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1. 发明授权

US4594456A Racemic and optically active 3-hydroxy-alpha-cyclocitral, its acetals and optically active 3-oxo-alpha-cyclocitral acetals, and their preparation 失效
标题翻译：外消旋和光学活性的3-羟基-α-环卟啉，其缩醛和光学活性的3-氧代-α-环ral缩醛及其制备
公开(公告)号：US4594456A
公开(公告)日：1986-06-10
申请号：US572239
申请日：1984-01-20
申请人： Ulrich Schaefer-Luederssen , Hagen Jaedicke , Joachim Paust , Manfred Eggersdorfer
发明人： Ulrich Schaefer-Luederssen , Hagen Jaedicke , Joachim Paust , Manfred Eggersdorfer
IPC分类号： C07C43/315 , C07C45/28 , C07C45/34 , C07C45/51 , C07C45/59 , C07C45/60 , C07C45/67 , C07C47/267 , C07C47/46 , C07C49/753 , C07C49/757 , C07C51/285 , C07D317/72 , C07D319/08 , C07F11/00
CPC分类号： C07D317/72 , C07C403/16 , C07C43/315 , C07C45/28 , C07C45/34 , C07C45/515 , C07C45/59 , C07C45/60 , C07C45/67 , C07C47/46 , C07C49/753 , C07C49/757 , C07C51/285 , C07D319/08 , C07F11/005
摘要： 3-Hydroxy-.alpha.-cyclocitral derivatives of the general formula I ##STR1## where R.sup.1 is ##STR2## wherein R.sup.2 and R.sup.3 can be identical or different and are each straight-chain or branched alkyl of 1 to 6 carbon atoms, or R.sup.2 and R.sup.3 together form an ethylene or propylene group which can be substituted by methyl or ethyl, processes for their preparation and their use for the preparation of safranal and 3-hydroxy-.beta.-cyclocitral, as well as optically active - cyclocitral derivatives of the general formulae A and B ##STR3## where R.sup.1 is ##STR4## if X is hydrogen and Y is OH, but is otherwise ##STR5## where R.sup.2 and R.sup.3 have the above meanings, and X and Y together are oxygen, or X is hydrogen if Y is OH, and a process for the preparation of optically active 3-oxo-.alpha.-cyclocitral acetals, wherein a mixture of the corresponding racemic 3-oxo-.alpha.-cyclocitral acetals is separated into the optically active compounds by chromatography over a suitable chiral adsorbent. The novel compounds open up a novel advantageous route to optically active 3-hydroxy-.beta.-cyclocitrals, which are desirable because they are important intermediates for carotinoids identical to the natural products.
摘要翻译：其中R 1为“其中R 2和R 3可以相同或不同并且各自是1至6个碳原子的直链或支链烷基”，其中R 1和R 3可以相同或不同，或R 2和R 3一起形成可被甲基或乙基取代的乙烯或亚丙基，其制备方法及其用于制备香草醛和3-羟基-β-环吖庚因的用途以及光学活性的环卟啉衍生物如果X是氢且Y是OH，则其中R1是的通式A和B ，否则其中R2和R3具有上述含义，X和Y一起是氧，或X是氢，如果Y是OH，以及制备光学活性3-氧代-α-环樟脑缩醛的方法，其中将相应的外消旋3-氧代-α-环樟脑缩醛的混合物通过色谱法分离成光学活性化合物合适的手性吸附剂。新型化合物开创了光学活性3-羟基-β-环化合物的新途径，因为它们是与天然产物相同的类胡萝卜素的重要中间体。

