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1. 发明申请

US20080206293A1 Absorbent substrate with a non-leaching antimicrobial activity and a controlled-release bioactive agent. 审中-公开
标题翻译：具有非浸出抗菌活性的吸收性底物和受控释放的生物活性剂。
公开(公告)号：US20080206293A1
公开(公告)日：2008-08-28
申请号：US12036107
申请日：2008-02-22
申请人： William Toreki , Bernd Liesenfeld , David Moore , Gregory Schultz , Gerald Olderman , Gregory Staab
发明人： William Toreki , Bernd Liesenfeld , David Moore , Gregory Schultz , Gerald Olderman , Gregory Staab
IPC分类号： A61K9/00 , A61F13/00 , A61K31/65 , A61K38/18 , A01N25/08 , A01P1/00 , A61P31/04 , A61K38/02 , A01N25/00 , A61K31/165 , A61K31/14
CPC分类号： A61L15/44 , A61L15/46
摘要： This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such as doxycycline. The Wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents as well as bioactive agents. More generally, this invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymeric molecules and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.
摘要翻译：本发明涉及具有非浸出抗微生物活性的抗微生物伤口敷料，可释放的抗微生物剂和抗蛋白酶试剂，以及控释释放生物活性剂如多西环素。伤口敷料材料是吸收剂并用作抗微生物剂和抗蛋白酶剂以及生物活性剂的底物。更一般来说，本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。将涂层施加到诸如纱布式伤口敷料，粉末和其它底物的基底上。在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。在多长度聚合物分子上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效能的吸收剂或超吸收剂表面。根据本发明使用具有多个阴离子或阳离子位点的非浸出涂层的使用以结合多个带相反电荷的生物或化学活性化合物，并通过一个或多个阴离子或化学活性化合物从所述底物上释放结合的带相反电荷的生物或化学活性化合物一段时间以达到预期的目标，如改善伤口愈合以减少体臭。

2. 发明申请

US20060194072A1 Antifungal gypsum board 失效
公开(公告)号：US20060194072A1
公开(公告)日：2006-08-31
申请号：US10546850
申请日：2004-02-25
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： B32B13/08 , B05D3/02 , B05D1/02
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel improved gypsum board having improved antifungal properties is disclosed. The board comprises a gypsum core, front and back paper facings and a polymeric antifungal agent effective at inhibiting fungal growth. A preferred polymeric antifungal agent is polyDADMAC or polyTMMC. In addition to the polymeric antifungal agent, a non-polymeric antifungal agent, such as cetyl pyridinium chloride, sodium or zinc pyrithione, or both, may be included. The polymeric antifungal agent can be present in the gypsum core and/or on one or both of the paper facings. In addition, the antifungal agent may be encapsulated in a material or ionically associated with the polymeric antifungal agent, that releases the antifungal agent over time and/or upon exposure to moisture. Also disclosed are methods for preparing the aforementioned improved antifungal gypsum board.

3. 发明申请

US20100311865A1 Gypsum Board Containing Antimicrobial And Antibacterial Compounds 失效
标题翻译：含有抗菌和抗菌化合物的石膏板
公开(公告)号：US20100311865A1
公开(公告)日：2010-12-09
申请号：US12845979
申请日：2010-07-29
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： C09D5/00
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel gypsum board having improved antimicrobial and antibacterial properties is disclosed. The board comprises a gypsum core, front and back paper facings, and a polymeric antimicrobial or antibacterial compound effective at inhibiting fungal growth. Preferred polymeric antimicrobial and antibacterial compounds include polyDADMAC, polyTMMC, and quaternized polyvinyl pyridine derivatives. The novel gypsum board further comprises a non-polymeric antimicrobial or antibacterial compound. Preferred non-polymeric antimicrobial or antibacteral compounds include cetyl pyridinium chloride and sodium pyrithione. The polymeric antimicrobial or antibacterial compound can be present in the gypsum core and/or on one or both of the paper facings. The non-polymeric antimicrobial or antibacterial compound may be encapsulated in a material or ionically associated with the polymeric antimicrobial or antibacterial compound to allow releases of the non-polymeric antimicrobial or antibacterial compound over time and/or upon exposure to moisture. Methods for preparing the aforementioned novel gypsum board are also disclosed.
摘要翻译：公开了具有改进的抗菌和抗菌性能的新型石膏板。该板包括石膏芯，正面和背面纸面，以及有效抑制真菌生长的聚合抗微生物或抗菌化合物。优选的聚合抗微生物和抗菌化合物包括polyDADMAC，polyTMMC和季铵化的聚乙烯吡啶衍生物。新型石膏板还包含非聚合抗微生物或抗菌化合物。优选的非聚合抗微生物或抗菌化合物包括氯化十六烷基吡啶鎓和吡啶硫酮钠。聚合物抗微生物或抗菌化合物可以存在于石膏芯中和/或在一个或两个纸面上。非聚合物抗微生物剂或抗菌化合物可以被包封在与聚合物抗微生物或抗菌化合物的离子缔合物质中，以允许随着时间和/或暴露于水分而释放非聚合物抗微生物剂或抗菌化合物。还公开了制备上述新型石膏板的方法。

