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1. 发明授权

US06530922B2 Cluster ablation electrode system 失效
公开(公告)号：US06530922B2
公开(公告)日：2003-03-11
申请号：US09491748
申请日：2000-01-27
申请人： Eric R. Cosman , William J. Rittman, III
发明人： Eric R. Cosman , William J. Rittman, III
IPC分类号： A61B1804
CPC分类号： A61B18/1477 , A61B18/02 , A61B18/14 , A61B18/1482 , A61B18/18 , A61B18/24 , A61B90/37 , A61B2017/00084 , A61B2017/00106 , A61B2018/00011 , A61B2018/00023 , A61B2018/00083 , A61B2018/0016 , A61B2018/00434 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/025 , A61B2018/1253 , A61B2018/1425 , A61B2018/143 , A61B2018/1467 , A61B2018/1475
摘要： A multiplicity of high frequency electrodes in a cluster configuration may be inserted into tissue of a patient's body for producing heat ablation of abnormal tissue such as a tumor. The electrodes are connected coherently to the voltage output of a high frequency generator. An enlarged ablation volume is accomplished by the electrode cluster with reduced risk of hemorrhage because of the smaller diameter of the individual electrodes of the cluster. The electrodes terminate in conductive tips, which are cooled by a fluid coolant to further facilitate enlarged ablation volumes. Very large ablation volumes are accomplished by this process and apparatus. Various cluster electrode configurations may be adapted to meet specific clinical requirements.

2. 发明授权

US06517534B1 Peri-urethral ablation 失效
标题翻译：尿道周围消融
公开(公告)号：US06517534B1
公开(公告)日：2003-02-11
申请号：US09375469
申请日：1999-08-15
申请人： Francis J. McGovern , S. Nahum Goldberg , Eric R. Cosman , William J. Rittman, III
发明人： Francis J. McGovern , S. Nahum Goldberg , Eric R. Cosman , William J. Rittman, III
IPC分类号： A61B1814
CPC分类号： A61B18/1485 , A61B18/08 , A61B18/1477 , A61B18/1815 , A61B2018/00005 , A61B2018/00083 , A61B2018/0022 , A61B2018/00261 , A61B2018/00505 , A61B2018/00517 , A61B2018/00547 , A61B2018/00553 , A61B2018/00577 , A61B2018/00678 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/1425 , A61B2018/1467 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Relief of urethral obstruction is achieved by heat ablation of prostatic tissue by an ablation probe passed within the urethra to a position in the prostate near the point of urethral obstruction. The probe is coupled to a power supply to deliver power to tissue near the probe and thus to ablatively heat the urethra and the prostatic tissue near the urethra. The temperature of the tissue is sensed at the probe to control the heating and ablation process. In one embodiment, the probe has a blunt tip to help prevent piercing of the wall of the urethra during insertion of the probe into the urethra through the penis and the positioning of the probe tip near to the point of urethral obstruction. Several forms of probes, apparatus, and methods accommodate the specific objectives.
摘要翻译：尿道阻塞的缓解是通过在尿道内通过的消融探针通过热消融前列腺组织达到在尿道阻塞点附近的前列腺中的位置来实现的。探针耦合到电源以将功率传递到探针附近的组织，并且因此可以对尿道和尿道附近的前列腺组织进行消融。在探针处感测组织的温度以控制加热和消融过程。在一个实施例中，探针具有钝头以帮助防止在将探针插入尿道穿过阴茎期间以及探针尖端靠近尿道阻塞点的位置时刺穿尿道壁。探针，仪器和方法的几种形式适应具体目标。