2. 发明授权

US4940805A Preparation of 1,4-butanediol or tetrahydrofuran or both 失效
标题翻译： 1,4-丁二醇或四氢呋喃或二者的制备
公开(公告)号：US4940805A
公开(公告)日：1990-07-10
申请号：US230015
申请日：1988-08-08
申请人： Rolf Fischer , Hans-Juergen Gosch , Wolfgang Harder , Klaus-Dieter Malsch , Manfred Eggersdorfer , Lothar Franz , Horst Zimmermann , Karl Brenner , Klaus Halbritter , Wolfgang Sauer , Hans-Juergen Scheiper
发明人： Rolf Fischer , Hans-Juergen Gosch , Wolfgang Harder , Klaus-Dieter Malsch , Manfred Eggersdorfer , Lothar Franz , Horst Zimmermann , Karl Brenner , Klaus Halbritter , Wolfgang Sauer , Hans-Juergen Scheiper
IPC分类号： B01J27/18 , B01J27/19 , C07B61/00 , C07C27/00 , C07C29/136 , C07C29/147 , C07C29/149 , C07C29/17 , C07C29/56 , C07C31/20 , C07C67/00 , C07D307/08
CPC分类号： C07D307/08 , C07C29/177
摘要： Process for the preparation of 1,4-butanediol or tetrahydrofuran or both by the catalytic hydrogenation of maleic anhydride, succinic anhydride, maleic acid, succinic acid, fumaric acid, or the alkyl esters of these acids at temperatures of from 100.degree. C. to 350.degree. C. and pressures of from 50 bar to 350 bar over a catalyst containing cobalt as the active metal and one or both of the elements copper and phosphorus, if necessary in the presence of an aliphatic alcohol.
摘要翻译：通过马来酸酐，琥珀酸酐，马来酸，琥珀酸，富马酸或这些酸的烷基酯的催化氢化制备1,4-丁二醇或四氢呋喃或二者的方法，温度为100℃至 350℃，并且在含有钴作为活性金属的催化剂和一种或两种元素铜和磷的催化剂中，如果需要，在脂族醇的存在下，压力为50巴至350巴。

3. 发明授权

US4707549A Preparation of esters of optically active 2-arylalkanoic acids 失效
标题翻译：光学活性2-芳基链烷酸酯的制备
公开(公告)号：US4707549A
公开(公告)日：1987-11-17
申请号：US697846
申请日：1985-02-04
申请人： Gerhard Fritz , Manfred Eggersdorfer , Hardo Siegel
发明人： Gerhard Fritz , Manfred Eggersdorfer , Hardo Siegel
IPC分类号： C07D333/24 , C07C67/30 , C07C69/612 , C07D213/55 , C07D215/14 , C07C69/76 , C07D241/12
CPC分类号： C07C67/30 , C07C69/612
摘要： Esters of optically active 2-arylalkanoic acids I ##STR1## where Ar is an isocyclic or heterocyclic aryl radical and R.sup.1 and R.sup.2 are each C.sub.1 -C.sub.4 -alkyl, are prepared by subjecting an optically active ester II ##STR2## where X is Cl, Br or --O--SO.sub.2 --Y and Y is Cl or a hydrocarbon radical, to a Friedel-Crafts reaction with an aromatic compound ArH (III).
摘要翻译：光学活性的2-芳基链烷酸I I，其中Ar是环状或杂环的芳基，R 1和R 2各自是C 1 -C 4 - 烷基的酯，是通过使光学活性酯II II，其中X是 Cl，Br或-O-SO 2 -Y，Y是Cl或烃基，与芳族化合物ArH（III）的Friedel-Crafts反应。

