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1. 发明授权

US08323896B2 Epidermal growth factor (EGF) expression and/or polymorphisms thereof for predicting the risk of developing cancer 失效
标题翻译：表皮生长因子（EGF）表达和/或其多态性用于预测发生癌症的风险
公开(公告)号：US08323896B2
公开(公告)日：2012-12-04
申请号：US12594010
申请日：2008-03-28
申请人： Kenneth K Tanabe , Bryan C Fuchs , Hiroshi Kawasaki
发明人： Kenneth K Tanabe , Bryan C Fuchs , Hiroshi Kawasaki
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates to diagnostic and prognostic methods to determine the likelihood of a subject who has a inflammatory disease or liver disease of developing cancer. In particular, the present invention relates to methods for identifying subjects with increased susceptibility to developing cancer, such as hepatocellular carcinoma (HCC) where the subject has an inflammatory disease, such as, but not limited to cirrhosis, by identifying a variance or polymorphism in the human EGF gene. In particular, the methods of the present invention relate to identifying subjects with increased susceptibility to developing cancer such as HCC, where the subject has an inflammatory disease, such as but not limited to cirrhosis, and the subject is identified to have a single nucleotide polymorphism 61A>G in the 5′UTR of the EGF gene. Alternatively, the methods of the present invention relate to identifying subjects with increased susceptibility to developing cancer such as HCC, where the subject has an inflammatory disease, such as but not limited to cirrhosis, and the subject is identified to have increased expression of EGF as compared to a reference level of EGF expression. The present invention also relates to administering an effective amount of an anti-cancer therapy to subjects identified to have an increased susceptibility of developing cancer such as HCC by the methods as disclosed herein, and kits to identify a subject with a 61A>G polymorphism in the 5′UTR of the EGF gene or kits to determine increased EGF expression in subjects with chronic inflammatory disease.
摘要翻译：本发明涉及确定具有发展中的癌症的炎性疾病或肝脏疾病的受试者的可能性的诊断和预后方法。特别地，本发明涉及用于识别对发展中的癌症易感性增加的受试者的方法，例如肝细胞癌（HCC），其中受试者具有炎性疾病，例如但不限于肝硬化，通过鉴定方差或多态性人类EGF基因。特别地，本发明的方法涉及识别对发展中的癌症如HCC的易感性增加的受试者，其中受试者具有炎性疾病，例如但不限于肝硬化，并且该受试者被鉴定为具有单核苷酸多态性 61A> G在EGF基因的5'UTR中。或者，本发明的方法涉及识别对发展中的癌症如HCC的易感性增加的受试者，其中受试者具有炎症性疾病，例如但不限于肝硬化，并且该受试者被鉴定为具有增加的EGF表达作为与EGF表达的参考水平相比。本发明还涉及通过本文公开的方法对被鉴定为具有增加的发展癌症易感性（例如HCC）的受试者施用有效量的抗癌疗法，以及用于鉴定具有61A> G多态性的受试者的试剂盒 EGF基因的5'UTR或试剂盒以确定慢性炎性疾病受试者中EGF表达的增加。

2. 发明申请

US20110263441A1 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS 审中-公开
标题翻译：组合物，用途及方法，用于鉴别，评估，预防和治疗HEPATIC DISORDERS
公开(公告)号：US20110263441A1
公开(公告)日：2011-10-27
申请号：US13124487
申请日：2009-10-15
申请人： Todd R. Golub , Yujin Hoshida , Bryan C. Fuchs , Kenneth K. Tanabe , Josep M. Llovet Bayer , Augusto Villanueva
发明人： Todd R. Golub , Yujin Hoshida , Bryan C. Fuchs , Kenneth K. Tanabe , Josep M. Llovet Bayer , Augusto Villanueva
IPC分类号： C40B30/00 , G01N33/566 , C40B40/10 , C12Q1/34 , C12Q1/48 , C40B40/06 , C12Q1/68 , C12Q1/26
CPC分类号： G01N33/57438 , G01N2800/08 , G01N2800/50
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating hepatic disorders such as hepatocellular carcinoma and/or cirrhosis. A variety of informative biomarkers corresponding thereto, are provided, wherein alterations in expression relative to a control is correlated with the presence of a hepatic disorder, likelihood of survival from a hepatic disorder, and likelihood of recurrence of a hepatic disorder.
摘要翻译：本发明涉及用于检测，表征，预防和治疗肝脏疾病如肝细胞癌和/或肝硬化的组合物，试剂盒和方法。提供了与其对应的各种信息性生物标志物，其中相对于对照的表达的改变与肝脏疾病的存在，肝脏疾病的存活可能性和肝脏疾病的复发的可能性相关。

3. 发明授权

US06312426B1 Method and system for performing plate type radiofrequency ablation 失效
标题翻译：执行板式射频消融的方法和系统
公开(公告)号：US06312426B1
公开(公告)日：2001-11-06
申请号：US08866765
申请日：1997-05-30
申请人： S. Nahum Goldberg , Kenneth K. Tanabe , William J. Rittman, III , Eric R. Cosman
发明人： S. Nahum Goldberg , Kenneth K. Tanabe , William J. Rittman, III , Eric R. Cosman
IPC分类号： A61B1804
CPC分类号： A61B18/1445 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/142 , A61B2090/3782
摘要： A method and apparatus for inducing large volume heat ablations of tissue in a patient involving electrodes that are in contact with the patient's external surface or the surface of an internal organ. A high frequency signal or output from a generator is applied to the tissue near the area electrodes by connection of the generator to the electrodes. Various applications and configurations of electrodes and temperature monitoring are appropriate for different clinical needs and thermal distributions. The use for interoperative ablation of a tumor site within an internal organ or for ablation of a tumor from electrodes placed on the surface of the patient provides a clinical advantage.
摘要翻译：一种用于诱导患者中组织的大量热消融的方法和装置，其涉及与患者的外表面或内脏器官的表面接触的电极。通过将发生器连接到电极，来自发生器的高频信号或输出被施加到区域电极附近的组织。电极和温度监测的各种应用和配置适用于不同的临床需要和热分布。用于内部器官中的肿瘤部位的术中消融或用于放置在患者表面上的电极消融肿瘤的用途提供临床优点。

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