3. 发明授权

US06312426B1 Method and system for performing plate type radiofrequency ablation 失效
标题翻译：执行板式射频消融的方法和系统
公开(公告)号：US06312426B1
公开(公告)日：2001-11-06
申请号：US08866765
申请日：1997-05-30
申请人： S. Nahum Goldberg , Kenneth K. Tanabe , William J. Rittman, III , Eric R. Cosman
发明人： S. Nahum Goldberg , Kenneth K. Tanabe , William J. Rittman, III , Eric R. Cosman
IPC分类号： A61B1804
CPC分类号： A61B18/1445 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/142 , A61B2090/3782
摘要： A method and apparatus for inducing large volume heat ablations of tissue in a patient involving electrodes that are in contact with the patient's external surface or the surface of an internal organ. A high frequency signal or output from a generator is applied to the tissue near the area electrodes by connection of the generator to the electrodes. Various applications and configurations of electrodes and temperature monitoring are appropriate for different clinical needs and thermal distributions. The use for interoperative ablation of a tumor site within an internal organ or for ablation of a tumor from electrodes placed on the surface of the patient provides a clinical advantage.
摘要翻译：一种用于诱导患者中组织的大量热消融的方法和装置，其涉及与患者的外表面或内脏器官的表面接触的电极。通过将发生器连接到电极，来自发生器的高频信号或输出被施加到区域电极附近的组织。电极和温度监测的各种应用和配置适用于不同的临床需要和热分布。用于内部器官中的肿瘤部位的术中消融或用于放置在患者表面上的电极消融肿瘤的用途提供临床优点。

4. 发明授权

US08000785B2 Method and apparatus for diagnosing and treating neural dysfunction 有权
标题翻译：用于诊断和治疗神经功能障碍的方法和装置
公开(公告)号：US08000785B2
公开(公告)日：2011-08-16
申请号：US12966550
申请日：2010-12-13
申请人： William J. Rittman, III
发明人： William J. Rittman, III
IPC分类号： A61N1/00
CPC分类号： A61N5/00 , A61B5/0488 , A61B5/4893 , A61B18/1477 , A61B2018/00434 , A61B2018/00702 , A61B2018/00791 , A61B2018/00839 , A61N1/06 , A61N1/36021 , A61N1/37247
摘要： A method and apparatus for diagnosing and treating neural dysfunction is disclosed. This device has the capability of delivering the therapeutic electrical energy to more than one treatment electrode simultaneously. In another exemplary embodiment, this device can perform EMG testing both before and after the therapeutic energy has been delivered, to assess whether the target nerve was successfully treated. In another embodiment, the device has the capability to record and store sensory stimulation thresholds both before and after treatment is described, which allows the clinician to accurately determine whether the target nerve has been desensitized. Energy control may achieved by simultaneously comparing the tip temperature of each treatment electrode to a set temperature selected by the operator, and regulating the therapeutic energy output to maintain the set temperature. In another embodiment, EMG, stimulation thresholds, and graphs of temperature versus time can be conveniently displayed on a two-dimensional graphics display.
摘要翻译：公开了用于诊断和治疗神经功能障碍的方法和装置。该装置具有将治疗电能同时递送到多于一个治疗电极的能力。在另一个示例性实施例中，该装置可以在治疗能量被递送之前和之后执行EMG测试，以评估目标神经是否被成功治疗。在另一个实施例中，该装置具有在描述治疗之前和之后记录和存储感觉刺激阈值的能力，其允许临床医生准确地确定目标神经是否已经脱敏。能量控制可以通过将每个处理电极的尖端温度与由操作者选择的设定温度进行比较来实现，并且调节治疗能量输出以维持设定温度。在另一个实施例中，可以方便地在二维图形显示器上显示EMG，刺激阈值和温度对时间的图形。

5. 再颁专利

USRE41045E1 Method and apparatus for altering neural tissue function 失效
标题翻译：改变神经组织功能的方法和装置
公开(公告)号：USRE41045E1
公开(公告)日：2009-12-15
申请号：US10460506
申请日：2003-06-12
申请人： Menno E. Sluijter , William J. Rittman, III , Eric R. Cosman
发明人： Menno E. Sluijter , William J. Rittman, III , Eric R. Cosman
IPC分类号： A61F2/00
CPC分类号： A61N1/36021 , A61N1/08 , A61N1/36017 , A61N1/403
摘要： A method and apparatus for altering a function of neural tissue in a patient. An electromagnetic signal is applied to the neural tissue through an electrode. The electromagnetic signal has a frequency component above the physiological stimulation frequency range and an intensity sufficient to product an alteration of the neural tissue, the alteration causing the patient to experience a reduction in pain, and a waveform that prevents lethal temperature elecation of the neural tissue during application of the electromagnetic signal to the neural tissue.
摘要翻译：一种改变患者神经组织功能的方法和装置。通过电极将电磁信号施加到神经组织。电磁信号具有高于生理刺激频率范围的频率分量，并且具有足以产生神经组织改变的强度，引起患者体验疼痛减轻的改变，以及防止神经组织致死温度升高的波形在向神经组织施加电磁信号期间。

