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1. 发明授权

US5376313A Injection molding a plastic assay cuvette having low birefringence 失效
标题翻译：注射成型具有低双折射率的塑料分析试管
公开(公告)号：US5376313A
公开(公告)日：1994-12-27
申请号：US915162
申请日：1992-07-20
申请人： William J. Kanewske, III , James A. Vaught , Richard L. Vickstrom , Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry E. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , David A. Yost
发明人： William J. Kanewske, III , James A. Vaught , Richard L. Vickstrom , Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry E. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , David A. Yost
IPC分类号： G01N21/64 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04
CPC分类号： H01J49/04 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1065 , Y10S435/809 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A plastic assay cuvette having the desired optical properties for the analysis of a test sample or reaction mixture thereof, and a method for making such plastic assay cuvette, are described. The optical properties of the plastic assay cuvette are substantially the same as the optical properties of glass wherein low birefringence throughout the optical read region thereof is provided. When used for the analysis of a test sample or reaction mixture thereof, such as in fluorescence polarization assays and absorbance assays, the plastic assay cuvette provides accurate and reproducible results while, at the same time, provides a low-cost disposable assay cuvette which can be used in place of conventional glass assay cuvettes.
摘要翻译：描述了具有用于分析测试样品或其反应混合物的所需光学性质的塑料分析比色皿以及制备这种塑料分析比色杯的方法。塑料分析试管的光学性质与玻璃的光学性质基本相同，其玻璃的光学读取区域的双折射率低。当用于分析测试样品或其反应混合物时，例如在荧光偏振测定和吸光度测定中，塑料分析比色杯提供精确和可重现的结果，同时提供了一种低成本的一次性分析比色杯，其可以用于代替常规玻璃分析比色皿。

2. 发明授权

US5578494A Cap actuator for opening and closing a container 失效
标题翻译：用于打开和关闭容器的盖致动器
公开(公告)号：US5578494A
公开(公告)日：1996-11-26
申请号：US600321
申请日：1996-02-13
申请人： Frederic L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
发明人： Frederic L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
IPC分类号： B01F11/00 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04 , B65D51/04
CPC分类号： B01L3/08 , B01F11/0022 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N21/645 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , H01J49/04 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1004 , G01N35/1065 , Y10T436/11 , Y10T436/113332 , Y10T436/119163
摘要： The present invention is a method for opening and closing a cap pivotally mounted on a container for storing reagents for use in an automated analytical instrument. The cap has one end for sealing the container and a tab extending from the other end for pivoting the cap. The method comprises the steps of positioning a closed container adjacent an actuating device mounted on the analytical system. The method further comprises the steps of projecting the actuating device against the top of the tab to pivotally open the cap to a position sufficiently vertical for aspirating reagent from the container, and retracting the actuating device from the cap to a position above the pivotal mounting thereof. The method comprises the final step of causing relative motion between the cap and the actuating device so that the actuating device drags along the top of the cap pivotally closing the cap to provide a sufficient seal on the container preventing evaporation of the reagent therefrom.
摘要翻译：本发明是一种用于打开和关闭枢转地安装在用于存储用于自动分析仪器的试剂的容器上的盖的方法。盖具有用于密封容器的一端和从另一端延伸以突出盖的突片。该方法包括以下步骤：将密封容器定位在安装在分析系统上的致动装置附近。该方法还包括以下步骤：将致动装置突出于突片的顶部，以将帽旋转到足够垂直的位置以从容器吸出试剂，并将致动装置从帽缩回到其枢转安装件上方的位置。该方法包括在帽和致动装置之间引起相对运动的最后步骤，使得致动装置沿着盖的顶部拖动，枢转地闭合盖，以在容器上提供足够的密封，防止试剂从其中蒸发。

