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1. 发明申请

US20090317458A1 Fluid-jet pens configured for making modulated release bioactive agents 有权
标题翻译：配置用于制备调制释放生物活性剂的流体喷枪
公开(公告)号：US20090317458A1
公开(公告)日：2009-12-24
申请号：US12551134
申请日：2009-08-31
申请人： JOHN STEPHEN DUNFIELD , JAMES W. AYRES
发明人： JOHN STEPHEN DUNFIELD , JAMES W. AYRES
IPC分类号： A61K9/127
CPC分类号： A61K9/10 , A61K9/1075 , A61K9/113 , A61K9/1277
摘要： The present invention is drawn to methods of preparing a bioactive agent-containing emulsion for delivery to a biological system. This method can comprise the step of jetting a bioactive agent and a first fluid medium from a fluid-jet pen into a second fluid medium to form a bioactive agent-containing emulsion, wherein the second fluid comprises a continuous phase of the emulsion. Alternatively, a method of preparing a bioactive agent-containing liposome can comprise jetting a lipid-containing composition and a bioactive agent from a fluid-jet pen into a medium to form a bioactive agent-containing liposome carried by the medium. The present invention is also drawn to fluid-jet pens and systems configured for making liposome- and emulsion-containing biological agents.
摘要翻译：本发明涉及制备用于递送至生物系统的含生物活性剂的乳液的方法。该方法可以包括将生物活性剂和第一流体介质从流体喷射笔喷射到第二流体介质中以形成含生物活性剂的乳液的步骤，其中第二流体包含乳液的连续相。或者，制备含生物活性剂的脂质体的方法可以包括将来自流体喷射笔的含脂质组合物和生物活性剂喷射到培养基中以形成由培养基携带的含生物活性剂的脂质体。本发明还涉及配置用于制备含脂质体和乳液的生物制剂的流体喷射笔和系统。

2. 发明授权

US06328405B1 Printhead comprising multiple types of drop generators 失效
标题翻译：打印头包括多种类型的液滴发生器
公开(公告)号：US06328405B1
公开(公告)日：2001-12-11
申请号：US09539298
申请日：2000-03-30
申请人： Timothy L. Weber , John Stephen Dunfield
发明人： Timothy L. Weber , John Stephen Dunfield
IPC分类号： B41J2205
CPC分类号： B41J2/2103 , B41J2/14 , B41J2002/14475
摘要： A printhead includes at least a first drop generator set and at least a second drop generator set. The first drop generator set includes a first type of drop generator, whereas the other drop generator sets include a second type of drop generator. The first and second types of drop generators are primarily different with regard to the drop weights they are capable of providing. Preferably, the first type of drop generator comprises a multi-nozzle configuration, whereas the second type comprises single nozzle configurations. In one embodiment, a first type of ink is ejected by the first type of drop generators and a second type of ink is ejected by the second type of drop generators. To prevent unwanted mixing of the black and color inks, a first orifice or nozzle layer is provided separate and apart from a second orifice layer. In this manner, a single printhead may be used for the delivery of both black and color inks.
摘要翻译：打印头至少包括第一液滴发生器组和至少第二液滴发生器组。第一液滴发生器组包括第一种液滴发生器，而其它液滴发生器组包括第二种液滴发生器。关于它们能够提供的落锤重量，第一和第二类型的液滴发生器主要是不同的。优选地，第一类型的液滴发生器包括多喷嘴构造，而第二类型包括单喷嘴构造。在一个实施例中，第一类型的墨水由第一类型的液滴发生器喷射，并且第二类型的墨水被第二类型的液滴发生器喷射。为了防止黑色和彩色墨水的不希望的混合，第一孔或喷嘴层与第二孔层分开设置并分开设置。以这种方式，单个打印头可用于输送黑色和彩色墨水。

3. 发明授权

US07141386B2 Cell culture device 失效
标题翻译：细胞培养装置
公开(公告)号：US07141386B2
公开(公告)日：2006-11-28
申请号：US10285800
申请日：2002-10-31
申请人： John Stephen Dunfield , Ronni J. Yenchik
发明人： John Stephen Dunfield , Ronni J. Yenchik
IPC分类号： C12Q1/24
CPC分类号： C12M29/06
摘要： A culture device for cellular media including a biomedia growth chamber defining a closed environment and an electronically controllable jetting device in communication with a source of material supporting biological function. The jetting device emits the material into the biomedia growth chamber.
摘要翻译：一种用于细胞培养基的培养装置，包括限定封闭环境的生物培养基生长室和与支持生物功能的材料源连通的电子可控喷射装置。喷射装置将材料发射到生物培养基生长室中。

