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1. 发明授权

US5344995A Preparation of cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride 失效
标题翻译：制备3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛
公开(公告)号：US5344995A
公开(公告)日：1994-09-06
申请号：US85903
申请日：1993-07-06
申请人： Wolfgang Krause , Joachim Paust , Walter Dobler , Hagen Jaedicke
发明人： Wolfgang Krause , Joachim Paust , Walter Dobler , Hagen Jaedicke
IPC分类号： C07F9/54 , C07D319/06 , C07F9/655 , C07C43/305 , C07C43/313
CPC分类号： C07F9/6552 , C07D319/06
摘要： An improved process for preparing cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride by acetalization of 3-formyl-2-butenyl acetate with an aliphatic 1,3-diol, conversion of the resulting 4-acetoxy acetal into the corresponding 4-hydroxy acetal, Vilsmeier chlorination to give the corresponding 4-chloro acetal and subsequent reaction with triphenylphosphine entails carrying out the first 3 steps in an aliphatic or cycloaliphatic hydrocarbon or mixture of hydrocarbons with 6-8 carbons and the reaction with triphenylphosphine in an alkanol with 1-3 carbons and/or in aliphatic or cycloaliphatic hydrocarbon with 6-8 carbons or a corresponding mixture of hydrocarbons. The process is particularly advantageous when conversion of the 4-acetoxy acetal into the 4-hydroxy acetal is carried out with an aqueous alkali metal hydroxide solution in the presence of phase-transfer catalysts, and the first three, or all four, reaction stages are carried out in the same C.sub.6 -C.sub.8 -hydrocarbon.
摘要翻译：通过用脂肪族1,3-二醇缩醛化3-甲酰基-2-丁烯基乙酸酯与3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛的改进方法，将得到的4-乙酰氧基缩醛转化为相应的4-羟基缩醛，Vilsmeier氯化，得到相应的4-氯缩醛，随后与三苯基膦反应需要在脂族或脂环族烃或碳原子数为6〜8的混合物中进行前3个步骤，并与三苯基膦在链烷醇中与1- 3个碳原子和/或具有6-8个碳原子的脂族或脂环族烃或相应的烃混合物。当在相转移催化剂存在下，用碱金属氢氧化物水溶液进行4-乙酰氧基缩醛转化为4-羟基缩醛时，该方法是特别有利的，而前三个或所有四个反应阶段是在相同的C6-C8-烃中进行。

2. 发明授权

US4120868A Cyclic 2-methyl-2,4-dialkoxy-3-buten-1-al-acetals, their preparation and use 失效
标题翻译：环己基-2-甲基-2,4-二烷氧基-3-丁烯-1-缩醛，其制备和用途
公开(公告)号：US4120868A
公开(公告)日：1978-10-17
申请号：US859020
申请日：1977-12-09
申请人： Hagen Jaedicke , Joachim Paust
发明人： Hagen Jaedicke , Joachim Paust
IPC分类号： C07D319/06 , C07D319/04
CPC分类号： C07D319/06 , C07C403/14 , C07C2101/16
摘要： New acetals, containing a 6-membered ring, of 2-methyl-2,4-dialkoxy-3-buten-1-al, are obtained by reacting the corresponding 2-methyl-2-alkoxy-3-butyn-1-al-acetals with a mixture of the appropriate alcohol and an alkali metal alcoholate of the said alcohol at from 100.degree. to 200.degree. C. The acetals are intermediates for the preparation of carotinoid-based physiologically safe food dyes.
摘要翻译：通过使相应的2-甲基-2-烷氧基-3-丁炔-1-基 - 丙酮与2-甲基-2,4-二烷氧基-3-丁烯-1-al的新的缩醛，含有6-元环的2-甲基-2,4-二烷氧基-3-丁烯-1- - 乙缩醛，其合适的醇和所述醇的碱金属醇化物的混合物在100至200℃下进行。缩醛是用于制备基于类胡萝卜素的生理安全食品染料的中间体。

3. 发明授权

US4100197A Manufacture of echinenone 失效
标题翻译：海胆酮的制造
公开(公告)号：US4100197A
公开(公告)日：1978-07-11
申请号：US705281
申请日：1976-07-14
申请人： Hagen Jaedicke , Joachim Paust , Joachim Schneider
发明人： Hagen Jaedicke , Joachim Paust , Joachim Schneider
IPC分类号： C07C403/24 , A23K1/16 , A23L1/272 , C07C20060101 , C07C49/76 , C07C67/00 , C07C401/00 , C07C403/00 , C07C45/02
CPC分类号： C07C403/24
摘要： Echinenone is produced by oxidizing .beta.-carotene or retro-dehyro-carotene with iodic acid or a salt of iodic acid in the presence of a catalyst and of an inert diluent or solvent.
摘要翻译：通过在催化剂和惰性稀释剂或溶剂的存在下，用碘酸或碘酸盐氧化β-胡萝卜素或逆 - 脱氢胡萝卜素来生产氢化en酮。