3. 发明授权

US5575978A Sample container segment assembly 失效
标题翻译：样品容器段装配
公开(公告)号：US5575978A
公开(公告)日：1996-11-19
申请号：US176551
申请日：1994-01-03
申请人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
发明人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
IPC分类号： B01F11/00 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04
CPC分类号： B01F11/0022 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N21/6445 , G01N21/645 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , H01J49/04 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1004 , G01N35/1065 , Y10S215/03 , Y10T436/11 , Y10T436/113332
摘要： A sample container segment assembly for use in an automated, continuous, and random access analytical system is disclosed. The assembly includes a sample container which is received by a sample container segment, and the sample container segment is received on a carousel of the automated analytical instrument. The test sample container includes an upper skirt and a body having a reservoir for receipt of the test sample. The segment includes a base, a frame, and a handle. The frame has a shelf for which the upper skirt of the test sample container rests on, and has openings for receipt of the body of the sample container. The carousel has a carousel trough for receipt of the base of the sample container segment, and has a plurality of alignment pins disposed in the carousel trough. The base of the sample container segment has a circular slot and an elongated slot for receiving the alignment pins and positioning the sample container segment relative to the carousel. The sample container segment can include a liquid level sensing sleeve which is made of a conductive material and surrounds the reservoir of the test sample container inserted therein. Alternatively, the test sample container can have a conductive core which surrounds the reservoir and extends therebelow. The container sample segment can also include various sleeves, or springs and arms, for securing and positioning the test sample container within the sample container segment.
摘要翻译：公开了一种用于自动化，连续和随机存取分析系统的样品容器段组件。组件包括由样品容器段接收的样品容器，并且样品容器段被接收在自动分析仪器的转盘上。测试样本容器包括上裙部和具有用于接收测试样品的容器的主体。该段包括基座，框架和手柄。框架具有搁置测试样本容器的上裙部的搁架，并且具有容纳样本容器的主体的开口。转盘具有用于接收样品容器段的底部的转盘槽，并且具有设置在转盘槽中的多个对准销。样品容器段的底部具有圆形狭槽和用于接收对准销并且相对于转盘定位样品容器段的细长槽。样品容器段可包括由导电材料制成并围绕插入其中的测试样品容器的储存器的液位感测套筒。或者，测试样本容器可以具有包围储存器并在其下方延伸的导电芯。容器样品片段还可以包括各种套筒或弹簧和臂，用于将测试样品容器固定并定位在样品容器段内。

4. 发明授权

US5635364A Assay verification control for an automated analytical system 失效
标题翻译：自动分析系统的分析验证控制
公开(公告)号：US5635364A
公开(公告)日：1997-06-03
申请号：US176173
申请日：1994-01-03
申请人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
发明人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
IPC分类号： B01F11/00 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04 , G01N33/546
CPC分类号： B01F11/0022 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N21/645 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , H01J49/04 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1004 , G01N35/1065 , Y10S435/962 , Y10S435/967 , Y10S436/805 , Y10T436/11
摘要： A method for verifying that an assay methodology is properly performed, that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.
摘要翻译：描述了用于验证测定方法被适当地进行的方法，所用的测定试剂具有用于精确地进行这种测定方法学的必要的效力，以及测试样品或测定试剂是否被篡改或掺杂。该方法通过采用包含正分析物组分和待分析的测试样品的测定验证样品进行，其中使用相同的测定试剂和用于分析测试样品的基本相同的测定方法分析测定验证样品。该方法对于在自动连续和随机存取分析系统上进行异质免疫测定特别有用。

5. 发明授权

US5610069A Apparatus and method for washing clinical apparatus 失效
标题翻译：用于洗涤临床装置的装置和方法
公开(公告)号：US5610069A
公开(公告)日：1997-03-11
申请号：US549020
申请日：1995-10-27
申请人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
发明人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny R. Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
IPC分类号： B01F11/00 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04
CPC分类号： G01N35/0092 , B01F11/0022 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/6445 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/025 , H01J49/04 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1004 , G01N35/1065 , Y10T436/114998 , Y10T436/115831 , Y10T436/12
摘要： A method and apparatus for washing clinical apparatus is disclosed. The apparatus is a device for washing clinical apparatus, wherein the clinical apparatus is employed, at different times, to contain a first test substance during a first testing step and a second test substance during a second testing step subsequent to the first testing step. The apparatus comprises a device for supplying a wash solution to the apparatus, and for varying the quantity of the wash solution supplied to the apparatus. The apparatus further comprises a control unit for controlling the device for varying quantity to vary the quantity of the wash solution in proportion to the potential for contamination between the first test substance and the second test substance contained in the apparatus.
摘要翻译：公开了一种用于洗涤临床装置的方法和装置。该装置是用于洗涤临床装置的装置，其中在第一测试步骤之后的第二测试步骤期间，临床装置在不同时间被使用以在第一测试步骤期间包含第一测试物质和第二测试物质。该装置包括用于将洗涤溶液供应到该装置并用于改变供应给该装置的洗涤溶液的量的装置。该装置还包括一个控制单元，用于控制装置的变化量，以便与包含在装置中的第一测试物质和第二测试物质之间的污染可能性成比例地改变洗涤溶液的量。

