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1. 发明授权

US07790217B2 Method of attaching an antimicrobial cationic polyelectrolyte to the surface of a substrate 有权
标题翻译：将抗微生物阳离子聚电解质连接到基底表面的方法
公开(公告)号：US07790217B2
公开(公告)日：2010-09-07
申请号：US11569942
申请日：2006-08-22
申请人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
发明人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
IPC分类号： B05D3/02
CPC分类号： A01N33/12 , A01N37/12 , A61L2/18 , A61L2/232 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , A61L2300/80 , A01N25/10 , A01N25/24 , A01N25/34 , A01N2300/00
摘要： A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
摘要翻译：描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出使用和存储。描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

2. 发明申请

US20050131458A1 Biodegradable embolic agents 审中-公开
标题翻译：可生物降解栓塞剂
公开(公告)号：US20050131458A1
公开(公告)日：2005-06-16
申请号：US10913511
申请日：2004-08-09
申请人： Christopher Batich , Matthew Eadens , Robert Mericle , Matthew Burry , Courtney Watkins , Swadeshmukul Santra , Patrick Leamy
发明人： Christopher Batich , Matthew Eadens , Robert Mericle , Matthew Burry , Courtney Watkins , Swadeshmukul Santra , Patrick Leamy
IPC分类号： A61B20060101 , A61B17/08 , A61B17/12 , A61K9/00 , A61K9/50 , A61K9/51 , A61K49/04 , A61L24/00 , A61L24/02 , A61L31/02 , A61L31/18
CPC分类号： A61L24/02 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B2017/00876 , A61K9/0009 , A61K9/0019 , A61K9/5015 , A61K9/5115 , A61K9/5153 , A61K49/0404 , A61K49/0423 , A61K49/0485 , A61L24/001 , A61L31/022 , A61L31/18 , A61L2400/06 , A61L2430/36 , B82Y5/00
摘要： A flowable, biodegradable endovascular embolic composition effective for embolizing a vascular defect consisting essentially of: (a) a biocompatible, biodegradable polymer or polymeric material forming composition; (b) a biocompatible embolic solvent for the polymer or polymer forming composition capable of diffusion into mammalian tissue; (c) biocompatible magnetic particles responsive to a magnetic field; wherein: the polymer or polymeric forming material and solvent are present in the composition in amounts and relative proportions such that (1) the composition is deliverable to a vascular defect site and (2) upon delivery to the site, solidifies into an embolic mass; and the magnetic particles are present in the composition in an amount sufficient to enable the composition being deliverable to the vascular site by a magnetic field. Also disclosed are methods and articles of manufacture embodying the above-described composition.
摘要翻译：一种可流动的，可生物降解的血管内栓塞组合物，其有效栓塞血管缺损，其基本上由以下组成：（a）生物相容的，可生物降解的聚合物或形成聚合物的组合物; （b）能够扩散入哺乳动物组织的聚合物或聚合物形成组合物的生物相容性栓塞溶剂; （c）响应于磁场的生物相容性磁性颗粒; 其中：聚合物或聚合物形成材料和溶剂以数量和相对比例存在于组合物中，使得（1）组合物可输送到血管缺损部位，和（2）在递送至部位后，固化成栓塞体; 并且磁性颗粒以足以使组合物通过磁场输送到血管部位的量存在于组合物中。还公开了体现上述组合物的方法和制品。

3. 发明授权

US08525666B2 Handwashing compliance detection system 有权
标题翻译：洗手法规检测系统
公开(公告)号：US08525666B2
公开(公告)日：2013-09-03
申请号：US12599743
申请日：2008-06-09
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
IPC分类号： G08B1/08
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用以确定是否符合手部卫生指南。洗手剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。在洗手事件之后，将受试者的手暴露于检测器（例如徽章），其包括能够检测挥发性化合物的传感器，以及指示挥发性化合物的检测，指示使用洗手剂和手卫生合规。

4. 发明授权

US08092854B2 Method of attaching an antimicrobial cationic polyelectrolyte to the surface of a substrate 有权
标题翻译：将抗微生物阳离子聚电解质连接到基底表面的方法
公开(公告)号：US08092854B2
公开(公告)日：2012-01-10
申请号：US12875741
申请日：2010-09-03
申请人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
发明人： William Toreki , Bernd Liesenfeld , David Moore , Susan Leander , Christopher Batich
IPC分类号： B05D3/02
CPC分类号： A01N33/12 , A01N37/12 , A61L2/18 , A61L2/232 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , A61L2300/80 , A01N25/10 , A01N25/24 , A01N25/34 , A01N2300/00
摘要： A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
摘要翻译：描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出使用和存储。描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

5. 发明申请

US20050142063A1 Microparticle-based diagnostic methods 失效
标题翻译：基于微粒的诊断方法
公开(公告)号：US20050142063A1
公开(公告)日：2005-06-30
申请号：US11021026
申请日：2004-12-23
申请人： Christopher Batich
发明人： Christopher Batich
IPC分类号： A61K9/14 , A61K49/00 , G01N33/543 , G01N33/574 , G01N33/58 , A61K7/16
CPC分类号： G01N33/585 , G01N33/54313 , G01N33/57492
摘要： The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the subject invention, the microspheres selectively adhere to any targeted surface marker.
摘要翻译：本发明涉及利用改性微球检测低频表面变化的新型材料和方法。当将表面暴露于本发明的改性微球体时，微球体选择性地粘附到任何目标表面标记物上。