4. 发明授权

US4212827A Manufacture of canthaxanthin 失效
标题翻译：角黄素的制造
公开(公告)号：US4212827A
公开(公告)日：1980-07-15
申请号：US841697
申请日：1977-10-13
申请人： Joachim Paust , Joachim Schneider , Hagen Jaedicke
发明人： Joachim Paust , Joachim Schneider , Hagen Jaedicke
IPC分类号： C07B61/00 , B01J21/00 , B01J23/00 , C07C20060101 , C07C49/21 , C07C49/653 , C07C67/00 , C07C67/30 , C07C69/52 , C07C401/00 , C07C403/00 , C07C403/24 , C07C45/02
CPC分类号： C07C403/24
摘要： Process for the manufacture of canthaxanthin by oxidizing .beta.-carotene, retro-dehydro-carotene or echinenone with a salt of chloric or bromic acid in the presence of a catalyst and of an inert diluent or solvent.
摘要翻译：通过在催化剂和惰性稀释剂或溶剂的存在下，用氯或溴酸的盐氧化β-胡萝卜素，逆 - 脱氢胡萝卜素或氢化chin酮来制造角黄素的方法。

5. 发明授权

US4594456A Racemic and optically active 3-hydroxy-alpha-cyclocitral, its acetals and optically active 3-oxo-alpha-cyclocitral acetals, and their preparation 失效
标题翻译：外消旋和光学活性的3-羟基-α-环卟啉，其缩醛和光学活性的3-氧代-α-环ral缩醛及其制备
公开(公告)号：US4594456A
公开(公告)日：1986-06-10
申请号：US572239
申请日：1984-01-20
申请人： Ulrich Schaefer-Luederssen , Hagen Jaedicke , Joachim Paust , Manfred Eggersdorfer
发明人： Ulrich Schaefer-Luederssen , Hagen Jaedicke , Joachim Paust , Manfred Eggersdorfer
IPC分类号： C07C43/315 , C07C45/28 , C07C45/34 , C07C45/51 , C07C45/59 , C07C45/60 , C07C45/67 , C07C47/267 , C07C47/46 , C07C49/753 , C07C49/757 , C07C51/285 , C07D317/72 , C07D319/08 , C07F11/00
CPC分类号： C07D317/72 , C07C403/16 , C07C43/315 , C07C45/28 , C07C45/34 , C07C45/515 , C07C45/59 , C07C45/60 , C07C45/67 , C07C47/46 , C07C49/753 , C07C49/757 , C07C51/285 , C07D319/08 , C07F11/005
摘要： 3-Hydroxy-.alpha.-cyclocitral derivatives of the general formula I ##STR1## where R.sup.1 is ##STR2## wherein R.sup.2 and R.sup.3 can be identical or different and are each straight-chain or branched alkyl of 1 to 6 carbon atoms, or R.sup.2 and R.sup.3 together form an ethylene or propylene group which can be substituted by methyl or ethyl, processes for their preparation and their use for the preparation of safranal and 3-hydroxy-.beta.-cyclocitral, as well as optically active - cyclocitral derivatives of the general formulae A and B ##STR3## where R.sup.1 is ##STR4## if X is hydrogen and Y is OH, but is otherwise ##STR5## where R.sup.2 and R.sup.3 have the above meanings, and X and Y together are oxygen, or X is hydrogen if Y is OH, and a process for the preparation of optically active 3-oxo-.alpha.-cyclocitral acetals, wherein a mixture of the corresponding racemic 3-oxo-.alpha.-cyclocitral acetals is separated into the optically active compounds by chromatography over a suitable chiral adsorbent. The novel compounds open up a novel advantageous route to optically active 3-hydroxy-.beta.-cyclocitrals, which are desirable because they are important intermediates for carotinoids identical to the natural products.
摘要翻译：其中R 1为“其中R 2和R 3可以相同或不同并且各自是1至6个碳原子的直链或支链烷基”，其中R 1和R 3可以相同或不同，或R 2和R 3一起形成可被甲基或乙基取代的乙烯或亚丙基，其制备方法及其用于制备香草醛和3-羟基-β-环吖庚因的用途以及光学活性的环卟啉衍生物如果X是氢且Y是OH，则其中R1是的通式A和B ，否则其中R2和R3具有上述含义，X和Y一起是氧，或X是氢，如果Y是OH，以及制备光学活性3-氧代-α-环樟脑缩醛的方法，其中将相应的外消旋3-氧代-α-环樟脑缩醛的混合物通过色谱法分离成光学活性化合物合适的手性吸附剂。新型化合物开创了光学活性3-羟基-β-环化合物的新途径，因为它们是与天然产物相同的类胡萝卜素的重要中间体。