4. 发明授权

US08007921B2 Gypsum board containing antimicrobial and antibacterial compounds 失效
标题翻译：石膏板含有抗菌和抗菌化合物
公开(公告)号：US08007921B2
公开(公告)日：2011-08-30
申请号：US12845979
申请日：2010-07-29
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： B32B23/04
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel gypsum board having improved antimicrobial and antibacterial properties is disclosed. The board comprises a gypsum core, front and back paper facings, and a polymeric antimicrobial or antibacterial compound effective at inhibiting fungal growth. Preferred polymeric antimicrobial and antibacterial compounds include polyDADMAC, polyTMMC, and quaternized polyvinyl pyridine derivatives. The novel gypsum board further comprises a non-polymeric antimicrobial or antibacterial compound. Preferred non-polymeric antimicrobial or antibacteral compounds include cetyl pyridinium chloride and sodium pyrithione. The polymeric antimicrobial or antibacterial compound can be present in the gypsum core and/or on one or both of the paper facings. The non-polymeric antimicrobial or antibacterial compound may be encapsulated in a material or ionically associated with the polymeric antimicrobial or antibacterial compound to allow releases of the non-polymeric antimicrobial or antibacterial compound over time and/or upon exposure to moisture. Methods for preparing the aforementioned novel gypsum board are also disclosed.
摘要翻译：公开了具有改进的抗菌和抗菌性能的新型石膏板。该板包括石膏芯，正面和背面纸面，以及有效抑制真菌生长的聚合抗微生物或抗菌化合物。优选的聚合抗微生物和抗菌化合物包括polyDADMAC，polyTMMC和季铵化的聚乙烯吡啶衍生物。新型石膏板还包含非聚合抗微生物或抗菌化合物。优选的非聚合抗微生物或抗菌化合物包括氯化十六烷基吡啶鎓和吡啶硫酮钠。聚合物抗微生物或抗菌化合物可以存在于石膏芯中和/或在一个或两个纸面上。非聚合物抗微生物剂或抗菌化合物可以被包封在与聚合物抗微生物或抗菌化合物的离子缔合物质中，以允许随着时间和/或暴露于水分而释放非聚合物抗微生物剂或抗菌化合物。还公开了制备上述新型石膏板的方法。

5. 发明授权

US07473474B2 Antifungal gypsum board 失效
标题翻译：防霉石膏板
公开(公告)号：US07473474B2
公开(公告)日：2009-01-06
申请号：US10546850
申请日：2004-02-25
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： B32B23/04
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel improved gypsum board having improved antifungal properties is disclosed. The board comprises a gypsum core, front and back paper facings and a polymeric antifungal agent effective at inhibiting fungal growth. A preferred polymeric antifungal agent is polyDADMAC or polyTMMC. In addition to the polymeric antifungal agent, a non-polymeric antifungal agent, such as cetyl pyridinium chloride, sodium or zinc pyrithione, or both, may be included. The polymeric antifungal agent can be present in the gypsum core and/or on one or both of the paper facings. In addition, the antifungal agent may be encapsulated in a material or ionically associated with the polymeric antifungal agent, that releases the antifungal agent over time and/or upon exposure to moisture. Also disclosed are methods for preparing the aforementioned improved antifungal gypsum board.
摘要翻译：公开了具有改进的抗真菌性能的新型改进的石膏板。该板包括石膏芯，正面和背面纸面和有效抑制真菌生长的聚合抗真菌剂。优选的聚合抗真菌剂是聚DADMAC或polyTMMC。除了聚合物抗真菌剂之外，还可以包括非聚合抗真菌剂，例如氯化十六烷基吡啶鎓，吡啶硫酮钠或锌二者。聚合物抗真菌剂可以存在于石膏芯中和/或一个或两个纸面上。此外，抗真菌剂可以被包封在与聚合抗真菌剂的离子缔合物质中，随着时间和/或暴露于水分时释放抗真菌剂。还公开了制备上述改进的抗真菌石膏板的方法。