4. 发明申请

US20050256178A1 Novel nutraceutical compositions comprising boitin 审中-公开
标题翻译：包含布丁蛋白的新型营养组合物
公开(公告)号：US20050256178A1
公开(公告)日：2005-11-17
申请号：US10525348
申请日：2003-08-18
申请人： Manfred Eggersdorfer , Daniel Raederstorff , Sandra Teixeira , Peter Weber
发明人： Manfred Eggersdorfer , Daniel Raederstorff , Sandra Teixeira , Peter Weber
IPC分类号： A23L2/38 , A21D2/36 , A23C9/13 , A23G3/00 , A23G3/36 , A23G9/32 , A23G9/36 , A23L1/30 , A23L1/302 , A23L2/02 , A23L2/52 , A61K31/045 , A61K31/13 , A61K31/16 , A61K31/20 , A61K31/35 , A61K31/353 , A61K31/381 , A61K31/385 , A61K31/4188 , A61K31/78 , A61K31/785 , A61P3/04 , A61P3/10 , C07D495/04 , A61K31/198
CPC分类号： A23G3/36 , A21D2/36 , A23C9/13 , A23C9/1315 , A23C9/1322 , A23G3/368 , A23G9/366 , A23L2/02 , A23L33/105 , A23L33/12 , A23L33/15 , A23V2002/00 , A61K31/045 , A61K31/13 , A61K31/16 , A61K31/35 , A61K31/385 , A61K31/785 , C07D495/04 , A61K2300/00 , A23V2250/211 , A23V2250/708 , A23V2250/5072 , A23V2250/72 , A23V2250/214
摘要： Nutraceutical compositions comprise biotin in an amount sufficient to administer to a subject a daily dosage of 0.01 mg per kg body weight to about 3 mg per kg body weight and at least one additional component selected from pantethine or a metabolite thereof, EGCG, phytanic acid, lipoic acid and policosanol. The compositions are useful for the treatment of both type 1 and 2 diabetes, and for the prevention of type 2 diabetes in those individuals with pre-diabetes, or impaired glucose tolerance (IGT) or obesity.
摘要翻译：营养组合物包含足以向受试者施用0.01mg / kg体重至约3mg / kg体重的每日剂量的生物素和至少一种选自泛酰胺或其代谢物的另外的组分，EGCG，植烷酸，硫辛酸和乳糖醇。该组合物可用于治疗1型和2型糖尿病以及用于预防糖尿病前期患者或葡萄糖耐量异常（IGT）或肥胖症的2型糖尿病。

5. 发明授权

US5616817A Preparation of 1,2-propanediol 失效
标题翻译： 1,2-丙二醇的制备
公开(公告)号：US5616817A
公开(公告)日：1997-04-01
申请号：US559625
申请日：1995-11-20
申请人： Ludwig Schuster , Manfred Eggersdorfer
发明人： Ludwig Schuster , Manfred Eggersdorfer
IPC分类号： B01J27/199 , C07B61/00 , C07C29/132 , C07C29/60 , C07C31/20
CPC分类号： C07C29/60 , Y02P20/52
摘要： A process for the preparation of 1,2-propanediol by catalytic hydrogenation of glycerol at elevated temperature and elevated pressure, which comprises using glycerol having a water content of up to 20% by weight and a catalyst comprising the metals cobalt, copper, manganese and molybdenum in amounts of, based on the total weight of the catalyst,from 40 to 70% by weight of cobalt,from 10 to 20% by weight of copper,from 0 to 10% by weight of manganese andfrom 0 to 10% by weight of molybdenum,where this catalytically active material may additionally contain inorganic polyacids and/or heteropolyacids in an amount of up to 10% by weight, based on the total weight of the catalyst.
摘要翻译：一种通过在升高的温度和升高的压力下对甘油进行催化氢化制备1,2-丙二醇的方法，其包括使用含水量高达20重量％的甘油和包含金属钴，铜，锰的催化剂和钼，以催化剂的总重量为40-70重量％的钴，10-20重量％的铜，0-10重量％的锰和0-10重量％钼的重量，其中该催化活性材料可以另外包含基于催化剂总重量高达10重量％的无机多酸和/或杂多酸。