6. 发明授权

US4335047A Preparation of cyclic acetals of trans-4-chloro-3-methyl-but-2-en-1-al, and preparation of trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals 失效
标题翻译：制备反式-4-氯-3-甲基丁-2-烯-1-醇的环状缩醛，制备反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛
公开(公告)号：US4335047A
公开(公告)日：1982-06-15
申请号：US138411
申请日：1980-04-08
申请人： Hagen Jaedicke , Joachim Paust
发明人： Hagen Jaedicke , Joachim Paust
IPC分类号： C07D319/06 , C07D319/04
CPC分类号： C07D319/06
摘要： A process for the preparation of 6-membered cyclic acetals of trans-4-chloro-3-methyl-but-2-en-1-al by reacting the corresponding acetals of 3-methyl-but-2-en-1-al (prenal), in a halohydrocarbon, with sulfuryl chloride and for their subsequent oxidation to trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals (3-methyl-fumarodialdehyde-1-monoacetals). The trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals are of great importance in terpene syntheses, since they make it possible to carry out successive Wittig reactions giving a very large number of compounds of biological and pharmacological importance.
摘要翻译：通过使相应的3-甲基 - 丁-2-烯-1-醇的缩醛反应制备反式-4-氯-3-甲基 - 丁-2-烯-1-醇的6元环状缩醛的方法（前体）在卤代烃中与磺酰氯反应，然后氧化成反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛（3-甲基 - 富马酸二醛-1-单缩醛）。反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛在萜烯合成中是非常重要的，因为它们可以进行连续的维蒂希反应，产生非常大量的生物化合物和药理重要性。

7. 发明授权

US4256643A 3-Chloro-3-methyl-butane-1,4-dial-bis-acetals and 3-methyl-but-2-ene-1,4-dial-bis-acetals, a process for the preparation of these compounds and their use 失效
标题翻译： 3-氯-3-甲基 - 丁烷-1,4-二 - 双 - 缩醛和3-甲基 - 丁-2-烯-1,4-二 - 双 - 缩醛，这些化合物的制备方法及其使用
公开(公告)号：US4256643A
公开(公告)日：1981-03-17
申请号：US76412
申请日：1979-09-17
申请人： Hagen Jaedicke , Joachim Paust
发明人： Hagen Jaedicke , Joachim Paust
IPC分类号： C07D319/06 , C07D319/04
CPC分类号： C07D319/06
摘要： 3-Chloro-3-methyl-butane-1,4-dial-bis-acetals and 3-methyl-but-2-ene-1,4-dial-bis-acetals are obtained by reacting a six-membered cyclic acetal of 3-methyl-but-3-en-1-al with an alkyl nitrite in the presence of methanol and hydrogen chloride and, if desired, eliminating HCl in the conventional manner.The butanedial-bis-acetals and butenedial-bis-acetals are valuable intermediates through which the trans-3-methyl-but-2-ene-1,4-dial-1-acetals, which are sought-after products for terpene syntheses, can be obtained in an industrially particularly advantageous manner.
摘要翻译： 3-氯-3-甲基 - 丁烷-1,4-二 - 双 - 缩醛和3-甲基 - 丁-2-烯-1,4-二 - 双 - 缩醛是通过使六元环戊缩醛 3-甲基 - 丁-3-烯-1-醇与亚硝酸烷基酯在甲醇和氯化氢的存在下反应，如果需要，以常规方式除去HCl。丁二醛 - 双缩醛和丁二醛双缩醛是有价值的中间体，通过该中间体，用于萜烯合成的追求产物的反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-缩醛，可以以工业上特别有利的方式获得。

