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1. 发明授权

US07932098B2 Microfluidic system utilizing thin-film layers to route fluid 有权
标题翻译：微流体系统利用薄膜层来引导流体
公开(公告)号：US07932098B2
公开(公告)日：2011-04-26
申请号：US10286314
申请日：2002-10-31
申请人： Winthrop D. Childers , Paul Crivelli , David Tyvoll , James A. Feinn , Douglas A. Sexton
发明人： Winthrop D. Childers , Paul Crivelli , David Tyvoll , James A. Feinn , Douglas A. Sexton
IPC分类号： G01N27/26 , G01N1/10
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/10 , B01L2200/12 , B01L2200/14 , B01L2300/02 , B01L2300/0645 , B01L2300/0887 , B01L2300/1827 , B01L2400/0415 , G01N1/28 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575 , Y10T436/25875
摘要： Systems, including apparatus and methods, for microfluidic processing and/or analysis of samples. The systems include a microfluidic device having a substrate and a thin-film layer formed on the substrate. The thin-film layer may be included in electronics formed on the substrate. The electronics may provide electronic devices configured to sense or modify a property of the sample. The thin-film layer defines an opening for routing movement of fluid and/or sample within the device.
摘要翻译：用于微流体处理和/或样品分析的系统，包括装置和方法。该系统包括具有衬底和形成在衬底上的薄膜层的微流体器件。薄膜层可以包含在基板上形成的电子元件中。电子设备可以提供被配置为感测或修改样品的性质的电子设备。薄膜层限定用于在装置内引导流体和/或样品的运动的开口。

2. 发明授权

US07741123B2 Microfluidic device with thin-film electronic devices 失效
标题翻译：具有薄膜电子器件的微流控器件
公开(公告)号：US07741123B2
公开(公告)日：2010-06-22
申请号：US12069628
申请日：2008-02-11
申请人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： G01N21/75 , B01J14/00
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
摘要翻译：用于分析样品的微流体装置。微流体装置包括至少部分地限定用于接收样品的室的基底部分。基板部分包括具有表面的基板。衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。薄膜层形成多个电子装置。至少两个电子设备中的每一个由不同的薄膜层组形成。

3. 发明申请

US20080164155A1 Microfluidic device with thin-film electronic devices 失效
标题翻译：具有薄膜电子器件的微流控器件
公开(公告)号：US20080164155A1
公开(公告)日：2008-07-10
申请号：US12069628
申请日：2008-02-11
申请人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： G01N27/26
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
摘要翻译：用于分析样品的微流体装置。微流体装置包括至少部分地限定用于接收样品的室的基底部分。基板部分包括具有表面的基板。衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。薄膜层形成多个电子装置。至少两个电子设备中的每一个由不同的薄膜层组形成。

4. 发明授权

US07338637B2 Microfluidic device with thin-film electronic devices 有权
标题翻译：具有薄膜电子器件的微流控器件
公开(公告)号：US07338637B2
公开(公告)日：2008-03-04
申请号：US10355397
申请日：2003-01-31
申请人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12 , G01N15/06
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers. The at least two electronic devices may include 1) a temperature control device for controlling the temperature of fluid in the chamber, and 2) an other electronic device configured to sense or modify a property of fluid in the chamber.
摘要翻译：用于分析样品的微流体装置。微流体装置包括至少部分地限定用于接收样品的室的基底部分。基板部分包括具有表面的基板。衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。薄膜层形成多个电子装置。至少两个电子设备中的每一个由不同的薄膜层组形成。所述至少两个电子设备可以包括：1）用于控制所述腔室中的流体的温度的温度控制装置，以及2）构造成感测或改变所述腔室中的流体性质的另一电子装置。

