专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5306717A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US5306717A
公开(公告)日：1994-04-26
申请号：US924598
申请日：1992-07-24
申请人： Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
发明人： Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/22 , C07D501/34 , C07D501/46
CPC分类号： C07D501/34
摘要： Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有抗细菌感染和含有此类头孢烯衍生物的通式为“IMAGE”+ TR 的药物制剂的头孢菌素衍生物，头孢烯衍生物和药物制剂的制备方法以及头孢烯衍生物用于对抗细菌感染。

2. 发明授权

US5100887A Cephalosporin derivatives 失效
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：US5100887A
公开(公告)日：1992-03-31
申请号：US555807
申请日：1990-07-23
申请人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
发明人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/32 , C07D501/34
CPC分类号： C07D501/34 , C07D501/00
摘要： Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有抗细菌感染活性的含有此类头孢烯衍生物的通式 + TR 药物制剂的头孢霉羧酸酯，制备头孢烯衍生物和药物制剂的方法，以及使用头孢烯衍生物用于对抗细菌感染。

3. 再颁专利

USRE34865E Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：USRE34865E
公开(公告)日：1995-02-21
申请号：US978980
申请日：1992-11-19
申请人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
发明人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/32 , C07D501/34
CPC分类号： C07D501/34 , C07D501/00
摘要： Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有抗细菌感染活性的含有此类头孢烯衍生物的通式 + TR 药物制剂的头孢霉羧酸酯，制备头孢烯衍生物和药物制剂的方法，以及使用头孢烯衍生物用于对抗细菌感染。

4. 发明授权

US5409918A Crystalline cephem acid addition salts and process for their preparation 失效
标题翻译：结晶头孢酸加成盐及其制备方法
公开(公告)号：US5409918A
公开(公告)日：1995-04-25
申请号：US931505
申请日：1992-08-21
申请人： Friedhelm Adam , Walter Durckheimer , Burkhard Mencke , Dieter Isert
发明人： Friedhelm Adam , Walter Durckheimer , Burkhard Mencke , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/34 , C07D501/56 , C07D501/32
CPC分类号： C07D501/00
摘要： Crystalline cephem acid addition salts of the general formula II ##STR1## pharmaceutical preparations effective against bacterial infections which contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有通式II的结晶头孢酸加成盐对于含有此类头孢烯衍生物的细菌感染药物制剂，制备头孢烯衍生物和药物制剂的方法，以及使用头孢烯防治细菌感染的衍生物。

5. 发明授权

US5091382A Cephalosporin derivatives 失效
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：US5091382A
公开(公告)日：1992-02-25
申请号：US552058
申请日：1990-07-13
申请人： Friedhelm Adam , Walter Durckheimer , Karl-Heinz Scheunemann , Dieter Isert , Gerhard Seibert
发明人： Friedhelm Adam , Walter Durckheimer , Karl-Heinz Scheunemann , Dieter Isert , Gerhard Seibert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/36 , C07D277/56 , C07D501/00 , C07D501/36
CPC分类号： C07D277/56 , C07D277/36 , C07D501/00
摘要： Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.
摘要翻译：具有通式的头孢菌素衍生物，其含有这种头孢菌素衍生物的细菌感染活性的药物制剂，头孢菌素衍生物的制备方法，头孢菌素衍生物用于制备抗菌细菌感染药物，以及起始产品头孢菌素衍生物的制备。

6. 发明授权

US5550232A Diastereomers of 1-(isopropoxycarbonyloxy) ethyl 3-cephem 4-carboxylate 失效
标题翻译： 1-（异丙氧基羰基氧基）乙基3-头孢烯-4-羧酸酯的非对映异构体
公开(公告)号：US5550232A
公开(公告)日：1996-08-27
申请号：US447229
申请日：1995-05-22
申请人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
发明人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/06 , C07D501/34 , C07D501/56 , C07D501/14
CPC分类号： C07D501/00
摘要： Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive partial steps and any desired sequence of addition of different acid components HY being possible, and optionally further purifying the obtained salts by crystallization, are described.
摘要翻译： 1-（异丙氧羰基氧基）乙基（6R，7R）-7- [2-（2-氨基噻唑-4-基）-2-（Z） - （甲氧基亚氨基）乙酰氨基] -3-（甲氧基甲基）-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐，其中HX是单或多元酸，其中X是无机或有机的生理学上可接受的阴离子，以及制备这些式I或II化合物的方法，其包括首先将式IV的较微溶的非对映体沉淀在1当量的式（I）的非对映体混合物的溶液中， III与0.2-2当量的酸组分HY的溶液并通过过滤分离，然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体，酸组分HY可能相同或不同在一起描述了部分步骤和任何期望的不同酸组分HY的加入顺序是可能的，并且任选地通过结晶进一步纯化得到的盐。