6. 发明授权

US06451015B1 Method and system for menu-driven two-dimensional display lesion generator 有权
标题翻译：菜单驱动二维显示病变发生器的方法和系统
公开(公告)号：US06451015B1
公开(公告)日：2002-09-17
申请号：US09195118
申请日：1998-11-18
申请人： William J. Rittman, III , Way Yin , Eric R. Cosman, Jr. , Eric R. Cosman
发明人： William J. Rittman, III , Way Yin , Eric R. Cosman, Jr. , Eric R. Cosman
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B2017/00199
摘要： A high frequency generator system with a computer graphic two-dimensional user-interactable interface is achieved to allow selection of menus associated with the function, state, and output parameters of the high frequency generator system. A two-dimensional graphics display is coupled directly or remotely to a high frequency power source system which is further connected to electrodes in contact or proximity to the tissue of a patient's body. A two-dimensional display allows the user to see, in a compact, convenient, and comprehensive way, selection menus for use of the high frequency generator system, control of its parameters, monitoring of its processes during clinical application, and graphics displays related to historic or current image scan data and real-time monitoring of output parameters related to the application. Pre-set or user-selectable arrays of parameters can be selected through the two-dimensional user interface to the high frequency generator system. Real-time plotting of single or multiple output parameters as a function of time course during the clinical application can be graphically displayed on the two-dimensional display. Digital displays, alphanumeric streams of information, help menus, prompts, and sequences of menus may be selected by the two-dimensional interface through actuators on the interface or on the panel of the high frequency generator system. Several forms of the interface, user actuators, screen layouts, and methods for use of this system accommodate the specific objectives.
摘要翻译：实现了具有计算机图形二维用户可交互界面的高频发生器系统，以允许选择与高频发生器系统的功能，状态和输出参数相关联的菜单。二维图形显示器直接或远程地耦合到高频电源系统，高频电源系统进一步连接到与患者身体的组织接触或接近的电极。二维显示器允许用户以紧凑，方便和全面的方式看到，使用高频发生器系统的选择菜单，其参数的控制，临床应用期间其过程的监视以及与历史或当前图像扫描数据和与应用相关的输出参数的实时监控。可以通过二维用户界面选择预设置或用户选择的参数阵列到高频发生器系统。在临床应用中，作为时间过程的函数的单个或多个输出参数的实时绘图可以图形地显示在二维显示器上。数字显示器，信息的字母数字信息，帮助菜单，提示和序列可以通过二维界面通过界面上的致动器或高频发生器系统的面板来选择。接口的几种形式，用户执行器，屏幕布局以及使用该系统的方法适应具体目标。