6. 发明授权

US4987229A Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate 失效
标题翻译：核黄素5'-磷酸盐，特别是核黄素5'-磷酸一钠的盐的纯化
公开(公告)号：US4987229A
公开(公告)日：1991-01-22
申请号：US323795
申请日：1989-03-15
申请人： Walter Dobler , Manfred Eggersdorfer , Joachim Paust
发明人： Walter Dobler , Manfred Eggersdorfer , Joachim Paust
IPC分类号： C07D475/14 , C07F9/6561
CPC分类号： C07F9/65618
摘要： Salts of riboflavin 5'-phosphate which are obtained by phosphorylation of riboflavin and reaction of the resulting riboflavin 5'-phosphate (5'-FMN), contaminated with unconverted riboflavin and isomeric riboflavin monophosphates and diphosphates, with an alkali metal hydroxide or a nitrogen base are purified by a process in which(a) a roughly 1-15% strength by weight homogeneous, clear, aqueous 5'-FMN salt solution having a pH of from 4 to 7 is prepared from the crude 5'-FMN obtained in the phosphorylation, water and the alkali metal hydroxide or the nitrogen base, preferably sodium hydroxide solution, if necessary with heating at from 30.degree. to 100.degree. C.,(b) the resulting solution is treated with a suitable polymeric adsorber resin and(c) the 5'-FMN salt substantially freed from unconverted riboflavin is isolated from the resulting solution and, if desired, the solution is fed to a subsequent fine purification.Treatment with the suitable polymeric adsorber resin is advantageously carried out in a column filled with adsorber resin. The subsequent fine purification can be effected by evaporative crystallization or by chromatographing a 5'-FMN solution, containing from 1 to 15% by weight of dry substance, in water or in a mixture of water and a lower aliphatic alcohol, having a pH of from 4 to 7, in a minimum amount of from 5 to 50% of the bed volume of the column over RP silica gel derivatized with alkyl groups, using water, or a mixture of water and a lower aliphatic alcohol, as the eluant. Preparative chromatography of 5'-FMN salts over derivatized RP silica gel using water, or a mixture of water and a lower aliphatic alcohol, as the solvent and eluant is also claimed independently of pretreatment with the suitable adsorber resin.
摘要翻译：通过核黄素磷酸化获得的核黄素5'-磷酸盐的盐和由未转化的核黄素和异构核黄素单磷酸酯和二磷酸酯污染的所得核黄素5'-磷酸（5'-FMN）与碱金属氢氧化物或氮碱通过以下方法纯化，其中（a）从所得粗制5'-FMN制备了具有约1-15％重量的均匀，透明的pH5-4的5-FMN盐水溶液，磷酸化，水和碱金属氢氧化物或氮碱，优选氢氧化钠溶液，如果需要，在30℃至100℃下加热，（b）所得溶液用合适的聚合物吸附树脂处理，（c ）从所得溶液中分离出基本上未转化的核黄素的5'-FMN盐，并且如果需要，将溶液加入到随后的精细纯化中。用合适的聚合物吸附树脂处理有利地在填充有吸附树脂的柱中进行。随后的精细纯化可以通过蒸发结晶或通过色谱法将含有1至15重量％干物质的5-FMN溶液在水或水和低级脂族醇的混合物中进行，其pH为作为洗脱剂，使用水或水和低级脂族醇的混合物，用烷基衍生的RP硅胶的柱体积的最小量为5至50％。独立于合适的吸附剂树脂的预处理，也要求使用水，或水和低级脂族醇的混合物作为溶剂和洗脱剂的衍生化RP硅胶的5-FMN盐的制备色谱法。

7. 发明授权

US4895984A Acylation of aromatics 失效
标题翻译：芳烃酰化
公开(公告)号：US4895984A
公开(公告)日：1990-01-23
申请号：US198676
申请日：1988-05-25
申请人： Manfred Eggersdorfer , Hardo Siegel , Alfred Schuhmacher , Walter Grosch , Jochem Henkelmann
发明人： Manfred Eggersdorfer , Hardo Siegel , Alfred Schuhmacher , Walter Grosch , Jochem Henkelmann
IPC分类号： C07B41/06 , B01J31/00 , B01J31/12 , B01J31/14 , C07B31/00 , C07B61/00 , C07C45/00 , C07C45/46 , C07C49/76 , C07C51/083 , C07C51/373 , C07C65/34 , C07C67/00
CPC分类号： C07C51/373 , C07C45/46 , C07C49/76
摘要： Aromatics are acylated by the Friedel-Crafts method by carrying out the acylation in the presence of metalalkyls or metalalkyl halides of metals or semimetals of main groups two to five and/or of metals of subgroups two or four of the Periodic Table.
摘要翻译：芳族化合物通过Friedel-Crafts方法进行酰化，在金属或金属的金属烷基卤化物或主要基团的半金属的两至五个和/或周期表中的2或4族的金属的存在下进行酰化。