7. 发明授权

US5556850A Crystalline acid addition salts of diastereomerically pure 1-(2,2-dimethyl-propionyloxy)-ethyl-3-cephem-4-carboxylate 失效
标题翻译：非对映体纯的1-（2,2-二甲基 - 丙酰氧基） - 乙基-3-头孢烯-4-羧酸的结晶酸加成盐
公开(公告)号：US5556850A
公开(公告)日：1996-09-17
申请号：US447635
申请日：1995-05-23
申请人： Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
发明人： Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07B57/00 , C07D417/12 , C07D501/00 , C07D501/12 , C07D501/18 , C07D501/32 , C07D501/34
CPC分类号： C07D501/00
摘要： The invention relates to crystalline acid addition salt of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl 3-cephem-4-carboxylate of the general formula II ##STR1## in which X is the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group .dbd.N--OH is in the syn-position, pharmaceutical formulations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：本发明涉及通式II II的1-（2,2-二甲基丙酰氧基）乙基3-头孢烯-4-羧酸酯的两种非对映异构体的结晶酸加成盐，其中X是生理上可接受的单 - 或多碱性，无机或有机酸，并且组= N-OH处于顺式位置，对细菌感染有活性并含有此类头孢烯衍生物的药物制剂，用于制备头孢烯衍生物的方法和使用用于对抗细菌感染的头孢烯衍生物。

8. 发明授权

US5614623A Diastereomers of 1-(isopropoxycarbonyloxy)ethyl 3-cephem-4-carboxylate and processes for their preparation 失效
标题翻译： 3-头孢烯-4-羧酸1-（异丙氧基羰基氧基）乙酯的非对映异构体及其制备方法
公开(公告)号：US5614623A
公开(公告)日：1997-03-25
申请号：US447249
申请日：1995-05-22
申请人： Gerd Fischer , Elisabeth Defo.beta.a , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
发明人： Gerd Fischer , Elisabeth Defo.beta.a , Uwe Gerlach , Rolf H orlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/06 , C07D501/34 , C07D501/56 , C07D501/22
CPC分类号： C07D501/00
摘要： Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R, 7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive steps.
摘要翻译： 1-（异丙氧羰基氧基）乙基（6R，7R）-7- [2-（2-氨基噻唑-4-基）-2-（Z） - （甲氧基亚氨基）乙酰氨基] -3-（甲氧基甲基）-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐，其中HX是单或多元酸，其中X是无机或有机的生理学上可接受的阴离子，以及制备这些式I或II化合物的方法，其包括首先将式IV的较微溶的非对映体沉淀在1当量的式（I）的非对映体混合物的溶液中， III与0.2-2当量的酸组分HY的溶液并通过过滤分离，然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体，酸组分HY可能相同或不同在consecu 有步骤。

9. 发明授权

US5594133A Crystalline acid addition salts of diastereomerically pure 1-(2,2-dimethylpropinonyloxy)-ethyl-3-cephem-4-carboxylate 失效
标题翻译：非对映体纯的1-（2,2-二甲基丙酰氧基） - 乙基-3-头孢烯-4-羧酸的结晶酸加成盐
公开(公告)号：US5594133A
公开(公告)日：1997-01-14
申请号：US447045
申请日：1995-05-22
申请人： Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
发明人： Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07B57/00 , C07D417/12 , C07D501/00 , C07D501/12 , C07D501/18 , C07D501/32 , C07D501/34 , C07D501/56 , C07D501/54
CPC分类号： C07D501/00
摘要： Crystalline acid addition salts of diastereomerically pure 1-(2,2-dimethylpropionyloxy)ethyl 3-cephem-4-carboxylateThe invention relates to crystalline acid addition salt of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl 3-cephem-4-carboxylate of the general formula II ##STR1## in which X is the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N--OH is in the syn-position, pharmaceutical formulations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：非对映异构纯的3-头孢烯-4-羧酸1-（2,2-二甲基丙酰氧基）乙酯的结晶酸加成盐本发明涉及3-（2,2-二甲基丙酰氧基）乙基3-头孢烯-4-羧酸酯的两种非对映异构体的结晶酸加成盐，头孢烯-4-羧酸酯，其中X是生理上可接受的，单或多碱性，无机或有机酸的阴离子，并且基团= N-OH在同一位置，药物制剂其对细菌感染有活性并含有此类头孢烯衍生物，头孢烯衍生物的制备方法和头孢烯衍生物用于抗菌感染的用途。

10. 发明授权

US5461043A Diastereomers of 1-(isopropoxycarbonyloxy)ethyl 3-cephem-4-carboxylate 失效
标题翻译： 3-头孢烯-4-羧酸1-（异丙氧基羰基氧基）乙酯的非对映异构体
公开(公告)号：US5461043A
公开(公告)日：1995-10-24
申请号：US940367
申请日：1992-09-03
申请人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf Horlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
发明人： Gerd Fischer , Elisabeth Defossa , Uwe Gerlach , Rolf Horlein , Norbert Krass , Rudolf Lattrell , Ulrich Stache , Theodor Wollmann , Dieter Isert
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/06 , C07D501/34 , C07D501/56 , C07D501/22
CPC分类号： C07D501/00
摘要： Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive partial steps and any desired sequence of addition of different acid components HY being possible, and optionally further purifying the obtained salts by crystallization, are described.
摘要翻译： 1-（异丙氧羰基氧基）乙基（6R，7R）-7- [2-（2-氨基噻唑-4-基）-2-（Z） - （甲氧基亚氨基）乙酰氨基] -3-（甲氧基甲基）-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐，其中HX是单或多元酸，其中X是无机或有机的生理上可接受的阴离子，以及制备这些式I或II化合物的方法，其包括首先将式IV的较微溶的非对映体沉淀在1当量的式（I）的非对映体混合物的溶液中， III与0.2-2当量的酸组分HY的溶液并通过过滤分离，然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体，酸组分HY可能相同或不同在一起描述了部分步骤和任何期望的不同酸组分HY的加入顺序是可能的，并且任选地通过结晶进一步纯化得到的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式