5. 发明授权

US08056556B2 Inhaler nozzle maintenance apparatus and method 有权
标题翻译：吸入嘴维修装置及方法
公开(公告)号：US08056556B2
公开(公告)日：2011-11-15
申请号：US10823475
申请日：2004-04-12
申请人： Winthrop D. Childers , Douglas A. Sexton , David Tyvoll
发明人： Winthrop D. Childers , Douglas A. Sexton , David Tyvoll
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , F16K31/02 , B05B1/08 , B05B17/04 , G01D15/16 , G01D15/02
CPC分类号： A61M15/025 , A61M11/001 , A61M15/0003 , A61M15/0065 , A61M2205/70
摘要： A medication dispenser includes a thermal drop generator ejector head. Medication is maintained in a pressurized container connected to a valve under the control of control electronics and to a compliant chamber. Fluid flows from the container to the chamber and to the ejector head. In a first mode the dispenser is operable to dispense aerosolized medication. In a second mode the ejector head is purged with fluid from the container to maintain the ejector head.
摘要翻译：药物分配器包括热滴发生器喷射头。在控制电子装置的控制下，将药物保持在连接到阀的加压容器中并且与顺应室相连。流体从容器流到腔室和喷射头。在第一模式中，分配器可操作以分配雾化药物。在第二模式中，喷射头用来自容器的流体吹扫以保持喷射头。

6. 发明授权

US07380550B2 Systems and methods for particle detection 有权
标题翻译：粒子检测系统和方法
公开(公告)号：US07380550B2
公开(公告)日：2008-06-03
申请号：US10768865
申请日：2004-01-30
申请人： Douglas A. Sexton , Winthrop D. Childers
发明人： Douglas A. Sexton , Winthrop D. Childers
IPC分类号： A61M11/00
CPC分类号： A61M15/0065 , A61M15/0013 , A61M15/0018 , A61M15/0085 , A61M15/0091 , A61M15/0093 , A61M15/0095 , A61M15/025 , A61M2016/0024 , A61M2205/331
摘要： An inhalation system is disclosed that, in an exemplary embodiment, includes an ejector that ejects medicated droplets during an activation event, a conduit fluidically coupled to the ejector and configured to transport the droplets to a patient during an in-breath, and a particle detection system configured to determine whether the droplets have properly passed through the conduit and to the patient during an activation event. Also disclosed are methods for detecting particles in an inhaler system, with an exemplary method including generating a dose of medicament particles from an inhaler system; detecting particles emitted in the inhaler system; and determining if a desired particle flux has been achieved for inhalation by a patient.
摘要翻译：公开了一种吸入系统，在示例性实施例中，包括在激活事件期间喷射药液液滴的喷射器，流体耦合到喷射器的导管，并配置成在呼吸过程中将液滴输送到患者，以及颗粒检测系统被配置为确定在激活事件期间液滴是否已经适当地通过导管和患者。还公开了用于检测吸入器系统中的颗粒的方法，其示例性方法包括从吸入器系统产生剂量的药物颗粒; 检测在吸入器系统中发射的颗粒; 以及确定是否已经实现了患者吸入所需的颗粒通量。

7. 发明授权

US06921156B2 Large thermal ink jet nozzle array printhead 有权
标题翻译：大型热喷墨喷嘴阵列打印头
公开(公告)号：US06921156B2
公开(公告)日：2005-07-26
申请号：US10439403
申请日：2003-05-16
申请人： Winthrop D. Childers , Douglas A. Sexton
发明人： Winthrop D. Childers , Douglas A. Sexton
IPC分类号： B41J2/05 , B41J2/14
CPC分类号： B41J2/04546 , B41J2/0458 , B41J2/14072 , B41J2/14129
摘要： The present invention includes as one embodiment a printhead including a flat panel substrate made of a non-crystalline material, an array of inkjet drop generators formed onto the flat panel substrate to define an inkjet printhead and thin film transistors formed on the flat panel substrate that are electrically coupled to the array of ink jet drop generators.
摘要翻译：本发明包括作为一个实施例的打印头，其包括由非结晶材料制成的平板基板，形成在平板基板上的喷墨墨滴发生器阵列，以限定形成在平板基板上的喷墨打印头和薄膜晶体管，电耦合到喷墨滴发生器阵列。

8. 发明授权

US06582062B1 Large thermal ink jet nozzle array printhead 有权
公开(公告)号：US06582062B1
公开(公告)日：2003-06-24
申请号：US09420141
申请日：1999-10-18
申请人： Winthrop D. Childers , Douglas A. Sexton
发明人： Winthrop D. Childers , Douglas A. Sexton
IPC分类号： B41J205
CPC分类号： B41J2/04546 , B41J2/0458 , B41J2/14072 , B41J2/14129
摘要： This present invention is embodied in a large array printhead having a large array of thin-film ink drop generators formed on a single monolithic substrate. The large array printhead includes a multiplexing device to reduce parasitic resistance and the number of incoming leads. In a preferred embodiment, the substrate is initially patterned and etched and the multiplexing device is attached to the substrate at a later time. The present invention also includes methods of fabricating a plurality of large array printhead embodiments using a single monolithic substrate made of a suitable material, preferably having a low coefficient of thermal expansion.