6. 发明申请

US20090104144A1 Gypsum board with a fluorine-containing antifungal agent 审中-公开
标题翻译：石膏板与含氟抗真菌剂
公开(公告)号：US20090104144A1
公开(公告)日：2009-04-23
申请号：US12347844
申请日：2008-12-31
申请人： William Toreki , Gerald Olderman , Gregory Staab
发明人： William Toreki , Gerald Olderman , Gregory Staab
IPC分类号： A01N33/02 , A01P3/00
CPC分类号： A01N25/34 , A01N33/12 , B32B13/08 , E04C2/043 , Y10T428/31986 , Y10T428/31993 , Y10T428/31996 , A01N43/40 , A01N37/12 , A01N55/02 , A01N2300/00
摘要： A novel gypsum board having improved antifungal properties is disclosed. The board comprises a gypsum core, front and back paper facings, and a polymeric antifungal agent effective at inhibiting fungal growth. A preferred polymeric antifungal agent is polyDADMAC or polyTMMC. The novel gypsum board further comprises a non-polymeric antifungal agent comprising a fluorine-containing quaternary ammonium compound. Preferred non-polymeric ammonium compounds include Tetra-n-butylammonium fluoride and Tetraethylammonium fluoride. The polymeric antifungal agent can be present in the gypsum core and/or on one or both of the paper facings. The non-polymeric antifungal agent may be encapsulated in a material or ionically associated with the polymeric antifungal agent to allow releases of the non-polymeric antifungal agent over time and/or upon exposure to moisture. Methods for preparing the aforementioned novel gypsum board are also disclosed.
摘要翻译：公开了具有改进的抗真菌性能的新型石膏板。该板包括石膏芯，正面和背面纸面，以及有效抑制真菌生长的聚合抗真菌剂。优选的聚合抗真菌剂是聚DADMAC或polyTMMC。新型石膏板还包含含有含氟季铵化合物的非聚合抗真菌剂。优选的非聚合铵化合物包括四正丁基氟化铵和四乙基氟化铵。聚合物抗真菌剂可以存在于石膏芯中和/或一个或两个纸面上。非聚合抗真菌剂可以被包封在与聚合物抗真菌剂的材料中或离子缔合，以允许非聚合抗真菌剂随时间和/或暴露于水分时释放。还公开了制备上述新型石膏板的方法。

7. 发明申请

US20050033251A1 Controlled release of biologically active substances from select substrates 审中-公开
标题翻译：从选择的底物控制释放生物活性物质
公开(公告)号：US20050033251A1
公开(公告)日：2005-02-10
申请号：US10786959
申请日：2004-02-25
申请人： William Toreki , Gregory Staab , Gerald Olderman
发明人： William Toreki , Gregory Staab , Gerald Olderman
IPC分类号： A61F13/15 , A61L15/46 , A61F13/20
CPC分类号： A61L15/46 , A01N25/34 , A61F13/8405 , A61L2300/206 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A01N25/10 , A01N33/12 , A01N47/44
摘要： This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.
摘要翻译：本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。将涂层施加到诸如纱布式伤口敷料，粉末和其它底物的基底上。在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。在多长度聚合物链上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效能的吸收剂或超吸收剂表面。根据本发明使用具有多个阴离子或阳离子位点的非浸出涂层的使用以结合多个带相反电荷的生物或化学活性化合物，并通过一个或多个化学活性化合物从所述底物上释放结合的带相反电荷的生物或化学活性化合物一段时间以达到预期的目标，如改善伤口愈合以减少体臭。

8. 发明授权

US08333743B2 Antimicrobial bandage material comprising superabsorbent and non-superabsorbent layers 失效
标题翻译：包含超吸收剂和非超吸收层的抗微生物绷带材料
公开(公告)号：US08333743B2
公开(公告)日：2012-12-18
申请号：US12772686
申请日：2010-05-03
申请人： William Toreki , Gerald Olderman , Gregory Schultz , Christopher Batich
发明人： William Toreki , Gerald Olderman , Gregory Schultz , Christopher Batich
IPC分类号： A61F13/00
CPC分类号： A01N25/34 , A61F13/8405 , A61L15/46 , A61L2300/206 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A01N25/10 , A01N33/12 , A01N47/44
摘要： This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.
摘要翻译：本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。将涂层施加到诸如纱布式伤口敷料的基底上。在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。在多长度聚合物链上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效果的吸收剂或超吸收剂表面。

9. 发明授权

US07790217B2 Method of attaching an antimicrobial cationic polyelectrolyte to the surface of a substrate 有权
标题翻译：将抗微生物阳离子聚电解质连接到基底表面的方法
公开(公告)号：US07790217B2
公开(公告)日：2010-09-07
申请号：US11569942
申请日：2006-08-22
申请人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
发明人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
IPC分类号： B05D3/02
CPC分类号： A01N33/12 , A01N37/12 , A61L2/18 , A61L2/232 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , A61L2300/80 , A01N25/10 , A01N25/24 , A01N25/34 , A01N2300/00
摘要： A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
摘要翻译：描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出使用和存储。描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

10. 发明授权

US08092854B2 Method of attaching an antimicrobial cationic polyelectrolyte to the surface of a substrate 有权
标题翻译：将抗微生物阳离子聚电解质连接到基底表面的方法
公开(公告)号：US08092854B2
公开(公告)日：2012-01-10
申请号：US12875741
申请日：2010-09-03
申请人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
发明人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
IPC分类号： B05D3/02
CPC分类号： A01N33/12 , A01N37/12 , A61L2/18 , A61L2/232 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , A61L2300/80 , A01N25/10 , A01N25/24 , A01N25/34 , A01N2300/00
摘要： A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
摘要翻译：描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出使用和存储。描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

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