8. 发明授权

US06740774B1 Preparation of N-acylamino acid esters and N-acylamino acetals 失效
标题翻译： N-酰基氨基酸酯和N-酰基氨基缩醛的制备
公开(公告)号：US06740774B1
公开(公告)日：2004-05-25
申请号：US09639681
申请日：2000-08-16
申请人： Joachim Paust , Hansgeorg Ernst , Reinhard Kaczmarek , Hagen Jaedicke
发明人： Joachim Paust , Hansgeorg Ernst , Reinhard Kaczmarek , Hagen Jaedicke
IPC分类号： C07C22900
CPC分类号： C07C231/08 , C07C233/18 , C07C233/47
摘要： A process for preparing N-acyl derivatives of the formula I, in which the substituents independently of one another have the following meanings: X is CH(OR3)2, COOR3; R1 is hydrogen, C1-C12-alkyl, aryl, unsubstituted or substituted; R2 is hydrogen, C1-C12-alkyl, aryl, unsubstituted or substituted; R3 is C1-C12-alkyl, which comprises reacting a carboxamide R1—CONH2 of the formula II with a glyoxal monoacetal derivative of the formula III, in the presence of a carboxylic acid R4—COOH of the formula IV where R4=C1-C12-alkyl, where the substituents R1 to R3 are as defined above, is described.
摘要翻译：制备式I的N-酰基衍生物的方法，其中取代基彼此独立地具有以下含义：X是CH（OR 3）2，COOR 3; R 1是氢，C 1 C 12 - 烷基，芳基，未取代或取代的; R 2是氢，C 1 -C 12 - 烷基，芳基，未取代或取代的; R 3是C 1 -C 12烷基，其包括使羧酰胺R 1， -CONH 2与式III的乙二醛单缩醛衍生物在式IV的羧酸R 4 -COOH的存在下反应，其中R 4 = C 1 -C 12 - 烷基，其中取代基R' 1> -R 3如上所定义。

9. 发明授权

US06348593B1 Process for preparing folic acid 失效
标题翻译：制备叶酸的方法
公开(公告)号：US06348593B1
公开(公告)日：2002-02-19
申请号：US09497151
申请日：2000-02-03
申请人： Jörg Botzem , Hagen Jaedicke , Michael John , Joachim Paust
发明人： Jörg Botzem , Hagen Jaedicke , Michael John , Joachim Paust
IPC分类号： C07D47500
CPC分类号： C07C237/36 , C07C49/175 , C07C251/08 , C07D475/04
摘要： A process for preparing folic acid, which comprises reacting a tetraalkoxypropanol of the general formula I, in which the substituents R are C1-C4-alkyl, with triaminopyrimidone of the formula II and p-aminobenzoyl-L-glutamic acid of the formula III
摘要翻译：一种制备叶酸的方法，其包括将取代基R为C1-C4烷基的通式I的四烷氧基丙醇与式II的三氨基吡啶酮和式III的对氨基苯甲酰基-L-谷氨酸反应

10. 发明授权

US4209450A Introduction of a carbonyl group into a cyclohexene ring 失效
标题翻译：将羰基引入环己烯环
公开(公告)号：US4209450A
公开(公告)日：1980-06-24
申请号：US868272
申请日：1978-01-10
申请人： Hagen Jaedicke , Joachim Paust
发明人： Hagen Jaedicke , Joachim Paust
IPC分类号： C07B61/00 , B01J23/00 , B01J23/16 , C07C20060101 , C07C45/00 , C07C45/30 , C07C49/00 , C07C49/647 , C07C67/00 , C07C401/00 , C07C403/00 , C07C403/02 , C07C403/08 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/24 , C09F5/08 , C11C3/00
CPC分类号： C07C403/02 , C07C403/10 , C07C403/12 , C07C403/14 , C07C403/16 , C07C403/20 , C07C403/24 , C07C2101/16
摘要： A process for introducing an allyl-positioned carbonyl group into a 2,6,6-trimethylcyclohexene ring which carries a polyenyl radical in the 1-position, by oxidizing the ring with a halogen(V)-oxyacid or a salt of such an acid, and the new oxo compounds obtainable by the said process, which may be used as dyes for foodstuffs or cosmetics. The oxidation is carried out in the presence of a catalyst and of an inert diluent or solvent, in an acid medium. Suitable catalysts are bromine and iodine and the oxides of elements of groups Va, VIa, VIIa and VIII of the periodic table.
摘要翻译：通过用卤素（V） - 氧酸或这种酸的盐氧化环，将烯丙基定位的羰基引入到携带1位上的聚烯基的2,6,6-三甲基环己烯环中的方法，以及可以通过所述方法获得的新的氧代化合物，其可以用作食品或化妆品的染料。在催化剂和惰性稀释剂或溶剂的存在下，在酸性介质中进行氧化。合适的催化剂是溴和碘，以及元素周期表Va，VIa，VIIa和VIII族元素的氧化物。

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