4. 发明授权

US06946362B2 Method and apparatus for forming high surface area material films and membranes 失效
标题翻译：用于形成高表面积材料膜和膜的方法和装置
公开(公告)号：US06946362B2
公开(公告)日：2005-09-20
申请号：US10236429
申请日：2002-09-06
申请人： Makarand P. Gore , John Stephen Dunfield
发明人： Makarand P. Gore , John Stephen Dunfield
IPC分类号： H01M4/90 , B29C33/38 , B29C33/56 , C23C14/00 , C25D1/10 , H01M4/04 , H01M4/86 , H01M4/88 , H01L21/30 , H01L21/46
CPC分类号： H01M4/8605 , B29C33/38 , B29C33/56 , C23C14/0005 , C25D1/10 , H01M4/0407 , H01M4/044 , H01M4/881 , Y10T428/24612
摘要： The present invention discloses a method and apparatus for producing high surface area material films and membranes on substrates. In one application, patterns of spikes or bristles are produced on wafers and transferred to films, such as conductive polymer or metal films, by using repetitive and inexpensive processes, such as electroplating and embossing. Such a technique provides low cost, high surface area materials and allows reuse of expensive patterned silicon. Membranes with high surface area are extremely valuable in fuel cells since the power density is generally proportional to the surface area and the patterns may be used to cast inexpensive fuel cell electrodes.
摘要翻译：本发明公开了一种在基板上制造高表面积材料膜和膜的方法和装置。在一个应用中，通过使用诸如电镀和压花的重复和便宜的工艺，在晶片上产生尖峰或刷毛的图案并转移到诸如导电聚合物或金属膜的膜。这种技术提供低成本，高表面积的材料并允许重新使用昂贵的图案化硅。具有高表面积的膜在燃料电池中是非常有价值的，因为功率密度通常与表面积成比例，并且图案可用于铸造便宜的燃料电池电极。

5. 发明授权

US06607415B2 Method for fabricating tiny field emitter tips 有权
公开(公告)号：US06607415B2
公开(公告)日：2003-08-19
申请号：US09880158
申请日：2001-06-12
申请人： John Stephen Dunfield , Donald J. Milligan , Paul H. McClelland
发明人： John Stephen Dunfield , Donald J. Milligan , Paul H. McClelland
IPC分类号： H01J1304
CPC分类号： H01J9/025 , Y10S977/731 , Y10S977/888
摘要： A method for fabricating tiny field emitter tips across the surface of a substrate. A substrate is first exposed to reactive molecular, ionic, or free radical species to produce nanoclusters within a thin surface layer of the substrate. The substrate may then be thermally annealed to produce regularly sized and interspaced nanoclusters. Finally, the substrate is etched to produce the field emitter tips.

6. 发明授权

US06903284B2 Timed switch control for electric devices 失效
标题翻译：定时开关控制电器
公开(公告)号：US06903284B2
公开(公告)日：2005-06-07
申请号：US10630996
申请日：2003-07-30
申请人： Linda Williams Dunfield , John Stephen Dunfield
发明人： Linda Williams Dunfield , John Stephen Dunfield
IPC分类号： G04G15/00 , H01R24/00
CPC分类号： G04G15/003 , Y10T307/951
摘要： A power switch control unit for controlling the operation of a controlled electric device connected to the unit includes a housing having a timing mechanism therein; a power cord having a plug on one end thereof, for connection to a power supply, and having the housing on the other end thereof, for supplying electrical power to the unit and to a connected-electric device controlled by the power switch control unit, and a receptacle for receiving a power cord from an electric device to be controlled by the power switch control unit; control buttons, including: an on/off button for connecting a controlled electric device to the power supply; a timer activation button for activating the timing mechanism, wherein, when the timing mechanism is activated, it connects a controlled electric device to the power supply for a predetermined amount of time in a timed cycle, and then disconnects the connected-electric device from the power supply; and a clear timer button for terminating the predetermined amount of time, and a display for displaying time remaining in the predetermined period of time.
摘要翻译：用于控制连接到该单元的受控电气设备的操作的电源开关控制单元包括其中具有定时机构的壳体; 电源线，其一端具有插头，用于与电源连接，并且在其另一端具有壳体，用于向该单元供电，以及由电源开关控制单元控制的连接电气设备，以及用于从电气设备接收电力线以由电源开关控制单元控制的插座; 控制按钮，包括：用于将受控电气设备连接到电源的开/关按钮; 用于启动定时机构的定时器启动按钮，其中，当定时机构被激活时，它以定时循环将受控电气设备连接到电源一段预定时间量，然后将连接的电气设备从电源; 以及用于终止预定时间量的清除定时器按钮，以及用于显示在预定时间段内剩余的时间的显示。