6. 发明授权

US5762878A Sample container segment assembly 失效
公开(公告)号：US5762878A
公开(公告)日：1998-06-09
申请号：US713553
申请日：1996-09-09
申请人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny Ray Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
发明人： Frederick L. Clark , Kendall B. Hendrick , Richard R. Martin , Larry W. Moore , William J. Raymoure , Paul R. Schrier , Edna S. Walker , Donny Ray Walker , Gary E. Winter , Kevin M. Cloonan , David A. Yost , John M. Clemens , William J. Kanewske, III , Douglas D. McDowell , Carl M. Oleksak , William D. Rumbaugh , B. Jane Smith , James A. Vaught , Apparao Tayi , Robert A. Wohlford , James E. Mitchell , Robert B. Hance , Peter A. Lagocki , Richard A. Merriam , Charles D. Pennington , Linda S. Schmidt , Adrian M. Spronk , Richard L. Vickstrom , William E. Watkins, III , Gilbert Clift , Alyn K. Stanton , David B. Hills
IPC分类号： B01F11/00 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/64 , G01N21/76 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04
CPC分类号： B01F11/0022 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N21/6445 , G01N21/645 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , H01J49/04 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1004 , G01N35/1065 , Y10S215/03 , Y10T436/11 , Y10T436/113332
摘要： A sample container segment assembly for use in an automated, continuous, and random access analytical system is disclosed. The assembly includes a sample container which is received by a sample container segment, and the sample container segment is received on a carousel of the automated analytical instrument. The test sample container includes an upper skirt and a body having a reservoir for receipt of the test sample. The segment includes a base, a frame, and a handle. The frame has a shelf for which the upper skirt of the test sample container rests on, and has openings for receipt of the body of the sample container. The carousel has a carousel trough for receipt of the base of the sample container segment, and has a plurality of alignment pins disposed in the carousel trough. The base of the sample container segment has a circular slot and an elongated slot for receiving the alignment pins and positioning the sample container segment relative to the carousel. The sample container segment can include a liquid level sensing sleeve which is made of a conductive material and surrounds the reservoir of the test sample container inserted therein. Alternatively, the test sample container can have a conductive core which surrounds the reservoir and extends therebelow. The container sample segment can also include various sleeves, or springs and arms, for securing and positioning the test sample container within the sample container segment.

7. 发明授权

US5358691A Automated continuous and random access analytical system 失效
标题翻译：自动连续随机存取分析系统
公开(公告)号：US5358691A
公开(公告)日：1994-10-25
申请号：US126447
申请日：1993-09-24
申请人： Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry W. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
发明人： Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry W. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
IPC分类号： G01N21/64 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04 , G01N35/06
CPC分类号： H01J49/04 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1065 , Y10S435/809 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.
摘要翻译：一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定时间段被披露。还公开了一种操作自动连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并分别转移将第一液体样品和试剂加入到反应容器中，而不引发测定反应顺序，随后将单位剂量一次性物理转移到加工工作站，由此在孵育期间实现单位剂量的一次性试剂和样品的混合物。该系统能够以任何顺序执行多于一次的计划分析，以及多于此类计划测定的测定。自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

8. 发明授权

US5482861A Automated continuous and random access analytical system 失效
标题翻译：自动连续随机存取分析系统
公开(公告)号：US5482861A
公开(公告)日：1996-01-09
申请号：US222520
申请日：1994-04-04
申请人： Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry W. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
发明人： Frederic L. Clark , Gilbert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry W. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
IPC分类号： G01N21/64 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04
CPC分类号： H01J49/04 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1065 , Y10S435/809 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.
摘要翻译：一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定时间段被披露。还公开了一种操作自动连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并分别转移将第一液体样品和试剂加入到反应容器中，而不引发测定反应顺序，随后将单位剂量一次性物理转移到加工工作站，由此在孵育期间实现单位剂量的一次性试剂和样品的混合物。该系统能够以任何顺序执行多于一次的计划分析，以及多于此类计划测定的测定。自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。