6. 发明授权

US08333743B2 Antimicrobial bandage material comprising superabsorbent and non-superabsorbent layers 失效
标题翻译：包含超吸收剂和非超吸收层的抗微生物绷带材料
公开(公告)号：US08333743B2
公开(公告)日：2012-12-18
申请号：US12772686
申请日：2010-05-03
申请人： William Toreki , Gerald Olderman , Gregory Schultz , Christopher Batich
发明人： William Toreki , Gerald Olderman , Gregory Schultz , Christopher Batich
IPC分类号： A61F13/00
CPC分类号： A01N25/34 , A61F13/8405 , A61L15/46 , A61L2300/206 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A01N25/10 , A01N33/12 , A01N47/44
摘要： This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.
摘要翻译：本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。将涂层施加到诸如纱布式伤口敷料的基底上。在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。在多长度聚合物链上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效果的吸收剂或超吸收剂表面。

7. 发明申请

US20100265059A1 Handwashing Compliance Detection System 有权
标题翻译：洗手合格检测系统
公开(公告)号：US20100265059A1
公开(公告)日：2010-10-21
申请号：US12599743
申请日：2008-06-09
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
IPC分类号： G08B1/08 , G01F23/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用以确定是否符合手部卫生指南。洗手剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。在洗手事件之后，将受试者的手暴露于检测器（例如徽章），其包括能够检测挥发性化合物的传感器，以及指示挥发性化合物的检测，指示使用洗手剂和手卫生合规。

8. 发明申请

US20060293729A1 Ferroelectric hyperthermia method for cancer treatment 失效
公开(公告)号：US20060293729A1
公开(公告)日：2006-12-28
申请号：US11512528
申请日：2006-08-29
申请人： Glen Flores , Christopher Batich
发明人： Glen Flores , Christopher Batich
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/04
摘要： A method of localized cell heating introduces a plurality of ferroelectric comprising particles into a target region of a patient, and applies a time varying electrical field to the target region. The ferroelectric particles absorb energy from the electrical field and heat the target region in response, such as to a temperature sufficient to induce apoptosis of cancer cells in the target region. A ferroelectric hyperthermia-based cancer treatment system includes a time varying electrical field source for applying a time varying electrical field to a plurality of ferroelectric particles disposed in a target cancer containing region of a patient. A composition of matter includes a particle having a ferroelectric portion, the particle being non-toxic, slowly biodegradable in body fluids, and less than 15 μm in its maximum dimension.

9. 发明申请

US20060015159A1 Ferroelectric hyperthermia system and method for cancer therapy 失效
标题翻译：铁电热疗系统及癌症治疗方法
公开(公告)号：US20060015159A1
公开(公告)日：2006-01-19
申请号：US10889871
申请日：2004-07-13
申请人： Glen Flores , Christopher Batich
发明人： Glen Flores , Christopher Batich
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/04
摘要： A method of localized cell heating introduces a plurality of ferroelectric comprising particles into a target region of a patient, and applies a time varying electrical field to the target region. The ferroelectric particles absorb energy from the electrical field and heat the target region in response, such as to a temperature sufficient to induce apoptosis of cancer cells in the target region. A ferroelectric hyperthermia-based cancer treatment system includes a time varying electrical field source for applying a time varying electrical field to a plurality of ferroelectric particles disposed in a target cancer containing region of a patient. A composition of matter includes a particle having a ferroelectric portion, the particle being non-toxic, slowly biodegradable in body fluids, and less than 15 μm in its maximum dimension.
摘要翻译：局部细胞加热的方法将多个含铁电体的颗粒引入患者的目标区域，并将时变电场施加到目标区域。铁电粒子从电场吸收能量，并响应于加热靶区域，例如足以诱导靶区域中癌细胞凋亡的温度。基于铁电热疗的癌症治疗系统包括时变电场源，用于对设置在患者的目标癌症包含区域中的多个铁电粒子施加时变电场。物质组合物包括具有铁电部分的颗粒，该颗粒是无毒的，在体液中缓慢生物降解，并且其最大尺寸小于15μm。

10. 发明授权

US06667368B1 Amino acid functionalized polymers for graft copolymerizations 失效
标题翻译：用于接枝共聚的氨基酸官能化聚合物
公开(公告)号：US06667368B1
公开(公告)日：2003-12-23
申请号：US09529926
申请日：2000-07-06
申请人： Anthony B. Brennan , Michael P. Zamora , Christopher Batich , Kenneth B. Wagener
发明人： Anthony B. Brennan , Michael P. Zamora , Christopher Batich , Kenneth B. Wagener
IPC分类号： C08L7900
CPC分类号： C08F2/38
摘要： Amino acid functionalized polymers useful for graft copolymerization prepared by reacting a mixture containing, for chain transfer, a thio-substituted amino acid and an ethylenically unsaturated monomer.
摘要翻译：可用于接枝共聚的氨基酸官能化聚合物，其通过使含有硫取代的氨基酸和烯属不饱和单体的链转移反应的混合物反应制备。

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