9. 发明授权

US07827983B2 Method for making a pharmaceutically active ingredient abuse-prevention device 失效
标题翻译：制备药物活性成分滥用预防装置的方法
公开(公告)号：US07827983B2
公开(公告)日：2010-11-09
申请号：US11017347
申请日：2004-12-20
申请人： Douglas A. Sexton , Winthrop D. Childers
发明人： Douglas A. Sexton , Winthrop D. Childers
IPC分类号： A61M11/00 , F16K31/02 , A62B9/00
CPC分类号： A61M15/00 , A61M15/025
摘要： A method of making a pharmaceutically active ingredient abuse-prevention device includes providing a pharmaceutically active ingredient and providing an antagonist of the pharmaceutically active ingredient. The antagonist is in selective fluid communication with the pharmaceutically active ingredient. Electronic circuitry is configured to selectively operate the fluid communication between the antagonist and the pharmaceutically active ingredient so as to mix the pharmaceutically active ingredient with the antagonist upon recognition of one or more predetermined fault conditions. Mixing the pharmaceutically active ingredient with the antagonist renders the pharmaceutically active ingredient substantially ineffective.
摘要翻译：制备药物活性成分滥用预防装置的方法包括提供药物活性成分并提供药学活性成分的拮抗剂。拮抗剂与药物活性成分选择性流体连通。电子电路被配置为选择性地操作拮抗剂和药物活性成分之间的流体连通，以便在识别一个或多个预定的故障条件时将药学活性成分与拮抗剂混合。将药物活性成分与拮抗剂混合使药物活性成分基本上无效。

10. 发明授权

US07819115B2 Inhalers and methods of controlling airflow in inhalers 失效
标题翻译：吸入器吸入器和控制气流的方法
公开(公告)号：US07819115B2
公开(公告)日：2010-10-26
申请号：US10768424
申请日：2004-01-30
申请人： Douglas A. Sexton , Winthrop D. Childers
发明人： Douglas A. Sexton , Winthrop D. Childers
IPC分类号： A61M11/00
CPC分类号： A61M15/0065 , A61M15/0013 , A61M15/0018 , A61M15/0085 , A61M15/0091 , A61M15/0095 , A61M15/025 , A61M2016/0024 , A61M2205/331
摘要： Inhaler systems and method of use thereof are disclosed. One exemplary inhaler system, among others, includes an inhalation/exhalation structure including an inhalation/exhalation orifice. In addition, the inhaler system includes a medicament supply system having a medicament ejector disposed adjacent the inhalation/exhalation orifice. The medicament supply system controllably ejects medicament droplets from the medicament ejector. Further, the inhaler system includes a flow control system in fluidic communication with the medicament ejector. The flow control system is configured to entrain the medicament droplets and pass the medicament droplets to the inhalation/exhalation orifice when the patient applies an in-breath to the inhalation/exhalation structure. In addition, the flow control system is configured to impede a flow of air from the inhalation/exhalation orifice to the medicament ejector when the patient applies an out-breath into the inhalation/exhalation structure.
摘要翻译：公开了吸入器系统及其使用方法。一个示例性的吸入器系统，其中包括吸入/呼出结构，其包括吸入/呼出孔。此外，吸入器系统包括药物供应系统，其具有邻近吸入/呼出孔设置的药物喷射器。药物供应系统可控制地从药物喷射器喷射药液。此外，吸入器系统包括与药物喷射器流体连通的流量控制系统。流量控制系统构造成当患者对吸入/呼气结构进行呼吸时，夹带药物液滴并将药物液滴传递到吸入/呼出孔。此外，流量控制系统构造成当患者将吸入/呼出结构中的呼吸呼吸时阻止空气从吸入/呼出孔流到药剂喷射器。

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