9. 发明授权

US5451528A Methods for providing homogeneous reagents 失效
标题翻译：提供均相试剂的方法
公开(公告)号：US5451528A
公开(公告)日：1995-09-19
申请号：US916737
申请日：1993-08-20
申请人： William J. Raymoure , Frederic L. Clark , Gibert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry E. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
发明人： William J. Raymoure , Frederic L. Clark , Gibert Clift , Kendall B. Hendrick , William J. Kanewske, III , Peter A. Lagocki , Richard R. Martin , James E. Mitchell , Larry E. Moore , Charles D. Pennington , Edna S. Walker , B. Jane Smith , Apparao Tayi , James A. Vaught , David A. Yost
IPC分类号： G01N21/64 , B01L3/00 , B01L3/08 , B01L9/06 , B29C45/00 , G01N1/00 , G01N21/03 , G01N21/25 , G01N21/27 , G01N21/49 , G01N21/59 , G01N33/53 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H01J49/04 , G01N33/546
CPC分类号： H01J49/04 , B01L3/08 , B01L3/5025 , B01L3/50853 , B29C45/00 , G01N21/03 , G01N21/253 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0092 , G01N35/025 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B01L3/5085 , B01L9/06 , B29K2995/0032 , B29L2023/22 , G01N2001/007 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , G01N35/0099 , G01N35/1065 , Y10S435/809 , Y10S436/807 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A method for modifiying a liquid assay reagent to provide prolonged homogeneity thereof, particularly where the liquid assay reagent comprises microparticles for performing a heterogeneous immunoassay, is provided wherein the addition of an inert material to a liquid assay reagent achieves neutral density to thereby prolong the homogeneity thereof for extended periods of time. A method for the automated agitation of assay reagents to maintain the homogeneity thereof with an automated, continuous and random access analytical instrument is also provided. The automated mixing is accomplished by a back and forth motion of a carousel onto which assay reagent containers or packs are mounted with asymmetric pauses which can be completed within a short period of time. The carousel acceleration, velocity, distance moved, and pause-asymmetry are optimized to provide rapid assay reagent resuspension without foaming or bubble formation. Accordingly, periodic removal of assay reagent packs by an operator in order to mix the reagents is not necessary.
摘要翻译：提供了一种用于修饰液体测定试剂以提供其延长的均匀性的方法，特别是在液体测定试剂包含用于进行非均相免疫测定的微粒的情况下，其中向液体测定试剂中加入惰性物质达到中性密度从而延长均匀性延长时间。还提供了一种用于自动搅拌测定试剂以保持其与自动化，连续和随机存取分析仪器的均匀性的方法。自动化混合是通过旋转木马的来回运动完成的，在该转盘上，分析试剂容器或包装件以不对称的停顿方式安装在该转盘上，可以在短时间内完成。旋转木马加速度，速度，移动距离和暂停不对称性被优化，以提供快速的测定试剂重悬浮而没有起泡或气泡形成。因此，为了混合试剂，由操作者定期去除测定试剂包是不必要的。

10. 发明授权

US5210040A Process for coupling antibodies or antibody fragments to liposomes 失效
标题翻译：将抗体或抗体片段与脂质体偶联的方法
公开(公告)号：US5210040A
公开(公告)日：1993-05-11
申请号：US485395
申请日：1990-02-22
申请人： Yi-Her Jou , Roger C. Hu , Peter A. Lagocki
发明人： Yi-Her Jou , Roger C. Hu , Peter A. Lagocki
IPC分类号： G01N33/543 , G01N33/58 , G01N33/68 , G01N33/76
CPC分类号： G01N33/6857 , G01N33/5432 , G01N33/586 , G01N33/76 , Y10S436/829
摘要： The present invention provides for novel homogeneous immunoassay systems involving complement-mediated lysis of marker-encapsulating lipid vesicles (liposomes) for detection of analyte in a fluid sample. These systems do not require the separation of unbound antigens and/or antibody conjugates yet provide highly sensitive procedures for analyte detection. Liposomes containing a marker, are coupled to antibody fragments in a way which confers the liposomes with immunological specificity yet avoids sensitizing the liposomes to complement mediated lysis in the absence of analyte. Antibody sensitized liposomes (the first reagent) are sequentially incubated with an analyte-containing sample, and optionally "dummy" liposomes, which do not contain encapsulated marker, a second antibody (the second reagent), and finally with a complement source such as plasma. Complement is activated by the liposome-antibody-antigen-second antibody complex causing liposome lysis and a concomitant release of marker. Also provided are methods for preparing antibody sensitized liposomes in the presence of a polysaccharide capable of forming a reversible gel and methods for preparing derivatized Fab' antibody fragments for coupling to lipid vesicles.
摘要翻译：本发明提供了用于检测流体样品中分析物的补体介导的用于标记包封的脂质囊泡（脂质体）的裂解的均相免疫测定系统。这些系统不需要分离未结合的抗原和/或抗体缀合物，同时为分析物检测提供高度敏感的程序。含有标记物的脂质体以使得脂质体具有免疫特异性的方式与抗体片段偶联，而避免在不存在分析物的情况下使脂质体对致敏介导的裂解进行敏化。将抗体致敏脂质体（第一试剂）与含分析物的样品和任选的“虚拟”脂质体（其不包含包封标记物），第二抗体（第二试剂），最后用补体来源例如血浆。补体由脂质体 - 抗体 - 抗原 - 第二抗体复合物激活，引起脂质体溶解和伴随释放标记物。还提供了在能够形成可逆凝胶的多糖存在下制备抗体致敏脂质体的方法以及用于制备用于偶联至脂质囊泡的衍生化Fab'抗体片段的方法。

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