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1. 发明授权

US3959074A Vaccine production 失效
标题翻译：疫苗生产
公开(公告)号：US3959074A
公开(公告)日：1976-05-25
申请号：US530109
申请日：1974-12-06
申请人： William J. Miller , Raymond E. Spier , William J. McAleer
发明人： William J. Miller , Raymond E. Spier , William J. McAleer
IPC分类号： C12N5/00 , A61K39/12 , A61K39/20 , C12B1/00 , C12K7/00
CPC分类号： C12N5/0018
摘要： A process for the controlled manufacture of cells and vaccines in which reproducable real time quantitative assays are utilized to ascertain the physical and chemical state of the system, in order to more efficiently manage the system, so that cell sheet formation may be determined and the vaccine may be harvested at its maximum titre, thereby resulting in significantly increased yields and decreased production costs.
摘要翻译：用于控制制造细胞和疫苗的方法，其中利用可重复的实时定量测定法来确定系统的物理和化学状态，以便更有效地管理系统，从而可以确定细胞片形成并且疫苗可以以其最大滴定度收获，从而导致产量显着增加并降低生产成本。

2. 发明授权

US4234564A Hepatitis B core antigen composition 失效
标题翻译：乙型肝炎核心抗原组成
公开(公告)号：US4234564A
公开(公告)日：1980-11-18
申请号：US861809
申请日：1977-12-19
申请人： William J. McAleer , William J. Miller , Edward H. Wasmuth
发明人： William J. McAleer , William J. Miller , Edward H. Wasmuth
IPC分类号： A61K39/00 , C07K14/02 , G01N33/576 , A61K39/29 , C12N7/00 , G01N33/54
CPC分类号： C07K14/005 , G01N33/5762 , A61K39/00 , C12N2730/10122 , Y10S436/82
摘要： Compositions comprising HB.sub.s Ag and a physiologically acceptable medium are useful as diagnostic and immunologic agents.
摘要翻译：包含HBsAg和生理学上可接受的培养基的组合物可用作诊断和免疫剂。

3. 发明授权

US4102996A Method of preparing hepatitis B core antigen 失效
标题翻译：乙型肝炎核心抗原的制备方法
公开(公告)号：US4102996A
公开(公告)日：1978-07-25
申请号：US789033
申请日：1977-04-20
申请人： William J. McAleer , William J. Miller , Edward H. Wasmuth
发明人： William J. McAleer , William J. Miller , Edward H. Wasmuth
IPC分类号： A61K39/29 , A61K39/00 , A61K39/42 , C07K14/02 , G01N33/576 , A61K39/12 , C12K7/00
CPC分类号： C07K14/005 , G01N33/5762 , A61K39/00 , C12N2730/10122 , Y10S435/961
摘要： HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
摘要翻译： HBcAg通过用HBsAg阳性供体的流体的等压条带分离来分离丹烷颗粒，任选但优选地颗粒化丹麦颗粒，然后通过使丹烷颗粒与具有约15至约35个氧化乙烯单元的非离子表面活性剂接触来除去表面抗原存在还原剂如巯基乙醇。分离的核心抗原用作诊断和免疫剂。

4. 发明授权

US4382076A Hepatitis A antibody assay 失效
标题翻译：甲型肝炎抗体测定
公开(公告)号：US4382076A
公开(公告)日：1983-05-03
申请号：US383668
申请日：1982-06-01
申请人： William M. Hurni , William J. Miller , William J. McAleer
发明人： William M. Hurni , William J. Miller , William J. McAleer
IPC分类号： G01N33/576 , G01N33/48 , G01N33/54 , C12Q1/70
CPC分类号： G01N33/5768 , Y10S435/961 , Y10S435/962 , Y10S436/804 , Y10S436/82
摘要： A diagnostic reagent for hepatitis A antibody is prepared by adhering hepatitis A antibody to a surface by non-specific adsorption followed by specific coupling of hepatitis A antigen to the antibody. This reagent is useful in an in vitro assay for hepatitis A antibody.
摘要翻译：通过非特异性吸附将甲型肝炎抗体粘附到表面，然后将甲型肝炎抗原与抗体特异性偶联来制备用于甲型肝炎抗体的诊断试剂。该试剂可用于甲型肝炎抗体的体外测定。

5. 发明授权

US4329424A Macroscopic method for determining cytopathic effects in viral assay 失效
标题翻译：用于确定病毒测定中细胞病变效应的宏观方法
公开(公告)号：US4329424A
公开(公告)日：1982-05-11
申请号：US881299
申请日：1978-02-27
申请人： Roy A. Machlowitz , William J. McAleer , William J. Miller
发明人： Roy A. Machlowitz , William J. McAleer , William J. Miller
IPC分类号： C12Q1/70 , G01N1/28 , G01N1/30 , G01N33/54
CPC分类号： C12Q1/70
摘要： Semi-automated assays for viral infectivity and an assay for serum neutralizing antibody content are based on staining the cells and macroscopic reading of the cytopathic effect.
摘要翻译：用于病毒感染性的半自动化测定和血清中和抗体含量的测定是基于细胞的染色和细胞病变效应的宏观读数。