7. 发明授权

US08265747B2 Method and apparatus for diagnosing and treating neural dysfunction 有权
标题翻译：用于诊断和治疗神经功能障碍的方法和装置
公开(公告)号：US08265747B2
公开(公告)日：2012-09-11
申请号：US13185646
申请日：2011-07-19
申请人： William J. Rittman, III , Howard Morgan Clarke
发明人： William J. Rittman, III , Howard Morgan Clarke
IPC分类号： A61N1/00
CPC分类号： A61N5/00 , A61B5/0488 , A61B5/4893 , A61B18/1477 , A61B2018/00434 , A61B2018/00702 , A61B2018/00791 , A61B2018/00839 , A61N1/06 , A61N1/36021 , A61N1/37247
摘要： A method and apparatus for diagnosing and treating neural dysfunction is disclosed. This device has the capability of delivering the therapeutic electrical energy to more than one treatment electrode simultaneously. In another exemplary embodiment, this device can perform EMG testing both before and after the therapeutic energy has been delivered, to assess whether the target nerve was successfully treated. In another embodiment, the device has the capability to record and store sensory stimulation thresholds both before and after treatment is described, which allows the clinician to accurately determine whether the target nerve has been desensitized. Energy control may achieved by simultaneously comparing the tip temperature of each treatment electrode to a set temperature selected by the operator, and regulating the therapeutic energy output to maintain the set temperature. In another embodiment, EMG, stimulation thresholds, and graphs of temperature versus time can be conveniently displayed on a two-dimensional graphics display.
摘要翻译：公开了用于诊断和治疗神经功能障碍的方法和装置。该装置具有将治疗电能同时递送到多于一个治疗电极的能力。在另一个示例性实施例中，该装置可以在治疗能量被递送之前和之后执行EMG测试，以评估目标神经是否被成功治疗。在另一个实施例中，该装置具有在描述治疗之前和之后记录和存储感觉刺激阈值的能力，其允许临床医生准确地确定目标神经是否已经脱敏。能量控制可以通过将每个处理电极的尖端温度与由操作者选择的设定温度进行比较来实现，并且调节治疗能量输出以维持设定温度。在另一个实施例中，可以方便地在二维图形显示器上显示EMG，刺激阈值和温度对时间的图形。

8. 发明申请

US20110144634A1 Method and Apparatus for Diagnosing and Treating Neural Dysfunction 有权
标题翻译：用于诊断和治疗神经功能障碍的方法和装置
公开(公告)号：US20110144634A1
公开(公告)日：2011-06-16
申请号：US12966550
申请日：2010-12-13
申请人： William J. Rittman, III
发明人： William J. Rittman, III
IPC分类号： A61B18/18
CPC分类号： A61N5/00 , A61B5/0488 , A61B5/4893 , A61B18/1477 , A61B2018/00434 , A61B2018/00702 , A61B2018/00791 , A61B2018/00839 , A61N1/06 , A61N1/36021 , A61N1/37247
摘要： A method and apparatus for diagnosing and treating neural dysfunction is disclosed. This device has the capability of delivering the therapeutic electrical energy to more than one treatment electrode simultaneously. In another exemplary embodiment, this device can perform EMG testing both before and after the therapeutic energy has been delivered, to assess whether the target nerve was successfully treated. In another embodiment, the device has the capability to record and store sensory stimulation thresholds both before and after treatment is described, which allows the clinician to accurately determine whether the target nerve has been desensitized. Energy control may achieved by simultaneously comparing the tip temperature of each treatment electrode to a set temperature selected by the operator, and regulating the therapeutic energy output to maintain the set temperature. In another embodiment, EMG, stimulation thresholds, and graphs of temperature versus time can be conveniently displayed on a two-dimensional graphics display.
摘要翻译：公开了用于诊断和治疗神经功能障碍的方法和装置。该装置具有将治疗电能同时递送到多于一个治疗电极的能力。在另一个示例性实施例中，该装置可以在治疗能量被递送之前和之后执行EMG测试，以评估目标神经是否被成功治疗。在另一个实施例中，该装置具有在描述治疗之前和之后记录和存储感觉刺激阈值的能力，其允许临床医生准确地确定目标神经是否已经脱敏。通过将每个处理电极的尖端温度与由操作者选择的设定温度进行比较，并调节治疗能量输出以维持设定温度，可以实现能量控制。在另一个实施例中，可以方便地在二维图形显示器上显示EMG，刺激阈值和温度对时间的图形。