8. 发明授权

US4853481A Preparation of alkyl-substituted aromatic ketones 失效
标题翻译：烷基取代的芳族酮的制备
公开(公告)号：US4853481A
公开(公告)日：1989-08-01
申请号：US126868
申请日：1987-11-30
申请人： Jochem Henkelmann , Manfred Eggersdorfer , Walter Grosch , Alfred Schuhmacher , Hardo Siegel
发明人： Jochem Henkelmann , Manfred Eggersdorfer , Walter Grosch , Alfred Schuhmacher , Hardo Siegel
IPC分类号： B01J27/125 , C07B61/00 , C07C45/00 , C07C45/46 , C07C51/00 , C07C51/083 , C07C51/373 , C07C65/34 , C07C67/00
CPC分类号： C07C51/373 , C07C45/46
摘要： Alkyl-substituted aromatic ketones are prepared by reacting alkylbenzenes with carboxylic anhydrides in the presence of a Friedel-Crafts catalyst by performing the reaction in the presence of a tertiary amine or diamine.
摘要翻译：烷基取代的芳族酮通过在Friedel-Crafts催化剂存在下使烷基苯与羧酸酐反应，在叔胺或二胺的存在下进行反应来制备。

9. 发明授权

US4835242A Aryl ether ketones 失效
标题翻译：芳基醚酮
公开(公告)号：US4835242A
公开(公告)日：1989-05-30
申请号：US142798
申请日：1988-01-11
申请人： Manfred Eggersdorfer , Jochem Henkelmann , Gerhard Heinz , Juergen Koch
发明人： Manfred Eggersdorfer , Jochem Henkelmann , Gerhard Heinz , Juergen Koch
IPC分类号： C07C69/16 , C07C45/00 , C07C45/71 , C07C49/84 , C07C67/00 , C07C69/78 , C07C69/96 , C08G65/40
CPC分类号： C08G65/4012 , C07C45/71 , C07C49/84
摘要： Aryl ether ketones of the general formula I ##STR1## where n is from 0 to 5,X is ##STR2## and Y is tert-butyl, acetyl, benzyl, benzoyl, tert-butoxycarbonyl or, in the case of n=0, H,and the ring-substituted C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, aryl, chlorine or fluorine derivatives thereof are useful for preparing highly heat-resistant polyaryl ether ketones.
摘要翻译：乙酰基，苄基，苯甲酰基，叔丁氧基羰基，或者其中n为0至5的芳基醚酮，其中n为0至5，X为“ n = 0的情况，H和环取代的C 1 -C 8烷基，C 1 -C 8 - 烷氧基，芳基，氯或氟衍生物可用于制备高耐热性聚芳醚酮。

10. 发明授权

US4820882A Preparation of beta-aryl alcohols 失效
标题翻译： β-芳基醇的制备
公开(公告)号：US4820882A
公开(公告)日：1989-04-11
申请号：US144169
申请日：1988-01-15
申请人： Heinz Eckhardt , Manfred Eggersdorfer
发明人： Heinz Eckhardt , Manfred Eggersdorfer
IPC分类号： B01J31/26 , B01J31/00 , C07B61/00 , C07C27/00 , C07C29/132 , C07C29/36 , C07C33/18 , C07C33/20 , C07C33/34 , C07C67/00 , C07C31/135 , C07C33/22
CPC分类号： C07C29/36 , C07C33/20 , C07C33/34 , C07C2102/08
摘要： .beta.-Aryl alcohols for the general forumla I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, aryl, C.sub.7 -C.sub.12 -aralkyl or C.sub.7 -C.sub.12 -alkaryl, n is 0, 1, 2, 3 or 4, or where two adjacent R.sup.1 's are linked to form a 5- or 6-membered ring, are prepared by reacting an aromatic of the formula II ##STR2## with an alkylene oxide of the formula III ##STR3## where R.sup.1, R.sup.2 and R.sup.3 have the abovementioned meanings, in the presence of a Friedel-Crafts catalyst, by carrying out the reaction in the presence of a titanium(IV) alcoholate at from -20.degree. to +40.degree. C. in the presence or absence of a solvent.
摘要翻译：其中R 1，R 2和R 3相同或不同并且各自为氢，C 1 -C 20 - 烷基，C 5 -C 7 - 环烷基，芳基，C 7 -C 12 - 芳烷基或C 7 -C 12 - 芳烷基， C 12 - 烷芳基，n为0,1,2,3或4，或其中两个相邻的R 1连接以形成5-或6-元环的化合物通过使式II II的芳族化合物与在Friedel-Crafts催化剂存在下，通过在-20℃的钛（IV）醇存在下进行反应，式III的烯化氧，其中R 1，R 2和R 3具有上述含义，在存在或不存在溶剂的情况下，温度至+ 40℃。

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