the color-coding includes selecting a cross section of a portion, determining average intensity of a wall in the organ from equally space ray vectors, determining confidence from a distribution of the average intensity, labeling sections of an organ image in reference to the average intensity, and color coding sections of the image in the memory according to the confidence.
摘要翻译：系统，方法和装置，其中呼吸结构成像的一些实施方案包括跟踪器官中的一部分，确定该部分中的壁轮廓并对壁轮廓中的置信度进行颜色编码。颜色编码的一些实施方式包括选择部分的横截面，从平均空间射线矢量确定器官中的壁的平均强度，根据平均强度的分布确定置信度，参考器官图像的标记部分根据置信度，存储器中的图像的平均强度和颜色编码部分。

9. 发明申请

US20110141102A1 SYSTEM AND METHOD OF VISUALIZING FEATURES IN AN IMAGE 有权
标题翻译：在图像中可视化特征的系统和方法
公开(公告)号：US20110141102A1
公开(公告)日：2011-06-16
申请号：US12635879
申请日：2009-12-11
申请人： John Skinner , Sandeep Dutta , Bernice E. Hoppel
发明人： John Skinner , Sandeep Dutta , Bernice E. Hoppel
IPC分类号： G06T15/00 , G06K9/00
CPC分类号： G06T11/206 , G06T11/008 , G06T19/00
摘要： An imaging system includes a detector configured to receive data that can be reconstructed into a three-dimensional (3D) image of an object, and a computer programmed to obtain 3D image data of the object, the 3D image data including an internal structure of the object, define a longitudinal dimension of the internal structure from the 3D image data along a length of the structure, extract a first set of parameter-of-interest data related to the internal structure from the 3D image data along a first ray extending from a first location along the length of the structure and at a first angular orientation with respect to a base vector that is generally perpendicular to the longitudinal dimension, and plot the extracted first set of parameter-of-interest data at a pixel location of a two-dimensional (2D) plot that corresponds to the first location and corresponds to the first angular orientation.
摘要翻译：成像系统包括检测器，其被配置为接收可以被重构成物体的三维（3D）图像的数据，以及被编程为获得对象的3D图像数据的计算机，3D图像数据包括内部结构对象，沿着结构的长度从3D图像数据定义内部结构的纵向维度，沿着从3D图像数据延伸的第一射线从3D图像数据提取与内部结构相关的第一组感兴趣参数数据沿着结构长度的第一位置和相对于大致垂直于纵向尺寸的基本向量以第一角度取向，并且将所提取的第一组感兴趣参数数据绘制在二维图像的像素位置处，对应于第一位置并对应于第一角度取向的二维（2D）绘图。

10. 发明申请

US20080118122A1 Methods and apparatus for generating a risk metric for soft plaque in vessels 有权
标题翻译：用于生成血管软斑块风险度量的方法和装置
公开(公告)号：US20080118122A1
公开(公告)日：2008-05-22
申请号：US11603490
申请日：2006-11-22
申请人： Saad Ahmed Sirohey , Gopal B. Avinash , John V. Skinner , Sandeep Dutta , Patricia Le Nezet , Deann Marie Haas
发明人： Saad Ahmed Sirohey , Gopal B. Avinash , John V. Skinner , Sandeep Dutta , Patricia Le Nezet , Deann Marie Haas
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/62 , G06T2207/10116 , G06T2207/30048 , G06T2207/30101
摘要： A method for generating a score for soft plaque in coronary arteries includes using the computer to estimate the soft plaque content within at least one object depicted in a medical image, using the computer to determine a plaque score dependent upon the estimated soft plaque content of the at least one object, and using the computer to report the plaque score.
摘要翻译：用于在冠状动脉中产生软斑块得分的方法包括使用计算机估计在医学图像中描绘的至少一个物体内的软斑块含量，使用计算机来确定取决于所估计的软斑块含量的斑块得分至少一个对象，并使用电脑报告斑块得分。

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