7. 发明授权

US07578951B2 Method of making microcapsules utilizing a fluid ejector 有权
标题翻译：利用流体喷射器制造微胶囊的方法
公开(公告)号：US07578951B2
公开(公告)日：2009-08-25
申请号：US10765402
申请日：2004-01-27
申请人： John Stephen Dunfield , James W. Ayres
发明人： John Stephen Dunfield , James W. Ayres
IPC分类号： B01J13/02 , B01J13/04 , A61K9/50 , B41J2/04
CPC分类号： B01J13/04 , B01J13/10 , B01J13/16 , Y10T428/2984
摘要： A method of making microcapsules including activating a fluid ejector at a frequency greater than 10 kilohertz where each activation of the fluid ejector generates essentially a drop, and the fluid ejector is fluidically coupled to a first fluid including a core component. The method further includes ejecting the drop of the first fluid into a second fluid, the drop having a volume. In addition, the method includes generating a microcapsule, that includes the core component, in the second fluid for each drop of the first fluid ejected.
摘要翻译：一种制造微胶囊的方法，包括以大于10千赫兹的频率活化流体喷射器，其中流体喷射器的每次激活基本上产生一滴，并且流体喷射器流体耦合到包括核心部件的第一流体。该方法还包括将第一流体的液滴喷射到第二流体中，该液滴具有一个体积。此外，该方法包括在喷射的第一流体的每一滴的第二流体中产生包括核心部件的微胶囊。

8. 发明申请

US20080164155A1 Microfluidic device with thin-film electronic devices 失效
标题翻译：具有薄膜电子器件的微流控器件
公开(公告)号：US20080164155A1
公开(公告)日：2008-07-10
申请号：US12069628
申请日：2008-02-11
申请人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L. Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： G01N27/26
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers.
摘要翻译：用于分析样品的微流体装置。微流体装置包括至少部分地限定用于接收样品的室的基底部分。基板部分包括具有表面的基板。衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。薄膜层形成多个电子装置。至少两个电子设备中的每一个由不同的薄膜层组形成。

9. 发明授权

US07338637B2 Microfluidic device with thin-film electronic devices 有权
标题翻译：具有薄膜电子器件的微流控器件
公开(公告)号：US07338637B2
公开(公告)日：2008-03-04
申请号：US10355397
申请日：2003-01-31
申请人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
发明人： Grant Pease , Adam L Ghozeil , John Stephen Dunfield , Winthrop D. Childers , David Tyvoll , Douglas A. Sexton , Paul Crivelli
IPC分类号： B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12 , G01N15/06
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0816 , B01L2300/0874 , B01L2300/1827 , B01L2300/1883 , B01L2400/0415 , Y10T436/11 , Y10T436/2575
摘要： A microfluidic device for analysis of a sample. The microfluidic device includes a substrate portion that at least partially defines a chamber for receiving the sample. The substrate portion includes a substrate having a surface. The substrate portion also includes a plurality of thin-film layers formed on the substrate adjacent the surface. The thin-film layers form a plurality of electronic devices. Each of at least two of the electronic devices is formed by a different set of the thin-film layers. The at least two electronic devices may include 1) a temperature control device for controlling the temperature of fluid in the chamber, and 2) an other electronic device configured to sense or modify a property of fluid in the chamber.
摘要翻译：用于分析样品的微流体装置。微流体装置包括至少部分地限定用于接收样品的室的基底部分。基板部分包括具有表面的基板。衬底部分还包括在邻近表面的衬底上形成的多个薄膜层。薄膜层形成多个电子装置。至少两个电子设备中的每一个由不同的薄膜层组形成。所述至少两个电子设备可以包括：1）用于控制所述腔室中的流体的温度的温度控制装置，以及2）构造成感测或改变所述腔室中的流体性质的另一电子装置。

10. 发明授权

US07132242B2 Method and device for targeted delivery of materials to selected single cells 有权
标题翻译：用于将材料靶向递送到选定的单个细胞的方法和装置
公开(公告)号：US07132242B2
公开(公告)日：2006-11-07
申请号：US10704993
申请日：2003-11-10
申请人： Paul H. McClelland , John Stephen Dunfield , Rosalyn H. Upson , Frank Chaplen
发明人： Paul H. McClelland , John Stephen Dunfield , Rosalyn H. Upson , Frank Chaplen
IPC分类号： C12Q1/68
CPC分类号： C12M35/00 , C12M41/48
摘要： A method and device for delivering a quantity of at least one material to a selected single cell in a manner that permits impingement of material with the cell. The material travels at a suitable trajectory and velocity and is ejected from an electronically controllable fluid device.
摘要翻译：一种用于以允许与电池冲击材料的方式将一定量的至少一种材料输送到所选择的单电池的方法和装置。材料以合适的轨迹和速度行进并从电子可控流体装置喷出。

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