6. 发明授权

US4293538A Assay for hepatitis A antigen 失效
标题翻译：甲型肝炎抗原测定
公开(公告)号：US4293538A
公开(公告)日：1981-10-06
申请号：US31712
申请日：1979-04-20
申请人： William J. McAleer , William M. Hurni , William J. Miller
发明人： William J. McAleer , William M. Hurni , William J. Miller
IPC分类号： G01N33/576 , G01N33/48 , A61K43/00 , G01T1/00
CPC分类号： G01N33/5768 , Y10S436/81 , Y10S436/82
摘要： Liquid containing hepatitis A antibody is adsorbed on a surface. The surface is then coated with a proteinaceous material and incubated in the presence of the sample to form a complex of hepatitis A antigen and hepatitis A antibody. The complex is incubated again in the presence of excess radioactively labelled hepatitis A antibody, and the resulting radionuclide is measured.
摘要翻译：含有甲型肝炎抗体的液体被吸附在表面上。然后将表面用蛋白质材料包被，并在样品存在下孵育以形成甲型肝炎抗原和甲型肝炎抗体的复合物。在过量放射性标记的甲型肝炎抗体存在下再次培养该复合物，并测量所得的放射性核素。

7. 发明授权

US4617260A RIA assay for HBcAg 失效
标题翻译： HBcAg的RIA检测
公开(公告)号：US4617260A
公开(公告)日：1986-10-14
申请号：US238780
申请日：1981-02-27
申请人： William J. McAleer , William J. Miller
发明人： William J. McAleer , William J. Miller
IPC分类号： G01N33/545 , G01N33/576 , C12Q1/70
CPC分类号： G01N33/545 , G01N33/5762 , Y10S435/948 , Y10S435/975 , Y10S436/804 , Y10S436/811 , Y10S436/82 , Y10S436/823
摘要： HBcAb in a biological fluid is adsorbed on a surface which is then coated with BSA. The coated surface is then incubated first in the sample and then in the presence of radiolabelled HBcAb.
摘要翻译：生物流体中的HBcAb被吸附在表面上，然后用BSA包被。然后将涂覆的表面首先在样品中孵育，然后在放射性标记的HBcAb存在下孵育。

8. 发明授权

US4296024A Human immune serum globulin with high hepatitis A antibody titer 失效
标题翻译：具有高甲型肝炎抗体滴度的人免疫血清球蛋白
公开(公告)号：US4296024A
公开(公告)日：1981-10-20
申请号：US1133
申请日：1979-01-05
申请人： William J. McAleer , William J. Miller
发明人： William J. McAleer , William J. Miller
IPC分类号： G01N33/576 , C07G7/00
CPC分类号： G01N33/5768 , Y10S514/894 , Y10S530/806 , Y10S530/83
摘要： An immune adherence hemagglutination assay for detection of hepatitis A antigen or antibody. Plasma having known high titer of hepatitis A antibody, and gamma globulin having known high titer of hepatitis A antibody.
摘要翻译：用于检测甲型肝炎抗原或抗体的免疫粘附血细胞凝集试验。具有已知高滴度甲型肝炎抗体的血浆和具有已知高滴度甲型肝炎抗体的γ球蛋白。

9. 发明授权

US4241175A Assay for hepatitis B core antibody 失效
标题翻译：测定乙型肝炎核心抗体
公开(公告)号：US4241175A
公开(公告)日：1980-12-23
申请号：US970721
申请日：1978-12-18
申请人： William J. Miller , William J. McAleer , Lynn T. Callahan
发明人： William J. Miller , William J. McAleer , Lynn T. Callahan
IPC分类号： G01N33/576 , C12Q1/66
CPC分类号： G01N33/5762 , Y10S435/81 , Y10S435/964
摘要： HB.sub.c Ab is detected in biological fluid by contacting HB.sub.c Ag derived from Dane particles and adhered to a surface with the biological fluid and an antibody-enzyme conjugate. The HB.sub.c Ag is adhered to the surface in the presence of a nonionic surfactant.
摘要翻译： HBcAb通过接触衍生自Dane颗粒的HBcAg并与生物流体和抗体 - 酶结合物粘附在表面上而在生物流体中检测。 HBcAg在非离子表面活性剂存在下粘附在表面上。

10. 发明授权

US4861706A Assay for hepatitis a virus 失效
标题翻译：甲型肝炎病毒检测
公开(公告)号：US4861706A
公开(公告)日：1989-08-29
申请号：US857695
申请日：1986-04-29
申请人： William M. Hurni , William J. Miller , William J. McAleer
发明人： William M. Hurni , William J. Miller , William J. McAleer
IPC分类号： A61K39/29 , C12Q1/70
CPC分类号： C12Q1/706 , Y10S435/948
摘要： A quantitative assay for HAV comprises infecting at a temperature of from about 30.degree. to about 37.degree. C. a cell sheet with a dilution series of hepatitis A virus and then adding Newcastle disease virus (NDV) to the infected cell sheet and incubating the infected cell sheet in the presence of NDV at an elevated temperature for a time sufficient to permit a cytopathic effect (CPE) to become manifest, this time typically being at least about 4 days and preferably about 5 days. At an incubation temperature of from about 31.degree. to about 33.degree. C. the absence of CPE indicates the presence of HAV and the presence of CPE indicates the absence of HAV. At an incubation temperature of from about 34.degree. to about 36.degree. C. the absence of CPE indicates the absence of HAV and the presence of CPE indicates the presence of HAV.
摘要翻译：用于HAV的定量测定包括在约30℃至约37℃的温度下感染具有稀释系列的甲型肝炎病毒的细胞片，然后向感染的细胞片中加入新城疫病毒（NDV）并孵育感染的细胞片在NDV存在下在升高的温度下持续足以允许细胞病变效应（CPE）变得明显的时间，此时通常为至少约4天，优选约5天。在约31℃至约33℃的温育温度下，不存在CPE表明存在HAV，而CPE的存在表明不存在HAV。在约34℃至约36℃的培养温度下，不存在CPE表明不存在HAV，且CPE的存在表明存在HAV。

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