9. 发明授权

US06575969B1 Cool-tip radiofrequency thermosurgery electrode system for tumor ablation 有权
标题翻译：用于肿瘤消融的冷端射频热手术电极系统
公开(公告)号：US06575969B1
公开(公告)日：2003-06-10
申请号：US09642309
申请日：2000-08-21
申请人： William J. Rittman, III , Eric R. Cosman
发明人： William J. Rittman, III , Eric R. Cosman
IPC分类号： A61B1818
CPC分类号： A61B18/1482 , A61B18/02 , A61B18/18 , A61B18/24 , A61B90/37 , A61B2017/00084 , A61B2017/00106 , A61B2018/00011 , A61B2018/00023 , A61B2018/00083 , A61B2018/00642 , A61B2018/00791 , A61B2018/00815 , A61B2018/00821 , A61B2018/0212 , A61B2018/1253
摘要： This patent application is a continuation-in-part of the patent application of the present authors related to target volume ablation in the body using a cooled-tip tissue-heating probe such as a fluid cooled (perfusion cooled) high frequency electrode. The present application relates in part to examples of specific embodiments of high frequency and radiofrequency electrode designs and heating and cooling system designs. It further describes embodiments in conjunction with 3-D or 2-D image data and computer graphic workstions to control, monitor, and pre-plan the process of target ablation. Specific examples of cooled-tip electrode constructions will be given which have utility for percutaneous or intraoperative cancerous tumor ablation. Cooled tip electrode systems with modular or separable components involving an insertion cannula, a radiofrequency electrode element, a cooling element, and a thermo-monitoring and/or radiofrequency connection electrode will be given. A high frequency and cooling system which is controlled and regulated based on the “thermally clamped tip” concept together with control of power, current, or other high frequency power parameters to pre-plan and control lesion size will be shown. Pre- or contemporaneous monitoring methods using CT, MR, ultrasound, and acoustic imaging or monitoring modalities in conjugation with the cooled tip high frequency ablation system will be exemplified. Variations in electrode design for specific target sites in the body will be described and illustrated.
摘要翻译：该专利申请是本申请人使用冷却末端组织加热探针（例如流体冷却（灌注冷却））高频电极在体内靶体积消融的专利申请的部分继续申请。本申请部分地涉及高频和射频电极设计以及加热和冷却系统设计的具体实施例的示例。它还结合3-D或2-D图像数据和计算机图形工作站来描述实施例，以控制，监视和预先设计目标消融的过程。将给出冷却尖端电极结构的具体实例，其可用于经皮或术中癌性肿瘤消融。将给出具有包括插入套管，射频电极元件，冷却元件以及热监测和/或射频连接电极的模块化或可分离组件的冷却尖端电极系统。将显示基于“热夹头”概念控制和调节的高频和冷却系统，以及功率，电流或其他高频功率参数的控制，以预先设计和控制损伤尺寸。将示例使用CT，MR，超声波和声学成像或与冷却的尖端高频消融系统共轭的监测模式的同时期监测方法。将描述和说明身体中特定靶位点的电极设计的变化。

10. 发明授权

US06506189B1 Cool-tip electrode thermosurgery system 有权
标题翻译：冷端电极热手术系统
公开(公告)号：US06506189B1
公开(公告)日：2003-01-14
申请号：US09642404
申请日：2000-08-21
申请人： William J. Rittman, III , Eric R. Cosman
发明人： William J. Rittman, III , Eric R. Cosman
IPC分类号： A61B1818
CPC分类号： A61B18/1482 , A61B18/02 , A61B18/18 , A61B18/24 , A61B90/37 , A61B2017/00084 , A61B2017/00106 , A61B2018/00011 , A61B2018/00023 , A61B2018/00083 , A61B2018/0022 , A61B2018/00642 , A61B2018/00791 , A61B2018/00815 , A61B2018/00821 , A61B2018/1253
摘要： For heat ablating living tissue of a body, an ablation electrode, contacting a surface of the tissue or within tissue, is coupled to an RF power supply referenced to a second electrode contacting the body. Fluid coolant is circulated to cool the contact surface extending the ablation to an increased volume of tissue. Temperature may be sensed contiguous to the surface to control the flows of RF heating energy and fluid coolant. Computer capability implements control and provides graphics of data, preplans, or controls relative to the ablation. Several forms of electrode structures accommodate specific objectives.
摘要翻译：对于身体的热消融活组织，与组织的表面或组织内接触的消融电极被耦合到参考与身体接触的第二电极的RF电源。流体冷却剂循环以冷却接触表面，从而将消融延伸至增加的组织体积。可以感测温度与表面相邻以控制RF加热能量和流体冷却剂的流动。计算机能力实现控制，并提供相对于消融的数据，预处理或控制的图形。几种形式的电极结构适应特定的目标。

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